Md Hemayet Hossain
@bcsir.gov.bd
Principal Scientific Officer, BCSIR Laboratories Dhaka, BCSIR
Bangladesh Council of Scientific and Industrial Research (BCSIR)
RESEARCH INTERESTS
Pharmacology; Pharmaceutical Sciences; Phytochemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Manik Chandra Shill, Heba A. S. El‐Nashar, Patricia Prova Mollick, Rabindra Nath Acharyya, Silvia Afrin, Hemayet Hossain, Shimul Halder, Muhammad Torequl Islam, Md. Shimul Bhuia, Hasan Mahmud Reza,et al.
Wiley
AbstractThis study focused to assess the efficacy of Gynura procumbens (GP) leaf extract against cisplatin (CP)‐induced hepatorenal complications in Wister albino rats. Additionally, it aims to detect polyphenolic compounds using high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). The rats were treated intraperitoneally with CP (7.5 mg/kg) to mediate hepatorenal damage. They were then treated with GP extract (75 and 150 mg/kg, P.O.) for 7 consecutive days. Although GP extract significantly ameliorated CP‐mediated hepatorenal biomarkers like alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and blood urea nitrogen (BUN) levels in a dose‐dependent manner, GP extract at 150 mg/kg dose normalized hepatorenal biomarkers ALP (45.11 U/L), ALT (34 U/L), AST (29 U/L), creatinine (10.3 mg/dl) and BUN (11.19 mg/dl) while comparing to control and disease group. Similarly, though it significantly reduced CP‐induced oxidative stress inducers, including nitric oxide (NO) and advanced oxidative protein products (AOPP), higher dose (150 mg/kg) exhibited better activity in reducing NO (281.54 mmol/gm tissue in liver and 52.73 mmol/gm tissue in the kidney) and AOPP (770.95 mmol/mg protein in liver and 651.90 mmol/mg protein in the kidney). Besides, it showed better enhancement in the antioxidant enzymes superoxide dismutase, and glutathione levels at a higher dose (150 mg/kg). Histopathological studies showed that CP caused collagen accumulation in the liver and kidney tissues. GP extract drained the collagen mass and acted against hepatorenal damage. Ellagic acid, gallic acid, quercetin hydrate, kaempferol, and rutin hydrate were revealed in GP extract. In‐silico modelling showed good docking scores of the polyphenolic compounds with molecular targets including CYP4502E1, NF‐κB, caspase‐3, and TNF‐α. GP could be an effective therapeutic option for management of anticancer drugs’ complications like CP‐induced organ damage, although clinical studies are required to establish herbal formulation.
Shakhawat Ahmed, Khondoker Shahin Ahmed, Md. Naiemur Rahman, Hemayet Hossain, Aixia Han, Peiwu Geng, A. F. M. Shahid Ud Daula, and Abdullah Al Mamun
Frontiers Media SA
Zingiber roseum (Roxb.) Roscoe, a perennial herb from the Zingiberaceae family, has a long history of traditional use in the treatment of several ailments including pain, inflammation, fever, cough, arthritis, skin diseases, and liver infections. This study sought to confirm the efficacy of Zingiber roseum (Roxb.) Roscoe leaves methanol extract (ZrlME) as reported in traditional usage by evaluating its analgesic, anti-inflammatory, and antipyretic capabilities. In addition, in silico molecular docking of the metabolites identified in ZrlME was studied to verify the experimental outcomes. ZrlME demonstrated strong dose-dependent analgesic efficacy against all analgesic tests. ZrlME (400 mg/kg) showed higher anti-inflammatory activity than the standard in the carrageenan-induced paw edema test model. A significant reduction of rectal temperature (3.97°F↓) was also recorded at the same dose of ZrLME after 24 h of treatment. Seven polyphenolic metabolites were identified and quantified by HPLC-DAD analysis, including 3, 4- dihydroxy benzoic acid, (-) epicatechin, rutin hydrate, p-coumaric acid, trans-ferulic acid, rosmarinic acid, and myricetin. Strong binding affinities (ranges from −5.8 to −8.5 Kcal/mol) between the aforesaid polyphenols and cyclooxygenase-2 were discovered. Moreover, molecular dynamics simulations (MDS) demonstrated that these polyphenols exhibit significant COX-2 inhibitory activity due to their high stability in the COX-2 active site. In computational prediction, the polyphenols were also found to be nontoxic, and a variety of biological activities, such as antioxidant, analgesic, anti-inflammatory, antipyretic, and hepatoprotective, were observed. The results of this study revealed that ZrlME possesses notable analgesic, anti-inflammatory, and antipyretic properties.
Manik Chandra Shill, Abdullah All Rakib, Sabrin Islam Khan, Murad Hossain, Shaiful Alam, Hemayet Hossain, Utpal Kumar Karmakar, Md. Shimul Bhuia, Masum Shahriar, Hasan Mahmud Reza,et al.
Hindawi Limited
Background. Diabetes is a rising disorder that affects millions of people annually. It also creates more complications, such as neuropathy, oxidative stress, and hepatic and kidney impairment. Aphanamixis polystachya plant, which possesses multiple medicinal values, is used in this study to explore its potential in treating diabetes. Methods. A single dose (65 mg/kg) of intraperitoneal streptozotocin injection was utilized to mediate diabetes in Sprague-Dawley rats. Diabetic animals were treated orally with 250 or 500 mg/kg of standardized leaves’ extract of A. polystachya (AP) for 28 days to evaluate the antidiabetic and organ-protective effects of the plant. Different biochemical and histological markers are measured according to the established protocol. Results. Our results demonstrated a significant decrease in blood glucose (p <0.001) and HbA1c (p <0.05) levels in the diabetic animal after administering AP (250 and 500 mg/kg doses) compared to the control groups. AP can also regularize lipids, glycogen, alanine aminotransferase, and aspartate aminotransferase. Furthermore, serum urea nitrogen and creatinine decreased after treatment with AP in diabetic rats. AP also reduced oxidative stress markers and showed a substantial elevation in antioxidant enzymes in diabetic animals. Overall, AP at 500 mg/kg revealed comparable results against the standard antidiabetic drug glyburide. Besides, the histological investigation showed the AP’s efficacy in attenuating kidney tissue inflammation and damage. HPLC data elucidated that the AP leaf extract contains polyphenols with potential antioxidant, antidiabetic, and organ protective agents: gallic acid, rutin hydrate, and quercetin hydrate. Conclusion. Taken together, AP may be one of the potential sources of antidiabetic agents.
Showmik Rohman Talukder, Md. Akhlakur Rahman, Protyasha Sikdar, Dipto Kumer Sarker, Lopa Saha, Khondoker Shahin Ahmed, Hemayet Hossain, Pritam Kundu, and Samir Kumar Sadhu
Elsevier BV
Muntasir Rahman, Fariha Chowdhury, Kamal Uddin, Khondoker Shahin Ahmed, Hemayet Hossain, Preeti Jain, Hasan Mahmud Reza, Kyueui Lee, and Shazid Md Sharker
Elsevier BV
Anirban Biswas, M Rabiul Islam, M Zakir Hosen, Khondoker Shahin Ahmed, Hemayet Hossain, and Sheikh Julfikar Hossain
Bangladesh Academy of Sciences
The analgesic and anthelmintic activities of the common fruits in the Sundarbans forest, Bangladesh were evaluated. Acetic acid-induced writhing test and hot plate test in mice model were demonstrated for examining the analgesic activity whereas an anthelmintic test was performed using a flatworm, Paramphistomum cervi of livestock ruminants. Among the fruits, Ceriops decandra showed the strongest analgesic activity through inhibiting acetic acid-induced writhing (45%) and increasing response time (16.8 sec) on a hot plate in mice at 250 mg extract/kg body weight (b.w.). Diclofenac sodium (25 mg/kg b.w.), a positive control, demonstrated writhing inhibition of 51.3% whereas morphine (10 mg/kg b.w.), a wellknown centrally active analgesic drug, increased response time of 18.2 sec. The fruits showed inhibition of acetic acid-induced writhing in mice with strong correlations to both the total polyphenols (r2 = 0.85) and the total flavonoids (r2 = 0.81) contents. Similar results were also observed for an increase of response time in mice on hot plate test. Therefore, both the peripheral and the central analgesic activities of the fruits were profoundly related to their total contents of polyphenols as well as flavonoids. Extract of Aegiceras corniculatum fruit displayed the strongest anthelmintic activity with the lowest CDT50 (concentration for death time 50) of 0.69 mg extract/ml whereas albendazole, a positive control, had CDT50 of 5.60 mg/ml for the parasite. The anthelmintic activity of the fruits was not dependent on their contents of polyphenols (r2 = 0.30) or flavonoids. The chromatograms of HPLC-DAD analysis detected caffeic acid, (+)-catechin hydrate, p-coumaric acid, (-)-epicatechin, rutin hydrate, and syringic acid in C. decandra fruit extract and quantified as 10.6, 598.4, 1.5, 28.5, 2 and 1.3 mg/100 g extract, respectively. Results revealed that C. decandra and A. corniculatum fruits are the potentials to treat pain and helminthiasis, respectively. Bangladesh J. Bot. 52(1): 79-86, 2023 (March)
Md. Naiemur Rahman, Khondoker Shahin Ahmed, Shakhawat Ahmed, Hemayet Hossain, and AFM Shahid Ud Daula
Elsevier BV
Rabindra Nath Acharyya, Shuvra Mithila, Suborna Rani, Md. Arman Islam, Mimi Golder, Khondoker Shahin Ahmed, Hemayet Hossain, Shrabanti Dev, and Asish Kumar Das
Springer Science and Business Media LLC
Khondoker Shahin Ahmed, Maisha Farzana, Shaikh Emdadur Rahman, Ismet Ara Jahan, Tanzir Ahmed Khan, Muhammad Abdullah Al-Mansur, Nadia Sultana, and Hemayet Hossain
Informa UK Limited
Monarul Islam, Khondoker Shahin Ahmed, Rezaul Karim, Bikash Dev Nath, Shyama Prosad Moulick, Rashedul Islam, Sharkar Md. Mahmudul Hassan, Hemayet Hossain, Mohammad Moniruzzaman, M. Sarwar Jahan,et al.
Wiley
Tanoy Mazumder, Tarek Hasan, Khondoker Shahin Ahmed, Hemayet Hossain, Tushar Debnath, Esrat Jahan, Naiemur Rahman, Md. Sadikur Rahman Shuvo, and A F M Shahid Ud Daula
Elsevier BV
Saduddin Talukder, Khondoker Shahin Ahmed, Hemayet Hossain, Tarek Hasan, Israt Jahan Liya, Muhammed Amanat, Nurun Nahar, Md. Sadikur Rahman Shuvo, and A. F. M. Shahid Ud Daula
Springer Science and Business Media LLC
Raju Kumar Das, Al Mizan, Fatema Tuj Zohra, Sobur Ahmed, Khondoker Shahin Ahmed, and Hemayet Hossain
Springer Science and Business Media LLC
AbstractThe use of vegetable tanning materials in leather processing has drawn attention as an alternative to basic chromium sulphate for its natural abundance and environmental aspects. In this work, an attempt has been made to extract vegetable tannins from Xylocarpus granatum bark using different solvents (e.g., water, methanol, ethanol, and chloroform) and compare with conventional vegetable tanning agents such as mimosa and quebracho. The highest extraction efficiency was observed 31.22% by methanol. The presence of tannin content and polyphenolic compounds, e.g. (-)epicatechin (503 mg/100 g dry extract), catechin hydrate (218 mg/100 g dry extract), catechol (29 mg/100 g dry extract) were ensured by UV–Vis, FT-IR spectroscopy and HPLC. Again, condensed tannins, moisture content, and pH of the methanol extracted tannin were found 47.80%, 5.82%, and 3.97 respectively. The leather tanned by Xylocarpus granatum tannin showed a shrinkage temperature of 86.34 ± 1.52 °C. Other properties such as tensile strength, tear strength, grain cracking load, and distention at grain cracking were comparable to conventional vegetable-tanned leather. The cross-sectional morphology of the tanned leathers was also characterized by scanning electron microscopy (SEM) which revealed a compact structure of the leather fibers. In light of the findings from the study, X. granatum bark tannin could be a well alternative to chromium and a new source of vegetable tannin for the leather industry. Graphical Abstract
Md. Abdul Halim, K. Kanan, Towrin Nahar, Md Jiaur Rahman, K. S. Ahmed, Hemayet Hossain, N. Mozumder and Maruf Ahmed
A. M. Swaraz, Fariha Sultana, Khondoker Shahin Ahmed, Mohammed A. Satter, Hemayet Hossain, Obayed Raihan, Afrina Brishti, Ibrahim Khalil, and Siew Hua Gan
Wiley
Blumea lacera (Burm. f.) DC. is attracting scientific interest due to the diverse biological activities of its various parts and its use in folk medicine. The present study was undertaken to investigate the tissue‐specific differential expression pattern of its total bioactive compounds. The study was further extended to whole plant phenolics profiling, in vitro enzyme inhibition activities, followed by in silico enzyme inhibition analysis to assess its potential as herbal medicine. The amount of total phenolics in different tissues was followed in decreasing order as old leaf, flower bud, root, young leaf, flower, old stem, and young stem, while that for the flavonoids was old leaf, root, young leaf, flower bud, flower, young stem, and old stem. This study identified rosmarinic acid, quercetin, and kaempferol in this plant for the first time. The solvent extracts demonstrated strong inhibition of lipase and tyrosinase activity, along with varying degrees of inhibition of acetylcholinesterase and butyrylcholinesterase activity. Among the detected compounds, ten displayed strong in silico binding affinities with the tested enzymes. The findings provide a new insight into further investigation of the medicinal potential of this species against obesity, neurological disorders, and aberrant skin color.
Tarek Hasan, Esrat Jahan, Khondoker Shahin Ahmed, Hemayet Hossain, Syed Mumtahin Mannan Siam, Nusrat Nahid, Tanoy Mazumder, Md. Sadikur Rahman Shuvo, and A F M Shahid Ud Daula
Elsevier BV
Susmita Paul, Kamrun Naher, Sanzida Yeasmin, Rabindra Nath Acharrya, Mimi Golder, Khondoker Shahin Ahmed, Hemayet Hossain, Shrabanti Dev, and Asish Kumar Das
Informa UK Limited
ABSTRACT Ethanolic leaf extract of Tamarix indica was evaluated for the antioxidant and anticancer activities and toxicological profiles. The flavonoid, phenolic, and tannin contents of leaves were estimated as 5.3068 mg of QE g−1, 8.786 mg of GAE g−1, and 8.5216 mg of GAE g−1, respectively. In DPPH scavenging assay, T. indica leaves’ extract had an IC50 value of 74.38 μg mL−1. HPLC-DAD analysis identified catechin hydrate, vanillic acid, rutin hydrate, p-coumaric acid, and myricetin in different concentrations. In brine shrimp lethality bioassay, the IC50 value of the extract was 19.928 µg mL−1. Chemopreventive activity was evaluated using DMBA/croton oil-induced skin cancinogenic model mice. Oral treatment of the extract at different doses reduced the size, number, yield, and burden of tumor in skin carcinogenic mice. Natural antioxidants GSH and SOD increased with extract treatment. Additionally, reduction in blood bilirubin, SGPT, and SGOT levels were observed in extract treated mice. In acute toxicity study, no mortality was observed in mice justifying the safety of the extract.
Md Nazmul Hasan Zilani, Md Aminul Islam, Partha Biswas, Md Anisuzzman, Hemayet Hossain, Jamil A. Shilpi, Md Nazmul Hasan, and Md Golam Hossain
Elsevier BV
Shahnaz Siddiqua, Faiza Hamid Jyoti, Nadia Saffoon, Pintu Miah, Soumen Lasker, Hemayet Hossain, Raushanara Akter, Md. Iqbal Ahmed, and Md Ashraful Alam
Elsevier BV
Pintu Miah, Surovi Binte Sharmin Mohona, Md. Mizanur Rahman, Nusrat Subhan, Ferdous Khan, Hemayet Hossain, Shazid Md. Sharker, and Md. Ashraful Alam
Elsevier BV
A.M. Swaraz, Fariha Sultana, Md. Wasim Bari, Khondoker Shahin Ahmed, Mehedi Hasan, Md. Monirul Islam, Mohammad Amirul Islam, Mohammed A. Satter, Md. Hemayet Hossain, Md. Shofiqul Islam,et al.
Elsevier BV
Muhammed Amanat, Md. Sharif Reza, Md. Sadikur Rahman Shuvo, Khondoker Shahin Ahmed, Hemayet Hossain, Muhammad Tawhid, Md. Saifuzzaman, Mohammad Shariful Islam, Tanoy Mazumder, Md. Amirul Islam,et al.
Elsevier BV
Md. Mizanur Rahman, Nusaira Beenta Shahab, Pintu Miah, Md Mahamudur Rahaman, Arafat Ulla Kabir, Nusrat Subhan, Ahad Ali Khan, Mirola Afroze, Mala Khan, K. Shahin Ahmed,et al.
Elsevier BV
Shariful Islam Nayan, Faizul Islam Chowdhury, Noushin Akter, Md Mizanur Rahman, Saima Selim, Nadia Saffoon, Ferdous Khan, Nusrat Subhan, Maqsud Hossain, K. Shahin Ahmed,et al.
Public Library of Science (PLoS)
Obesity is an enduring medical issue that has raised concerns around the world. Natural plant extracts have shown therapeutic potential in preventing oxidative stress and inflammation related to obesity complications. In this study, Senna alexandrina Mill. leaves were utilized to treat high-fat diet-related metabolic disorders and non-alcoholic fatty liver diseases. Plasma biochemical assays were conducted to determine the lipid profiles and oxidative stress parameters, and the gene expression of antioxidant enzymes and inflammatory mediators was measured. Histological stained livers of high-fat diet-fed rats were observed. S. alexandrina leaf powder supplementation prevented the increase in cholesterol and triglyceride levels in high-fat diet-fed rats. Moreover, S. alexandrina leaves also reduced lipid peroxidation and nitric oxide production in these rats. Prevention of oxidative stress by S. alexandrina leaf supplementation in high-fat diet-fed rats is regulated by enhancing the antioxidant enzyme activity, followed by the restoration of corresponding gene expressions, such as NRF-2, HO-1, SOD, and CAT. Histological staining provides further evidence that S. alexandrina leaf supplementation prevents inflammatory cell infiltration, lipid droplet deposition, and fibrosis in the liver of high-fat diet-fed rats. Furthermore, this investigation revealed that S. alexandrina leaf supplementation controlled non-alcoholic fatty liver disease by modulating the expression of fat metabolizing enzymes in high-fat diet-fed rats. Therefore, S. alexandrina leaf supplementation inhibits fatty liver inflammation and fibrosis, suggesting its usefulness in treating non-alcoholic steatohepatitis. Thus, this natural leaf extract has potential in treatment of obesity related liver dysfunction.