Andreea SOARE

@campusbiomedicohospital.com

Department of Medicine Campus Bio-Medico University Hospital Prevention and Check-up Medicine
Campus Bio-Medico University Hospital

Andreea SOARE


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https://researchid.co/andreeasoare

RESEARCH INTERESTS

cardio metabolic
preventive medicine
14

Scopus Publications

Scopus Publications

  • An extra virgin olive oil-enriched chocolate spread positively modulates insulin-resistance markers compared with a palm oil-enriched one in healthy young adults: A double-blind, cross-over, randomised controlled trial
    Dario Tuccinardi, Antonio Di Mauro, Greta Lattanzi, Giovanni Rossini, Lavinia Monte, Ivan Beato, Chiara Spiezia, Maria Bravo, Mikiko Watanabe, Andreea Soare, Shadi Kyanvash, Andrea Armirotti, Sine Mandrup Bertozzi, Amalia Gastaldelli, Claudio Pedone, Yeganeh Manon Khazrai, Paolo Pozzilli, Silvia Manfrini
    Diabetes Metabolism Research and Reviews, 2022
    To investigate if extra virgin olive oil (EVOO) or palm oil enriched chocolate spreads consumption leads to different results in terms of plasma ceramides concentration, glucose and lipid metabolism, inflammatory markers and appetite regulation in young healthy subjects.
  • The Mediterranean diet increases glucagon-like peptide 1 and oxyntomodulin compared with a vegetarian diet in patients with type 2 diabetes: A randomized controlled cross-over trial
    Antonio Di Mauro, Dario Tuccinardi, Mikiko Watanabe, Rossella Del Toro, Lavinia Monte, Riccardo Giorgino, Lorenzo Rampa, Giovanni Rossini, Shadi Kyanvash, Andreea Soare, Milena Rosati, Alessandra Piccoli, Nicoli Napoli, Elvira Fioriti, Paolo Pozzilli, Yeganeh M. Khazrai, Silvia Manfrini
    Diabetes Metabolism Research and Reviews, 2021
    To compare a Mediterranean diet (MED) with a high‐fibre vegetarian diet (HFV) in terms of hunger‐satiety perception through post‐prandial assessment of appetite‐related hormones glucagon‐like peptide 1 (GLP‐1) and oxyntomodulin, as well as self‐rated visual analogue scale (VAS) quantification, in overweight/obese subjects with type 2 diabetes (T2D).
  • Increased sclerostin and bone turnover after diet-induced weight loss in type 2 diabetes: a post hoc analysis of the MADIAB trial
    R. Strollo, A. Soare, Yeganeh Manon Khazrai, A. Di Mauro, A. Palermo, R. Del Toro, S. Fallucca, Maria Giovanna Belluomo, L. Dugo, M. Pianesi, P. Pozzilli, N. Napoli
    Endocrine, 2017
  • Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial
    Andreea Soare, Yeganeh Manon Khazrai, Lucia Fontana, Rossella Del Toro, Maria Concetta Lazzaro, Claudia Di Rosa, Antonia Buldo, Elvira Fioriti, Ernesto Maddaloni, Silvia Angeletti, Antonio Di Mauro, Rosaria Gesuita, Edlira Skrami, Dario Tuccinardi, Sara Fallucca, Mario Pianesi, Paolo Pozzilli
    Metabolism Clinical and Experimental, 2017
  • A 6-month follow-up study of the randomized controlled Ma-Pi macrobiotic dietary intervention (MADIAB trial) in type 2 diabetes
    A Soare, R Del Toro, Y M Khazrai, A Di Mauro, S Fallucca, S Angeletti, E Skrami, R Gesuita, D Tuccinardi, S Manfrini, F Fallucca, M Pianesi, P Pozzilli
    Nutrition and Diabetes, 2016
    BACKGROUND: In the MADIAB trial (a 21-day randomized, controlled trial in patients with type 2 diabetes (T2D)), intervention with the Ma-Pi 2 macrobiotic diet resulted in significantly greater improvements in metabolic control compared with a standard recommended diet for patients with T2D. We report on a 6-month follow-up study, which investigated, whether these benefits extended beyond the 21-day intensive dietary intervention, in real-world conditions. SUBJECTS: At the end of the MADIAB trial (baseline of this follow-up study), all participants continued their assigned diet (Ma-Pi or control) for 6 months. The Ma-Pi 2 group followed the Ma-Pi 4 diet during this follow-up study. Forty of the original 51 subjects (78.4%) participated in the follow-up (body mass index, 27-45 kg m(-2); age, 40-75 years). Primary outcome was percentage change from baseline in HbA1c; secondary outcomes were anthropometric data and lipid panel. RESULTS: A significantly greater median percentage reduction was observed for HbA1c in the Ma-Pi group (-11.27% (95% confidence interval (CI): -10.17; -12.36)) compared with the control group (-5.88% (95% CI: -3.79; -7.98)) (P < 0.001). Total and low-density lipoprotein (LDL) cholesterol increased in both groups with no differences between groups (P=0.331 and P=0.082, respectively). After correcting for age and gender, the Ma-Pi diet was associated with a higher percentage reduction in HbA1c (95% CI: 2.56; 7.61) and body weight (95% CI: 0.40; 3.99), and a higher percentage increase in LDL cholesterol (95% CI: -1.52; -33.16). However, all participants' total and LDL cholesterol levels remained within recommended ranges (<200 mg dl(-1) and <100 mg dl(-1), respectively). The Ma-Pi diet group achieved the target median HbA1c value (<5.7% (39 mmol mol(-1))) at 6 months. CONCLUSIONS: Both the Ma-Pi and control diets maintained their benefits beyond the 21-day intensive monitored intervention over a 6-month follow-up in real-world conditions. The Ma-Pi diet resulted in greater improvement in glycemic control.
  • The effect of macrobiotic Ma-Pi 2 diet on systemic inflammation in patients with type 2 diabetes: A post hoc analysis of the MADIAB trial
    Andreea Soare, Rossella Del Toro, Elena Roncella, Yeganeh Manon Khazrai, Silvia Angeletti, Laura Dugo, Sara Fallucca, Lucia Fontana, Maria Altomare, Valeria Formisano, Francesca Capata, Rosaria Gesuita, Silvia Manfrini, Francesco Fallucca, Mario Pianesi, Paolo Pozzilli
    BMJ Open Diabetes Research and Care, 2015
    Introduction Current guidelines for the management of type 2 diabetes (T2D) emphasize diet as essential therapy. However, the effect of diet on systemic inflammation remains unclear. We investigated the effects of consuming a macrobiotic Ma-Pi 2 diet versus a standard recommended diet (control diet) on markers of inflammation in patients with T2D. Methods This was a post hoc analysis of the MADIAB trial, a 21-day randomized controlled trial conducted in 51 patients (25 males and 26 females) with T2D. Patients were randomized 1:1 to the Ma-Pi 2 macrobiotic diet or a control diet based on dietary guidelines for T2D. Biological antioxidant potential of plasma and circulating levels of high-sensitivity C reactive protein, interleukin-6, tumor necrosis factor-α, and insulin-like growth factor-1 were assessed. Results After 21 days on the Ma-Pi 2 or control diet, markers of inflammation were reduced in both groups. The antioxidant potential of plasma improved significantly in the Ma-Pi group. A significant reduction in insulin growth factor-1 was observed in the Ma-Pi group versus control group (p<0.001). Conclusions Findings of this post hoc analysis demonstrated that the Ma-Pi 2 diet is a safe dietary strategy to reduce levels of the markers of insulin resistance and inflammation, compared with baseline values, in the short term. Furthermore, the Ma-Pi 2 diet was superior to the control diet in reducing insulin growth factor-1 and may be beneficial for patients with T2D. Trial registration number Current Controlled Trials ISRCTN10467793.
  • Benefits of caloric restriction for cardiometabolic health, including type 2 diabetes mellitus risk
    A. Soare, E. Weiss, P. Pozzilli
    Diabetes Metabolism Research and Reviews, 2014
    In the United States, life expectancy has markedly increased during the past century, and population ageing is expected to double within the next 25 years. The process of ageing in a population is associated with the development of chronic diseases, such as type 2 diabetes mellitus, that can be prevented, and even reversed, with the implementation of healthy lifestyle interventions. The evidence to date, consolidated by the numerous epidemiological studies and clinical trials conducted, suggests that caloric restriction is an effective nutritional intervention for preventing most of these age‐related conditions. At a metabolic level, caloric restriction with adequate nutrition has been shown to improve insulin sensitivity, reduce fasting glucose and insulin concentration and prevent obesity, type 2 diabetes, hypertension and chronic inflammation. The purpose of this article is to review current knowledge of the metabolic and clinical implications of caloric restriction with adequate nutrition for the prevention of type 2 diabetes and cardiovascular disease. Copyright © 2013 John Wiley & Sons, Ltd.
  • Multiple dietary supplements do not affect metabolic and cardiovascular health
    Andreea Soare, Edward P. Weiss, John O. Holloszy, Luigi Fontana
    Aging, 2014
    Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. This study was a 6-month randomized, single-blind controlled trial, in which 56 non-obese (BMI 21.0-29.9 kg/m2) men and women, aged 38 to 55 yr, were assigned to a dietary supplement (SUP) group or control (CON) group, with a 6-month follow-up. The SUP group took 10 dietary supplements each day (100 mg of resveratrol, a complex of 800 mg each of green, black, and white tea extract, 250 mg of pomegranate extract, 650 mg of quercetin, 500 mg of acetyl-l-carnitine, 600 mg of lipoic acid, 900 mg of curcumin, 1 g of sesamin, 1.7 g of cinnamon bark extract, and 1.0 g fish oil). Both the SUP and CON groups took a daily multivitamin/mineral supplement. The main outcome measures were arterial stiffness, endothelial function, biomarkers of inflammation and oxidative stress, and cardiometabolic risk factors. Twenty-four weeks of daily supplementation with 10 dietary supplements did not affect arterial stiffness or endothelial function in nonobese individuals. These compounds also did not alter body fat measured by DEXA, blood pressure, plasma lipids, glucose, insulin, IGF-1, and markers of inflammation and oxidative stress. In summary, supplementation with a combination of popular dietary supplements has no cardiovascular or metabolic effects in non-obese relatively healthy individuals.
  • The effect of the macrobiotic Ma-Pi 2 diet vs. The recommended diet in the management of type 2 diabetes: The randomized controlled MADIAB trial
    Andreea Soare, Yeganeh M Khazrai, Rossella Del Toro, Elena Roncella, Lucia Fontana, Sara Fallucca, Silvia Angeletti, Valeria Formisano, Francesca Capata, Vladimir Ruiz, Carmen Porrata, Edlira Skrami, Rosaria Gesuita, Silvia Manfrini, Francesco Fallucca, Mario Pianesi, Paolo Pozzilli
    Nutrition and Metabolism, 2014
    BACKGROUND: Diet is an important component of type 2 diabetes therapy. Low adherence to current therapeutic diets points out to the need for alternative dietary approaches. This study evaluated the effect of a different dietary approach, the macrobiotic Ma-Pi 2 diet, and compared it with standard diets recommended for patients with type 2 diabetes. METHODS: A randomized, controlled, open-label, 21-day trial was undertaken in patients with type 2 diabetes comparing the Ma-Pi 2 diet with standard (control) diet recommended by professional societies for treatment of type 2 diabetes. Changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) were primary outcomes. HbA1c, insulin resistance (IR), lipid panel and anthropometrics were secondary outcomes. RESULTS: After correcting for age, gender, BMI at baseline, and physical activity, there was a significantly greater reduction in the primary outcomes FBG (95% CI: 1.79; 13.46) and PPBG (95% CI: 5.39; 31.44) in those patients receiving the Ma-Pi 2 diet compared with those receiving the control diet. Statistically significantly greater reductions in the secondary outcomes, HbA1c (95% CI: 1.28; 5.46), insulin resistance, total cholesterol, LDL cholesterol and LDL/HDL ratio, BMI, body weight, waist and hip circumference were also found in the Ma-Pi 2 diet group compared with the control diet group. The latter group had a significantly greater reduction of triglycerides compared with the Ma-Pi 2 diet group. CONCLUSIONS: Intervention with a short-term Ma-Pi 2 diet resulted in significantly greater improvements in metabolic control in patients with type 2 diabetes compared with intervention with standard diets recommended for these patients. TRIAL REGISTRATION: Current Controlled Trials ISRCTN10467793.
  • Wrist circumference: An independent predictor of both insulin resistance and chronic kidney disease in an elderly population
    Adina Mitrea, Andreea Soare, Simona Georgiana Popa, Mirela Nicoleta Tudor, Maria Mota, Paolo Pozzilli
    Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 2013
    Background and aim: It was recently reported that wrist circumference is associated with insulin resistance (IR) both in children and adults. We aimed to evaluate whether wrist circumference is a useful anthropometrical parameter for the evaluation of IR in an elderly population. Material and method: We performed a study on 40 subjects, 20 with type 2 diabetes (T2D) and 20 control subjects. IR was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). We measured the following anthropometrical parameters: weight, height, waist circumference (WC), hip circumference, wrist circumference, waist to hip ratio (WHR), waist to height ratio (WHtR), body mass index (BMI) and body adiposity index (BAI). Results: We found statistically significant differences between the subjects with T2D and the control group for all the analyzed parameters. Statistically significant correlations between all the anthropometrical parameters and HOMA-IR were observed. However, only WC was an independent predictor of IR. Wrist circumference was the only parameter negatively correlated with the estimated glomerular filtration rate (eGFR). Furthermore, this measurement was an independent predictor of chronic kidney disease (CKD) in the studied subjects. Conclusion: Wrist circumference can be used in the general practice as a surrogate marker of IR in the elderly, being both easily determined and a cost-free method
  • Buccal spray insulin in subjects with impaired glucose tolerance: Improvement in HbA1c is lost after 6 months washout therapy
    Satish K. Garg
    Diabetes Technology and Therapeutics, 2013
  • Searching the missing link between alzheimer's disease and diabetes
    Adina Mitrea, Simona Georgiana Popa, Cristina Muntean, Andreea Soare, Laura Trotta, Antonio Callea, Maria Moţa
    Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 2013
  • Caloric restriction may reverse age-related autonomic decline in humans
    Phyllis K. Stein, Andreea Soare, Timothy E. Meyer, Roberto Cangemi, John O. Holloszy, Luigi Fontana
    Aging Cell, 2012
  • Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
    Aging, 2011