Dinal
@ddu.ac.in
Assistant professor, Faculty of Pharmacy, Dharmsinh Desai University
Faculty of Pharmacy, Dharmsinh Desai University
RESEARCH INTERESTS
Pharmacy
Scopus Publications
Scopus Publications
Dinal V. Patel, Mansi Dholakia, Harshida Chauhan, and Bhanubhai N. Suhagia
Bentham Science Publishers Ltd.
Aim: The present study developed an oral in-situ gel containing the leaf extract of Tarax-acum officinale (T.O.) using an experimental design. Background: Peptic ulcer disease was an epidemic in the 19th and early 20th centuries. The applica-tion of herbal drugs for peptic diseases is an attractive area for research and implementation as compared to the allopathic system in the recent era. From the number of plants, the antioxidant effect of an aqueous extract of Taraxacum officinale, which is the dandelion leaf, was proven by an animal study in previous literature. However, most of the marketed preparations consist of root ex-tract primarily used for the detoxification of the liver in comparison to the leaf extract having a non-specific application. Hence, the aqueous extract of dandelion leaf was taken as the active ingredient in the formulation. Over the past 30 years, greater attention has been given to the development of controlled and sustained drug delivery systems. The development of in situ gel systems has received considerable attention over the past few years due to the number of advantages. Objective: By considering the merits of herbal ingredients with drug delivery technology, herbal in-situ gel was developed using statistical analysis. Methods: Herbal in-situ oral gel was developed using a factorial design. The concentration of sodi-um alginate, xanthan gum, and HPMC K15 M was taken as the factors, and viscosity and drug re-lease (total phenol content) in 10 h were selected as the responses. By evaluating the designed batches, the optimized batch was chosen as the promising formulation for curing the peptic ulcer. Results: The batch consisting of 1.711% w/v sodium alginate, 0.727% w/v xanthan gum, and 0.869% w/v HPMC K15M was selected as the optimized batch, as per the software, and the viscosi-ty and % drug release in 10 h were found to be 299.5 cps and 70.2%, respectively. Other evaluation parameters such as gelling capacity, floating parameters, and stability were also found to be good for the designed batches. Conclutions: The improved in-situ gel was found to be effective for extending the floating of the drug incorporated into the formulation as well as the residence time in the stomach for sustained drug release.
Dinal V. Patel, Mehul N. Patel, Mansi S. Dholakia, and B.N. Suhagia
Elsevier BV
Dinal Patel, Mehul Patel, Tejal Soni, and Bhanubhai Suhagia
Elsevier BV
Dinal Patel and Viral Patel
Informa UK Limited
Abstract The rabble-rousing skin condition can be conventionally treated, but due to some demerits, there is a need to find a novel approach with an appropriate release profile. The research work narrates the optimization of the topical delivery system of Fluocinolone acetonide loaded in pluronic lecithin organogel. The preliminary studies were carried out and, the ternary phase diagram was established by Chemix school version 3.60. The formulation was optimized by taking a different concentration of polymers as independent and viscosity and drug release (6 h) as dependent variables by applying 32 full factorial design. The optimized batch was further compared with marketed preparation and also kept for the stability study. The release profile of the optimized batch exhibited a sustained release of up to 6 h (77.00%). It gave ex vivo drug release up to 6 h (90.64%) which is more prolonged than marketed preparation and, cutaneous disposition was found to be higher. Besides, the texture analysis was compared to that of the marketed formulation of the drug. However, the proof of the effectiveness of the formulated pluronic lecithin organogel will require further in vivo study for future aspects. In a nutshell, the proposed formulation of fluocinolone acetonide is the simplest and promising dosage form for the treatment of psoriasis.
DDinal Patel, VNirav Patel, TVaishali Thakkar, and RTejal Gandhi
Medknow
Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In present work, mucoadhesive chitosan microspheres of Levosalbutamol sulphate were prepared by Spray drying method. Formulations were characterized for various physicochemical attributes size, encapsulation efficiency, swelling ability, in vitro release study and mucoadhesion study by rat ileum. Through these parameters we conclude that the batch B2 was found to be best mainly by mucoadhesion study and in vitro drug release. Mucoadhesion was found to be increased with incresed concentration of polymer and visa versa in case of drug release. Batch B3 had also similar results with that of Batch B2. That's why here Batch B2 was said to be the best batch with less polymeric content as compare to Batch B3.