PhD in clinical pharmacy. postdoctoral fellowship in critical care pharmacotherapy
RESEARCH INTERESTS
Clinical pharmacy. Therapeutics. Critical care pharmacotherapy. Pharmacokinetics
9
Scopus Publications
Scopus Publications
Comparative evaluation of renal function in patients using different antihypertensive drug classes Qutaiba Qasim, Ali Hadi, Kadhim Kadhim, Hany Al-Hussaniy Tropical Journal of Pharmaceutical Research, 2026 Purpose: To compare renal function in hypertensive adults treated with antihypertensive drug classes in a tertiary private clinic in Basra, Iraq.Method: A retrospective cohort comprised 450 adults with hypertension on stable therapy for 6 months from January 2024 to December 2025 in Al-Fayhaa Teaching Hospital, Basra, Iraq. Five monotherapy groups (60 patients each): angiotensin converting enzyme (ACE) inhibitor, angiotensin receptor blocker (ARB), calcium channel blocker (CCB), β-blocker, diuretic, and combination therapy (150 patients) comprising any two or more antihypertensive medications. Demographic and laboratory data were obtained. Analysis of variance and the Kh2 test were used to compare estimated glomerular filtration rate (eGFR), serum creatinine, and urine albumin-creatinine ratio (UACR).Results: The highest mean eGFR occurred in ACE-inhibitor and ARB-groups, and the lowest mean eGFR in β-blocker and diuretic groups. Non-RAAS monotherapy groups (Group 3 (calcium channel blockers), Group 4 (beta blockers)) were more common in terms of chronic kidney disease (CKD; eGFR < 60 mL/min/1.73 m2) and moderate-to-severe albuminuria. Diuretic and β-blocker monotherapy were associated with lower eGFR and a twofold increase in the odds of CKD and albuminuria in comparison with ACE inhibitor therapy after confounder adjustment. Still, ARB and RAAS-combination therapy had renal profiles comparable to ACE inhibitor therapy.Conclusion: The RAAS-blocking regimens comprising ARB and ACE inhibitors were associated with more favorable renal outcomes than non-RAAS monotherapies (CCB, β-blocker, and diuretic), supporting the prioritization of ACE inhibitors or ARBs as first-line therapy in hypertensive patients at renal risk.
A prospective study of metformin effectiveness as a mammalian target of rapamycin inhibitor and immunoregulator in women with polycystic ovarian syndrome. Asmaa Moslim Allawi, Nisreen Waleed Mustafa, Ali Mohammed Hadi Journal of Neonatal Surgery, 2025 BackgroundPolycystic ovarian syndrome (PCOS) is a common disorder affecting ovary function. it’s thought that an autoimmune regulatory mechanism could mediate its onset. Metformin is an effective medication for PCOS treatment and is proposed to act as an immunoregulatory drug.ObjectiveThe present work aimed to study the effectiveness of metformin as a mammalian target of rapamycin (mTOR) inhibitor and immunoregulator in PCOS women.Subjects and MethodsA total of 80 blood samples were collected, 30 of them from newly diagnosed PCOS women. Once more, blood samples were taken from them following 500 mg of metformin treatment period. In addition, 20 healthy women enrolled as a control group. The levels of mTOR, IL6, and TGFβ1 were measured using the ELISA technique.ResultsThe present work showed that after metformin treatment, levels of mTOR and TGFβ1 dropped significantly, but IL6 levels remained constant. Patients on longer-term metformin treatment experienced a significant decrease in mTOR and TGFβ1 levels, but TGFβ1 remained higher than in healthy controls. No significant differences were found in IL6 levels between treatment duration groups and the body mass index (BMI) groups, according to Spearman correlation, there were no correlation found between mTOR and other studied marker neither pre nor post treatment groups.ConclusionThis study concluded that metformin has pleiotropic effects on immune reprogramming due to its role as an mTOR inhibitor and immune modulation of regulatory cytokines.
SURFACE TREATED ACIDIFY ACTIVATED CARBON OF PALM FOR ADSORPTION OF CONGO RED (CR) DYE FROM AQUEOUS SOLUTIONS Procedia Environmental Science Engineering and Management, 2024
Evaluating the Benefits of Using Mobile Application (diarrhea management step by step) in the Management of Diarrhea by Community Pharmacists Ehab Mudher Mikhael, Fadya Yaqoob Al-Hamadani, Ali Mohammed Hadi Iraqi Journal of Pharmaceutical Sciences, 2023 Diarrhea is one of the most commonly encountered minor ailments in the community pharmacies. It is associated with significant morbidity and mortality. However, the majority of pharmacists in Iraq did not manage diarrheal cases in a proper way. Therefore, the current study aimed to evaluate the benefit of a new mobile application (diarrhea management step by step) to improve the pharmacist's role in the management of diarrhea. The study was conducted from 21th September to 21th October 2021 using a pre-post design via a simulated patient (SP) technique. A validated diarrhea scenario was presented to each pharmacist by the SP twice, once before and the other after giving the mobile application to the pharmacist. Furthermore, pharmacists were asked to rate the application in regard to its ease of use, reducing the time needed for management of diarrhea cases, reducing diagnostic errors, reducing medication errors, and applicability in daily clinical practice. The study sample involved 50 community pharmacists. However, only 47 completed the study. After using the application, all questions necessary to assess diarrhea were significantly improved. Moreover, the average number of questions asked to the SP was significantly increased. On the other hand, providing the SP with an appropriate non-pharmacological and pharmacological treatment was also significantly improved. Additionally, counseling the SP with the necessary information about dispensed medication was improved; however, significant improvement was detected only in regard to information about the drug dose and dosing frequency. Most participated pharmacists strongly agreed with the application ease of use, its ability to reduce diagnosis and medication errors, and its applicability for use in daily clinical practice. In conclusion the tested application is an effective method to improve the pharmacist's role in the assessment and management of diarrhea.
Design and evaluation of a new mobile application to improve the management of minor ailments: a pilot study Ehab Mudher Mikhael, Fadya Yaqoob Al-Hamadani, Ali Mohammed Hadi BMC Health Services Research, 2022 Background Seeking pharmacist advice about minor ailments is a common practice among Iraqi patients because such advice is free and quick. Unfortunately, the assessment and management of minor ailments by Iraqi pharmacists were inappropriate. Therefore, this study aimed to develop a model for a mobile application that can assist community pharmacists in the diagnosis and management of minor ailments. Methods The scientific content of the application was based on the information in the symptoms in the pharmacy and British National Formulary books. The design and content of the application were approved by two experts. Thereafter, the application was built for Android mobiles using flutter technology and dart language. A pre-post pilot study was conducted to assess outcomes associated with use of the application, including user acceptance and appropriateness of clinical recommendations. Fifteen students from the College of Pharmacy/University of Baghdad who had an Android mobile participated in this study. Two different scenarios about diarrhea were used during the pilot study, in which the researcher acted as a patient (SP) and the participant student as a pharmacist. Results After using the application, the number of questions asked by the participated student to the SP was significantly increased to about double. Additionally, providing the SP with appropriate non-pharmacological and pharmacological therapy along with optimum counseling and education were also significantly improved. All study participants agreed on the application’s ease of use and ability to reduce diagnosis and medication errors. Conclusions The implementation of the newly developed mobile application, diarrhea management step by step, was associated with improvements in assessment and recommended treatments for diarrhea cases with good acceptance by a pilot sample of pharmacy students at Baghdad University.
Evaluation of amikacin dosing schedule in critically ill elderly patients with different stages of renal dysfunction Saeideh Ghaffari, Ali Mohammad Hadi, Farhad Najmeddin, Bita Shahrami, Mohammad-Reza Rouini, et al. European Journal of Hospital Pharmacy, 2022 Objectives Amikacin is still a widely used aminoglycoside for the treatment of life-threatening infections. The pharmacokinetic parameters of this antibiotic may be altered in critically ill conditions. Moreover, in the elderly population, pathophysiological changes affect these pharmacokinetic variables, making it difficult to predict the appropriate dose and dosing schedule for amikacin. This study aimed to characterise the pharmacokinetics of amikacin in critically ill elderly patients with renal dysfunction, and to evaluate if the available dose adjustment schedules dependent on renal function would be appropriate for empirical dosing. Methods Critically ill patients aged >60 years with a creatinine clearance of >20 mL/min in need of treatment with amikacin were randomly enrolled. All the patients received approximately 25 mg/kg amikacin. The patients were then divided into three groups according to the stages of their renal dysfunction based on creatinine clearance, and the optimum time to re-dosing was calculated for each group. The pharmacokinetic parameters of the patients were calculated and estimated as population pharmacokinetic data. Results Of 30 patients, only 20% attained the target peak levels of amikacin of >64 mg/L. In addition, the mean volume of distribution was 0.47 L/kg. There was a poor correlation between amikacin clearance and creatinine clearance. The difference in amikacin half-life was not statistically significant among any of the stages of renal impairment. Conclusions The initial dosing of amikacin in critically ill elderly patients should not be reduced, even in the context of renal impairment. Regarding the dose adjustment in renal impairment, dosing intervals estimation, no decision can be made based on the creatinine clearance and the first dose individualisation method in terms of the two-sample measurements may be considered as an appropriate strategy.
Improving the iraqi oil well cement properties using barolift: An experimental investigation Ali M. Hadi, Ayad A. Al-Haleem Iraqi Journal of Science, 2021 Cement is a major component in oil and gas drilling operations that is used to maintain the integrity of boreholes by preventing the movement of formation fluids through the annular space and outside the casing. In 2019, Iraq National Oil Company ordered all international oil and gas companies which are working in Iraq to use Iraqi cement (made in Iraq) in all Iraqi oil fields; however, the X-ray fluorescence (XRF) and compressive strength results in this study show that this cement is not matching with American Petroleum Institute (API) standards.
 During this study, barolift was used to improve the properties of Iraqi cement used in oil wells at high pressure and high temperature (HPHT). Barolift (1 g) was added to cement admixture to evaluate its influence on improving the performance of cement, mainly related to the property of toughness. 
 Primarily, the quality and quantity of cement contents were determined using X-ray fluorescence. Experiments were conducted to examine the characteristics of the base cement and the cement system containing 1g of barolift, such as thickening time, free water, compressive strength, and porosity. X-ray diffraction (XRD), scanning electron microscope (SEM), and energy dispersive X-ray spectroscopy (EDS) were conducted for analyzing the microstructure of cement powder.
 The experimental results showed that barolift acted as a retarder and improved the thickening time, slightly increased the free water, enhanced the mechanical properties, reduced the porosity, and aided in scheming new cement slurry to withstand the HPHT conditions. Microstructure analysis showed that barolift particles blocked the capillaries by filling cement spaces and, thus, a denser and stricter cement network was achieved.
