Cell biology, Infectious diseases, Protein therapeutics
111
Scopus Publications
2417
Scholar Citations
23
Scholar h-index
55
Scholar i10-index
Scopus Publications
The Venom Revolution in Biomedicine: Unlocking Nature's Toxin Toolkit for Therapeutic Innovation Debalina Bose, Kishore Srinivasan, Sanskruti Shrenik Patil, Akshatha Ganesh Nayak, Raghu Chandrashekhar Hariharapura Toxicology Reports, 2026 Once known only for its deadly effects, venom is now valued for its medicinal potential. The transformation of venomous substances into therapeutic agents, focusing on the synergy between natural toxins and drugs, is a recent topic of interest to the scientific community worldwide. Venom is a concoction of various biomolecules, including proteins, enzymes, peptides, protease inhibitors, and more. This review focuses on different categories of venomous species, their venom composition, the mechanism of venom deployment, and the pharmacokinetics. Besides this, it also focuses on the technological innovations while tracing venom's medical use from ancient practices to modern therapies. Additionally, it addresses the challenges and future directions, such as regulatory obstacles related to the approval processes for venom-derived drugs, illustrating the ongoing evolution from toxins to cure. • Discusses the transformation of venoms into therapeutic agents. • Highlights key venom-based drugs and their potential in treating diseases. • Reviews challenges and evolution in venom drug discovery. • Provides perspective on the future of venom-derived pharmaceuticals.
Hyperglycaemia to heart failure: molecular pathophysiology, clinical manifestations, and novel therapeutic targets for diabetic cardiomyopathy Bhagyalakshmi Balakrishnan, Raghu Chandrashekar Hariharapura, Veena Nayak, Divyashree M. Somashekara Archives of Physiology and Biochemistry, 2026 Context Diabetic cardiomyopathy (DCM) is a chronic cardiac disorder that develops independently of coronary artery disease or hypertension in individuals with diabetes. Despite being identified over fifty years ago, it remains poorly recognized, and its management lacks standardization. The rising global prevalence of diabetes has amplified the incidence of DCM, underscoring the urgent need to clarify its molecular underpinnings and clinical progression.Objective To provide a comprehensive review of the molecular and physiological mechanisms underlying diabetic cardiomyopathy, elucidating how metabolic dysregulation contributes to cardiac structural and functional alterations. This study also aims to highlight the potential therapeutic targets involved in the key signaling pathways of DCM pathogenesis.Methods A systematic literature review was conducted using major scientific databases, including PubMed, Scopus, and Web of Science, covering studies published between 2000 and 2025. Keywords used included “diabetic cardiomyopathy,” “hyperglycemia,” “insulin resistance,” “oxidative stress,” “inflammation,” “mitochondrial dysfunction,” and “therapeutic targets.”Data Sources, Study Selection, and Data Extraction Peer-reviewed articles, original research papers, and review articles focusing on molecular mechanisms, signaling pathways, and therapeutic interventions related to DCM were included. Studies involving both experimental models and human subjects were considered. Data were extracted regarding metabolic alterations, key signaling cascades (NF-κB, PARP1, GLUT4, AT1R), and their association with cardiac remodeling, fibrosis, and functional impairment. The information was synthesized to illustrate the progression from metabolic imbalance to clinical manifestations and to identify promising molecular targets for therapy.
Bayesian dosage adjustment of tacrolimus in kidney transplantation: a systematic review Pasumarthi Tejashree, Mandar B. Rao, Pattanaik Smita, Vijay Ivaturi, Raghu Chandrashekar, Anbu Raj Elstin, Surulivelrajan Mallayasamy Postgraduate Medicine, 2026 BACKGROUND: ) is common, it may not consistently reflect true drug exposure. The area under the concentration-time curve (AUC) is a more realistic metric, and Bayesian estimation methods often improve the precision of AUC estimations using prior pharmacokinetic knowledge. METHODS: We conducted a systematic literature search of PubMed, Scopus, and Embase from inception to August 2024 for studies utilizing Bayesian approaches for estimating tacrolimus exposure in renal transplant patients. Studies were included if they employed Bayesian techniques for AUC estimation, dose adjustment using population pharmacokinetic (PopPk) models, or limited sampling strategies. Data were extracted, appraised using the Critical Appraisal of Clinical Pharmacokinetic Studies (CACPK) tool, and summarized. RESULTS: Most studies reported that Bayesian methods, particularly Maximum a Posteriori Bayesian Estimation (MAP-BE), provided superior AUC prediction compared to traditional methods. Tools such as Immunosuppressants Bayesian dose Adjustment (ISBA) and softwares such as NONMEM were frequently used. Most studies support the inclusion of trough and post-dose samples for >2 h for accurate predictions. CONCLUSION: Bayesian approaches demonstrate enhanced accuracy in tacrolimus dose adjustment for renal transplant patients, outperforming conventional TDM strategies, and showing potential for broader clinical applications.
Nanoemulsion as a promising drug delivery strategy for effective eradication of Helicobacter pylori: current insights Moumita Saha, Ashutosh Gupta, Shivani Kunkalienkar, Namdev Dhas, Shiran Shetty, Abhishek Gupta, Srinivas Mutalik, Nandakumar Krishnadas, Raghu Chandrashekar, Nagalakshmi Narasimhaswamy, Sudheer Moorkoth Drug Delivery and Translational Research, 2026 Helicobacter pylori (H. pylori) have infected about 50% of the world’s population and is a leading cause of gastrointestinal diseases, including gastritis, peptic ulcer, and stomach cancer. Current treatment regimens often fail to completely eradicate the bacteria due to the failure of antibiotics to penetrate into stomach’s inner mucosa, where the bacteria reside. Additional factors such as the ability of the organism to neutralize the stomach’s acidic environment and biofilm formation further contribute to treatment failure leading to antibiotic resistance. These challenges underscore the urgent need for new treatment options and strategies to combat H. pylori effectively. The current review delivers an overview of the pathophysiology of H. pylori, the limitations of the current regimens, and the potential of nanoemulsion as a smart carrier addressing the limitations associated with H. pylori treatment. The nanoemulsion offers specific advantages like mucoadhesion potential, targeted delivery, controlled release, and co-delivery options that ultimately results in an enhancement of bioavailability of the antibiotics to H. pylori, which resides in the inner walls of the stomach mucosa. Further, the ability of nanoemulsions to encapsulate the drug molecules helps in protecting the antibiotics from the stomach acidity facilitating drug stability. In conclusion, the review highlights the importance of tapping this unexplored potential of nanoemulsion as a promising drug delivery option for the treatment of H. pylori infection. Graphical abstract
Diabetic cardiomyopathy: a comprehensive review of diagnosis, management, and future directions Bhagyalakshmi Balakrishnan, Divyashree M. Somashekara, Veena Nayak, Raghu Chandrashekar Hariharapura Diabetology and Metabolic Syndrome, 2025 Diabetic cardiomyopathy is a growing challenge to global public health. The clinical characteristics are mainly fibrosis, hypertrophy, ventricular dysfunction, cardiac remodelling, and finally, heart failure. This alarming condition is often difficult to diagnose. Routine tests such as echocardiogram, electrocardiogram, and magnetic resonance imaging, along with specialized techniques such as transmitral Doppler, tissue Doppler imaging, and positron emission tomography, help diagnose and offer clearer insight into the condition. Current treatment strategies mainly address this medical condition as a condition secondary to diabetes. The main therapeutic practices involve glucose-lowering drugs such as glucagon-like peptide-1 modulators and sodium‒glucose cotransporter-2 inhibitors, along with other conventional lines of treatment to manage complications. Promising new potential therapeutic methods include gene therapy and noncoding RNA-mediated regulation of disarrayed signalling cascades. In this review, we address the benefits and limitations of the current system in the diagnosis and treatment of diabetic cardiomyopathy as well as the possibilities and advantages of novel techniques. In addition to discussing biomarkers for screening, diagnosis, and drug response for diabetic cardiomyopathy, we also discuss management and prevention strategies, adversities, and quality of life, and provide a brief outlook for research in this area. Graphical abstract
Harnessing the potential of HSV glycoproteins as cell penetrating peptides through in-silico methods Rakesh Rahangdale, Mukesh Pasupuleti, Fayaz Shaik Mohammad, H. Raghu Chandrashekar Network Modeling Analysis in Health Informatics and Bioinformatics, 2025 Cell-penetrating peptides (CPPs) are short amino acid sequences that can cross cell membranes. This is novel emerging approach for cell imaging, gene editing, and drug delivery. In-silico tools help identify and optimize CPPs efficiently, reducing time and cost. Virus-derived efficient CPPs such as TAT, Pep-1, and C105Y (HIV-1), MPG (SV40), pepR and pepM (DENV), and VP22 (HSV-1) suggest potential for discovering additional novel CPPs. This study is the first to employ an in-silico approach to systematically identify CPPs from all eleven surface glycoproteins (gC, gB, gD, gH, gL, gK, gJ, gM, gG, gE, and gI) of HSV-1 and HSV-2. Glycoprotein sequences were analyzed with CellPPD to assess their potential as CPP. Predicted CPPs were assessed using C2Pred for individual peptide probability, while uptake efficiency was evaluated through MLCPP. The physicochemical properties of CPPs were determined using CellPPD, Heliquest, ProtParam, and PepCalc. The potential for membrane binding and localization was evaluated using APD3 and DeepTMHMM. Immunogenicity, allergenicity, toxicity, and hemolytic properties were predicted utilizing IEDB, AllerTop, ToxinPred, and HAPPENN servers. Tertiary structure and helical projection were predicted using PEP-FOLD4 and Heliquest servers. Novel CPPs were identified, including tumor-penetrating CPPs (peptides 5, 6, and 10), nuclear localization signal (NLS)-CPP (peptide 1), and heparan sulfate (HS)-binding CPPs (peptides 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, and 16). The identified CPPs exhibit diverse functional properties, indicating their potential applications in gene editing and targeted drug delivery. These findings lay the groundwork for further experimental validation and therapeutic exploration.
Deciphering the role of crucial miRNAs involved in diabetic cardiomyopathy through a multiomics approach Bhagyalakshmi Balakrishnan, Raghu Chandrashekar Hariharapura, Divyashree Somashekara, Fayaz Shaik Mahammad Scientific Reports, 2025 Conventional drug discovery routes take decades to identify critical gene signatures involved in a disease. Though in silico platforms and software have simplified the process by reducing the time and energy needed to arrive at significant molecular targets for disease conditions, they are not accessible to everyone. Here, we propose a systematic strategic protocol to identify critical players in the disease pathogenesis using the vast amount of molecular omics data available on various public domains, setting diabetic cardiomyopathy as the case study. We use databases like KEGG, DisGeNET, HMDD, and literature to curate the key genes and miRNAs associated with the disease. We analysed 395 genes and 20 miRNAs for our analysis. Critical pathways like the insulin resistance pathway, the AGE–RAGE pathway, and the PI3K–AKT–mTOR pathway were enriched in our analysis through the Metascape platform. A protein–protein interaction network was generated using the STRING database. The export of this network to the Cytoscape platform helped to identify the clusters, node interactions, and hub genes. Our approach finally identified hsa-miR-302a-3p as the critical miRNA that regulates the highest-ranked hub gene, AKT1. This systematic methodology lays a solid foundation for the identification of critical therapeutic targets for any disease condition, thereby increasing the success rate for further stages of development.
Design and Characterization of Novel Gastroretentive Drug Delivery System of Antibiotics and Piperine for the Eradication of H. pylori Infection Ashutosh Gupta, Moumita Saha, Shivani Shailesh Kunkalienkar, Aadarsh Ghurye, Shweta Verma, Jahnavy Joshi, Abhishek Jha, Srinivas Mutalik, Shiran Shetty, Raghu Chandrashekar Hariharapura, Ashwini Aithal, K Nandakumar, Raviraja N. Seetharam, Sudheer Moorkoth Molecular Pharmaceutics, 2025 Helicobacter pylori (H. pylori) infection affects about half the world population, and if left untreated, can cause painful sores in the stomach lining and intestinal bleeding, leading to peptic ulcer disease (PUD) and stomach cancer. Treatment of H. pylori infection is always a challenge to the treating doctor because of the treatment inefficiency resulting from the poor bioavailability of the drug at the inner layers of the gastric mucosa, where the bacteria reside. This also results in the development of antibiotic resistance. In this work, we developed a mucoadhesive gastroretentive drug delivery system (M-GRDDS) for the effective delivery of antibiotics and piperine to the gastric mucosa. The GRDDS system was formulated by using the ion-gelation method and was evaluated for its entrapment efficiency, particle size, swelling behavior, drug release, mucoadhesion property, and H. pylori eradication efficacy. The efficacy of the drug-loaded mucoadhesive GRDDS formulation was compared with that of the free drug. Results showed that the percentage entrapment efficiency was more than 80% for all the drugs. M-GRDDS beads showed controlled release at pH 1.2 and 7.4. The optimized mucoadhesive beads showed good in vitro mucoadhesion in X-ray photography, with a mean gastric residence time of more than 8 h in rabbits. Tissue distribution study in rats revealed local delivery of the drugs to the gastric mucosa from the M-GRDDS beads. The in vivo efficacy study performed on Sprague–Dawley rats showed that the colony-forming units in the group treated with the novel GRDDS formulation were fewer than those in the group treated with the free drugs. Biochemical tests, gene expression studies, and histopathology studies corroborated the enhanced efficacy of the M-GRDDS formulation in eradicating the infection and curing peptic ulcers. The results conclude that the developed M-GRDDS formulation holds significant potential for improving local bioavailability, contributing to the more effective eradication of H. pylori-based gastric ulcers.
Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections Sanskruti Patil, Rakesh Rahangdale, Mukesh Pasupuleti, Puttur Santhoshkumar, Raghu Chandrashekar Hariharapura Microbial Biotechnology, 2025 Neurotropic viral infections continue to pose significant global health challenges, with pathogens such as herpes simplex virus (HSV), varicella‐zoster virus, human immunodeficiency virus, poliovirus, enteroviruses, parechovirus, West Nile virus and Japanese encephalitis virus driving the search for more effective therapeutic interventions. Current antiviral strategies, including small molecules and monoclonal antibodies, often face limitations such as drug resistance, narrow spectrum activity and adverse side effects, underscoring the need for alternative approaches. Antiviral peptides are emerging as potential therapeutic agents against these viral infections as entry and fusion inhibitors. However, their clinical development is limited by poor stability, low bioavailability and insufficient cellular penetration. To address these limitations, peptide stapling, a chemical modification that stabilises peptide α‐helices through covalent linkage, has emerged as a transformative technique to enhance the therapeutic potential of peptides, especially in antiviral drug development. Stapling techniques, including hydrocarbon staples, lactam bridges and metal‐coordination bonds, are explored for their ability to improve peptide stability, bioavailability and target binding affinity. This review examines the application of stapling in the development of antiviral peptides with a focus on stapled peptides targeting viral fusion and entry mechanisms, highlighting their potential against neurotropic viruses such as HSV and influenza. By integrating the structural rigidity conferred by stapling, these constructs promise to overcome delivery barriers and achieve superior antiviral efficacy. This paper underscores the pivotal role of peptide stapling by highlighting recent advancements in antiviral therapeutics and presents a roadmap for future research into multifunctional stapled peptides.
Strategic design of dicer substrate siRNA to mitigate the resistance mediated by ABCC1 in doxorubicinresistant breast cancer Indian Journal of Pharmaceutical Sciences, 2020
Potent selective cytotoxic activity of kaempferia galanga L. Rhizome against cancer cell cultures International Journal of Pharma and Bio Sciences, 2010
Hepatoprotective properties of Caesalpinia sappan Linn. heartwood on carbon tetrachloride induced toxicity Indian Journal of Experimental Biology, 2010
Anticancer activity of Hypericum mysorense H. Raghu Chandrasekhar, P. Vasanth Raj, J. Venkata Rao, N. Udupa 2nd International Conference on Biomedical and Pharmaceutical Engineering Icbpe 2009 Conference Proceedings, 2009
Free radical scavenging activity of selected essential oils Indian Drugs, 2004
In vitro cytotoxic properties of Grewia tiliaefolia bark and lupeol Indian Journal of Pharmacology, 2003
RECENT SCHOLAR PUBLICATIONS
Bayesian dosage adjustment of tacrolimus in kidney transplantation: a systematic review P Tejashree, MB Rao, P Smita, V Ivaturi, R Chandrashekar, AR Elstin, ... Postgraduate Medicine, 1-13 , 2026 2026
The Venom Revolution in Biomedicine: Unlocking Nature’s Toxin Toolkit for Therapeutic Innovation D Bose, K Srinivasan, SS Patil, AG Nayak, RC Hariharapura Toxicology Reports, 102227 , 2026 2026
RNA diagnostics and therapeutics: a comprehensive review AF Saju, A Mukundan, MS Divyashree, RC Hariharapura, ... RNA biology 22 (1), 1-11 , 2025 2025 Citations: 18
Exploring the Potential of HIV Integrase Inhibitors as Therapeutic Agents Against HSV and HCMV: A Molecular Docking Study AM Rao, F Sm, D Somashekara, PKR Gayam, RR Rahangdale, SS Patil, ... Journal of Experimental Pharmacology, 507-518 , 2025 2025
Anti-HSV activity of nectin-1-derived peptides targeting HSV gD: an in-silico and in-vitro approach R Rahangdale, P Ghormode, T Tender, S Balireddy, S Birangal, ... Journal of Biomolecular Structure and Dynamics 43 (18), 10451-10464 , 2025 2025 Citations: 10
Design and Characterization of Novel Gastroretentive Drug Delivery System of Antibiotics and Piperine for the Eradication of H. pylori Infection A Gupta, M Saha, SS Kunkalienkar, A Ghurye, S Verma, J Joshi, A Jha, ... Molecular Pharmaceutics 22 (12), 7641-7663 , 2025 2025 Citations: 2
Diabetic cardiomyopathy: a comprehensive review of diagnosis, management, and future directions B Balakrishnan, DM Somashekara, V Nayak, RC Hariharapura Diabetology & Metabolic Syndrome 17 (1), 422 , 2025 2025 Citations: 5
Association of Serum Vitamin D Status with Multidimensional Health Parameters in Patients with Diabetic Foot Infections: A Cross-Sectional Analysis in a Tertiary Healthcare … R Benson, SJ Kurian, SS Prasad, B Banerjee, VK Sudha Gururaj, ... The International Journal of Lower Extremity Wounds, 15347346251385348 , 2025 2025
Hyperglycaemia to heart failure: molecular pathophysiology, clinical manifestations, and novel therapeutic targets for diabetic cardiomyopathy B Balakrishnan, RC Hariharapura, V Nayak, DM Somashekara Archives of Physiology and Biochemistry, 1-14 , 2025 2025 Citations: 1
Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections S Patil, R Rahangdale, M Pasupuleti, P Santhoshkumar, ... Microbial Biotechnology 18 (9), e70221 , 2025 2025 Citations: 1
Optimizing MYCi975 delivery using PLGA nanoparticles for triple negative breast cancer therapy: Characterization and in vitro evaluation A Raj, A Paul, RC Hariharapura, JM Aranjani, S Soman, S Mutalik, ... Journal of Drug Delivery Science and Technology 111, 107180 , 2025 2025
Targeting Urease: A Promising Adjuvant Strategy for Effective Helicobacter pylori Eradication S Kunkalienkar, NS Gandhi, A Gupta, M Saha, A Pai, S Shetty, A Gupta, ... ACS omega 10 (27), 28643-28669 , 2025 2025 Citations: 16
Importance of advancing antifungal treatments: a focus on chitinases and glucanases in Candida therapy A Ghurye, KK Kolathur, MS Divyashree, VM Subrahmanyam, ... Archives of Microbiology 207 (7), 168 , 2025 2025 Citations: 3
Harnessing the potential of HSV glycoproteins as cell penetrating peptides through in-silico methods R Rahangdale, M Pasupuleti, FS Mohammad, HR Chandrashekar Network Modeling Analysis in Health Informatics and Bioinformatics 14 (1), 52 , 2025 2025 Citations: 1
Uncovering the Anti-Herpetic Activity of Anionic Peptides Derived From the Cytoplasmic Domain of Nectin-1 R Rahangdale, S Birangal, G Shenoy, FS Mohammad, M Pasupuleti, ... Bioinformatics and Biology Insights 19, 11779322251344130 , 2025 2025
Design and evaluation of siRNA molecules targeting conserved UL15 sequence in the HSV genome: An in silico and in vitro study AM Rao, FS Mohammad, DM Somashekara, RR Rahangdale, SS Patil, ... Journal of Applied Pharmaceutical Science 15 (6), 128-136 , 2025 2025 Citations: 1
Modulation of neuroplasticity and neuroinflammation by exosomal proteins and microRNA in depression: a review R Daksh, P Sharma, S Khanna, J Mudgal, RC Hariharapura, ... International Journal of Biological Macromolecules 309, 142829 , 2025 2025 Citations: 6
Assessing the Cytotoxicity and Wound Healing Potential of Pranic Healing Colours: An in vitro Study on HaCaT Cell Line. SN Jois, RR Rahangdale, V Vijayakumar, RC Hariharapura, ... Indian Journal of Pharmaceutical Education & Research 59 (2) , 2025 2025 Citations: 3
Pharmaceutical waste management through microbial bioremediation K Srinivasan, RC Hariharapura, SV Mallikarjuna Environmental Monitoring and Assessment 197 (4), 488 , 2025 2025 Citations: 15
Developing novel indoles as antitubercular agents and simulated annealing-based analysis of their binding with MmpL3 R Ray, S Das, SR Birangal, HI Boshoff, JS Roma, M Lobo, ... Future medicinal chemistry 17 (1), 19-34 , 2025 2025 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
Antiviral activity of medicinal plants of Nilgiris P Vijayan, C Raghu, G Ashok, SA Dhanaraj, B Suresh Indian Journal of medical research 120, 24-29 , 2004 2004 Citations: 429
Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage. MS Avadhani KS, Manikkath J, Tiwari M, Misra C, Godavarthi A, Vidya SM ... Drug Delivery 14 (1), 61-74 , 2017 2017 Citations: 348
Biosynthesis of copper nanoparticles using copper-resistant Bacillus cereus, a soil isolate. JVR Mradul Tiwari, Prateek Jain, Raghu Chandrashekhar Hariharapura, K ... Process Biochemistry 51, 1348-1356 , 2016 2016 Citations: 136
The cytotoxic activity of the total alkaloids isolated from different parts of Solanum pseudocapsicum P Vijayan, P Vijayaraj, PHC Setty, RC Hariharpura, A Godavarthi, ... Biological and Pharmaceutical Bulletin 27 (4), 528-530 , 2004 2004 Citations: 79
In vitro and in vivo hepatoprotective effects of the total alkaloid fraction of Hygrophila auriculata leaves VP Raj, RH Chandrasekhar, P Vijayan, SA Dhanaraj, MC Rao, VJ Rao, ... Indian journal of pharmacology 42 (2), 99-104 , 2010 2010 Citations: 76
Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data B Vastrad, C Vastrad, A Godavarthi, R Chandrashekar Medical Oncology 34 (11), 182 , 2017 2017 Citations: 74
Hepatoprotective properties of Caesalpinia sappan Linn. heartwood on carbon tetrachloride induced toxicity VS Srilakshmi, P Vijayan, PV Raj, SA Dhanaraj, HR Chandrashekhar Indian journal of experimental biology 48, 905-910 , 2010 2010 Citations: 62
Improvement of therapeutic efficacy of PLGA nanoformulation of siRNA targeting anti-apoptotic Bcl-2 through chitosan coating HV Jagani, VR Josyula, VR Palanimuthu, RC Hariharapura, SS Gang European Journal of Pharmaceutical Sciences 48 (4-5), 611-618 , 2013 2013 Citations: 59
Antitumor activity of the methanol extract of Hypericum hookerianum stem against Ehrlich ascites carcinoma in Swiss albino mice SH Dongre, S Badami, S Natesan Journal of pharmacological sciences 103 (4), 354-359 , 2007 2007 Citations: 49
Improvement of the Production and Characterisation of Polyhydroxyalkanoate by Bacillus endophyticus Using Inexpensive Carbon Feedstock M Geethu, R Vrundha, S Raja, H Raghu Chandrashekar, MS Divyashree Journal of Polymers and the Environment 27 (5), 917-928 , 2019 2019 Citations: 48
Dissolved oxygen as a propulsive parameter for polyhydroxyalkanoate production using Bacillus endophyticus cultures G Madhusoodanan, RC Hariharapura, D Somashekara Environment, Development and Sustainability 24 (4), 4641-4658 , 2022 2022 Citations: 36
Quinone scaffolds as potential therapeutic anticancer agents: Chemistry, mechanism of Actions, Structure-Activity relationships and future perspectives S Faizan, MMA Mohsen, C Amarakanth, A Justin, RR Rahangdale, ... Results in Chemistry 7, 101432 , 2024 2024 Citations: 35
Protective Role of Catechin on d -Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway P Vasanth Raj, K Nitesh, S Sagar Gang, V Hitesh Jagani, ... Indian Journal of Clinical Biochemistry 25 (4), 349-356 , 2010 2010 Citations: 34
Statistical Optimization for Coproduction of Chitinase and Beta 1, 4-Endoglucanase by Chitinolytic Paenibacillus elgii PB1 Having Antifungal Activity NV Philip, A Koteshwara, GA Kiran, S Raja, VM Subrahmanyam, ... Applied biochemistry and biotechnology 191 (1), 135-150 , 2020 2020 Citations: 31
A Nanoformulation of siRNA and its role in cancer therapy: In vitro and in vivo evaluation SSG Hitesh V. Jagani, Venkata R. Josyula, Vasanth R Cellular and Molecular Biology Letters 17, 120-136 , 2012 2012 Citations: 31
Cytotoxicity, platelet aggregation inhibitory and antioxidant activity of Curcuma amada Roxb. extracts RS Policegoudra, RH Chandrashekhar, SM Aradhya, L Singh Food technology and biotechnology 49 (2), 162 , 2011 2011 Citations: 30
Stimuli-responsive and cellular targeted nanoplatforms for multimodal therapy of skin cancer BS Padya, A Pandey, M Pisay, KB Koteshwara, RC Hariharapura, ... European Journal of Pharmacology 890, 173633 , 2021 2021 Citations: 28
Survivin inhibition by piperine sensitizes glioblastoma cancer stem cells and leads to better drug response NM Warrier, RK Krishnan, V Prabhu, RC Hariharapura, P Agarwal, ... International Journal of Molecular Sciences 23 (14), 7604 , 2022 2022 Citations: 27
Melittin, a honeybee venom derived peptide for the treatment of chemotherapy-induced peripheral neuropathy T Tender, RR Rahangdale, S Balireddy, M Nampoothiri, KK Sharma, ... Medical Oncology 38 (5), 52 , 2021 2021 Citations: 27
Statistical optimisation of polyhydroxyalkanoate production in Bacillus endophyticus using sucrose as sole source of carbon M Geethu, HR Chandrashekar, MS Divyashree Archives of microbiology 203 (10), 5993-6005 , 2021 2021 Citations: 26
