Sébastien Ferreira-Cerca
@ur.de
University of Regensburg
Scopus Publications
- Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Miguel A. Garcia-Campos, Joe Georgeson, Ronit Nir, Robert Reichelt, Kristin A. Fluke, Donna Matzov, Vinithra Iyer, Brett W. Burkhart, Lauren Lui, Anatoly Kustanovich, Felix Grünberger, Supuni Thalalla-Gamage, Shereen A. Howpay-Manage, Milan Gerovac, Nicolas Alexandre, Yuko Nobe, Jakub S. Nowak, Manoj Perera, Alexander Apostle, Shiyue Fang, Sebastian Glatt, Ghil Jona, Sébastien Ferreira-Cerca, Jörg Vogel, Masato Taoka, Jordan L. Meier, Eric Westhof, Thomas J. Santangelo, Dina Grohmann, Moran Shalev-Benami, Schraga Schwartz
Cell, 2025 - Circular RNAs in Archaea
Hubert F. Becker, Sébastien Ferreira-Cerca
Advances in Experimental Medicine and Biology, 2025 - Ribosome and Transfer RNA Biogenesis
Tamara BASTA, Sébastien FERREIRA‐CERCA
Biology of Archaea 2 Molecular Biology of Archaea from Genome Maintenance to the Regulation of Gene Expression, 2025
This chapter focuses on the birth and maturation of ribosomal subunits and transfer RNA (tRNA) molecules in archaea. The ribosomal subunits and tRNA biogenesis processes ensure the production of some of the core molecular components of the translation process. Despite being a distinct domain of life, archaea are often characterized by a mixture of bacterial and eukaryotic features. Ribosome and tRNA biogenesis pathways are not an exception to this rule and as such their studies provide valuable insights into the evolution of these molecular processes and ultimately the evolution of life on Earth. When possible, key conceptual similarities and differences between the biogenesis pathways across the different domains of life will be highlighted. The chapter presents some general information about the diversity, distribution and function of tRNA modifications. It describes, as an example, the synthesis and function of two tRNA modifications specific for archaea. - RNase W, a conserved ribonuclease family with a novel active site
Marlène Vayssières, Michael Jüttner, Karina Haas, Aurélie Ancelin, Anita Marchfelder, Nicolas Leulliot, Sébastien Ferreira-Cerca, Magali Blaud
Nucleic Acids Research, 2024
Ribosome biogenesis is a complex process requiring multiple precursor ribosomal RNA (rRNA) cleavage steps. In archaea, the full set of ribonucleases (RNases) involved in rRNA processing remains to be discovered. A previous study suggested that FAU-1, a conserved protein containing an RNase G/E-like protein domain fused to a domain of unknown function (DUF402), acts as an RNase in archaea. However, the molecular basis of this activity remained so far elusive. Here, we report two X-ray crystallographic structures of RNase G/E-like–DUF402 hybrid proteins from Pyrococcus furiosus and Sulfolobus acidocaldarius, at 2.1 and 2.0 Å, respectively. The structures highlight a structural homology with the 5′ RNA recognition domain of Escherichia coli RNase E but no homology with other known catalytic nuclease domains. Surprisingly, we demonstrate that the C-terminal domain of this hybrid protein, annotated as a putative diphosphatase domain, harbors the RNase activity. Our functional analysis also supports a model by which the RNase G/E-like domain acts as a regulatory subunit of the RNase activity. Finally, in vivo experiments in Haloferax volcanii suggest that this RNase participates in the maturation of pre-16S rRNA. Together, our study defines a new RNase family, which we termed the RNase W family, as the first archaea-specific contributor to archaeal ribosome biogenesis. - Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius
Rani Baes, Felix Grünberger, Sébastien Pyr dit Ruys, Mohea Couturier, Sarah De Keulenaer, Sonja Skevin, Filip Van Nieuwerburgh, Didier Vertommen, Dina Grohmann, Sébastien Ferreira-Cerca, Eveline Peeters
Mbio, 2023
High-temperature stress is critical for all organisms and induces a profound cellular response. For Crenarchaeota, little information is available on how heat shock affects cellular processes and on how this response is regulated. We set out to study heat shock response in the thermoacidophilic model crenarchaeon Sulfolobus acidocaldarius, which thrives in volcanic hot springs and has an optimal growth temperature of 75°C. Pulse-labeling experiments demonstrated that a temperature shift to 86°C induces a drastic reduction of the transcriptional and translational activity, but that RNA and protein neosynthesis still occurs. By combining RNA sequencing and mass spectrometry, an integrated mapping of the transcriptome and proteome was performed. This revealed that heat shock causes an immediate change in the gene expression profile, with RNA levels of half of the genes being affected, followed by a more subtle reprogramming of the protein landscape. Functional enrichment analysis indicated that nearly all cellular processes are affected by heat shock. A limited correlation was observed in the differential expression on the RNA and protein level, suggesting a prevalence of post-transcriptional and post-translational regulation. Furthermore, promoter sequence analysis of heat shock regulon genes demonstrated the conservation of strong transcription initiation elements for highly induced genes, but an absence of a conserved protein-binding motif. It is, therefore, hypothesized that histone-lacking archaea such as Sulfolobales use an evolutionarily ancient regulatory mechanism that relies on temperature-responsive changes in DNA organization and compaction induced by the action of nucleoid-associated proteins, as well as on enhanced recruitment of initiation factors. IMPORTANCE Heat shock response is the ability to respond adequately to sudden temperature increases that could be harmful for cellular survival and fitness. It is crucial for microorganisms living in volcanic hot springs that are characterized by high temperatures and large temperature fluctuations. In this study, we investigated how S. acidocaldarius , which grows optimally at 75°C, responds to heat shock by altering its gene expression and protein production processes. We shed light on which cellular processes are affected by heat shock and propose a hypothesis on underlying regulatory mechanisms. This work is not only relevant for the organism’s lifestyle, but also with regard to its evolutionary status. Indeed, S. acidocaldarius belongs to the archaea, an ancient group of microbes that is more closely related to eukaryotes than to bacteria. Our study thus also contributes to a better understanding of the early evolution of heat shock response. - Nanopore-based RNA sequencing deciphers the formation, processing, and modification steps of rRNA intermediates in archaea
Felix Grünberger, Michael Jüttner, Robert Knüppel, Sébastien Ferreira-Cerca, Dina Grohmann
RNA, 2023
Ribosomal RNA (rRNA) maturation in archaea is a complex multistep process that requires well-defined endo- and exoribonuclease activities to generate fully mature linear rRNAs. However, technical challenges prevented detailed mapping of rRNA processing steps and a systematic analysis of rRNA maturation pathways across the tree of life. In this study, we used long-read (PCR)-cDNA and direct RNA nanopore-based sequencing to study rRNA maturation in three archaeal model organisms, namely the EuryarchaeaHaloferax volcaniiandPyrococcus furiosusand the CrenarchaeonSulfolobus acidocaldarius. Compared to standard short-read protocols, nanopore sequencing facilitates simultaneous readout of 5′- and 3′-positions, which is required for the classification of rRNA processing intermediates. More specifically, we (i) accurately detect and describe rRNA maturation stages by analysis of terminal read positions of cDNA reads and thereupon (ii) explore the stage-dependent installation of the KsgA-mediated dimethylations inH. volcaniiusing base-calling and signal characteristics of direct RNA reads. Due to the single-molecule sequencing capacity of nanopore sequencing, we could detect hitherto unknown intermediates with high confidence, revealing details about the maturation of archaea-specific circular rRNA intermediates. Taken together, our study delineates common principles and unique features of rRNA processing in euryarchaeal and crenarchaeal representatives, thereby significantly expanding our understanding of rRNA maturation pathways in archaea. - Ribosome biogenesis in archaea
Michael Jüttner, Sébastien Ferreira-Cerca
Biospektrum, 2022
The ribosome is a universally conserved macromolecular machine responsible for the translation of mRNAs into proteins. The synthesis of ribosomes is a crucial task that has been well characterized in bacteria and eukarya, but not in archaea. Here we summarize our current understanding of ribosome biogenesis in archaea and how it might help to further answer evolutionary questions. - Nanopore sequencing of RNA and cDNA molecules in Escherichia coli
Felix Grünberger, Sébastien Ferreira-Cerca, Dina Grohmann
RNA, 2022
High-throughput sequencing dramatically changed our view of transcriptome architectures and allowed for ground-breaking discoveries in RNA biology. Recently, sequencing of full-length transcripts based on the single-molecule sequencing platform from Oxford Nanopore Technologies (ONT) was introduced and is widely used to sequence eukaryotic and viral RNAs. However, experimental approaches implementing this technique for prokaryotic transcriptomes remain scarce. Here, we present an experimental and bioinformatic workflow for ONT RNA-seq in the bacterial model organism Escherichia coli, which can be applied to any microorganism. Our study highlights critical steps of library preparation and computational analysis and compares the results to gold standards in the field. Furthermore, we comprehensively evaluate the applicability and advantages of different ONT-based RNA sequencing protocols, including direct RNA, direct cDNA, and PCR-cDNA. We find that (PCR)-cDNA-seq offers improved yield and accuracy compared to direct RNA sequencing. Notably, (PCR)-cDNA-seq is suitable for quantitative measurements and can be readily used for simultaneous and accurate detection of transcript 5′ and 3′ boundaries, analysis of transcriptional units, and transcriptional heterogeneity. In summary, based on our comprehensive study, we show nanopore RNA-seq to be a ready-to-use tool allowing rapid, cost-effective, and accurate annotation of multiple transcriptomic features. Thereby nanopore RNA-seq holds the potential to become a valuable alternative method for RNA analysis in prokaryotes. - The dark side of the ribosome life cycle
Sébastien Ferreira-Cerca
RNA Biology, 2022
Thanks to genetics, biochemistry, and structural biology many features of the ribosome´s life cycles in models of bacteria, eukaryotes, and some organelles have been revealed to near-atomic details. Collectively, these studies have provided a very detailed understanding of what are now well-established prototypes for ribosome biogenesis and function as viewed from a ‘classical’ model organisms perspective. However, very important challenges remain ahead to explore the functional and structural diversity of both ribosome biogenesis and function across the biological diversity on earth. Particularly, the ‘third domain of life’, the archaea, and also many non-model bacterial and eukaryotic organisms have been comparatively neglected. Importantly, characterizing these additional biological systems will not only offer a yet untapped window to enlighten the evolution of ribosome biogenesis and function but will also help to unravel fundamental principles of molecular adaptation of these central cellular processes. - Preface
Methods in Molecular Biology, 2022 - Differential Translation Activity Analysis Using Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT) in Archaea
Michael Kern, Sébastien Ferreira-Cerca
Methods in Molecular Biology, 2022 - A Comparative Perspective on Ribosome Biogenesis: Unity and Diversity Across the Tree of Life
Michael Jüttner, Sébastien Ferreira-Cerca
Methods in Molecular Biology, 2022 - Looking through the Lens of the Ribosome Biogenesis Evolutionary History: Possible Implications for Archaeal Phylogeny and Eukaryogenesis
Michael Jüttner, Sébastien Ferreira-Cerca
Molecular Biology and Evolution, 2022 - Non-radioactive In Vivo Labeling of RNA with 4-Thiouracil
Christina Braun, Robert Knüppel, Jorge Perez-Fernandez, Sébastien Ferreira-Cerca
Methods in Molecular Biology, 2022 - Editorial: Archaeal Ribosomes: Biogenesis, Structure and Function
Sébastien Ferreira-Cerca, Anna La Teana, Paola Londei
Frontiers in Microbiology, 2021 - Ribosome Biogenesis in Archaea
Paola Londei, Sébastien Ferreira-Cerca
Frontiers in Microbiology, 2021 - Insights into synthesis and function of KsgA/Dim1-dependent rRNA modifications in archaea
Robert Knüppel, Christian Trahan, Michael Kern, Alexander Wagner, Felix Grünberger, Winfried Hausner, Tessa E F Quax, Sonja-Verena Albers, Marlene Oeffinger, Sébastien Ferreira-Cerca
Nucleic Acids Research, 2021 - The Archaeal Proteome Project advances knowledge about archaeal cell biology through comprehensive proteomics
Stefan Schulze, Zachary Adams, Micaela Cerletti, Rosana De Castro, Sébastien Ferreira-Cerca, Christian Fufezan, María Inés Giménez, Michael Hippler, Zivojin Jevtic, Robert Knüppel, Georgio Legerme, Christof Lenz, Anita Marchfelder, Julie Maupin-Furlow, Roberto A. Paggi, Friedhelm Pfeiffer, Ansgar Poetsch, Henning Urlaub, Mechthild Pohlschroder
Nature Communications, 2020 - Splicing Endonuclease Is an Important Player in rRNA and tRNA Maturation in Archaea
Thandi S. Schwarz, Sarah J. Berkemer, Stephan H. Bernhart, Matthias Weiß, Sébastien Ferreira-Cerca, Peter F. Stadler, Anita Marchfelder
Frontiers in Microbiology, 2020 - A versatile cis-acting element reporter system to study the function, maturation and stability of ribosomal RNA mutants in archaea
Michael Jüttner, Matthias Weiß, Nina Ostheimer, Corinna Reglin, Michael Kern, Robert Knüppel, Sébastien Ferreira-Cerca
Nucleic Acids Research, 2020 - In vivo RNA chemical footprinting analysis in archaea
Robert Knüppel, Martin Fenk, Michael Jüttner, Sébastien Ferreira-Cerca
Methods in Molecular Biology, 2020 - Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism
Valentin Mitterer, Ramtin Shayan, Sébastien Ferreira-Cerca, Guillaume Murat, Tanja Enne, Dana Rinaldi, Sarah Weigl, Hajrija Omanic, Pierre-Emmanuel Gleizes, Dieter Kressler, Celia Plisson-Chastang, Brigitte Pertschy
Nature Communications, 2019 - The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stability
Giovanna Berto, Sébastien Ferreira-Cerca, Peter De Wulf
Current Genetics, 2019 - Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors
Jan Linnemann, Gisela Pöll, Steffen Jakob, Sébastien Ferreira-Cerca, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit
Plos One, 2019 - Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae
Maria G Iacovella, Michael Bremang, Omer Basha, Luciano Giacò, Walter Carotenuto, Cristina Golfieri, Barnabas Szakal, Marianna Dal Maschio, Valentina Infantino, Galina V Beznoussenko, Chinnu R Joseph, Clara Visintin, Alexander A Mironov, Rosella Visintin, Dana Branzei, Sébastien Ferreira-Cerca, Esti Yeger-Lotem, Peter De Wulf
Nucleic Acids Research, 2018 - Insights into the evolutionary conserved regulation of Rio ATPase activity
Robert Knüppel, Regitse H Christensen, Fiona C Gray, Dominik Esser, Daniela Strauß, Jan Medenbach, Bettina Siebers, Stuart A MacNeill, Nicole LaRonde, Sébastien Ferreira-Cerca
Nucleic Acids Research, 2018 - Toward time-resolved analysis of RNA metabolism in archaea using 4-thiouracil
Robert Knüppel, Corinna Kuttenberger, Sébastien Ferreira-Cerca
Frontiers in Microbiology, 2017 - Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation
Maria G. Iacovella, Cristina Golfieri, Lucia F. Massari, Sara Busnelli, Cinzia Pagliuca, Marianna Dal Maschio, Valentina Infantino, Rosella Visintin, Karl Mechtler, Sébastien Ferreira-Cerca, Peter De Wulf
Nature Communications, 2015 - Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes
Sébastien Ferreira-Cerca, Irene Kiburu, Emma Thomson, Nicole LaRonde, Ed Hurt
Nucleic Acids Research, 2014 - Eukaryotic ribosome biogenesis at a glance
Emma Thomson, Sébastien Ferreira-Cerca, Ed Hurt
Journal of Cell Science, 2013 - ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit
Sébastien Ferreira-Cerca, Vatsala Sagar, Thorsten Schäfer, Momar Diop, Anne-Maria Wesseling, Haiyun Lu, Eileen Chai, Ed Hurt, Nicole LaRonde-LeBlanc
Nature Structural and Molecular Biology, 2012 - Cell biology: Arrest by ribosome
Sébastien Ferreira-Cerca, Ed Hurt
Nature, 2009 - Analysis of the In Vivo Assembly Pathway of Eukaryotic 40S Ribosomal Proteins
Sébastien Ferreira-Cerca, Gisela Pöll, Holger Kühn, Andreas Neueder, Steffen Jakob, Herbert Tschochner, Philipp Milkereit
Molecular Cell, 2007 - Roles of eukaryotic ribosomal proteins in maturation and transport of pre-18S rRNA and ribosome function
Sébastien Ferreira-Cerca, Gisela Pöll, Pierre-Emmanuel Gleizes, Herbert Tschochner, Philipp Milkereit
Molecular Cell, 2005 - The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast
Isabelle Léger-Silvestre, Philipp Milkereit, Sébastien Ferreira-Cerca, Cosmin Saveanu, Jean-Claude Rousselle, Valérie Choesmel, Cécile Guinefoleau, Nicole Gas, Pierre-Emmanuel Gleizes
EMBO Journal, 2004
RECENT SCHOLAR PUBLICATIONS
- Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
MA Garcia-Campos, J Georgeson, R Nir, R Reichelt, KA Fluke, D Matzov, ...
Cell 188 (24), 6825-6844. e28 , 2025
2025
Citations: 5 - Circular RNAs in Archaea
HF Becker, S Ferreira-Cerca
Advances in Circular RNAs: The Basis and Disease Relevance, 451-464 , 2025
2025
Citations: 1 - RNA Biogenesis
T BASTA¹, S FERREIRA-CERCA
Biology of Archaea 2: Molecular Biology of Archaea, From Genome Maintenance … , 2025
2025 - Ribosome and Transfer RNA Biogenesis
T Basta-Le Berre, S Ferreira-Cerca
Biology of Archaea 2: Molecular Biology of Archaea, From Genome Maintenance … , 2025
2025 - Ribosome and Transfer RNA Biogenesis
T BASTA, S FERREIRA‐CERCA
Biology of Archaea 2: Molecular Biology of Archaea, From Genome Maintenance … , 2025
2025 - RNase W, a conserved ribonuclease family with a novel active site
M Vayssières, M Jüttner, K Haas, A Ancelin, A Marchfelder, N Leulliot, ...
Nucleic Acids Research 52 (21), 13386-13401 , 2024
2024
Citations: 4 - Chapitre 5-Biogenèse des ribosomes et des ARN de transfert
T BASTA, S FERREIRA-CERCA
ISTE Group , 2024
2024 - Biogenèse des ribosomes et des ARN de transfert
T Basta, S Ferreira-Cerca
Les archées, micro-organismes du troisième domaine du vivant 2, 119-175 , 2024
2024 - Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius
R Baes, F Grünberger, S Pyr dit Ruys, M Couturier, S De Keulenaer, ...
MBio 14 (5), e03593-22 , 2023
2023
Citations: 18 - Nanopore-based RNA sequencing deciphers the formation, processing, and modification steps of rRNA intermediates in archaea
F Grünberger, M Jüttner, R Knüppel, S Ferreira-Cerca, D Grohmann
Rna 29 (8), 1255-1273 , 2023
2023
Citations: 26 - The dark side of the ribosome life cycle
S Ferreira-Cerca
RNA biology 19 (1), 1045-1049 , 2022
2022
Citations: 5 - Ribosomenbiogenese in Archaeen
M Jüttner, S Ferreira-Cerca
BIOspektrum 28 (5), 478-480 , 2022
2022 - Post-transcriptional regulation of the heat shock response in the thermoacidophilic Crenarchaeon Sulfolobus acidocaldarius
R Baes, F Grünberger, SP dit Ruys, M Couturier, S De Keulenaer, ...
EMBO: Molecular Biology of Archaea 2022 , 2022
2022 - A comparative perspective on ribosome biogenesis: unity and diversity across the tree of life
M Jüttner, S Ferreira-Cerca
Ribosome Biogenesis: Methods and Protocols, 3-22 , 2022
2022
Citations: 25 - Non-radioactive In Vivo Labeling of RNA with 4-Thiouracil
C Braun, R Knüppel, J Perez-Fernandez, S Ferreira-Cerca
Ribosome Biogenesis: Methods and Protocols, 199-213 , 2022
2022
Citations: 1 - Differential Translation Activity Analysis Using Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT) in Archaea
M Kern, S Ferreira-Cerca
Ribosome Biogenesis: Methods and Protocols, 229-246 , 2022
2022
Citations: 5 - Looking through the lens of the ribosome biogenesis evolutionary history: possible implications for archaeal phylogeny and eukaryogenesis
M Jüttner, S Ferreira-Cerca
Molecular Biology and Evolution 39 (4), msac054 , 2022
2022
Citations: 25 - A General Microbiology
R Baes, SP dit Ruys, S De Keulenaer, S Skevin, F Van, DV Nieuwerburgh, ...
Annual symposium 2022 Future Challenges in Microbiology, 49 , 2022
2022
Citations: 19 - Nanopore sequencing of RNA and cDNA molecules in Escherichia coli
F Grünberger, S Ferreira-Cerca, D Grohmann
Rna 28 (3), 400-417 , 2022
2022
Citations: 106 - Archaea
S Ferreira-Cerca
Springer US , 2022
2022
Citations: 12
MOST CITED SCHOLAR PUBLICATIONS
- Eukaryotic ribosome biogenesis at a glance
E Thomson, S Ferreira-Cerca, E Hurt
Journal of cell science 126 (21), 4815-4821 , 2013
2013
Citations: 412 - Roles of eukaryotic ribosomal proteins in maturation and transport of pre-18S rRNA and ribosome function
S Ferreira-Cerca, G Pöll, PE Gleizes, H Tschochner, P Milkereit
Molecular cell 20 (2), 263-275 , 2005
2005
Citations: 404 - Analysis of the in vivo assembly pathway of eukaryotic 40S ribosomal proteins
S Ferreira-Cerca, G Pöll, H Kühn, A Neueder, S Jakob, H Tschochner, ...
Molecular cell 28 (3), 446-457 , 2007
2007
Citations: 210 - ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit
S Ferreira-Cerca, V Sagar, T Schäfer, M Diop, AM Wesseling, H Lu, ...
Nature structural & molecular biology 19 (12), 1316-1323 , 2012
2012
Citations: 151 - The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast
I Léger‐Silvestre, P Milkereit, S Ferreira‐Cerca, C Saveanu, JC Rousselle, ...
The EMBO journal 23 (12), 2336-2347 , 2004
2004
Citations: 138 - Nanopore sequencing of RNA and cDNA molecules in Escherichia coli
F Grünberger, S Ferreira-Cerca, D Grohmann
Rna 28 (3), 400-417 , 2022
2022
Citations: 106 - Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes
S Ferreira-Cerca, I Kiburu, E Thomson, N LaRonde, E Hurt
Nucleic acids research 42 (13), 8635-8647 , 2014
2014
Citations: 100 - The Archaeal Proteome Project advances knowledge about archaeal cell biology through comprehensive proteomics
S Schulze, Z Adams, M Cerletti, R De Castro, S Ferreira-Cerca, C Fufezan, ...
Nature Communications 11 (1), 3145 , 2020
2020
Citations: 57 - Ribosome biogenesis in archaea
P Londei, S Ferreira-Cerca
Frontiers in Microbiology 12, 686977 , 2021
2021
Citations: 52 - Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism
V Mitterer, R Shayan, S Ferreira-Cerca, G Murat, T Enne, D Rinaldi, ...
Nature communications 10 (1), 2754 , 2019
2019
Citations: 52 - Insights into the evolutionary conserved regulation of Rio ATPase activity
R Knüppel, RH Christensen, FC Gray, D Esser, D Strauß, J Medenbach, ...
Nucleic Acids Research 46 (3), 1441-1456 , 2018
2018
Citations: 49 - Exploring prokaryotic transcription, operon structures, rRNA maturation and modifications using Nanopore-based native RNA sequencing
F Grünberger, R Knüppel, M Jüttner, M Fenk, A Borst, R Reichelt, ...
BioRxiv 10 (2019.12), 18.880849 , 2020
2020
Citations: 36 - Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation
MG Iacovella, C Golfieri, LF Massari, S Busnelli, C Pagliuca, ...
Nature communications 6 (1), 6643 , 2015
2015
Citations: 36 - Insights into synthesis and function of KsgA/Dim1-dependent rRNA modifications in archaea
R Knüppel, C Trahan, M Kern, A Wagner, F Grünberger, W Hausner, ...
Nucleic Acids Research 49 (3), 1662-1687 , 2021
2021
Citations: 30 - A versatile cis -acting element reporter system to study the function, maturation and stability of ribosomal RNA mutants in archaea
M Jüttner, M Weiß, N Ostheimer, C Reglin, M Kern, R Knüppel, ...
Nucleic Acids Research 48 (4), 2073-2090 , 2020
2020
Citations: 30 - Arrest by ribosome
S Ferreira-Cerca, E Hurt
Nature 459 (7243), 46-47 , 2009
2009
Citations: 29 - Nanopore-based RNA sequencing deciphers the formation, processing, and modification steps of rRNA intermediates in archaea
F Grünberger, M Jüttner, R Knüppel, S Ferreira-Cerca, D Grohmann
Rna 29 (8), 1255-1273 , 2023
2023
Citations: 26 - Splicing endonuclease is an important player in rRNA and tRNA maturation in archaea
TS Schwarz, SJ Berkemer, SH Bernhart, M Weiß, S Ferreira-Cerca, ...
Frontiers in microbiology 11, 594838 , 2020
2020
Citations: 26 - A comparative perspective on ribosome biogenesis: unity and diversity across the tree of life
M Jüttner, S Ferreira-Cerca
Ribosome Biogenesis: Methods and Protocols, 3-22 , 2022
2022
Citations: 25 - Looking through the lens of the ribosome biogenesis evolutionary history: possible implications for archaeal phylogeny and eukaryogenesis
M Jüttner, S Ferreira-Cerca
Molecular Biology and Evolution 39 (4), msac054 , 2022
2022
Citations: 25
