Robert Paul Coppes

Scopus Publications

Radiation-induced interferon-I response impairs thyroid organoid function
Rufina Maturi, Davide Cinat, Anne L Jellema-de Bruin, Gabriella De Vita, Schelto Kruijff, Rob P. Coppes, Abel Soto-Gamez
Radiotherapy and Oncology, 2026
BACKGROUND AND AIM: Radiotherapy is a standard cancer treatment, but radiation exposure to surrounding healthy tissues may lead to adverse side effects that compromise patient quality of life. In patients with head and neck cancer treated with radiotherapy, thyroid damage is a frequent complication, resulting in hypothyroidism or secondary thyroid malignancies. Although clinically recognized, the molecular mechanisms underlying these side effects remain mostly unexplored. This study aims to characterize the radiation-induced molecular alterations in thyroid organoids. METHODS: Bulk RNA sequencing was performed to investigate transcriptomic changes in tissue-derived thyroid organoids following gamma-irradiation. Observed changes were further validated and explored using qPCRs, western blotting, immunofluorescence, caspase 3/7 activity and organoid forming efficiency. RESULTS: Our findings identify interferon-β signaling as a key mediator of radiation-induced inflammation in the thyroid. Additionally, the intrinsic apoptotic pathway was found to be the predominant mechanism of radiation-induced thyroid cell death. Notably, while IFN-β exhibited a protective effect against apoptosis, it concurrently reduced thyroid stem progenitor cell potential. CONCLUSIONS: These results highlight the dual role of interferon-β signaling in modulating thyroid cell fate after irradiation, potentially promoting survival upon injury at the expense of regenerative potential.
Brain irradiation drives remote liver changes via senescence-independent mechanisms
Yuting Jiang, Daniëlle C. Voshart, Alessandro Gustinelli, Ayla C. Scholma, Eline Hageman, Luiza Reali Nazario, Uilke Brouwer, Marco Demaria, Rob P. Coppes, Lara Barazzuol
Radiotherapy and Oncology, 2026
BACKGROUND AND PURPOSE: Although radiotherapy is essential for treating brain tumors, it often damages surrounding healthy brain tissue, causing long-term neurocognitive dysfunction. Cellular senescence, a stable state of cell cycle arrest triggered by various stressors including radiation-induced DNA damage, has been implicated in aging- and neurodegeneration-associated cognitive decline via its pro-inflammatory secretome and has been reported to exert paracrine effects on distant organs. However, whether brain irradiation, particularly through the induction of cellular senescence, can trigger changes in peripheral tissues remains largely unknown. MATERIALS AND METHODS: Adult male rats received 14 Gy X-ray irradiation to the brain. Senescence-associated markers were assessed in the brain at 6 and 12 weeks post-irradiation and in peripheral tissues, including the kidney, small intestine, skeletal muscle, and liver, at 17 weeks post-irradiation. Liver samples were further examined for proliferation and fibrosis markers, as well as for liver enzyme activity. The senolytic ABT263 was administered to eliminate senescent cells. RESULTS: Brain irradiation induced senescence-like features in the brain but did not trigger p21-dependent senescence in the tested peripheral tissues. However, brain-irradiated rats exhibited increased proliferation, elevated GFAP levels, and enhanced ALT and AST activity in the liver. These hepatic changes were likely independent of cellular senescence, as they were not reversed by treatment with ABT263. CONCLUSION: Brain irradiation induces liver proliferation, increased GFAP levels, and altered ALT and AST activity, via mechanisms likely independent of senescence. Future investigation of blood GFAP levels is needed to determine whether the enhanced hepatic GFAP levels originate from the brain.
Differential synaptic signaling responses in human cortical organoids after photon and proton irradiation
Yuting Jiang, Danieli Born Guerra, Daniëlle C. Voshart, Eline Hageman, Luiza Reali Nazario, Marc-Jan van Goethem, Rob P. Coppes, Lara Barazzuol
Stem Cell Reports, 2026
Brain tumors are the most common solid cancer in children, with radiotherapy being a primary treatment. Proton therapy, with its precise dose distribution, is increasingly being used in these patients to minimize damage to the developing brain. However, the biological effects of proton irradiation on the human brain remain unclear. To investigate this, human cortical organoids were exposed to conventional photons, plateau protons, and spread-out Bragg peak (SOBP) protons, followed by comparative transcriptomic profiling. While photons and protons induced similar transcriptional profiles characterized by apoptosis and downregulation of DNA replication, SOBP protons uniquely downregulated genes involved in brain development and synaptic signaling. Functional calcium imaging, cell deconvolution analysis, and immunostaining indicated that SOBP protons impaired neural network function, due to reduced synaptic density and loss in excitatory neuron progenitors. These findings underscore the distinct biological effects of SOBP protons and their potential impact on the developing brain.
Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
Davide Cinat, Rufina Maturi, Jeremy P Gunawan, Anne L Jellema-de Bruin, Laura Kracht, Paola Serrano Martinez, Yi Wu, Abel Soto-Gamez, Marc-Jan van Goethem, Inge R Holtman, Sarah Pringle, Lara Barazzuol, Rob P Coppes
EMBO Journal, 2026
Organoid models have significantly enhanced our understanding of adult stem cell function, however, uncovering regulatory mechanisms governing rare and often quiescent stem cells in glandular organs remains challenging. Here, we employ an integrative multi-omics approach, combining single-cell RNA sequencing, bulk ATAC and RNA sequencing, to profile the cellular populations and signaling pathways characterizing a mouse salivary gland organoid model across different temporal stages and after radiation-induced damage. Our findings identify Sox9- and Itgb1/Cd44- expressing cells as primitive adult stem/progenitor populations with a critical migratory role in tissue repair. Notch signaling is a key driver of self-renewal and migration in response to irradiation. Additionally, scRNA-seq analysis of irradiated salivary gland tissue confirms these findings in an in vivo setting. Extending these findings to murine and patient-derived salivary, mammary and thyroid gland organoids, we reveal the conserved role of Notch signaling in coordinating stem/progenitor cell-mediated regeneration across glandular tissues. These insights position Notch signaling as a central regulator of glandular stem cell-like populations and as a promising therapeutic target for enhancing glandular tissue regeneration following cancer therapies.
lncRNAs: a new generation of targets and biomarkers in thyroid cancer
Rufina Maturi, Matteo Esposito, Rob P Coppes, Gabriella De Vita
European Thyroid Journal, 2026
Long non-coding RNAs (lncRNAs) are untranslated RNA molecules that regulate gene expression through diverse mechanisms, acting as scaffolds, guides, decoys, or signals. In thyroid cancer, the most prevalent endocrine malignancy, lncRNAs are increasingly recognized as key contributors to tumor development and progression. Elucidating these molecular mechanisms is essential for advancing diagnostic, prognostic, and therapeutic strategies. This review highlights major lncRNAs implicated in thyroid cancer, categorizing them as upregulated/oncogenes or downregulated/tumor suppressors and describing their mechanisms of action and interactions. lncRNAs are typically expressed at low levels and tightly regulated to preserve normal cell behavior. In thyroid cancer, they serve as crucial regulators of oncogenesis, frequently acting as competing endogenous RNAs that influence key signaling pathways. While most studies focus on miRNA sponging, other mechanisms are underexplored. Circulating lncRNAs offer potential for non-invasive diagnostics, and several lncRNAs show promise as therapeutic targets. Thus, continued research into the diverse functions of lncRNAs is vital to fully harness their clinical potential in thyroid cancer.
Hyaluronic Acid-silk Fibroin Hydrogel for Salivary Gland Tissue Engineering
Maryam Hajiabbas, Cibele Pelissari, Dorian Parisis, Tobias Putz, Claudia D'Agostino, Mirjam Baanstra, Nasiha M'Rabet, Nargis Bolaky, Françoise Gregoire, Nayana Rodrigues Lé, Julia Stanny, Muhammad Shahnawaz Soyfoo, Jason Perret, Armin Shavandi, Robert P. Coppes, Christine Delporte
Advanced Healthcare Materials, 2026
Cell‐material‐based therapies have emerged as a promising avenue within tissue engineering strategies for salivary gland (SG) regeneration. However, replicating the complex architecture and functional properties of SG tissue remains a challenge. In this study, we used an engineered in situ cross‐linked hydrogel designed to recapitulate the biochemical and rheological characteristics of SG, providing a platform for investigating SG cell behavior and organoid differentiation. Among hydrogel formulations, derived from enzymatically cross‐linked blends of tyramine‐conjugated hyaluronic acid (HA‐Tyr) and silk fibroin (SF), a blend of 2.5% HA‐Tyr and 4% SF4 (HA‐Tyr‐SF4) showed rheological properties partially comparable to native submandibular glands (SMG), achieving high cell viability. Comparative analyses of cell‐scaffold interactions in 2D and 3D cultures revealed that cell encapsulation within HA‐Tyr‐SF4 hydrogel enhanced cell‐cell spatial organization. Encapsulated NS‐SV‐AC cells and human SG organoids (hSGOs) exhibited morphogenesis, supported by transcriptomic data indicating upregulation of genes associated with SG development, extracellular matrix remodeling, and epithelial phenotype stabilization. Furthermore, hSGOs grown in HA‐Tyr‐SF4 or matrix (MA) of basement membrane extract (BME) displayed similar transcriptomic profiles. This study establishes HA‐Tyr‐SF4 as a reproducible, biologically active scaffold with substantial potential for SG tissue engineering and regenerative medicine applications.
Development of a National Indication Protocol for Proton Therapy in Patients With Seminoma Testis to Reduce the Risk on Subsequent Primary Cancers
Nienke Kuijsters, Peter Sinnige, Pauline A. Bakker, Shafak Al Uwini, Charlotte L. Brouwer, Tom Budiharto, Rob P. Coppes, Maarten Dirkx, Martine Franckena, Steven Habraken, Marianne AA de Jong, Yvonne L.B. Klaver, Johannes A. Langendijk, Ada Oele, Erik Schimmel, Ewoud Schuit, Robert Jan Smeenk, Mirko Unipan, Ben Vanneste, Wilma D. Heemsbergen, Liesbeth J. Boersma
International Journal of Radiation Oncology Biology Physics, 2026
PURPOSE: To develop a National Indication Protocol for Proton therapy (PT) (NIPP) for selecting seminoma testis patients (STPs) for PT in the Netherlands, aiming at reducing the risk of subsequent primary cancers (SPCs). METHODS AND MATERIALS: A multidisciplinary workgroup developed criteria for an NIPP based on a systematic literature search. To estimate its potential, PT-photon plan comparisons were constructed for 13 historical patients, after which NIPP version 1 was finalized. First clinical results of NIPP-v1 were evaluated. RESULTS: From cohort studies, it was established that the kidney, pancreas, stomach, and bladder were the main organs at risk contributing to excess SPC risks in STPs treated with radiation therapy. Estimated excess relative risks per 1 Gy increase in mean dose were as follows: kidney, 0.13; pancreas, 0.12; stomach, 0.47; and bladder, 0.50. Combined with absolute lifetime risks from the Dutch male population (age, 30-79 years), the corresponding lifetime absolute excess risks (AERs) per 1 Gy increase were +0.20%, +0.16%, +0.28%, and +0.65%, respectively. A first exploratory analysis in 13 replanned historical patients showed potential for an NIPP, as the required AER reduction of ≥2% for a grade 4 adverse event was achievable in 11 cases (85%). In a provisional NIPP version 1, criteria were as follows: age ≤50 years; paraortic and/or para-iliac RT; and no life-threatening comorbidity. In NIPP version 2 (approved and implemented), an estimated lifetime AER reduction of ≥2% by PT was required as well. From the first 76 PT patients based on NIPP-v1, 71% would qualify for NIPP-v2 as well. In 39 available PT-photon comparisons, we found an average 3.0% (median, 2.9%; IQR, 2.1%) AER reduction by PT. CONCLUSIONS: We defined an NIPP for the selection of STPs for PT in the Netherlands, aimed to reduce the risk of SPC. According to this NIPP, about 75% of these patients qualify for PT. Further studies are required to allow inclusion of nononcological late effects as selection criteria in the NIPP.
Establishment of salivary tissue-organoid biorepository: characterizing salivary gland stem/progenitor cells and novel differentiation marker PSMA/FOLH1
Syed Mohammed Musheer Aalam, Ana Rita Varela, Aalim Khaderi, Ronsard J. Mondesir, Dong-Gi Mun, Andrew Ding, Isabelle M. A. Lombaert, Rob P. Coppes, Chitra Priya Emperumal, Akhilesh Pandey, Jeffrey R. Janus, Nagarajan Kannan
Npj Regenerative Medicine, 2025
The salivary gland (SG) is vital for oral function and overall health through secretion of saliva. However salivary dysfunction due to aging, medications, autoimmune disorders, and cancer treatments poses significant challenges. We established the first diverse and clinically annotated salivary regenerative biobank at Mayo Clinic to study salivary gland stem/progenitor cells (SGSPCs). Optimization of cell isolation and progenitor assays revealed SGSPCs enriched within the CD24/EpCAM/CD49f+ and PSMA- phenotypes of both submandibular and parotid glands, with clonal differentiation assays highlighting heterogeneity. Induction of PSMA/FOLH1 expression was associated with SGSPC differentiation. Using mass spectrometry-based single cell proteomics, we identified 2461 proteins in SGSPC-enriched cells, including co-expressed cytokeratins, expressed in rare salivary ductal basal cells. Additionally, PRDX, a unique class of peroxiredoxin peroxidases enriched in SGSPCs, demonstrated H 2 O 2 -dependent growth, suggesting a role in salivary homeostasis. These findings provide a foundation for SGSPC research and potential regenerative therapies for salivary gland dysfunction.
IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation
Davide Cinat, Ryan van der Wal, Mirjam Baanstra, Abel Soto-Gamez, Rufina Maturi, Anne L. Jellema-de Bruin, Uilke Brouwer, Marc-Jan van Goethem, Marcel A. T. M. van Vugt, Lara Barazzuol, Rob P. Coppes
Science Signaling, 2025
The goal of radiotherapy in cancer treatment is to maximize DNA damage in tumors while minimizing harm to surrounding healthy tissues, especially to stem and progenitor cells essential for tissue regeneration and organ function. Here, we investigated the molecular responses to photon and proton irradiation, two key modalities in head and neck cancer treatment. Multiomics and in vitro analyses revealed that both photon and proton irradiation of mouse salivary gland organoids induced similar early responses, including DNA damage, micronuclei formation, increased amounts of the cytosolic DNA sensor cGAS, and type I interferon (IFN-I) signaling. In addition, both types of radiation induced comparable increases in the release of mitochondrial DNA (mtDNA) into the cytoplasm and stimulated the production of ZBP1, a cytosolic nucleic acid sensor involved in mtDNA recognition. However, proton irradiation resulted in a more pronounced loss of heterochromatin regulators and derepression of transposable elements at later times after irradiation, which was accompanied by increased accumulation of intracellular double-stranded RNA (dsRNA) and an enhanced RIG-I–mediated IFN-I response. Genetic and pharmacological modulation demonstrated its critical role for IFN-I signaling in enhancing salivary gland stem and progenitor cell activity after irradiation in vitro and in vivo. Our findings reveal more pronounced molecular changes after proton irradiation as compared with photon irradiation and uncover a proregenerative role of IFN-I signaling in the salivary gland, suggesting this pathway as a promising therapeutic target to mitigate radiation-induced side effects.
Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy
Eline C Jager, Luc H J Sondorp, Rufina Maturi, Inês F Antunes, Bettien M van Hemel, Uilke Brouwer, Liesbeth Jansen, Wouter T Zandee, Adrienne H Brouwers, Thera P Links, Rob P Coppes, Schelto Kruijff
European Thyroid Journal, 2025
Objective Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid tumor, with only 30 new patients annually in the Netherlands. PET imaging provides information on distant metastases, after which tyrosine kinase inhibitors (TKIs) may be initiated. The rarity of the disease impedes large controlled trials, and therefore the challenge of selecting the best TKI and PET tracer for individual patients persists. To explore whether an in vitro model could be developed to guide the selection of appropriate PET tracers or TKI therapies in the future, we aimed to establish an MTC organoid model for the first time. Methods Dispersed cells from MTC biopsies were suspended in Matrigel, allowing organoid formation. The self-renewal potential was tested by dissociation and re-plating cells and determining organoid-forming efficiency. MTC-specific gene and protein expression were characterized by qPCR and immunofluorescent staining. Moreover, MTC-organoids (MTOs) were exposed to TKIs and PET tracers in proof-of-principle experiments. Results Ten MTC biopsies were processed and successfully cultured as MTOs. MTC-derived cells showed self-renewal potency for several passages, indicating the presence of putative stem cells. Gene and protein expression of MTC-specific markers in tissue and MTOs, and function measurements showed the production of calcitonin and CEA. Interpretation of the preliminary experiments with TKIs and PET tracers was limited by sample size but demonstrates their future potential. Conclusion We were able to culture MTC organoids that resemble the original tissue in gene expression, protein expression, and functionality. However, international, multi-center studies are required to meet the standards for future clinical applications.
Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer
Liesbeth J. Boersma, Arno Hessels, Sander Roberti, Enrica Seravalli, Nina Bijker, et al.
Radiotherapy and Oncology, 2025
Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations
Rutger Jan Cornelis de Koster, Jeremy Putra Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol, Marc-Jan van Goethem, Alexander Gerbershagen, Robert Paul Coppes, Stefan Both
Clinical and Translational Radiation Oncology, 2025
Sustainable radiation oncology in a world with grand environmental and societal challenges: Society Matters – A new section in the Green Journal
Kari Tanderup, Birgitte V. Offersen, Dietmar Georg, Rob P. Coppes, Pierre Blanchard
Radiotherapy and Oncology, 2025
Clinical applications of human organoids
Monique M. A. Verstegen, Rob P. Coppes, Anne Beghin, Paolo De Coppi, Mattia F. M. Gerli, Nienke de Graeff, Qiuwei Pan, Yoshimasa Saito, Shaojun Shi, Amir A. Zadpoor, Luc J. W. van der Laan
Nature Medicine, 2025
BIOLOGICAL MODIFIERS OF NORMAL TISSUE EFFECTS
Robert P. Coppes, Wolfgang Dörr
Basic Clinical Radiobiology Sixth Edition, 2025
VOLUME EFFECTS, REGIONAL RESPONSES AND RISK MODELS
Peter van Luijk, Robert P. Coppes, Wolfgang Dörr, Albert J. van der Kogel
Basic Clinical Radiobiology Sixth Edition, 2025
EARLY EFFECTS IN EPITHELIAL TISSUES: The role of stem cells and time factors
Robert P. Coppes, Wolfgang Dörr, Peter van Luijk, Lara Barazzuol
Basic Clinical Radiobiology Sixth Edition, 2025
Driving innovation in radiation oncology in a changing world: The Green Journal's roadmap for the next decade
Pierre Blanchard, Dietmar Georg, Rob P. Coppes, Birgitte Vrou Offersen
Radiotherapy and Oncology, 2025
CANCER STEM CELLS IN RADIOTHERAPY
Robert P. Coppes, Michael Baumann, Mechthild Krause, Richard P. Hill
Basic Clinical Radiobiology Sixth Edition, 2025
PATHOGENESIS OF LATE NORMAL TISSUE EFFECTS
Lara Barazzuol, Peter van Luijk, Robert P. Coppes, Albert J. van der Kogel, Wolfgang Dörr
Basic Clinical Radiobiology Sixth Edition, 2025
Sparing of the Heart Facilitates Recovery From Cardiopulmonary Side Effects After Thoracic Irradiation
Julia Wiedemann, Sai K. Paruchuru, Lisette E. den Boef, Uilke Brouwer, Herman H.W. Silljé, Elisabeth M. Schouten, Michael G. Dickinson, Marc-Jan van Goethem, Robert P. Coppes, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2025
Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome
Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan van Es, Inga Lange, Cornelia Brunner, Jovan Mircetic, Robert P. Coppes, Olivier Gires, Andreas Dahl, Michael Seifert, Nils Cordes
Molecular Cancer, 2024
Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS)
Wilhelmina E. Radstake, Alessio Parisi, Silvana Miranda, Kiran Gautam, Randy Vermeesen, Emil Rehnberg, Kevin Tabury, Rob Coppes, Marc-Jan van Goethem, Sytze Brandenburg, Ulrich Weber, Claudia Fournier, Marco Durante, Bjorn Baselet, Sarah Baatout
Scientific Reports, 2024
Radiation-induced Xerostomia is Related to Stem Cell Dose-dependent Reduction of Saliva Production
Maria I. van Rijn-Dekker, Sacha la Bastide-van Gemert, Monique A. Stokman, Arjan Vissink, Robert P. Coppes, Johannes A. Langendijk, Peter van Luijk, Roel J.H.M. Steenbakkers
International Journal of Radiation Oncology Biology Physics, 2024
Future of Team-based Basic and Translational Science in Radiation Oncology
Robert P. Coppes, Lisanne V. van Dijk
Seminars in Radiation Oncology, 2024
Pursuing New Horizons With New Collaborators: This Is the Future of Radiation Oncology
David A. Jaffray, Robert P. Coppes, Helen McNair, Akila Viswanathan
Seminars in Radiation Oncology, 2024
Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms
Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan, Nad'a Majerníková, Tingting Chen, Zhangping Xiao, Jeaunice Adriana, Andrew J. Griffith, Abel Soto Gamez, Petra E. van der Wouden, Robert P. Coppes, Amalia M. Dolga, Hidde J. Haisma, Frank J. Dekker
Advanced Science, 2024
MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer
Madelon J. H. Metman, Pascal K. C. Jonker, Luc H. J. Sondorp, Bettien M. van Hemel, Mark S. Sywak, Anthony J. Gill, Liesbeth Jansen, Paul J. van Diest, Tessa M. van Ginhoven, Clemens W. G. M. Löwik, Anh H. Nguyen, Dominic J. Robinson, Gooitzen M. van Dam, Thera P. Links, Rob P. Coppes, Rudolf S. N. Fehrmann, Schelto Kruijff
European Journal of Nuclear Medicine and Molecular Imaging, 2024
Organoid-based personalized medicine: from tumor outcome prediction to autologous transplantation
Abel Soto-Gamez, Jeremy P Gunawan, Lara Barazzuol, Sarah Pringle, Rob P Coppes
Stem Cells, 2024
Proton therapy induces a local microglial neuroimmune response
Daniëlle C. Voshart, Myrthe Klaver, Yuting Jiang, Hilmar R.J. van Weering, Fleur van Buuren-Broek, Gideon P. van der Linden, Davide Cinat, Harry H. Kiewiet, Justin Malimban, Daniel A. Vazquez-Matias, Luiza Reali Nazario, Ayla C. Scholma, Jeffrey Sewdihal, Marc-Jan van Goethem, Peter van Luijk, Rob P. Coppes, Lara Barazzuol
Radiotherapy and Oncology, 2024
Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer
Jacoba van Zanten, Annelies Jorritsma-Smit, Hans Westra, Mirjam Baanstra, Anne de Bruin-Jellema, Derk Allersma, Bahez Gareb, Rob P. Coppes
Pharmaceutics, 2024
Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R.J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
Cell Reports, 2024
Mitophagy induction improves salivary gland stem/progenitor cell function by reducing senescence after irradiation
Davide Cinat, Anna Lena De Souza, Abel Soto-Gamez, Anne L. Jellema-de Bruin, Rob P. Coppes, Lara Barazzuol
Radiotherapy and Oncology, 2024
Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation
A. Soto-Gamez, M. van Es, E. Hageman, S.A. Serna-Salas, H. Moshage, M. Demaria, S. Pringle, R.P. Coppes
Radiotherapy and Oncology, 2024
Clinical research for global needs of radiation oncology
Michael Baumann, Carol Bacchus, Marianne C. Aznar, Rob P. Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W.M. Lee, Steffen Löck, Birgitte V. Offersen, David I. Thwaites, Uulke A. van der Heide, Vincenzo Valentini, Jens Overgaard
Radiotherapy and Oncology, 2024
Are hybrid conferences the new standard?
Michael Baumann, Carol Bacchus, Marianne C. Aznar, Rob P. Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W.M. Lee, Steffen Löck, Birgitte V. Offersen, Jens Overgaard, David I. Thwaites, Albert J. van der Kogel, Uulke A. van der Heide, Vincenzo Valentini
Radiotherapy and Oncology, 2023
Roadmap for precision preclinical x-ray radiation studies
Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan van Hoof, Ioannis L Verginadis, Jan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois
Physics in Medicine and Biology, 2023
Organoids as a model to study intestinal and liver dysfunction in severe malnutrition
José M. Horcas-Nieto, Christian J. Versloot, Miriam Langelaar-Makkinje, Albert Gerding, Tjasso Blokzijl, Mirjam H. Koster, Mirjam Baanstra, Ingrid A. Martini, Robert P. Coppes, Céline Bourdon, Sven C.D. van Ijzendoorn, Peter Kim, Robert H.J. Bandsma, Barbara M. Bakker
Biochimica Et Biophysica Acta Molecular Basis of Disease, 2023
Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels
Paulien Schaafsma, Laura Kracht, Mirjam Baanstra, Anne L. Jellema-de Bruin, Robert P. Coppes
Frontiers in Molecular Biosciences, 2023
The role of ESTRO guidelines in achieving consistency and quality in clinical radiation oncology practice
Birgitte Vrou Offersen, Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dieter Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W.M. Lee, Steffen Löck, David I. Thwaites, Albert J. van der Kogel, Uulke van der Heide, Vincenzo Valentini, Jens Overgaard, Michael Baumann
Radiotherapy and Oncology, 2023
Patient-derived parathyroid organoids as a tracer and drug-screening application model
Milou E. Noltes, Luc H.J. Sondorp, Laura Kracht, Inês F. Antunes, René Wardenaar, Wendy Kelder, Annelies Kemper, Wiktor Szymanski, Wouter T. Zandee, Liesbeth Jansen, Adrienne H. Brouwers, Robert P. Coppes, Schelto Kruijff
Stem Cell Reports, 2022
Erratum to: In reply to Kashid et al. (International Journal of Radiation Oncology, Biology, Physics (2022) 113(4) (904–905), (S0360301622003340), (10.1016/j.ijrobp.2022.04.021))
Roel J.H.M. Steenbakkers, Maria I. van Rijn – Dekker, Monique A. Stokman, Roel G.J. Kierkels, Arjen van der Schaaf, Johanna G.M. van den Hoek, Hendrik P. Bijl, Maria C.A. Kramer, Rob P. Coppes, Johannes A. Langendijk, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2022
Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland
Paola Serrano Martinez, Martti Maimets, Reinier Bron, Ronald van Os, Gerald de Haan, Sarah Pringle, Robert P. Coppes
Iscience, 2022
FLASH Radiotherapy & Particle Therapy conference, FRPT2021
Marie-Catherine Vozenin, Andreas Schüller, Marie Dutreix, Karen Kirkby, Michael Baumann, Rob P. Coppes, David Thwaites
Radiotherapy and Oncology, 2022
Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection
P. K. Jonker, M. Metman, Luc Sondorp, M. Sywak, A. Gill, L. Jansen, T. Links, P. V. van Diest, T. V. van Ginhoven, C. Löwik, Anh-Hien Nguyen, R. Coppes, Dominic J. Robinson, G. V. van Dam, B. V. van Hemel, R. Fehrmann, S. Kruijff
European Journal of Nuclear Medicine and Molecular Imaging, 2022
Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention
Julia Wiedemann, Robert P. Coppes, Peter van Luijk
Frontiers in Oncology, 2022
In Reply to Kashid et al.
Roel J.H.M. Steenbakkers, Maria I. van Rijn-Dekker, Monique A. Stokman, Arjen van der Schaaf, Johanna G.M. van den Hoek, Hendrik P. Bijl, Maria C.A. Kramer, Johannes A. Langendijk, Peter van Luijk, Roel G.J. Kierkels, Rob P. Coppes
International Journal of Radiation Oncology Biology Physics, 2022
Thyroid Gland Organoids: Current Models and Insights for Application in Tissue Engineering
Vivian M.L. Ogundipe, John T.M. Plukker, Thera P. Links, Rob P. Coppes
Tissue Engineering Part A, 2022
Role of mTOR through Autophagy in Esophageal Cancer Stemness
Liang Du, Da Wang, Peter W. Nagle, Andries A. H. Groen, Hao Zhang, Christina T. Muijs, John Th. M. Plukker, Robert P. Coppes
Cancers, 2022
In Reply to Sari and Yazici
R. Steenbakkers, Maria I. van Rijn-Dekker, M. Stokman, R. Kierkels, A. van der Schaaf, J. G. van den Hoek, H. Bijl, Maria C.A. Kramer, R. Coppes, J. Langendijk, P. van Luijk
International Journal of Radiation Oncology Biology Physics, 2022
Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance
Hongmei Dong, L. Du, Song-wang Cai, Wan Lin, Chaoying Chen, Matthew Still, Zhimeng Yao, R. Coppes, Yunlong Pan, Dianzheng Zhang, Shegan Gao, Hao Zhang
Frontiers in Pharmacology, 2022
Parotid Gland Stem Cell Sparing Radiation Therapy for Patients With Head and Neck Cancer: A Double-Blind Randomized Controlled Trial
Roel J.H.M. Steenbakkers, Maria I. van Rijn–Dekker, Monique A. Stokman, Roel G.J. Kierkels, Arjen van der Schaaf, Johanna G.M. van den Hoek, Hendrik P. Bijl, Maria C.A. Kramer, Robert P. Coppes, Johannes A. Langendijk, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2022
Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal
I. Orhon, C. Rocchi, B. Villarejo-Zori, Paola Serrano Martinez, Mirjam Baanstra, U. Brouwer, P. Boya, R. Coppes, F. Reggiori
Autophagy, 2022
Generation and Application of Inducible Chimeric RNA ASTN2-PAPPAas Knockin Mouse Model
Yichen Luo, L. Du, Zhimeng Yao, Fan-Jian Liu, Kai Li, Li Fei-Fei, Jianlin Zhu, R. Coppes, Dianzheng Zhang, Yun-long Pan, Shegan Gao, Hao Zhang
Cells, 2022
Personalised radiation therapy taking both the tumour and patient into consideration
Jens Overgaard, Marianne Aznar, Carol Bacchus, Robert P. Coppes, Éric Deutsch, et al.
Radiotherapy and Oncology, 2022
The Hippo signaling pathway effector YAP promotes salivary gland regeneration after injury
C. Rocchi, D. Cinat, Paola Serrano Martinez, A. D. Bruin, Mirjam Baanstra, U. Brouwer, Cinthya Del Angel Zuivre, H. Schepers, R. van Os, L. Barazzuol, R. Coppes
Science Signaling, 2021
The evolving definition of salivary gland stem cells
C. Rocchi, L. Barazzuol, R. Coppes
Npj Regenerative Medicine, 2021
β-Adrenergic signaling induces Notch-mediated salivary gland progenitor cell control
X. Wang, P. S. Martinez, J. Terpstra, A. Shaalan, G. Proctor, F. Spijkervet, A. Vissink, H. Bootsma, F. Kroese, R. Coppes, S. Pringle
Stem Cell Reports, 2021
DNA Damage-Induced Inflammatory Microenvironment and Adult Stem Cell Response
D. Cinat, R. Coppes, L. Barazzuol
Frontiers in Cell and Developmental Biology, 2021
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline
V. Mercadante, S. Jensen, Derek K. Smith, K. Bohlke, J. Bauman, M. Brennan, R. Coppes, Niels Jessen, Narinder K Malhotra, Barbara Murphy, D. Rosenthal, A. Vissink, Jonn Wu, D. Saunders, D. Peterson
Journal of Clinical Oncology, 2021
Addition of HER2 and CD44 to 18F-FDG PET–based clinico-radiomic models enhances prediction of neoadjuvant chemoradiotherapy response in esophageal cancer
R. J. Beukinga, Da Wang, A. Karrenbeld, W. Dijksterhuis, H. Faber, J. Burgerhof, V. Mul, R. Slart, R. Coppes, J. Plukker
European Radiology, 2021
Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids
Vivian M.L. Ogundipe, Andries H. Groen, Nynke Hosper, Peter W.K. Nagle, Julia Hess, Hette Faber, Anne L. Jellema, Mirjam Baanstra, Thera P. Links, Kristian Unger, John T.M. Plukker, Rob P. Coppes
Stem Cell Reports, 2021
The radiation‐induced regenerative response of adult tissue‐specific stem cells: Models and signaling pathways
Paola Serrano Martinez, Lorena Giuranno, Marc Vooijs, Robert P. Coppes
Cancers, 2021
Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response
Paola Serrano Martinez, D. Cinat, P. Luijk, Mirjam Baanstra, G. Haan, S. Pringle, R. Coppes
Oral Diseases, 2021
Radiation oncology in the new virtual and digital era
Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Steffen Löck, Birgitte Offersen, Jens Overgaard, David I. Thwaites, Albert J. van der Kogel, Uulke A. van der Heide, Vincenzo Valentini, Michael Baumann
Radiotherapy and Oncology, 2021
Macrophages come to the rescue
Robert P. Coppes
Cancer Research, 2020
Current and future perspectives of the use of organoids in radiobiology
Peter W. Nagle, R. Coppes
Cells, 2020
Patient-derived papillary thyroid cancer organoids for radioactive iodine refractory screening
Luc Sondorp, Vivian M L Ogundipe, Andries H. Groen, W. Kelder, Annelies Kemper, T. Links, R. Coppes, S. Kruijff
Cancers, 2020
Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche
Xiaohong Peng, Yi Wu, U. Brouwer, T. van Vliet, Boshi Wang, M. Demaria, L. Barazzuol, R. Coppes
Cell Death and Disease, 2020
Prevention and treatment of radiotherapy-induced side effects
L. Barazzuol, R. Coppes, P. Luijk
Molecular Oncology, 2020
MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis
L. Du, Lu Wang, J. Gan, Zhimeng Yao, Wan Lin, Junkuo Li, Yi Guo, Yu-ping Chen, Fuyou Zhou, Sai-Ching Jim Yeung, R. Coppes, Dianzheng Zhang, Hao Zhang
Iscience, 2019
FLASH radiotherapy International Workshop
M. Vozenin, M. Baumann, R. Coppes, J. Bourhis
Radiotherapy and Oncology, 2019
Micro cone beam computed tomography for sensitive assessment of radiation-induced late lung toxicity in preclinical models
D. van Berlo, A. Khmelinskii, A. Gasparini, F.J. Salguero, B. Floot, N. de Wit, M. van de Ven, J.Y. Song, R.P. Coppes, M. Verheij, J.J. Sonke, C. Vens
Radiotherapy and Oncology, 2019
In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field
Peter W. Nagle, Marc-Jan van Goethem, Marco Kempers, Harry Kiewit, Antje Knopf, Johannes A. Langendijk, Sytze Brandenburg, Peter van Luijk, Rob P. Coppes
Radiotherapy and Oncology, 2019
Hedgehog pathway as a potential intervention target in esophageal cancer
Da Wang, Peter Nagle, Helena Wang, Justin Smit, Hette Faber, Mirjam Baanstra, Arend Karrenbeld, Roland Chiu, John Plukker, Robert Coppes
Cancers, 2019
MTA3-SOX2 module regulates cancer stemness and contributes to clinical outcomes of tongue carcinoma
Zhimeng Yao, Liang Du, Min Xu, Kai Li, Haipeng Guo, Guodong Ye, Dianzheng Zhang, Robert P. Coppes, Hao Zhang
Frontiers in Oncology, 2019
Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome
Sarah Pringle, Xiaoyan Wang, Gwenny M. P. J. Verstappen, Janneke H. Terpstra, Clarence K. Zhang, Aiqing He, Vishal Patel, Rhiannon E. Jones, Duncan M. Baird, Fred K. L. Spijkervet, Arjan Vissink, Hendrika Bootsma, Robert P. Coppes, Frans G. M. Kroese
Arthritis and Rheumatology, 2019
Lack of DNA damage response at low radiation doses in adult stem cells contributes to organ dysfunction
Peter W. Nagle, Nynke A. Hosper, Lara Barazzuol, Anne L. Jellema, Mirjam Baanstra, Marc-Jan van Goethem, Sytze Brandenburg, Ulrich Giesen, Johannes A. Langendijk, Peter van Luijk, Rob P. Coppes
Clinical Cancer Research, 2018
Patient-derived tumor organoids for prediction of cancer treatment response
Peter W. Nagle, John Th. M. Plukker, Christina T. Muijs, Peter van Luijk, Robert P. Coppes
Seminars in Cancer Biology, 2018
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P. Coppes, Nikolai Engedal, Muriel Mari, Fulvio Reggiori
Autophagy, 2018
Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation
Xiaohong Peng, Kärt Varendi, Martti Maimets, Jaan-Olle Andressoo, Rob P. Coppes
Radiotherapy and Oncology, 2017
Targeting Stem Cells in Radiation Oncology
R.P. Coppes, A. Dubrovska
Clinical Oncology, 2017
Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer
D. Wang, J.Th.M. Plukker, R.P. Coppes
Seminars in Cancer Biology, 2017
Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia
Peter van Luijk, Johannes Albertus Langendijk, Robert Paul Coppes
Annals of Translational Medicine, 2017
Effects of radioiodine treatment on salivary gland function in patients with differentiated thyroid carcinoma: A prospective study
Esther N. Klein Hesselink, Adrienne H. Brouwers, Johan R. de Jong, Anouk N.A. van der Horst-Schrivers, Rob P. Coppes, Joop D. Lefrandt, Piet L. Jager, Arjan Vissink, Thera P. Links
Journal of Nuclear Medicine, 2016
The in Vitro Response of Tissue Stem Cells to Irradiation with Different Linear Energy Transfers
Peter W. Nagle, Nynke A. Hosper, Emily M. Ploeg, Marc-Jan van Goethem, Sytze Brandenburg, Johannes A. Langendijk, Roland K. Chiu, Robert P. Coppes
International Journal of Radiation Oncology Biology Physics, 2016
Human salivary gland stem cells functionally restore radiation damaged salivary glands
Sarah Pringle, Martti Maimets, Marianne van der Zwaag, Monique A. Stokman, Djoke van Gosliga, Erik Zwart, Max J.H. Witjes, Gerald de Haan, Ronald van Os, Rob P. Coppes
Stem Cells, 2016
Long-Term in Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals
Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben N.G. Giepmans, Robert G.J. Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P. Coppes
Stem Cell Reports, 2016
Decreasing irradiated rat lung volume changes dose-limiting toxicity from early to late effects
Sonja J. van der Veen, Hette Faber, Ghazaleh Ghobadi, Sytze Brandenburg, Johannes A. Langendijk, Robert P. Coppes, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2016
A new CT-based method to quantify radiation-induced lung damage in patients
Ghazaleh Ghobadi, Erwin M. Wiegman, Johannes A. Langendijk, Joachim Widder, Robert P. Coppes, Peter van Luijk
Radiotherapy and Oncology, 2015
Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer
Peter van Luijk, Sarah Pringle, Joseph O. Deasy, Vitali V. Moiseenko, Hette Faber, Allan Hovan, Mirjam Baanstra, Hans P. van der Laan, Roel G. J. Kierkels, Arjen van der Schaaf, Max J. Witjes, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk, Jonn Wu, Robert P. Coppes
Science Translational Medicine, 2015
Similar ex vivo expansion and post-irradiation regenerative potential of juvenile and aged salivary gland stem cells
Martti Maimets, Reinier Bron, Gerald de Haan, Ronald van Os, Robert P. Coppes
Radiotherapy and Oncology, 2015
Current ideas to reduce or salvage radiation damage to salivary glands
A Vissink, P van Luijk, JA Langendijk, RP Coppes
Oral Diseases, 2015
ACE inhibition attenuates radiation-induced cardiopulmonary damage
Sonja J. van der Veen, Ghazaleh Ghobadi, Rudolf A. de Boer, Hette Faber, Megan V. Cannon, Peter W. Nagle, Sytze Brandenburg, Johannes A. Langendijk, Peter van Luijk, Robert P. Coppes
Radiotherapy and Oncology, 2015
Purification and Ex vivo expansion of fully functional salivary gland stem cells
Lalitha S.Y. Nanduri, Mirjam Baanstra, Hette Faber, Cecilia Rocchi, Erik Zwart, Gerald de Haan, Ronald van Os, Robert P. Coppes
Stem Cell Reports, 2014
Future prevention and treatment of radiation-induced hyposalivation
Robert P. Coppes, Tara A. van de Water
Dry Mouth A Clinical Guide on Causes Effects and Treatments, 2014
Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation
Karin de Cortie, Nicola S. Russell, Rob P. Coppes, Fiona A. Stewart, Marion Scharpfenecker
International Journal of Radiation Biology, 2014
Stem cell therapies for the treatment of radiation-induced normal tissue side effects
Marc Benderitter, Fabio Caviggioli, Alain Chapel, Robert P. Coppes, Chandan Guha, Marco Klinger, Olivier Malard, Fiona Stewart, Radia Tamarat, Peter van Luijk, Charles L. Limoli
Antioxidants and Redox Signaling, 2014
Thalidomide ameliorates inflammation and vascular injury but aggravates tubular damage in the irradiated mouse kidney
Marion Scharpfenecker, Ben Floot, Nicola S. Russell, Rob P. Coppes, Fiona A. Stewart
International Journal of Radiation Oncology Biology Physics, 2014
Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice
Marion Scharpfenecker, Ben Floot, Nicola S. Russell, Rob P. Coppes, Fiona A. Stewart
Radiotherapy and Oncology, 2013
Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland
Lalitha S.Y. Nanduri, Isabelle M.A. Lombaert, Marianne van der Zwaag, Hette Faber, Jeanette F. Brunsting, Ronald P. van Os, Robert P. Coppes
Radiotherapy and Oncology, 2013
Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers
Justin K. Smit, Hette Faber, Maarten Niemantsverdriet, Mirjam Baanstra, Johan Bussink, Harry Hollema, Ronald P. van Os, John Th. M. Plukker, Robert P. Coppes
Radiotherapy and Oncology, 2013
Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia
Sarah Pringle, Ronald Van Os, Robert P. Coppes
Stem Cells, 2013
ΔNp73 Enhances Promoter Activity of TGF-β Induced Genes
Maarten Niemantsverdriet, Peter Nagle, Roland K. Chiu, Johannes A. Langendijk, Harm H. Kampinga, Robert P. Coppes
Plos One, 2012
Physiological interaction of heart and lung in thoracic irradiation
Ghazaleh Ghobadi, Sonja van der Veen, Beatrijs Bartelds, Rudolf A. de Boer, Michael G. Dickinson, Johan R. de Jong, Hette Faber, Maarten Niemantsverdriet, Sytze Brandenburg, Rolf M.F. Berger, Johannes A. Langendijk, Robert P. Coppes, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2012
High and low LET radiation differentially induce normal tissue damage signals
Maarten Niemantsverdriet, Marc-Jan van Goethem, Reinier Bron, Wytse Hogewerf, Sytze Brandenburg, Johannes A. Langendijk, Peter van Luijk, Robert P. Coppes
International Journal of Radiation Oncology Biology Physics, 2012
Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension
G Ghobadi, B Bartelds, S J van der Veen, M G Dickinson, S Brandenburg, R M F Berger, J A Langendijk, R P Coppes, P van Luijk
Thorax, 2012
Volume-Dependent Expression of In-Field and Out-of-Field Effects in the Proton-Irradiated Rat Lung
Robert P. Coppes, Christina T. Muijs, Hette Faber, Sascha Gross, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2011
Regeneration of irradiated salivary glands with stem cell marker expressing cells
Lalitha S.Y. Nanduri, Martti Maimets, Sarah A. Pringle, Marianne van der Zwaag, Ronald P. van Os, Robert P. Coppes
Radiotherapy and Oncology, 2011
Stem cells and the repair of radiation-induced salivary gland damage
RP Coppes, MA Stokman
Oral Diseases, 2011
Development of a facility for high-precision irradiation of cells with carbon ions
Marc‐Jan van Goethem, Maarten Niemantsverdriet, Sytze Brandenburg, Johannes A. Langendijk, Robert P. Coppes, Peter van Luijk
Medical Physics, 2011
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: Successes and barriers
Arjan Vissink, James B. Mitchell, Bruce J. Baum, Kirsten H. Limesand, Siri Beier Jensen, Philip C. Fox, Linda S. Elting, Johannes A. Langendijk, Robert P. Coppes, Mary E. Reyland
International Journal of Radiation Oncology Biology Physics, 2010
Synergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53
Maarten Niemantsverdriet, Edwin de Jong, Johannes A. Langendijk, Harm H. Kampinga, Robert P. Coppes
Radiotherapy and Oncology, 2010
Quantifying Local Radiation-Induced Lung Damage From Computed Tomography
Ghazaleh Ghobadi, Laurens E. Hogeweg, Hette Faber, Wim G.J. Tukker, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk, Robert P. Coppes, Peter van Luijk
International Journal of Radiation Oncology Biology Physics, 2010
Isolation of mouse salivary gland stem cells
Sarah Pringle, Lalitha S. Y. Nanduri, van der Zwaag Marianne, van Os Ronald, Rob P. Coppes
Journal of Visualized Experiments, 2010
Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation
Jielin Feng, Marianne van der Zwaag, Monique A. Stokman, Ronald van Os, Robert P. Coppes
Radiotherapy and Oncology, 2009
Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials
Wendy A. Woodward, Robert G. Bristow, Michael F. Clarke, Robert P. Coppes, Massimo Cristofanilli, Dan G. Duda, John R. Fike, Dolores Hambardzumyan, Richard P. Hill, Craig T. Jordan, Luka Milas, Frank Pajonk, Walter J. Curran, Adam P. Dicker, Yuhchyau Chen
International Journal of Radiation Oncology Biology Physics, 2009
Bath and Shower Effects in the Rat Parotid Gland Explain Increased Relative Risk of Parotid Gland Dysfunction After Intensity-Modulated Radiotherapy
Peter van Luijk, Hette Faber, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk, Harm Meertens, Robert P. Coppes
International Journal of Radiation Oncology Biology Physics, 2009
Stem Cell Therapy to Reduce Radiation-Induced Normal Tissue Damage
Rob P. Coppes, Annemieke van der Goot, Isabelle M.A. Lombaert
Seminars in Radiation Oncology, 2009
Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands
Fred R. Burlage, Hette Faber, Harm H. Kampinga, Johannes A. Langendijk, Arjan Vissink, Rob P. Coppes
Radiotherapy and Oncology, 2009
Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation
Isabelle M.A. Lombaert, Jeanette F. Brunsting, Pieter K. Wierenga, Harm H. Kampinga, Gerald de Haan, Robert P. Coppes
Clinical Cancer Research, 2008
Can we rescue salivary gland function after irradiation?
Jielin Feng, Robert P. Coppes
Thescientificworldjournal, 2008
Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool
Isabelle M.A. Lombaert, Jeanette F. Brunsting, Pieter K. Wierenga, Harm H. Kampinga, Gerald de Haan, Robert P. Coppes
Stem Cells, 2008
Preoperative irradiation with 5×5 Gy in a murine isolated colon loop model does not cause anastomotic weakening after colon resection
A. Karliczek, C. J. Zeebregts, D. A. Benaron, R. P. Coppes, T. Wiggers, G. M. van Dam
International Journal of Colorectal Disease, 2008
Rescue of Salivary gland function after stem cell transplantation in irradiated glands
Isabelle M. A. Lombaert, Jeanette F. Brunsting, Pieter K. Wierenga, Hette Faber, Monique A. Stokman, Tineke Kok, Willy H. Visser, Harm H. Kampinga, Gerald de Haan, Robert P. Coppes
Plos One, 2008
Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment
Fred Ronald Burlage, Judith M. Roesink, Hette Faber, Arjan Vissink, Johannes A. Langendijk, Harm H. Kampinga, Rob P. Coppes
Radiotherapy and Oncology, 2008
Protection of Salivary Function by Concomitant Pilocarpine During Radiotherapy: A Double-Blind, Randomized, Placebo-Controlled Study
Fred R. Burlage, Judith M. Roesink, Harm H. Kampinga, Rob P. Coppes, Chris Terhaard, Johannes A. Langendijk, Peter van Luijk, Monique A. Stokman, Arjan Vissink
International Journal of Radiation Oncology Biology Physics, 2008
The Impact of Heart Irradiation on Dose-Volume Effects in the Rat Lung
Peter van Luijk, Hette Faber, Harm Meertens, Jacobus M. Schippers, Johannes A. Langendijk, Sytze Brandenburg, Harm H. Kampinga, Robert P. Coppes
International Journal of Radiation Oncology Biology Physics, 2007
SOCS box: Fine-tuning inflammatory responses
Robert P. Coppes
Blood, 2007
Irradiation of rat brain reduces P-glycoprotein expression and function
J Bart, W B Nagengast, R P Coppes, T D Wegman, W T A van der Graaf, H J M Groen, W Vaalburg, E G E de Vries, N H Hendrikse
British Journal of Cancer, 2007
TGFβ-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFβ-receptor I signalling
Erwin M. Wiegman, Marcel A. Blaese, Heidi Loeffler, Rob P. Coppes, H. Peter Rodemann
Radiotherapy and Oncology, 2007
Changes in Expression of Injury After Irradiation of Increasing Volumes in Rat Lung
Alena Novakova-Jiresova, Peter van Luijk, Harry van Goor, Harm H. Kampinga, Robert P. Coppes
International Journal of Radiation Oncology Biology Physics, 2007
Relation between radiation-induced whole lung functional loss and regional structural changes in partial irradiated rat lung
Peter van Luijk, Alena Novakova-Jiresova, Hette Faber, Marloes N.J. Steneker, Harm H. Kampinga, Haarm Meertens, Robert P. Coppes
International Journal of Radiation Oncology Biology Physics, 2006
Influence of adjacent low-dose fields on tolerance to high doses of protons in rat cervical spinal cord
Hendrik P. Bijl, Peter van Luijk, Rob P. Coppes, Jacobus M. Schippers, Antonius W.T. Konings, Albert J. van der Kogel
International Journal of Radiation Oncology Biology Physics, 2006
Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands
Isabelle M.A. Lombaert, Pieter K. Wierenga, Tineke Kok, Harm H. Kampinga, Gerald deHaan, Robert P. Coppes
Clinical Cancer Research, 2006
Secondary radiation damage as the main cause for unexpected volume effects: A histopathologic study of the parotid gland
Antonius W.T. Konings, Hette Faber, Femmy Cotteleer, Arjan Vissink, Rob P. Coppes
International Journal of Radiation Oncology Biology Physics, 2006
Radioprotective effect of amifostine on parotid gland functioning is region dependent
Antonius W.T. Konings, Hette Faber, Arjan Vissink, Rob P. Coppes
International Journal of Radiation Oncology Biology Physics, 2005
Variability of flow rate when collecting stimulated human parotid saliva
Fred R. Burlage, Justin Pijpe, Rob P. Coppes, Martin E. W. Hemels, Harm Meertens, Alof Canrinus, Arjan Vissink
European Journal of Oral Sciences, 2005
Radiation and transforming growth factor-β cooperate in transcriptional activation of the profibrotic plasminogen activator inhibitor-1 gene
Jurre Hageman, Bart J. Eggen, Tom Rozema, Kevin Damman, Harm H. Kampinga, Robert P. Coppes
Clinical Cancer Research, 2005
Radiation damage to the heart enhances early radiation-induced lung function loss
Peter van Luijk, Alena Novakova-Jiresova, Hette Faber, Jacobus M. Schippers, Harm H. Kampinga, Harm Meertens, Rob P. Coppes
Cancer Research, 2005
On the mechanism of salivary gland radiosensitivity
Antonius W.T. Konings, Rob P. Coppes, Arjan Vissink
International Journal of Radiation Oncology Biology Physics, 2005
Volume effects and region-dependent radiosensitivity of the parotid gland
Antonius W.T. Konings, Femmy Cotteleer, Hette Faber, Peter van Luijk, Harm Meertens, Rob P. Coppes
International Journal of Radiation Oncology Biology Physics, 2005
Pulmonary radiation injury: Identification of risk factors associated with regional hypersensitivity
Alena Novakova-Jiresova, Peter van Luijk, Harry van Goor, Harm H. Kampinga, Robert P. Coppes
Cancer Research, 2005
Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: Evidence for a non-DNA target of radiation
R P Coppes, A Meter, S P Latumalea, A F Roffel, H H Kampinga
British Journal of Cancer, 2005
Regional differences in radiosensitivity across the rat cervical spinal cord
Hendrik P. Bijl, Peter van Luijk, Rob P. Coppes, Jacobus M. Schippers, Antonius W.T. Konings, Albert J. van Der Kogel
International Journal of Radiation Oncology Biology Physics, 2005
SU‐FF‐T‐365: Measurement of Radiation Induced Lung Damage in the Rat by CT Image Analysis
H Meertens, P Luijk, M Steneker, A Novakova-Jiresova, R Coppes
Medical Physics, 2005
Post-irradiation dietary vitamin e does not affect the development of radiation-induced lung damage in rats
Erwin M Wiegman, Mieke M van Gameren, Harm H Kampinga, Ben G Szabó, Rob P Coppes
Radiotherapy and Oncology, 2004
Transforming growth factor-β plasma dynamics and post-irradiation lung injury in lung cancer patients
Alena Novakova-Jiresova, Mieke M. van Gameren, Rob P. Coppes, Harm H. Kampinga, Harry J.M. Groen
Radiotherapy and Oncology, 2004
Oral sequelae of head and neck radiotherapy
A. Vissink, J. Jansma, F.K.L. Spijkervet, F.R. Burlage, R.P. Coppes
Critical Reviews in Oral Biology and Medicine, 2003
Prevention and treatment of the consequences of head and neck radiotherapy
A. Vissink, F.R. Burlage, F.K.L. Spijkervet, J. Jansma, R.P. Coppes
Critical Reviews in Oral Biology and Medicine, 2003
Three-dimensional dose distribution for partial irradiation of rat parotid glands with 200 kV X-rays
F. Cotteleer, H. Faber, A. W. T. Konings, P. C. Van Der Hulst, R. P. Coppes, H. Meertens
International Journal of Radiation Biology, 2003
Unexpected changes of rat cervical spinal cord tolerance caused by inhomogeneous dose distributions
Hendrik P Bijl, Peter van Luijk, Rob P Coppes, Jacobus M Schippers, Antonius W.T Konings, Albert J van der Kogel
International Journal of Radiation Oncology Biology Physics, 2003
Loco-regional differences in pulmonary function and density after partial rat lung irradiation
E.M Wiegman, H Meertens, A.W.T Konings, H.H Kampinga, R.P Coppes
Radiotherapy and Oncology, 2003
Comparison of radiosensitivity of rat parotid and submandibular glands after different radiation schedules
Rob P. Coppes, Arjan Vissink, Antonius W.T. Konings
Radiotherapy and Oncology, 2002
Comments on: Extended-term effects of head and neck irradiation in a rodent (multiple letters)
A.W.T. Konings, A. Vissink, R.P. Coppes
European Journal of Cancer, 2002
Salivary gland-sparing prophylactic pilocarpine treatment has no effct on tumor regrowth after irradiation
R. Licht, H. H. Kampinga, R. P. Coppes
Radiation Research, 2002
Dose-volume effects in the rat cervical spinal cord after proton irradiation
Hendrik P Bijl, Peter van Luijk, Rob P Coppes, Jacobus M Schippers, Antonius W.T Konings, Albert J van der Kogel
International Journal of Radiation Oncology Biology Physics, 2002
Parotid and submandibular/sublingual salivary flow during high dose radiotherapy
Fred R. Burlage, Rob P. Coppes, Harm Meertens, Monique A. Stokman, Arjan Vissink
Radiotherapy and Oncology, 2001
Techniques for precision irradiation of the lateral half of the rat cervical spinal cord using 150 MeV protons
P van Luijk, H P Bijl, R P Coppes, A J van der Kogel, A W T Konings, J A Pikkemaat, J M Schippers
Physics in Medicine and Biology, 2001
Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists
R P Coppes, L J W Zeilstra, H H Kampinga, A W T Konings
British Journal of Cancer, 2001
Radiation induced cell loss in rat submandibular gland and its relation to gland function
L. J. W. Zeilstra, A. Vissink, A. W. T
International Journal of Radiation Biology, 2000
Early radiation effects on muscarinic receptor-induced secretory responsiveness of the parotid gland in the freely moving rat
Rob P. Coppes, Ad F. Roffel, Liekele J. W. Zeilstra, Arjan Vissink, Antonius W. T. Konings
Radiation Research, 2000
Preservation of the rat parotid gland function after radiation by prophylactic pilocarpine treatment: Radiation dose dependency and compensatory mechanisms
Judith M Roesink, Antonius W.T Konings, Chris H.J Terhaard, Jan J Battermann, Harm H Kampinga, Rob P Coppes
International Journal of Radiation Oncology Biology Physics, 1999
Radiation-induced apoptosis in relation to acute impairment of rat salivary gland function
G. M. R. M. PAARDEKOOPER, S CAMMELLI, L.J.W ZEILSTRA, R. P. COPPES, A. W. T KONINGS
International Journal of Radiation Biology, 1998
Sialogogue-related radioprotection of salivary gland function: The degranulation concept revisited
Rob P. Coppes, Liekele J. W. Zeilstra, Arjan Vissink, Antonius W. T. Konings
Radiation Research, 1997
Prejunctional histamine H3-receptors inhibit electrically evoked endogenous noradrenaline overflow in the portal vein of freely moving rats
J. Smit, Rob P. Coppes, Eric J. J. van Tintelen, A. F. Roffel, Johan Zaagsma
Naunyn Schmiedeberg S Archives of Pharmacology, 1997
Muscarinic receptor stimulation increases tolerance of rat salivary gland function to radiation damage
R. P. COPPES, A. VISSINK, L. J. W. ZEI
International Journal of Radiation Biology, 1997
Co-released adrenaline markedly facilitates noradrenaline overflow through prejunctional β2-adrenoceptors during swimming exercise
Rob P. Coppes, Jenneke Smit, Lambertus Benthem, Jaap Van der Leest, Johan Zaagsma
European Journal of Pharmacology, 1995
Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the portal vein of freely moving rats
Rob P. Coppes, Jenneke Smit, Alwin M.S. Geurtsen, Ad F. Roffel, Carl Dahlöf, Henry N. Doods, Johan Zaagsma
European Journal of Pharmacology, 1994
Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional β2-adrenoceptor-mediated control mechanism in the pithed rat
V. I. Tarizzo, R. P. Coppes, C. Dahlöf, J. Zaagsma
Naunyn Schmiedeberg S Archives of Pharmacology, 1994
Influence of the baroreceptor reflex on the modulation of noradrenaline overflow through prejunctional receptors in the portal vein of freely moving rats
R. P. Coppes, R. Remie, J. Zaagsma
Journal of Autonomic Pharmacology, 1994
Sustained prejunctional facilitation of noradrenergic neurotransmission by adrenaline as a co‐transmitter in the portal vein of freely moving rats
R.P. Coppes, F. Brouwer, I. Freie, J. Smit, J. Zaagsma
British Journal of Pharmacology, 1994
Strong activation of vascular prejunctional β2-adrenoceptors in freely moving rats by adrenaline released as a co-transmitter
Rob P. Coppes, Jenneke Smit, Nabil Nashid Khali, Frans Brouwer, Johan Zaagsma
European Journal of Pharmacology, 1993
Dysfunctional presynaptic α2-adrenoceptors expose facilitatory β2-adrenoceptors in the vasculature of spontaneously hypertensive rats
René Remie, Jaques X.M. Van Rossum, Rob P. Coppes, Johan Zaagsma
European Journal of Pharmacology, 1992
The role of angiotensin II in the facilitation of noradrenaline release by prejunctional β2-adrenoceptors in the vasculature of the freely moving rat
R.P. Coppes, L.J.W. Zeilstra, J.A. Aarents, J. Zaagsma
European Journal of Pharmacology, 1990
Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat
R. Remie, R. P. Coppes, H. Meurs, A.F. Roffel, J. Zaagsma
British Journal of Pharmacology, 1990
Presynaptic muscarinic receptors inhibiting endogenous noradrenaline release in the portal vein of the freely moving rat
R. Remie, R.P. Coppes, J. Zaagsma
British Journal of Pharmacology, 1989

Robert Paul Coppes

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