Dr. Bhuvaneswari C

@pmchri.ac.in

Associate Professor and Anatomy
Panimalar Medical College Hospital and Reserach Institute

Dr. Bhuvaneswari C


                              Download Compact PDF  
https://researchid.co/rsbdrdind
Mrs. Bhuvaneswari C has more than 17+ years of teaching, including 5 years of research experience in the field of Anatomy. I did my PhD in Medical Anatomy from SRM Medical college hospital and research institute, Chennai, MSc in Human Anatomy at Mudaliar PG institute of basic medical science (IBMS), Taramani, University Madras in the 2002. My field of interest includes Osteoporosis and herbal drug discovery. I worked in grades of Tutor, Assistant professor and Associate professor in Department of Anatomy, SRM medical college hospital and research centre, Potheri, Kanchipuram dist. and working at Panimalar Medical College and reserach institute. Currently I'm fascinated towards research on the effect of medicinal plants on osteoporosis, which made me to take over this research area.

EDUCATION

Ph.D in Medical Anatomy
MSc in Anatomy
BSc in Zooology

RESEARCH, TEACHING, or OTHER INTERESTS

Anatomy, Multidisciplinary, Drug Guides, Plant Science

FUTURE PROJECTS

IMMUNO HISTOLOGICAL EVIDENCE OF ORMOCARPUM SENNOIDES EXTRACT IN THE EXPRESSION OF BAX AND BCL2 IN WISTER RATS WITH GLUCOCORTICOID INDUCED OSTEOPOROSIS

Objective: Evaluate the effect of Ormocarpum sennoides through immunohistological evidence in the expression of Bax and Bcl2 in glucocorticoid induced Osteoporosis in Wister rats Method: Rats were divided into five groups (Control, MPA(Osteoporosis), Alendronate (2mg/kg), 100mg (EOS) and 200mg (EOS). The treatment were conducted for 45 days the Bax and Bcl2 expression were evaluated in osteoclast of distal femur diaphysis.


Applications Invited
Funding / Research fellow
4

Scopus Publications

10

Scholar Citations

2

Scholar h-index

Scopus Publications

  • RFF-JSS: A radiomic feature fusion and joint space segmentation framework for automated knee osteoarthritis assessment
    K. Pugazharasi, Bhuvaneswari Srinivasan, Anandh Nagarajan, I. Govindharaj
    Journal of Orthopaedic Reports, 2026
    Knee osteoarthritis (KOA) is a leading cause of pain and functional disability worldwide. Radiographic severity grading using the Kellgren–Lawrence (KL) scale is widely adopted in clinical practice but remains subjective and susceptible to inter- and intra-observer variability, particularly when distinguishing adjacent grades. This study aims to develop an accurate, interpretable, and anatomically guided framework for automated KOA severity grading from plain knee radiographs. A novel Radiomic Feature Fusion and Joint Space Segmentation (RFF-JSS) framework is proposed for automated KOA severity assessment. The pipeline includes (i) standardized preprocessing of knee radiographs, (ii) anatomically informed tibiofemoral joint space segmentation using a U-Net model, (iii) IBSI-compliant multiscale radiomic feature extraction from medial and lateral compartments, (iv) PCA-based radiomic feature fusion for dimensionality reduction and redundancy suppression, and (v) ordinal-aware KOA severity classification using a Random Forest classifier. The framework was evaluated on 5,820 knee radiographs from two large public cohorts—the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST)—with stratified training, validation, and testing splits. The proposed RFF-JSS framework achieved an accuracy of 94.87%, precision of 95.12%, sensitivity of 94.68%, specificity of 96.10%, F1-score of 94.89%, ROC-AUC of 0.972, and a Quadratic Weighted Kappa (QWK) of 0.947. The method consistently outperformed state-of-the-art approaches, including ResNet-SVM, UNet-Radiomics, Deep-KOA, JSN-Net, RF-RFE, and CNN-KLNet. Ablation studies confirmed the critical contributions of joint space segmentation, compartment-wise analysis, feature standardization, and PCA-based radiomic fusion in improving classification robustness and reducing misclassification between adjacent KL grades. The RFF-JSS framework provides a robust, interpretable, and anatomically grounded solution for automated KOA severity grading from plain radiographs. By synergistically combining joint space segmentation with radiomic feature fusion and ordinal-aware classification, the proposed approach bridges the gap between high predictive performance and clinical interpretability, demonstrating strong potential for large-scale screening and clinical decision support in knee osteoarthritis assessment.
  • Immuno histological evidence of ormocarpum sennoides dc extract in the expression of bax and bcl2 in wister rats with glucocorticoid induced osteoporosis
    Bhuvaneswari C. Srinivasan, Radhika Krishnan
    Journal of the Anatomical Society of India, 2023
    Introduction: Glucocorticoid therapy is the most common cause for secondary osteoporosis leading to a resurgence of interest in traditional medicine that could have bone sparing effects by naturally occurring bioactive molecules. Therefore, this study was done to evaluate the effect of Ormocarpum sennoides DC through immunohistological evidence in the expression of Bax and Bcl2 in glucocorticoid-induced Osteoporosis in Wister albino rats. Materials and Methods: Rats were divided into five groups (Control, MPA (Osteoporosis), Alendronate (2 mg/kg), 100 mg (EOS), and 200 mg (EOS). The treatment was conducted for 45 days the Bax and Bcl2 expressions were evaluated in osteoclast of distal femur diaphysis. Results: When compared the MPA to control group (P < 0.05) Bax increased and Bcl2 reduced, when compared with MPA (P < 0.05) Alendronate, EOS 100 mg and EOS 200 mg increased the Bcl2 expressions, Alendronate, EOS 100 mg, and EOS 200 mg reduced the Bax expression. Discussion and Conclusion: EOS 100 mg and EOS 200 mg increased Bcl2 expression and reduced the Bax expression Ormocarpum sennoides prevents glucocorticoid-induced Apoptosis of preosteoblast; therefore, Bcl2 may be an important regulator of bone growth thus reporting antiapoptotic property of Ormocarpum sennoides DC.
  • The effect of Ormocarpum sennoides DC on bone histomorphometry in steroid induced osteoporotic rats
    International Journal of Research in Pharmaceutical Sciences, 2015
  • Preliminary phytochemical screening and spectroscopic analysis of Ormocarpum sennoides DC
    International Journal of Research in Pharmaceutical Sciences, 2014

RECENT SCHOLAR PUBLICATIONS

  • RFF-JSS: A radiomic feature fusion and joint space segmentation framework for automated knee osteoarthritis assessment
    IG K. Pugazharasi, Bhuvaneswari Srinivasan, Anandh Nagarajan
    Journal of Orthopaedic Reports , 2026
    2026
  • Immuno Histological Evidence of Ormocarpum Sennoides DC Extract in the Expression of Bax and Bcl2 in Wister Rats with Glucocorticoid induced Osteoporosis
    BC Srinivasan
    Journal of the Anatomical Society of India 72 (2), 93-97 , 2023
    2023
    Citations: 3
  • Disorders of Sexual Differentiation: A study on the Incidence and Types of Female Pseudo Hermaphrodites
    BS Radhika Krishnan
    https://imedsciences.com/ijims-2016-156/ 3 (12), 455-60 , 2016
    2016
  • The effect of Ormocarpum sennoides DC on bone histomorphometry in steroid induced osteoporotic rats
    B Srinivasan, R Krishnan
    JK Welfare & Pharmascope Foundation , 2015
    2015
  • Preliminary phytochemical screening and spectroscopic analysis of Ormocarpum sennoides DC
    B Srinivasan
    International Journal of Research in Pharmaceutical Sciences 5 (3), 217-221 , 2014
    2014
    Citations: 7
  • HPTLC fingerprint profile of Ormocarpumsennoides leaves
    SS Bhuvaneswari Srinivasan, Radhika Krishnan
    International Journal of Advance Research in Science and Engineering 3 (9 … , 2014
    2014

MOST CITED SCHOLAR PUBLICATIONS

  • Preliminary phytochemical screening and spectroscopic analysis of Ormocarpum sennoides DC
    B Srinivasan
    International Journal of Research in Pharmaceutical Sciences 5 (3), 217-221 , 2014
    2014
    Citations: 7
  • Immuno Histological Evidence of Ormocarpum Sennoides DC Extract in the Expression of Bax and Bcl2 in Wister Rats with Glucocorticoid induced Osteoporosis
    BC Srinivasan
    Journal of the Anatomical Society of India 72 (2), 93-97 , 2023
    2023
    Citations: 3
  • RFF-JSS: A radiomic feature fusion and joint space segmentation framework for automated knee osteoarthritis assessment
    IG K. Pugazharasi, Bhuvaneswari Srinivasan, Anandh Nagarajan
    Journal of Orthopaedic Reports , 2026
    2026
  • Disorders of Sexual Differentiation: A study on the Incidence and Types of Female Pseudo Hermaphrodites
    BS Radhika Krishnan
    https://imedsciences.com/ijims-2016-156/ 3 (12), 455-60 , 2016
    2016
  • The effect of Ormocarpum sennoides DC on bone histomorphometry in steroid induced osteoporotic rats
    B Srinivasan, R Krishnan
    JK Welfare & Pharmascope Foundation , 2015
    2015
  • HPTLC fingerprint profile of Ormocarpumsennoides leaves
    SS Bhuvaneswari Srinivasan, Radhika Krishnan
    International Journal of Advance Research in Science and Engineering 3 (9 … , 2014
    2014