Magnesium Aluminum Silicate Nanoparticles Functionalized with Carboxylic Acids as Hemostatic Agents Vishwa S, Marvaan M. S, S. Sudhakar, G. Devanand Venkatasubbu ACS Applied Nano Materials, 2026 Developing an affordable and effective inorganic hemostatic agent remains a priority for addressing trauma-related mortality, specifically in a low resource constrained environment. This paper describes the synthesis of magnesium aluminum silicate (MAS) via the coprecipitation method. It was surface modified with carboxylic functionalization (MASC) to enhance the interfacial activity with blood components. Structural and compositional analysis using XRD (X-ray diffraction), FTIR (Fourier transform infrared spectroscopy), HRSEM (high-resolution scanning electron microscopy), HRTEM (high-resolution transmission electron microscopy), EDS (energy-dispersive X-ray spectroscopy), and XPS (X-ray photoelectron spectroscopy) confirm the formation of an amorphous, layered silicate network with uniform elemental distribution and successful carboxylation. Zeta-potential analysis reveals a moderate negative charge, favoring electrostatic interaction with plasma proteins and platelets. In vitro assays demonstrate that both MAS and MASC significantly reduced blood clotting time, lowered prothrombin time (PT), activated partial thrombin time (aPTT), and promoted erythrocyte and thrombocyte aggregation in a concentration-dependent manner. Notably MASC exhibits enhanced procoagulant activity compared with MAS, expressing benefits of carboxylic surface modification. Both MAS and MASC show good hemocompatibility, indicating their suitability for blood-related applications. MAS-based nanomaterials could offer a valuable approach for managing severe bleeding in a clinical and emergency environment.
MoO3–Naringin-Loaded CMC/PVA/PVP Patch: A Rapid Biofunctional Wound Dressing Suresh Krishna. Pandian, Marvaan MS, Samantha Raj Sah, Balashanmugam Pannerselvam, G. Devanand Venkatasubbu ACS Applied Bio Materials, 2026 Chronic wounds result in extended healing durations and increased susceptibility to infections. Wound infections pose a major obstacle to the healing process. Dressings with improved antibacterial properties should be used to treat chronic, infected wounds. In this work, carboxymethyl cellulose (CMC), poly(vinyl alcohol) (PVA), and polyvinylpyrrolidone (PVP) were used to fabricate a polymeric patch with molybdenum oxide (MoO3) nanoparticles and naringin. Molybdenum oxide (MoO3) nanoparticles were synthesized using the wet chemical method and characterized by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The antibacterial activity of MoO3 was evaluated using diffusion, colony count, growth curve analysis, and biofilm disruption methods. Biocompatibility, swelling behavior, degradation rate, porosity, drug release profile, water vapor transmission rate (WVTR), and MTT and scratch assays were used to evaluate the fabricated polymer patches (CMC/PVA/PVP with and without MoO3 and naringin). In an in vivo wound healing study, the CMC/PVA/PVP/MoO3/naringin patch demonstrated enhanced healing, with 91% wound closure in 15 days in a full-thickness excisional wound model in Wistar rats.
Borate bioglass-incorporated xanthan hydrogel as an effective hemostat Vanshika Singh, Marvaan M. S., Vishwa S., Balashanmugan Panneerselvam, G. Devanand Venkatasubbu Rsc Advances, 2026 In borate bioglass-incorporating hemostasis hydrogels, clotting is facilitated by the release of ions such as boron, calcium, and sodium. Such hydrogels are biocompatible, biodegradable and ideal for hemostasis applications. Herein, we synthesized and characterized borate bioglass nanoparticles.
Accelerated wound healing by PrO2 incorporated PVA/SA fibers V. Ken Hiytesh, Dinesh Sivalingam, J. Prakash, M.S. Marvaan, Madasamy Sundar, Balashanmugan Pannerselvam, G. Devanand Venkatasubbu Journal of Industrial and Engineering Chemistry, 2024
