SRIKRISHNA THEERDHALA

@pharmacy

Professor & Head, Pharmaceutics Department
Swathi College of Phamacy

SRIKRISHNA THEERDHALA


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https://researchid.co/srikrishna.nlr
16 Years of Teaching Experience in Pharmacy Curriculum, Handled PG, UG and Pharm.D Courses. Ratified from the JNTUA, Anantapuramu. Ability to handle various apparatus in the Pharmaceutics department. Impressive Teaching skills through various modes. Interested in the areas of Novel Drug Delivery Systems (Nano, Transdermal, Floating & Targeted Drug Delivery Systems etc)

EDUCATION

Professional Qualifications:
 Ph.D (Pharmaceutical Sciences) Registered in 2020
(Faculty of Pharmacy, . Educational and Research Institute, University, Chennai., India)
 M. Pharmacy (Pharmaceutics) 2010
(SRM College of Pharmacy, SRM University, Chennai, India)
Percentage: 77.6 %
 B. Pharmacy 2007
(Sri Padmavathi School of Pharmacy, Tirupati, A.P. India)
(Affiliated to JNT University, A.P., India)
Percentage: 68.41 %

Academic Qualifications:
 Passed 10th Examination in 2001 with 77.5 % marks from AP SSC Board.
 Passed 12th Examination in 2003 with 78 % marks from AP Intermediate Board.

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science
8

Scopus Publications

55

Scholar Citations

4

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Mupirocin Loaded Niosomal Gel for Topical Wound Healing Applications
    Srikrishna Theerdhala, Narayanaswamy Harikrishnan
    Tropical Journal of Natural Product Research, 2023
    Mupirocin-loaded niosomal gel has been developed to enhance the drug deposition for a longer period at the targeted site and sustained the rate of release of the drug. A lipid hydration technique was employed to formulate niosome with polymers Carbopol and Chitosan at various concentrations. Tween 80 is a non-ionic surfactant utilized in the formulation to improve the entrapment efficiency of the drug. Cholesterol is utilized in the formulation to improve vesicle stability and glycerin is a gelling and moistening agent. In addition, to improve the stability of the niosomal gel Methylparaben is also added to the formulation.FTIR and DSC studies are used to find out the compatibility study of the drug and other excipients. The post-evaluation studies confirm that yield percentage lies between 85 - 93%, entrapment efficiency 83 - 97%, drug content lies within the limit of 87 – 98%, pH range matches the skin pH and the obtained range is 6.25 - 7.3. Viscosity and Spreadability show the result within the limit of 410 - 560 cps and 3.8 - 5.4 gcm/s respectively. The post-evaluation study was further subjected to an in-vitro diffusion study. The formulation F5 has shown a better sustained release of active drug (98% at 12hr) which contains a higher ratio of carbopol and tween 80. A higher concentration of tween 80 increases the entrapment efficiency of mupirocin in the niosome and carbopol helps to sustain the release rate to an optimum period as a swellable gelling agent. 
  • Mupirocin niosomal gel with bee honey & curcumin as nano-drug delivery in wound healing applications
    Srikrishna Theerdhala, Narayanaswamy Harikrishnan
    Current Trends in Biotechnology and Pharmacy, 2023
    <p style="text-align: justify;">Wound healing research is still aiming toward complete regeneration and restoration of the skin’s function and structure with the least amount of scarring. Controlled and target-ed medication distribution to wounds is more convenient than systemic administration, which allows for larger drug concentrations to be de-livered to the targeted site over time. The nano wound healing gel demonstrated a dependable administration strategy, excellent local tolerabil-ity, and superior drug delivery methods, which can promote faster healing. Recently, niosome formulations have been developed to reduce toxicity while increasing accumulation at the target site. Curcuma longa (CU) and honey are effective at inhibiting the growth of wound-as-sociated pathogens and hastening the healing process. The wound healing potential activity of mupirocin-loaded niosomal gel formulated with honey and curcumin, as well as their blends, by ether injection method and investigated for fur-ther studies. FTIR and DSC study reveals the compatibility of the drug and other excipients. In the case of post-approval study the param-eters evaluated are entrapment efficiency, drug content, pH, viscosity, spreadability, SEM, in-vi-tro drug release study, release kinetic study, stability study, and in-vivo wound healing study followed by histopathological study. This study aimed to create an excision wound model in al-bino rats and compare it to a commercially avail-able ointment (Mupicip by Cipla). The blended formulation (Formulation F7) was administered twice daily, and the wound healing effect was determined by the highest percentage of wound contraction, epithelisation period, and histoar-chitecture studies. The obtained results con-cluded that formulation F7 is considered as best formulation and has shown a higher percentage of wound contraction 99.08%. The histological study also confirms that formulation F7 pro-motes faster wound healing.</p>
  • Recent advancement in Nano-drug delivery for Topical Wound Healing
    Srikrishna T., Harikrishnan N.
    Research Journal of Pharmacy and Technology, 2022
    Advanced technology is needed for quicker and better wound healing management by minimizing infection, keeping moisturizing the wound surface, speeding up tissue growth, and reducing infection at the specific area. The advancement of drug delivery in nano form is gradually increasing and shows a greater response towards healing wounds. The drug's in nano shape potential to hold the drug and facilitate rapid targeted effect in tissue growth and repair. Research outcomes confirm that shortcomings of the traditional form of dosage may be revived by nanomedicine because of its better target-specific application for wound treatment. The present analysis concentrated on further growth and applicants for medications in nano form targeting to accelerate healing of wound treatments for a different wound style. The latest development in nanomedicine has been created by different researchers in the shape of nanoparticles, niosomes, dendrimers, nanosomes, hydrogels, liposomes, and micelles, etc. which emphasize clinical value and provide better therapeutic benefits. Past few years significant development has been observed on nanomedicines to satisfy the clinical needs for chronic and wounds that are diabetic. The occurrence of wounds nonhealing gradually increasing which affects the patient mentally and financially. This current review article summarized with latest developments within the area of nanomedicine, which dramatically expanded its clinical value towards wound healing.
  • Design & formulation of twice daily Nifedipine sustained release tablets using EC & HPMC E15
    International Journal of Pharmaceutical Research, 2016
  • Development and in-vitro characterization of sustained release tramadol hydrochloride by film coating technique
    Der Pharmacia Lettre, 2015
  • Development and in-vitro characterization of sustained release tramadol hydrochloride by film coating technique
    Der Pharmacia Lettre, 2015
  • Solid dispersions: A review
    Research Journal of Pharmacy and Technology, 2011
  • Formulation and in-vitro evaluation of osmotic drug delivery system of Metoprolol succinate
    International Journal of Pharmacy and Pharmaceutical Sciences, 2010

RECENT SCHOLAR PUBLICATIONS

  • BIOACTIVE COMPONENTS IN MORINGA OLEIFERA: PHYTOCHEMICAL SCREENING, GC-MS PROFILE, IN-VIVO AND IN-SILICO COMPONENTS AGAINST ANTI-DEPRESSANT ACTIVITY
    ST S.Sucharitha*, Vasanth Kumar PM
    Journal of Chemical Health Risks 14 (03), 1095-1101 , 2024
    2024
  • Mupirocin Loaded Niosomal Gel for Topical Wound Healing Applications
    NH Srikrishna Theerdhala
    Tropical Journal of Natural Product Research (TJNPR) 7 (8), 3676-3682 , 2023
    2023
    Citations: 4
  • Mupirocin niosomal gel with bee honey & curcumin as nano-drug delivery in wound healing applications
    S Theerdhala, N Harikrishnan
    Curr Trends Biotechnol Pharm 17 (2), 885-900 , 2023
    2023
    Citations: 2
  • FORMULATION & IN-VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF FROVATRIPTAN FOR THE TREATMENT OF MIGRAINE
    YR Srikrishna.T*, A.Datta Charan, P.Venugopalaiah
    Journal of Xi’an Shiyou University, Natural Science Edition 18 (12), 53-70 , 2022
    2022
  • Role of the Extracellular Matrix Components in Cutaneous Wound Healing
    SKT Sreenivasulu.M, Shaik Reshma*
    International Journal Experimental and Biomedical Research (IJEBR) 1 (3 … , 2022
    2022
  • Preparation and In-Vitro Evaluation of Sodium Alginate Microspheres loaded with Saxagliptin
    CA Srikrishna.T, Vasanth PM*,Yatham Priyanka, V Sarath Babu
    International Journal of Research and Analytical Reviews 9 (03), 775-787 , 2022
    2022
  • Preparation and Evaluation of Vigabatrin Microspheres loaded with Saxagliptin
    CA Srikrishna.T, Vasanth PM*,Jayanthi K, V Sarath Babu
    International Journal of Creative Research Thoughts 10 (09), 375-386 , 2022
    2022
  • Recent advancement in Nano-drug delivery for Topical Wound Healing
    NH Srikrishna T.*
    Research Journal of Pharmacy & Technology (RJPT) 15 (5), 2320 - 2326 , 2022
    2022
    Citations: 4
  • PREPARATION AND IN-VITRO EVALUATION OF SODIUM ALGINATE MICROSPHERES LOADED WITH SAXAGLIPTIN
    V PM, Y Priyanka, VS Babu, T Srikrishna, C Apparao
    2022
  • DESIGN & DEVELOPMENT OF FAST DISSOLVING ORAL FILMS OF KETOPROFEN
    MT Srikrishna T.*, Dr. M. Gobinath, Bharath P., Y. Nagarjuna Reddy, G ...
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 7 (7), 1053-1068 , 2018
    2018
    Citations: 2
  • Study of Stavudine Multiparticulate Floating Drug Delivery System Prepared by Emulsion Gelation Technique
    SS Srikrishna. T*, M. Gobinath, P. Venkata Anudeep, M. Sai Giridhar
    Saudi Journal of Medical and Pharmaceutical Sciences 3 (7A), 714-727 , 2017
    2017
  • Design, Development and Evaluation of Buccal Tablets of Pregabalin
    T Srikrishna, KM Anees, SL Priyanka, K Lavanya, B Mounika, MM Krishna
    Research Journal of Pharmacy and Technology 10 (2), 579-588 , 2017
    2017
    Citations: 4
  • Study of effect of sodium alginate and calcium carbonate composition difference on in situ gelling gastroretentive amoxicillin liquid formulation
    BPCRPR Srikrishna T.*, S. Sudheer, S. Srividya, V. Meghana Sai Kumar, B ...
    Journal of Chemical and Pharmaceutical Research 8 (5), 736-745 , 2016
    2016
    Citations: 2
  • A COMPREHENSIVE REVIEW ON PROGERIA
    TPK Srikrishna.T, S.Srividya, B.Prasanth, B.Jonathan Wilson, P.Sudheer Kumar
    AMERICAN JOURNAL OF PHARMTECH RESEARCH 6 (1), 40-56 , 2016
    2016
  • Development and Characterization of Floating Microspheres of Acyclovir as Gasroretentive Dosage Form
    MSG Srikrishna T*, P.V.Prasad, Md.Nayeem, Sk.Mubashira
    American Journal of Pharmacy and Health Research (AJPHR). 4 (6), 67-83 , 2016
    2016
  • Design & Formulation of Twice Daily Nifedipine Sustained Release Tablets using EC & HPMC E15
    MSG Srikrishna T*, Dr.M.Sreenivasulu, Md.Nayeem, Sk.Mubashira
    International Journal of Pharmaceutical Research (IJPR) 8 (2), 21-26 , 2016
    2016
  • Comprehensive Review on Gastroretentive Floating In situ Gel
    PVP Srikrishna T*, S.Sudheer, Sk.Mubashira, Md.Nayeem
    International Journal of Pharmacometrics and Integrated Biosciences 1 (1), 26-34 , 2016
    2016
  • Development and in-vitro characterization of sustained release tramadol hydrochloride by film coating technique
    VAMVSLK Srikrishna T.*, Rambabu P., Sirisha D.
    Der Pharmacia Lettre 7 (2), 71-83 , 2015
    2015
  • FORMULATION AND EVALUATION OF SODIUM VALPROATE SUSTAINED RELEASE TABLETS
    DS T.Srikrishna*, M.V.Sai Lalith Kumar, Vasanth Kumar.PM, Y.N.Sujitha
    JOURNAL OF GLOBAL TRENDS IN PHARMACEUTICAL SCIENCES 6 (1), 2446-2452 , 2015
    2015
  • FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAINED RELEASE TABLETS OF OMEPRAZOLE FOR DUODENAL ULCER
    PM Dr.M.Sreenivasulu, Srikrishna.T * , Vasanthi.P, Prasanthi.K, Ishrath.Sk
    World Journal of Pharmaceutical Research 4 (5), 1433-1444 , 2015
    2015

MOST CITED SCHOLAR PUBLICATIONS

  • Fomulation and in vitro evaluation of osmotic drug delivery system of metoprolol succinate
    B Srikrishna.T, Mothilal.M, Damodharan.N, Lakshmi.KS, Sharanya.V
    IJPPS 2, 64-8 , 2010
    2010
    Citations: 19
  • Solid Dispersions: A Review
    ST 9. Punitha.S*, Srinivasa Reddy.G
    Research Journal of Pharmacy and Technology 4 (3), 331-334 , 2011
    2011
    Citations: 18
  • Mupirocin Loaded Niosomal Gel for Topical Wound Healing Applications
    NH Srikrishna Theerdhala
    Tropical Journal of Natural Product Research (TJNPR) 7 (8), 3676-3682 , 2023
    2023
    Citations: 4
  • Recent advancement in Nano-drug delivery for Topical Wound Healing
    NH Srikrishna T.*
    Research Journal of Pharmacy & Technology (RJPT) 15 (5), 2320 - 2326 , 2022
    2022
    Citations: 4
  • Design, Development and Evaluation of Buccal Tablets of Pregabalin
    T Srikrishna, KM Anees, SL Priyanka, K Lavanya, B Mounika, MM Krishna
    Research Journal of Pharmacy and Technology 10 (2), 579-588 , 2017
    2017
    Citations: 4
  • Mupirocin niosomal gel with bee honey & curcumin as nano-drug delivery in wound healing applications
    S Theerdhala, N Harikrishnan
    Curr Trends Biotechnol Pharm 17 (2), 885-900 , 2023
    2023
    Citations: 2
  • DESIGN & DEVELOPMENT OF FAST DISSOLVING ORAL FILMS OF KETOPROFEN
    MT Srikrishna T.*, Dr. M. Gobinath, Bharath P., Y. Nagarjuna Reddy, G ...
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 7 (7), 1053-1068 , 2018
    2018
    Citations: 2
  • Study of effect of sodium alginate and calcium carbonate composition difference on in situ gelling gastroretentive amoxicillin liquid formulation
    BPCRPR Srikrishna T.*, S. Sudheer, S. Srividya, V. Meghana Sai Kumar, B ...
    Journal of Chemical and Pharmaceutical Research 8 (5), 736-745 , 2016
    2016
    Citations: 2
  • BIOACTIVE COMPONENTS IN MORINGA OLEIFERA: PHYTOCHEMICAL SCREENING, GC-MS PROFILE, IN-VIVO AND IN-SILICO COMPONENTS AGAINST ANTI-DEPRESSANT ACTIVITY
    ST S.Sucharitha*, Vasanth Kumar PM
    Journal of Chemical Health Risks 14 (03), 1095-1101 , 2024
    2024
  • FORMULATION & IN-VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF FROVATRIPTAN FOR THE TREATMENT OF MIGRAINE
    YR Srikrishna.T*, A.Datta Charan, P.Venugopalaiah
    Journal of Xi’an Shiyou University, Natural Science Edition 18 (12), 53-70 , 2022
    2022
  • Role of the Extracellular Matrix Components in Cutaneous Wound Healing
    SKT Sreenivasulu.M, Shaik Reshma*
    International Journal Experimental and Biomedical Research (IJEBR) 1 (3 … , 2022
    2022
  • Preparation and In-Vitro Evaluation of Sodium Alginate Microspheres loaded with Saxagliptin
    CA Srikrishna.T, Vasanth PM*,Yatham Priyanka, V Sarath Babu
    International Journal of Research and Analytical Reviews 9 (03), 775-787 , 2022
    2022
  • Preparation and Evaluation of Vigabatrin Microspheres loaded with Saxagliptin
    CA Srikrishna.T, Vasanth PM*,Jayanthi K, V Sarath Babu
    International Journal of Creative Research Thoughts 10 (09), 375-386 , 2022
    2022
  • PREPARATION AND IN-VITRO EVALUATION OF SODIUM ALGINATE MICROSPHERES LOADED WITH SAXAGLIPTIN
    V PM, Y Priyanka, VS Babu, T Srikrishna, C Apparao
    2022
  • Study of Stavudine Multiparticulate Floating Drug Delivery System Prepared by Emulsion Gelation Technique
    SS Srikrishna. T*, M. Gobinath, P. Venkata Anudeep, M. Sai Giridhar
    Saudi Journal of Medical and Pharmaceutical Sciences 3 (7A), 714-727 , 2017
    2017
  • A COMPREHENSIVE REVIEW ON PROGERIA
    TPK Srikrishna.T, S.Srividya, B.Prasanth, B.Jonathan Wilson, P.Sudheer Kumar
    AMERICAN JOURNAL OF PHARMTECH RESEARCH 6 (1), 40-56 , 2016
    2016
  • Development and Characterization of Floating Microspheres of Acyclovir as Gasroretentive Dosage Form
    MSG Srikrishna T*, P.V.Prasad, Md.Nayeem, Sk.Mubashira
    American Journal of Pharmacy and Health Research (AJPHR). 4 (6), 67-83 , 2016
    2016
  • Design & Formulation of Twice Daily Nifedipine Sustained Release Tablets using EC & HPMC E15
    MSG Srikrishna T*, Dr.M.Sreenivasulu, Md.Nayeem, Sk.Mubashira
    International Journal of Pharmaceutical Research (IJPR) 8 (2), 21-26 , 2016
    2016
  • Comprehensive Review on Gastroretentive Floating In situ Gel
    PVP Srikrishna T*, S.Sudheer, Sk.Mubashira, Md.Nayeem
    International Journal of Pharmacometrics and Integrated Biosciences 1 (1), 26-34 , 2016
    2016
  • Development and in-vitro characterization of sustained release tramadol hydrochloride by film coating technique
    VAMVSLK Srikrishna T.*, Rambabu P., Sirisha D.
    Der Pharmacia Lettre 7 (2), 71-83 , 2015
    2015

Publications

Mupirocin Niosomal Gel with Bee Honey & Curcumin as Nano-Drug Delivery in Wound Healing Applications
Current Trends in Biotechnology and PharmacyVol. 17(2) 885 - 900, April 2023, ISSN 0973-8916 (Print), 2230-7303 (Online)DOI: 10.5530/