Mobile Phone Usage and Willingness to Use Mobile Phones to Support Medication Adherence and Receive Text Message Appointment Reminders in Older Outpatients With Type 2 Diabetes Huyen Thi Thanh Vu, Thu Thi Hoai Nguyen, Minh Ngoc Luu, Thuy Phuong Nguyen, Huong Thi Thu Nguyen, Tam Ngoc Nguyen, Thanh Xuan Nguyen, Linh Vu Huyen Ha, Huong Thi Thanh Nguyen, Janani Thillainadesan, Vasi Naganathan, Toan Thi Thanh Do, Anh Trung Nguyen Journal of Diabetes Science and Technology, 2026 Background: Information technology can be used to improve the management of non-communicable diseases, such as diabetes. This study aims to evaluate the willingness of older outpatients with type 2 diabetes to use mobile phones to support medication adherence and receive text message appointment reminders and investigated the factors associated with this willingness. Methods: This study was a cross-sectional study conducted at the outpatient department of Dong Da General Hospital. Participants aged 60 and over managed and treated for type 2 diabetes were asked about mobile phone usage. Data were also collected on sociodemographic information, diabetes characteristics, and medical history. Results: In the 584 study participants recruited, the mean age was 73.2 (SD: 8.3) years. Approximately 80% patients with diabetes had medium or high treatment adherence and 52.4% had hemoglobin A1c (HbAlc) < 7.5%. In the multilevel logistic regression analysis, the following factors were significantly associated with willingness to using phones to support medication adherence: college, university, or higher level (odds ratio [OR] = 2.35, 95% confidence interval [CI] = 1.10, 4.99), current smoking (OR = 5.40, 95% CI = 1.01, 28.94), whether they had a mobile phone and type of phone (basic phone: OR = 2.47, 95% CI = 1.42, 4.30; smartphone: OR = 17.93, 95% CI = 8.81, 36.47) . The following factors were significantly associated with willingness to receive these appointment reminders via mobile phone: whether they had a mobile phone and type of phone (basic phone: OR = 2.79, 95% CI = 1.70, 4.59; smartphone: OR = 9.61, 95% CI = 4.61, 19.99) and HbA1c < 7.5 (OR = 0.65, 95% CI = 0.43, 0.99). Conclusions: Our study would suggest that there is potential value in using mobile phone to improve the management of diabetes in community living older people but this alone cannot be relied upon.
Surveillance of adverse events following immunisation in Australia, 2023 Thuy Nguyen, Belinda Jones, Megan Hickie, Kristine Macartney, Nicholas Wood, Lucy Deng Communicable Diseases Intelligence 2018, 2026 This report summarises Australia’s spontaneous surveillance data for adverse events following immunisation (AEFI) for all vaccines administered in 2023, reported to the Therapeutic Goods Administration (TGA). This report combines coronavirus disease 2019 (COVID-19) and non-COVID-19 AEFI that were previously reported separately in 2022 and 2021.Overall, there were 5,534 AEFI reports for vaccines administered in 2023. This represents an annual AEFI reporting rate of 20.8 per 100,000 population, compared with 79.2 per 100,000 population in 2022. The sharp decrease in the AEFI reporting rate in 2023 was likely driven by a change in COVID-19 vaccination policy. This included limiting COVID-19 vaccine booster dose recommendation to high-risk populations rather than to the wider community, resulting in a steep decline in both the number of administered doses and the number of AEFIs reported. The most commonly reported adverse events were medication errors, injection site reaction, hypersensitivity, pyrexia, and gastrointestinal nonspecific symptoms. The most commonly reported adverse events for new vaccines introduced in 2023 were medication errors and headache for COVID-19 vaccines; hypersensitivity and pyrexia for DTPa-HepB-IPV-Hib vaccine (Vaxelis); and injection site reaction and hypersensitivity for recombinant zoster vaccine (Shingrix). There was reduction in deaths reported following vaccination in 2023 compared to 2022 and 2021. None of the 34 reported deaths in 2023 were determined to be causally related to the vaccine(s) received.
Bayesian spatio-temporal modelling of tuberculosis in Vietnam: Insights from a local-area analysis Long Viet Bui, Romain Ragonnet, Angus E. Hughes, Hoa Binh Nguyen, Nam Hoang Do, Emma S. McBryde, Justin Sexton, Thuy Phuong Nguyen, David S. Shipman, Greg J. Fox, James M. Trauer Epidemiology and Infection, 2025 Spatial analysis and disease mapping have the potential to enhance understanding of tuberculosis (TB) dynamics, whose spatial dynamics may be complicated by the mix of short and long-range transmission and long latency periods. TB notifications in Nam Dinh Province for individuals aged 15 and older from 2013 to 2022 were analyzed with a variety of spatio-temporal methods. The study commenced with an analysis of spatial autocorrelation to identify clustering patterns, followed by the evaluation of several candidate Bayesian spatio-temporal models. These models varied from simple assessments of spatial heterogeneity to more complex configurations incorporating covariates and interactions. The findings highlighted a peak in the TB notification rate in 2017, with 98 cases per 100,000 population, followed by a sharp decline in 2021. Significant spatial autocorrelation at the commune level was detected over most of the 10-year period. The Bayesian model that best balanced goodness-of-fit and complexity indicated that TB trends were associated with poverty: each percentage point increase in the proportion of poor households was associated with a 1.3% increase in TB notifications, emphasizing a significant socioeconomic factor in TB transmission dynamics. The integration of local socioeconomic data with spatio-temporal analysis could further enhance our understanding of TB epidemiology.
Tobacco retail availability and smoking—A systematic review and meta-analysis Veronica Martin‐Gall, Amanda Neil, Kate Macintyre, Sabah Rehman, Thuy Phuong Nguyen, Ben Harding, Seana Gall Drug and Alcohol Review, 2024 IssuesHealth policy makers worldwide have adopted evidence‐based legislation, largely directed at consumers, to reduce tobacco‐related harm. It is suggested that limiting supply by decreasing retail availability can also reduce cigarette smoking. To inform policy makers this systematic literature review assesses whether reducing availability is associated with smoking behaviours.ApproachSystematic literature searches of five databases were carried out up to January 2023. Included studies had at least one exposure (tobacco retail density, proximity or mixed measures thereof) and outcomes of smoking behaviour. Meta‐analysis of effect estimates were undertaken if there were at least three studies with similar population, exposure and outcome measures.Key FindingsSixty‐two studies were included, and positive associations were found between tobacco outlet density and cigarette smoking in pregnancy, youth, adults and cessation. Meta‐analyses were undertaken for retail density and ever smoking (odds ratio [OR] 1.20; 95% confidence interval [CI] 1.04, 1.37; I2 = 87.3%), and current youth smoking (OR 1.23; 95% CI 1.08, 1.40; I2 = 0.0%), adult smoking (OR 1.11; 95% CI 1.01, 1.22; I2 = 74.8%); and mixed measures of retail availability near schools and current youth smoking (OR 1.03; 95% CI 1.01, 1.05; I2 = 0.0%).Implications and ConclusionThere is evidence higher tobacco retail density is consistently associated with cigarette smoking in pregnant women, young people and adults when ecological studies are included in meta‐analysis. Meanwhile, evidence synthesis reveals restrictive tobacco retail laws based on proximity or mixed measures near home or very near school may not reduce smoking except in men who smoke heavily. Mechanisms to reduce retailer density should be thus considered part of tobacco control strategies.
Assessment of availability, readiness, and challenges for scaling-up hypertension management services at primary healthcare facilities, Central Highland region, Vietnam, 2020 Thang Nghia Hoang, Thuy Phuong Nguyen, Mai Phuong Pham, Hue Kim Le Nguyen, Hieng H, Y Dech Buonya, Tram Dinh Le, Chaisiri Angkurawaranon BMC Primary Care, 2023 Introduction Vietnam aims for 95% of commune health stations (CHSs) to have functional hypertension management programs by 2025. However, limited resources may impede the Central Highland region health system from achieving this goal. We assessed the availability and readiness of hypertension management services at CHSs in the Central Highland region and identified challenges to facilitate evidence-based planning. Methods We used a mixed-methods cross-sectional design to assess hypertension management services using WHO’s service availability and readiness assessment (SARA) tools in all 579 CHSs in the region, combined with twenty in-depth interviews of hypertension program focal points at communal, district, and provincial levels in all four provinces. We descriptively analyzed quantitative data and thematically analyzed qualitative data. Results Hypertension management services were available at 65% of CHSs, and the readiness of the services was 62%. The urban areas had higher availability and readiness indices in most domains (basic amenities, basic equipment, and essential medicines) compared to rural areas, except for staff and training. The qualitative results showed a lack of trained staff and ambiguity in national hypertension treatment guidelines, insufficient essential medicines supply mechanism, and low priority and funding limitations for the hypertension program. Conclusion The overall availability and readiness for hypertension diagnosis and management service at CHSs in the Central Highland region were low, reflecting inadequate capacity of the primary healthcare facilities. Some measures to strengthen hypertension programs in the region might include increased financial support, ensuring a sufficient supply of basic medicines, and providing more specific treatment guidelines.
Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission Valery L Feigin, Mayowa O Owolabi, Valery L Feigin, Foad Abd-Allah, Rufus O Akinyemi, Natalia V Bhattacharjee, Michael Brainin, Jackie Cao, Valeria Caso, Bronte Dalton, Alan Davis, Robert Dempsey, Joseph Duprey, Wuwei Feng, Gary A Ford, Seana Gall, Dorcas Gandhi, David C Good, Vladimir Hachinski, Werner Hacke, Graeme J Hankey, Marie Ishida, Walter Johnson, Julie Kim, Pablo Lavados, Patrice Lindsay, Ajay Mahal, Sheila Martins, Christopher Murray, Thuy Phuong Nguyen, Bo Norrving, Muideen T Olaiya, Oladotun V Olalusi, Jeyaraj Pandian, Hoang Phan, Thomas Platz, Anna Ranta, Sabah Rehman, Greg Roth, Ivy Anne Sebastian, Amanda E Smith, Nijasri C Suwanwela, P N Sylaja, Rajshree Thapa, Amanda G Thrift, Ezinne Uvere, Stein Emil Vollset, Dileep Yavagal, Joseph Yaria, Mayowa O Owolabi, Mayowa O Owolabi, Valery L Feigin, Foad Abd-Allah, Semaw Ferede Abera, Rufus Akinyemi, Michael Brainin, Valeria Caso, Robert J Dempsey, Gary A Ford, Seana Gall, Dorcas Gandhi, Vladimir Hachinski, Werner Hacke, Graeme J Hankey, Norlinah Mohamed Ibrahim, Walter Johnson, Pablo Lavados, Liping Liu, Patrice Lindsay, Sheila Martins, Bo Norrving, Muideen T Olaiya, Bruce Ovbiagele, Jeyaraj Pandian, Hoang Phan, Michael Piradov, Thomas Platz, Anna Ranta, Greg Roth, Ivy Anne Sebastian, Nijasri Suwanwela, P N Sylaja, Amanda G Thrift, Ezinne Uvere, Joseph Yaria, Carlos Abanto, Adamu Addissie, Amos O Adeleye, Yerzhan Adilbekov, Bibigul Adilbekova, Thierry A Adoukonou, Diana Aguiar de Sousa, Zauresh Akhmetzhanova, Albert Akpalu, Mustapha El Alaoui-Faris, Sebastian F Ameriso, Silva Andonova, Anita Arsovska, Folorunso E Awoniyi, Moiz Bakhiet, Miguel A Barboza, Hamidon Basri, Philip M Bath, Daniel Bereczki, Simone Beretta, Aaron L Berkowitz, Julie Bernhardt, Guna Berzina, Bhavan Bhavsar, Mher S Bisharyan, Manoj Bohara, Pascal Bovet, Hrvoje Budincevic, Dominique A Cadilhac, Denis Čerimagić, Augustina Charway-Felli, Christopher Chen, Jerome H Chin, Hanne Christensen, Kamil Chwojnicki, Adriana B Conforto, Manuel Correia, Daissy L Mora Cuervo, Anna Członkowska, Marco D'Amelio, Kristine E Danielyan, Stephen Davis, Vida Demarin, Andrew M Demchuk, Martin Dichgans, Klara Dokova, Geoffrey Donnan, Juan Carlos Duran, Gloria Ekeng, Mitchell S Elkind, Matthias Endres, Urs Fischer, Yuriy Flomin, Fortuné Gankpe, Martin Gavidia, Andrés Gaye Saavedra, Mehari Gebreyohanns, Mary George, Marek Gierlotka, Maurice Giroud, Elena V Gnedovskaya, Ivete Pillo Gonçalves, Fernando Gongora-Rivera, Padma S Gunaratne, Randah R Hamadeh, Tal-hatu K Hamzat, Mirjam R Heldner, Etedal Ibrahim, Hanne Ihle-Hansen, Sungju Jee, Jeng Jiann-Shing, S Clay Johnston, Dejana Jovanovic, Kristaps Jurjāns, Rizwan Kalani, Yogeshwar Kalkonde, Saltanat Kamenova, Bartosz Karaszewski, Peter Kelly, Stefan Kiechl, Aida Kondybayeva, Janika Kõrv, Grzegorz Kozera, Michael Kravchenko, Yakup Krespi, Rita Krishnamurthi, Jera Kruja, Kursad Kutluk, Peter Langhorne, Zhe K Law, Dmytro Lebedynets, Tsong-Hai Lee, Thomas W Leung, David S Liebeskind, Patricio López-Jaramillo, Paulo A Lotufo, M Julia Machline-Carrion, Luis F Maia, Branko Malojcic, Hugh S Markus, Juan M Marquez-Romero, Marco T Medina, Sabina Medukhanova, Man Mohan Mehndiratta, Evija Miglāne, Illa Mihejeva, Robert Mikulik, Erkin Mirrakhimov, Stephanie Mohl, Sunil Munakomi, Sean Murphy, Kamarul I Musa, Ahmed Nasreldein, Raul G Nogueira, Christian H Nolte, Jean Jacques Noubiap, Nelson Novarro-Escudero, Cassandra Ocampo, Martin O'Donnell, Yomi Ogun, Adesola Ogunniyi, Mohammed I Oraby, Dilek N Ōrken, Atilla O Ōzdemir, Serefnur Ozturk, Mélanie Paccot, Telmo Pereira, André Peeters, Tatjana Potpara, Hariklia Proios, Farooq A Rathore, Ralph L Sacco, Ramesh Sahathevan, Else S Sandset, Irving Renato Santos, Gustavo Saposnik, Fred S Sarfo, João Sargento-Freitas, Mukul Sharma, Louise Shaw, Kevin N Sheth, Yong-Il Shin, A Shobhana, S Nishan Silva, Vitor Tedim Cruz, Kiran Thakur, Lekh Jung Thapa, Danilo Toni, Mehmetakif A Topcuoglu, Julio Torales, Amytis Towfighi, Thomas Truelsen, Alexander Tsiskaridze, Marshall Tulloch-Reid, Juan N Useche, Peter Vanacker, Sophia Vassilopoulou, Gorana Vukorepa, Vladimira Vuletic, Kolawole W Wahab, Wenzhi Wang, Tissa Wijeratne, Bogdan Wojtyniak, Charles Wolfe, Mapoure N Yacouba, Jie Yang, Yared M Yifru, Adriana Yock-Corrales, Naohiro Yonemoto, Laetitia Yperzeele, Pawel Zagożdżon Lancet Neurology, 2023
Safety and immunogenicity of Nanocovax, a SARS-CoV-2 recombinant spike protein vaccine: Interim results of a double-blind, randomised controlled phase 1 and 2 trial Thuy P. Nguyen, Quyet Do, Lan T. Phan, Duc V. Dinh, Hiep Khong, Luong V. Hoang, Thuong V. Nguyen, Hung N. Pham, Men V. Chu, Toan T. Nguyen, Quang D. Pham, Tri M. Le, Tuyen N.T. Trang, Thanh T. Dinh, Thuong V. Vo, Thao T. Vu, Quynh B.P. Nguyen, Vuong T. Phan, Luong V. Nguyen, Giang T. Nguyen, Phong M. Tran, Thuan D. Nghiem, Tien V. Tran, Tien G. Nguyen, Tuynh Q. Tran, Linh T. Nguyen, Anh T. Do, Dung D. Nguyen, Son A. Ho, Viet T. Nguyen, Dung T. Pham, Hieu B. Tran, Son T. Vu, Su X. Hoang, Trung M. Do, Hoan Vu Ngoc, Xuan T. Nguyen, Giang Q. Le, Ton Tran, Thang M. Cao, Huy M. Dao, Thao T.T. Nguyen, Uyen Y Doan, Vy T.T. Le, Linh P. Tran, Ngoc M. Nguyen, Ngoc T. Nguyen, Hang T.T. Pham, Quan H. Nguyen, Hieu T. Nguyen, Hang L.K. Nguyen, Vinh T. Tran, Mai T.N. Tran, Truc T.T. Nguyen, Phat T. Ha, Hieu T. Huynh, Khanh D. Nguyen, Ung T. Thuan, Chung C. Doan, Si M. Do Lancet Regional Health Western Pacific, 2022 Background: Nanocovax is a recombinant severe acute respiratory syndrome coronavirus 2 subunit vaccine composed of full-length prefusion stabilized recombinant SARS-CoV-2 spike glycoproteins (S-2P) and aluminium hydroxide adjuvant. Methods: We conducted a dose-escalation, open label trial (phase 1) and a randomized, double-blind, placebo-controlled trial (phase 2) to evaluate the safety and immunogenicity of the Nanocovax vaccine (in 25 mcg, 50 mcg, and 75 mcg doses, aluminium hydroxide adjuvanted (0·5 mg/dose) in 2-dose regime, 28 days apart (ClinicalTrials.gov number, NCT04683484). In phase 1, 60 participants received two intramuscular injection of the vaccine following dose-escalation procedure. The primary outcomes were reactogenicity and laboratory tests to evaluate the vaccine safety. In phase 2, 560 healthy adults received either vaccine doses similar in phase 1 (25 or 50 or 75 mcg S antigen in 0·5 mg aluminium per dose) or adjuvant (0·5 mg aluminium) in a ratio of 2:2:2:1. One primary outcome was the vaccine safety, including solicited adverse events for 7 day and unsolicited adverse events for 28 days after each injection as well as serious adverse event or adverse events of special interest throughout the study period. Another primary outcome was anti-S IgG antibody response (Index unit/ml). Secondary outcomes were surrogate virus neutralisation (inhibition percentage), wild-type SARS-CoV-2 neutralisation (dilution fold), and T-cell responses by intracellular staining for interferon gamma (IFNg). Anti-S IgG and neutralising antibody levels were compared with convalescent serum samples from symptomatic Covid-19 patients. Findings: For phase 1 study, no serious adverse events were observed for all 60 participants. Most adverse events were grade 1 and disappeared shortly after injection. For phase 2 study, after randomisation, 480 participants were assigned to receive the vaccine with adjuvant, and 80 participants were assigned to receive the placebo (adjuvant only). Reactogenicity was absent or mild in the majority of participants and of short duration (mean ≤3 days). Unsolicited adverse events were mild in most participants. There were no serious adverse events related to Nanocovax. Regarding the immunogenicity, Nanocovax induced robust anti-S antibody responses. In general, there humoral responses were similar among vaccine groups which reached their peaks at day 42 and declined afterward. At day 42, IgG levels of vaccine groups were 60·48 [CI95%: 51·12-71·55], 49·11 [41·26-58·46], 57·18 [48·4-67·5] compared to 7·10 [6·32-13·92] of convalescent samples. IgG levels reported here can be converted to WHO international standard binding antibody unit (BAU/ml) by multiplying them to a conversion factor of 21·8. Neutralising antibody titre of vaccine groups at day 42 were 89·2 [52·2-152·3], 80·0 [50·8-125.9] and 95·1 [63·1-143·6], compared to 55·1 [33·4-91·0] of the convalescent group. Interpretation: Up to day 90, Nanocovax was found to be safe, well tolerated, and induced robust immune responses. Funding: This work was funded by the Coalition for Epidemic Preparedness Innovations (CEPI), the Ministry of Science and Technology of Vietnam, and Nanogen Pharmaceutical Biotechnology JSC.
Identifying lower limb problems and the types of safety footwear worn in the Australian wine industry: a cross-sectional survey Alexander Willem Copper, Rolf Scharfbillig, Thuy Phuong Nguyen, Cassandra Collins Journal of Foot and Ankle Research, 2021 Background The Australian wine industry is a valuable part of the wider Australian economy worth approximately A$45 billion annually and employs 163,790 people either full time or part time. Australian agricultural industries are amongst the nation’s most dangerous workplaces with joint, ligament, muscle and tendon injuries being commonplace along with wounds, lacerations and musculoskeletal diseases. It is therefore important to try and minimise the risk of injuries to workers. The aims of this study were to (1) identify whether lower limb problems occur in the Australian wine industry and (2) identify the types of safety footwear worn. Methods Participants were recruited from the Australian wine industry. The study was a cross-sectional anonymous survey of 82 questions with n = 207 respondents. Questions related to job role performed, types of lower limb problems experienced, level of pain, restriction of activities, types of footwear worn, general health and physical health. Results The main working roles were winery (73.4%), vineyard (52.2%), laboratory (39.6%), cellar door (32.4%) and office (8.2%), with 63.3% of participants working in more than one role. Lower back pain was the most commonly reported problem at 56% followed by foot pain (36.7%), knee pain (24.6%), leg pain (21.3%), ankle pain (17.9%), hip pain (15.5%), toe pain (13%) and heel pain (11.1%). The most popular footwear used by participants were elastic sided safety boots, followed by high cut lace up safety boots with side zip. Overall, although the pain experienced was moderate, it did not impact the workers ability to perform their duties and the majority self-reported as being in very good general and physical health. Conclusion To date no data have been published on the types of lower limb problems or the types of safety footwear worn in the Australian wine industry. This study is the first to demonstrate that elastic sided safety boots were the most popular amongst respondents and that lower limb problems occur with workers. Therefore, further research into the safety footwear used in the Australian wine industry is needed to better support workers health while working in their varied roles and conditions.
Attributable causes of cancer in Vietnam Thuy Phuong Nguyen, Hung N. Luu, Mai Vu Tuyet Nguyen, Mo Thi Tran, Thuy Thi Van Tuong, Chi Thi Du Tran, Paolo Boffetta Journal of Global Oncology, 2020
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