Jung-Yaw Lin

Scopus Publications

Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice under Oligomeric Aβ-Induced Stress
Hei-Jen Huang, Ching-Yi Huang, Mingchung Lee, Jung-Yaw Lin, Hsiu Mei Hsieh-Li
American Journal of Chinese Medicine, 2019
To evaluate the therapeutic effects of Chinese herbal medicine (CHM) for Alzheimer’s disease (AD), we evaluated five CHMs in oligomeric A[Formula: see text]-treated mouse primary hippocampal neuronal cultures. The aqueous extract from the root of Pueraria lobata (Puerariae Radix; PR) showed better neuroprotective effects than did the other four CHM aqueous extracts, including Gardenia jasminoides, Eleutherococcus senticosus, Rhodiola rosea, and Panax, in the primary culture treated with saline or oligomeric A[Formula: see text]. Furthermore, the neuroprotective effects of aqueous extract of PR were also better than its well-known active compound, puerarin, against the neurotoxicity of oligomeric A[Formula: see text] in a primary culture. For in vivo experiments, C57BL/6J male mice that received direct infusion of soluble oligomeric A[Formula: see text] into the bilateral hippocampal CA1 subregion were used as an alternative AD mouse model. The effects and molecular mechanisms of chronic systemic administration of PR aqueous extract were evaluated in the alternative AD model. PR aqueous extract prevented anxiety and cognitive impairment in mice associated with a decrease in the levels of A[Formula: see text] deposition, tau protein phosphorylation, inflammation, loss of noradrenergic, and serotonergic neurons and an increase in the levels of synaptophysin and insulin degrading enzyme (IDE) against the toxicity of oligomeric A[Formula: see text]. Furthermore, no obvious damage to the liver and kidney was detected after chronic systemic administration of PR aqueous extract. Therefore, using PR could be a safer, more effective therapeutic strategy than using its active compound puerarin to prevent both cognitive and noncognitive dysfunction and related pathological features of AD.
Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3
I-Cheng Chen, Chia-Ning Chang, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, Hsuan-Yuan Lin, Mei-Ling Cheng, Mu-Chun Chiang, Jung-Yaw Lin, Yih-Ru Wu, Guey-Jen Lee-Chen, Chiung-Mei Chen
American Journal of Chinese Medicine, 2019
Nine autosomal dominant spinocerebellar ataxias (SCAs) are caused by an abnormal expansion of CAG trinucleotide repeats that encodes a polyglutamine (polyQ) tract within different genes. Accumulation of aggregated mutant proteins is a common feature of polyQ diseases, leading to progressive neuronal dysfunction and degeneration. SCA type 3 (SCA3), the most common form of SCA worldwide, is characterized by a CAG triplet expansion in chromosome 14q32.1 ATXN3 gene. As accumulation of the mutated polyQ protein is a possible initial event in the pathogenic cascade, clearance of aggregated protein by ubiquitin proteasome system (UPS) has been proposed to inhibit downstream detrimental events and suppress neuronal cell death. In this study, Chinese herbal medicine (CHM) extracts were studied for their proteasome-activating, polyQ aggregation-inhibitory and neuroprotective effects in GFPu and ATXN3/Q[Formula: see text]-GFP 293/SH-SY5Y cells. Among the 14 tested extracts, 8 displayed increased proteasome activity, which was confirmed by 20S proteasome activity assay and analysis of ubiquitinated and fused GFP proteins in GFPu cells. All the eight extracts displayed good aggregation-inhibitory potential when tested in ATXN3/Q[Formula: see text]-GFP 293 cells. Among them, neuroprotective effects of five selected extracts were shown by analyses of polyQ aggregation, neurite outgrowth, caspase 3 and proteasome activities, and ATXN3-GFP, ubiquitin, BCL2 and BAX protein levels in neuronal differentiated ATXN3/Q[Formula: see text]-GFP SH-SY5Y cells. Finally, enhanced proteasome function, anti-oxidative activity and neuroprotection of catalpol, puerarin and daidzein (active constituents of Rehmannia glutinosa and Pueraria lobata) were demonstrated in GFPu and/or ATXN3/Q[Formula: see text]-GFP 293/SH-SY5Y cells. This study may have therapeutic implication in polyQ-mediated disorders.
Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells
Yu-Huei Liu, Yui-Ping Weng, Hsin-Ying Tsai, Chao-Jung Chen, Der-Yen Lee, Ching-Liang Hsieh, Yang-Chang Wu, Jung-Yaw Lin
Phytomedicine, 2018
Chinese Herbal Medicine Glycyrrhiza inflata Reduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation
Ya-Jen Chiu, Chi-Mei Lee, Te-Hsien Lin, Hsuan-Yuan Lin, Shin-Ying Lee, Mina Mesri, Kuo-Hsuan Chang, Jung-Yaw Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
American Journal of Chinese Medicine, 2018
Amyloid [Formula: see text] (A[Formula: see text]) plays a major role in the pathogenesis of Alzheimer’s disease (AD). The accumulation of misfolded A[Formula: see text] causes oxidative and inflammatory damage leading to apoptotic cell death. Chinese herbal medicine (CHM) has been widely used in clinical practice to treat neurodegenerative diseases associated with oxidative stress and neuroinflammation. This study examined the neuroprotection effects of CHM extract Glycyrrhiza inflata (G. inflata) and its active constituents, licochalcone A and liquiritigenin in AD. We examined A[Formula: see text] aggregation inhibition, anti-oxidation and neuroprotection in Tet-On A[Formula: see text]-GFP 293/SH-SY5Y cells and anti-inflammatory potential in lipopolysaccharide (LPS)-stimulated RAW 264.7 and LPS and interferon (IFN)-[Formula: see text] (LPS/IFN-[Formula: see text])-activated BV-2 cells. In addition, we applied conditioned media (CM) of BV-2 cells primed with LPS/IFN-[Formula: see text] to A[Formula: see text]-GFP SH-SY5Y cells to uncover the neuroprotective mechanisms. Our results showed that G. inflata extract and its two constituents displayed potentials of A[Formula: see text] aggregation inhibition and radical-scavenging in biochemical assays, A[Formula: see text] misfolding inhibition and reactive oxygen species (ROS) reduction in A[Formula: see text]-GFP 293 cells, as well as neurite outgrowth promotion, acetylcholinesterase inhibition and SOD2 up-regulation in A[Formula: see text]-GFP SH-SY5Y cells. Meanwhile, both G. inflata extract and its constituents suppressed NO, TNF-[Formula: see text], IL-1[Formula: see text], PGE2 and/or Iba1 productions in inflammation-stimulated RAW 264.7 or BV-2 cells. G. inflata extract and its constituents further protected A[Formula: see text]-GFP SH-SY5Y cells from BV-2 CM-induced cell death by ameliorating reduced BCL2 and attenuating increased IGFBP2, cleaved CASP3, BAD and BAX. Collectively, G. inflata extract, licochalcone A and liquiritigenin display neuroprotection through exerting anti-oxidative and anti-inflammatory activities to suppress neuronal apoptosis.
Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome
Tsung-Wei Su, Chao-Yu Yang, Wen-Pin Kao, Bai-Jiun Kuo, Shan-Meng Lin, Jung-Yaw Lin, Yu-Chih Lo, Su-Chang Lin
Structure, 2017
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells
Yu-Huei Liu, Yui-Ping Weng, Hsuan-Yuan Lin, Sai-Wen Tang, Chao-Jung Chen, Chi-Jung Liang, Chung-Yu Ku, Jung-Yaw Lin
Scientific Reports, 2017
Hepatocellular carcinoma (HCC) remains the leading cause of cancer mortality with limited therapeutic targets. The endoplasmic reticulum (ER) plays a pivotal role in maintaining proteostasis in normal cells. However, alterations in proteostasis are often found in cancer cells, making it a potential target for therapy. Polygonum bistorta is used in traditional Chinese medicine owing to its anticancer activities, but the molecular and pharmacological mechanisms remain unclear. Using hepatoma cells as a model system, this study demonstrated that P. bistorta aqueous extract (PB) stimulated ER stress by increasing autophagosomes but by blocking degradation, followed by the accumulation of ubiquitinated proteins and cell apoptosis. In addition, an autophagy inhibitor did not enhance ubiquitinated protein accumulation whereas a reactive oxygen species (ROS) scavenger diminished both ubiquitinated protein accumulation and ligand-stimulated epidermal growth factor receptor (EGFR) expression, suggesting that ROS generation by PB may be upstream of PB-triggered cell death. Nevertheless, PB-exerted proteostasis impairment resulted in cytoskeletal changes, impairment of cell adhesion and motility, and inhibition of cell cycle progression. Oral administration of PB delayed tumour growth in a xenograft model without significant body weight loss. These findings indicate that PB may be a potential new alternative or complementary medicine for HCC.
Protective Effects of Wogonin against Alzheimer's Disease by Inhibition of Amyloidogenic Pathway
Ding-Siang Huang, Yu-Chen Yu, Chung-Hsin Wu, Jung-Yaw Lin
Evidence Based Complementary and Alternative Medicine, 2017
One of the pathogenic systems of Alzheimer’s disease (AD) is the formation ofβ-amyloid plaques in the brains of patients, and amyloidogenic activity becomes one of the therapeutic targets. Here, we report wogonin, one of the major active constituting components inScutellaria baicalensis, which has the neuroprotective effects on amyloid-βpeptides- (Aβ-) induced toxicity. Oral wogonin treatment improved the performance of triple transgenic AD mice (h-APPswe, h-Tau P301L, and h-PS1 M146V) on the Morris water maze, Y-maze, and novel object recognition. Furthermore, wogonin activated the neurite outgrowth of AD cells by increasing neurite length and complexity of Tet-On Aβ42-GFP SH-SY5Y neuroblastoma cells (AD cells) and attenuated amyloidogenic pathway by decreasing the levels ofβ-secretase, APPβ-C-terminal fragment, Aβ-aggregation, and phosphorylated Tau. Wogonin also increased mitochondrial membrane potential (∆ψm) and protected against apoptosis by reducing the expression of Bax and cleaved PARP. Collectively, these results conclude that wogonin may be a promising multifunctional drug candidate for AD.
The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease
Guey-Jen Lee-Chen, Kuo-Hsuan Chang, I-Cheng Chen, Husan-Yuan Lin, Hsuan-Chiang Chen, Chih-Hsin Lin, Te-Hsien Lin, Yu-Ting Weng, Chih-Ying Chao, Yih-Ru Wu, Jung-Yaw Lin, Chiung-Mei Chen
Drug Design Development and Therapy, 2016
Background Alzheimer’s disease (AD) and several neurodegenerative disorders known as tauopathies are characterized by misfolding and aggregation of tau protein. Although several studies have suggested the potential of traditional Chinese medicine (TCM) as treatment for neurodegenerative diseases, the role of TCM in treating AD and tauopathies have not been well explored. Materials and methods Tau protein was coupled to the DsRed fluorophore by fusing a pro-aggregation mutant of repeat domain of tau (ΔK280 tauRD) with DsRed. The ΔK280 tauRD-DsRed fusion gene was then used to generate Tet-On 293 and SH-SY5Y cell clones as platforms to test the efficacy of 39 aqueous extracts of TCM in reducing tau misfolding and in neuroprotection. Results Seven TCM extracts demonstrated a significant reduction in tau misfolding and reactive oxidative species with low cytotoxicity in the ΔK280 tauRD-DsRed 293 cell model. Glycyrrhiza inflata and Panax ginseng also demonstrated the potential to improve neurite outgrowth in the ΔK280 tauRD-DsRed SH-SY5Y neuronal cell model. G. inflata further rescued the upregulation of ERN2 (pro-apoptotic) and downregulation of unfolded-protein-response-mediated chaperones ERP44, DNAJC3, and SERP1 in ΔK280 tauRD-DsRed 293 cells. Conclusion This in vitro study provides evidence that G. inflata may be a novel therapeutic for AD and tauopathies. Future applications of G. inflata on animal models of AD and tauopathies are warranted to corroborate its effect of reducing misfolding and potential disease modification.
Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17
Chung-Hsin Wu, Ding-Siang Huang, Husan-Yuan Lin, Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Jung-Yaw Lin
Drug Design Development and Therapy, 2016
Spinocerebellar ataxia type 17 (SCA 17) is a polyglutamine disease caused by the expansion of CAG/CAA repeats in the TATA box-binding protein (TBP) gene. The Ginkgo biloba extract, EGb 761, contains flavonoids and terpenoids with a potential use for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. The neuroprotective effects of EGb 761 are obvious, but whether the EGb 761 has therapeutic effects in SCA 17 is still unclear. To manage our issues, we have generated TBP/79Q-expressing SH-SY5Y cells and SCA 17 transgenic mice with the mutant hTBP gene. In in vitro experiment, we observed that the EGb 761 treatment decreased the amount of sodium dodecyl sulfate-insoluble proteins in the TBP/79Q-expressing SH-SY5Y cells. We further found that the EGb 761 treatment could inhibit excitotoxicity and calcium influx and reduce the expression of apoptotic markers in glutamate-treated SH-SY5Y neuroblastoma cells. In in vivo experiment, we observed that the EGb 761 treatment (100 mg/kg intraperitoneal injection per day) could relieve the motor deficiencies of the SCA 17 transgenic mice. Our findings provide evidence that the EGb 761 treatment can be a remedy for SCA 17 via suppressing excitotoxicity and apoptosis in SCA 17 cell and animal models. Therefore, we suggest that EGb 761 may be a potential therapeutic agent for treating SCA 17.
The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
Kuo-Hsuan Chang, Ya-Jen Chiu, Shu-Ling Chen, Chen-Hsiang Huang, Chih-Hsin Lin, Te-Hsien Lin, Chi-Mei Lee, Chintakunta Ramesh, Chung-Hsin Wu, Chin-Chang Huang, Hon-Chung Fung, Yi-Chun Chen, Jung-Yaw Lin, Ching-Fa Yao, Hei-Jen Huang, Guey-Jen Lee-Chen, Ming-Chung Lee, Hsiu Mei Hsieh-Li
Neuropharmacology, 2016
Liver fatty acid-binding protein (L-FABP) promotes cellular angiogenesis and migration in hepatocellular carcinoma
Chung-Yu Ku, Yu-Huei Liu, Hsuan-Yuan Lin, Shao-Chun Lu, Jung-Yaw Lin
Oncotarget, 2016
Corosolic acid inhibits hepatocellular carcinoma cell migration by targeting the VEGFR2/Src/FAK pathway
Chung-Yu Ku, Ying-Ren Wang, Hsuan-Yuan Lin, Shao-Chun Lu, Jung-Yaw Lin
Plos One, 2015
The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment
Guan-Chiun Lee, Chih-Hsin Lin, Yu-Chen Tao, Jinn-Moon Yang, Kai-Cheng Hsu, Yin-Jung Huang, Shih-Han Huang, Pin-Jui Kung, Wan-Ling Chen, Chien-Ming Wang, Yih-Ru Wu, Chiung-Mei Chen, Jung-Yaw Lin, Hsiu Mei Hsieh-Li, Guey-Jen Lee-Chen
Neurotoxicology, 2015
Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
Guey-Jen Lee-Chen, Pin-Jui Kung, Yu-Chen Tao, Ho-Chiang Hsu, Donala Janreddy, Ching-Fa Yao, Jung-Yaw Lin, Ming-Tsan Su, Chung-Hsin Wu, Hsiu-Mei Hsieh-Li, Wan-Ling Chen, Te-Hsien Lin, Kuo-Hsuan Chang
Drug Design Development and Therapy, 2014
Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3
Kuo-Hsuan Chang, Wan-Ling Chen, Yih-Ru Wu, Te-Hsien Lin, Yi-Ci Wu, Chih-Ying Chao, Jung-Yaw Lin, Li-Ching Lee, Yi-Chun Chen, Guey-Jen Lee-Chen, Chiung-Mei Chen
Neuropharmacology, 2014
Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3
Chiung-Mei Chen, Yu-Ting Weng, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, I-Cheng Chen, Li-Ching Lee, Hsuan-Yuan Lin, Yih-Ru Wu, Yi-Chun Chen, Kuo-Hsuan Chang, Hsiang-Yu Tang, Mei-Ling Cheng, Guey-Jen Lee-Chen, Jung-Yaw Lin
Free Radical Biology and Medicine, 2014
Yang-Dan-Tang, identified from 15 Chinese herbal formulae, inhibits human lung cancer cell proliferation via cell cycle arrest
Tien-Chun Wang, Chih-Nan Fang, Chih-Chien Shen, Hui-Yu Wei, Yui-Ping Weng, Jung-Yaw Lin, Hsiu Mei Hsieh-Li, Chen-Yu Lee
Evidence Based Complementary and Alternative Medicine, 2012
Full-length enrich c-DNA libraries-clear cell-renal cell carcinoma
Sai-Wen Tang, Jung-Yaw Lin
Journal of Oncology, 2012
Role of the CCAAT-binding protein NFY in SCA17 pathogenesis
Li-Ching Lee, Chiung-Mei Chen, Hao-Chun Wang, Hsiao-Han Hsieh, I-Sheng Chiu, Ming-Tsan Su, Hsiu-Mei Hsieh-Li, Chung-Hsin Wu, Guan-Chiun Lee, Guey-Jen Lee-Chen, Jung-Yaw Lin
Plos One, 2012
Aqueous extract of Paeonia suffruticosa inhibits migration and metastasis of renal cell carcinoma cells via suppressing VEGFR-3 pathway
Shih-Chin Wang, Sai-Wen Tang, Sio-Hong Lam, Chung-Chieh Wang, Yu-Huei Liu, Hsuan-Yuan Lin, Shoei-Sheng Lee, Jung-Yaw Lin
Evidence Based Complementary and Alternative Medicine, 2012
Effects of a Chinese herbal medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on renal cancer cell growth and metastasis
Yu-Huei Liu, Meng-Luen Li, Meng-Yu Hsu, Ya-Yueh Pang, I-Ling Chen, Ching-Kuei Chen, Sai-Wen Tang, Hsuan-Yuan Lin, Jung-Yaw Lin
Evidence Based Complementary and Alternative Medicine, 2012
Involvement of prohibitin upregulation in abrin-triggered apoptosis
Yu-Huei Liu, Konan Peck, Jung-Yaw Lin
Evidence Based Complementary and Alternative Medicine, 2012
Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells
Sai-Wen Tang, Tsung-Cheng Yang, Wei-Chou Lin, Wen-Hsin Chang, Chung-Chieh Wang, Ming-Kuen Lai, Jung-Yaw Lin
Carcinogenesis, 2011
Recognition intensities of submolecular structures, mammalian glyco-structural units, ligand cluster and polyvalency in abrin-a-carbohydrate interactions
June H. Wu, Albert M. Wu, Zhangung Yang, Yuen-Yuen Chen, Biswajit Singha, Lu-Ping Chow, Jung-Yaw Lin
Biochimie, 2010
A biophysical elucidation for less toxicity of Agglutinin than Abrin-a from the seeds of Abrus Precatorius in consequence of crystal structure
Jack Cheng, Tian-Huey Lu, Chao-Lin Liu, Jung-Yaw Lin
Journal of Biomedical Science, 2010
Roles of mammalian structural units, ligand cluster and polyvalency in the Abrus precatorius agglutinin and glycoprotein recognition process
Albert M. Wu, June H. Wu, Jia-Hau Liu, Yuen-Yuen Chen, Biswajit Singha, Lu-Ping Chow, Jung-Yaw Lin
Molecular Immunology, 2009
Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis
Li-Ching Lee, Chiung-Mei Chen, Fen-Lin Chen, Pei-Ying Lin, Ya-Chin Hsiao, Pin-Rong Wang, Ming-Tsan Su, Hsiu-Mei Hsieh-Li, Ji-Chuu Hwang, Chung-Hsin Wu, Guan-Chiun Lee, Sher Singh, Yenshou Lin, Sen-Yung Hsieh, Guey-Jen Lee-Chen, Jung-Yaw Lin
Clinica Chimica Acta, 2009
MYC pathway is activated in clear cell renal cell carcinoma and essential for proliferation of clear cell renal cell carcinoma cells
Sai-Wen Tang, Wen-Hsin Chang, Yih-Ching Su, Yu-Chi Chen, Yen-Han Lai, Pei-Tzu Wu, Chyong-Ing Hsu, Wei-Chou Lin, Ming-Kuen Lai, Jung-Yaw Lin
Cancer Letters, 2009
Up-regulation of vascular endothelial growth factor-D expression in clear cell renal cell carcinoma by CD74: A critical role in cancer cell tumorigenesis
Yu-Huei Liu, Chang-Yueh Lin, Wei-Chou Lin, Sai-Wen Tang, Ming-Kuen Lai, Jung-Yaw Lin
Journal of Immunology, 2008
Inhibitory effects of nontoxic protein volvatoxin A1 on pore-forming cardiotoxic protein volvatoxin A2 by interaction with amphipathic α-helix
Pei‐Tzu Wu, Su‐Chang Lin, Chyong‐Ing Hsu, Yen‐Chywan Liaw, Jung‐Yaw Lin
FEBS Journal, 2006
Identification of differentially expressed genes in clear cell renal cell carcinoma by analysis of full-length enriched cDNA library
Sai-Wen Tang, Wen-Hsin Chang, Yu-Wei Chao, Chung-Yei Lin, Hsiao-Fen Chen, Yen-Han Lai, Bo-Wen Zhan, Yih-Ching Su, Sen-Wen Jane, Yu-Chi Chen, Chyong-Ing Hsu, Wei-Chou Lin, Kao-Chung Wang, Ming-Kuen Lai, Jung-Yaw Lin
Journal of Biomedical Science, 2006
Gene expression analysis of human hepatocellular carcinoma by using full-length cDNA library
Chia-Chu Tsai, Kai-Wen Huang, Hsiao-Fen Chen, Bo-Wen Zhan, Yen-Han Lai, Fa-han Lee, Chung-Yei Lin, Yi-Cheng Ho, Yu-Wei Chao, Yih-Ching Su, Sen-Wen Jane, Yu-Chi Chen, Chyong-Ing Hsu, Po-Huang Li, Hey-Chi Hsu, Yutaka Suzuki, Sumio Sugano, Jung-Yaw Lin
Journal of Biomedical Science, 2006
Crystal structures and electron micrographs of fungal volvatoxin A2
Su-Chang Lin, Yu-Chih Lo, Jung-Yiaw Lin, Yen-Chywan Liaw
Journal of Molecular Biology, 2004
Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans
Kadali S Sagar, Chia-Chuan Chang, Wei-Kung Wang, Jung-Yaw Lin, Shoei-Sheng Lee
Bioorganic and Medicinal Chemistry, 2004
Fungal Immunomodulatory Protein from Flammulina velutipes Induces Interferon-γ Production through p38 Mitogen-Activated Protein Kinase Signaling Pathway
Po-Hui Wang, Chyong-Ing Hsu, Sheau-Chung Tang, Yu-Lu Huang, Jung-Yaw Lin, Jiunn-Liang Ko
Journal of Agricultural and Food Chemistry, 2004
Ricin Triggers Apoptotic Morphological Changes through Caspase-3 Cleavage of BAT3
Yu-Hauh Wu, Sheue-Fang Shih, Jung-Yaw Lin
Journal of Biological Chemistry, 2004
Functional Domains of a Pore-forming Cardiotoxic Protein, Volvatoxin A2
Yui-Ping Weng, Ya-Ping Lin, Chyong-Ing Hsu, Jung-Yaw Lin
Journal of Biological Chemistry, 2004
Oral administration of an edible-mushroom-derived protein inhibits the development of food-allergic reactions in mice
K.‐Y. Hsieh, C.‐I. Hsu, J.‐Y. Lin, C.‐C. Tsai, R.‐H. Lin
Clinical and Experimental Allergy, 2003
Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme
Ju-Chi Liu, Feng-Lin Hsu, Jen-Chen Tsai, Paul Chan, Jenny Ya-Hsin Liu, G.Neil Thomas, Brian Tomlinson, Ming-Yu Lo, Jung-Yaw Lin
Life Sciences, 2003
Antibiotic activity of lectins from marine algae against marine vibrios
W.-R. Liao, J.-Y. Lin, W.-Y. Shieh, W.-L. Jeng, R. Huang
Journal of Industrial Microbiology and Biotechnology, 2003
Large-scale sequencing analysis of the full-length cDNA library of human hepatocellular carcinoma
Chia-Chu Tsai, Yi-Da Chung, Hong-Jen Lee, Wen-Hsin Chang, Yutaka Suzuku, Sumio Sugano, Jung-Yaw Lin
Journal of Biomedical Science, 2003
The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on vero cells
Ju-Chi Liu, Paul Chan, Feng-Lin Hsu, Yi-Jen Chen, Ming-Hsiung Hsieh, Ming-Yu Lo, Jung-Yaw Lin
American Journal of Chinese Medicine, 2002
Chimeric polypeptide of thymidine kinase and thymidylate kinase of shrimp white spot syndrome virus: Thymidine kinase activity of the recombinant protein expressed in a baculovirus/insect cell system
Huey-Fen Tzeng, Zee-Fen Chang, Shao-En Peng, Chung-Hsiung Wang, Jung-Yaw Lin, Guang-Hsiung Kou, Chu-Fang Lo
Virology, 2002
Ribonucleotide reductase of shrimp white spot syndrome virus (WSSV): Expression and enzymatic activity in a baculovirus/insect cell system and WSSV-infected shrimp
Shinn-Tsuen Lin, Yun-Shiang Chang, Han-Ching Wang, Huey-Fen Tzeng, Zee-Fen Chang, Jung-Yaw Lin, Chung-Hsiung Wang, Chu-Fang Lo, Guang-Hsiung Kou
Virology, 2002
Cloning, characterization, and phylogenetic analysis of a shrimp white spot syndrome virus gene that encodes a protein kinase
Wang-Jing Liu, Hon-Tsen Yu, Shao-En Peng, Yun-Shiang Chang, Hsiu-Wen Pien, Ching-Ju Lin, Chiu-Jung Huang, Meng-Feng Tsai, Chang-Jen Huang, Chung-Hsiung Wang, Jung-Yaw Lin, Chu-Fang Lo, Guang-Hsiung Kou
Virology, 2001
Carbohydrate specificity of a toxic lectin, abrin A, from the seeds of Abrus precatorius (jequirity bean)
Albert M. Wu, June H. Wu, Anthony Herp, Lu-Ping Chow, Jung-Yaw Lin
Life Sciences, 2001
Abrin Triggers Cell Death by Inactivating a Thiol-specific Antioxidant Protein
Sheue-Fang Shih, Yu-Hauh Wu, Chih-Hung Hung, Hui-Yu Yang, Jung-Yaw Lin
Journal of Biological Chemistry, 2001
The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells
Jun-Jen Chang, Tso-Hsiao Chen, Paul Chan, Yi-Jen Chen, Feng-Lin Hsu, Ming-Yu Lo, Jung-Yaw Lin
Pharmacology, 2001
Transcriptional analysis of the ribonucleotide reductase genes of shrimp white spot syndrome virus
Meng-Feng Tsai, Chu-Fang Lo, Mariëlle C.W. van Hulten, Huey-Fen Tzeng, Chih-Ming Chou, Chang-Jen Huang, Chung-Hsiung Wang, Jung-Yaw Lin, Just M. Vlak, Guang-Hsiung Kou
Virology, 2000
Crystallization of agglutinin from the seeds of Abrus precatorius
Kaliyamoorthy Panneerselvam, Su-Chang Lin, Chao-Lin Liu, Yen-Chywan Liaw, Jung-Yaw Lin, Tian-Huey Lu
Acta Crystallographica Section D Biological Crystallography, 2000
Primary structure and function analysis of the Abrus precatorius agglutinin A chain by site-directed mutagenesis. Pro199 of amphiphilic α- helix h impairs protein synthesis inhibitory activity
Chao-Lin Liu, Chia-Chu Tsai, Su-Chang Lin, Li-In Wang, Chong-Ing Hsu, Ming-Jing Hwang, Jung-Yaw Lin
Journal of Biological Chemistry, 2000
Identification and characterization of a shrimp white spot syndrome virus (WSSV) gene that encodes a novel chimeric polypeptide of cellular-type thymidine kinase and thymidylate kinase
Meng-Feng Tsai, Hon-Tsen Yu, Huey-Fen Tzeng, Jiann-Horng Leu, Chih-Ming Chou, Chang-Jen Huang, Chung-Hsiung Wang, Jung-Yaw Lin, Guang-Hsiung Kou, Chu-Fang Lo
Virology, 2000
Purification, characterization and molecular cloning of trichoanguin, a novel type I ribosome-inactivating protein from the seeds of Trichosanthes anguina
Lu-Ping CHOW, Ming-Huei CHOU, Cheng-Ying HO, Chyh-Chong CHUANG, Fu-Ming PAN, Shih-Hsiung WU, Jung-Yaw LIN
Biochemical Journal, 1999
Sechiumin, a ribosome-inactivating protein from the edible gourd, Sechium edule Swartz - Purification, characterization, molecular cloning and expression
Tsann‐Huei Wu, Lu‐Ping Chow, Jung‐Yaw Lin
European Journal of Biochemistry, 1998
Bioactive kaurane diterpenoids from Annona glabra
Fang-Rong Chang, Pey-Yuh Yang, Jung-Yaw Lin, Kuo-Hsiung Lee, Yang-Chang Wu
Journal of Natural Products, 1998
Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling
Medicinal Chemistry Research, 1997
Dimerization of the N-terminal amphipathic α-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis
Wen-Huei Lin, Chih-Hung Hung, Chyong-Ing Hsu, Jung-Yaw Lin
Journal of Biological Chemistry, 1997
Molecular cloning and expression of a fungal immunomodulatory protein, FIP-fve, from Flammulina velutipes
Journal of the Formosan Medical Association, 1997
Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea
Hao-Chi HSU, Chyong-Ing HSU, Rong-Hwa LIN, Chian-Liang KAO, Jung-Yaw LIN
Biochemical Journal, 1997
Establishment and characterization of an abrin-resistant cell line
J.-L. Ko, J.-Y. Lin
Cell Biology and Toxicology, 1997
Identification of amino acid residues of abrin-a A chain is essential for catalysis and reassociation with abrin-a B chain by site-directed mutagenesis
J. K. Chen, C. H. Hung, Y. C. Liaw, J. Y. Lin
Protein Engineering, 1997
The importance of the helix 2 region for the cis-cleaving and trans- cleaving activities of hepatitis delta virus ribozymes
Chuan-Bin Lee, Yen-Chein Lai, Yueh-Hsin Ping, Zhi-Shun Huang, Jung-Yaw Lin, Huey-Nan Wu
Biochemistry, 1996
Crystallization and preliminary X-ray analysis of volvatoxin A2 from Volvariella volvacea
Su-Chang Lin, Jung-Yaw Lin, Yen-Chywan Liaw
Proteins Structure Function and Genetics, 1996
Effects of circular permutation on the cis-cleavage reaction of a hepatitis delta virus ribozyme: Application to trans-acting ribozyme design
Yen-Chein Lai, Jing-Yu Lee, Huey-Juan Liu, Jung-Yaw Lin, Huey-Nan Wu
Biochemistry, 1996
Probing the domain structure of abrin-a by tryptic digestion
Song‐How Lin, Lu‐Ping Chow, Yung‐Liang Chen, Yen‐Chywan Liaw, Jeen‐Kuan Chen, Jung‐Yaw Lin
European Journal of Biochemistry, 1996
Amino acid sequence of trichoanguina, a ribosomal-inactivating protein from Trichosanthes anguina seeds
Lu-Ping Chow, Masaharu Kamo, Jung-Yaw Lin, Shiuan-Huei Wang, Yoshio Ueno, Akira Tsugita
Journal of Biomedical Science, 1996
Growth suppression of human colorectal carcinoma in nude mice by monoclonal antibody C27-abrin A chain conjugate
Lai-Chen Tsai, Yung-Liang Chen, Chung Lee, Horng-Min Chen, Zo-Nan Chang, Mei-Whey Hung, Pei-Ling Chao, Jung-Yaw Lin
Diseases of the Colon Rectum, 1995
Crystal Structure of Abrin-a at 2.14 Å
Tahir H. Tahirov, Tian-Huey Lu, Yen-Chywan Liaw, Yung-Lian Chen, Jung-Yaw Lin
Journal of Molecular Biology, 1995
Native and/or asialo-Tamm-Horsfall glycoproteins Sd(a+) are important receptors for Triticum vulgaris (wheat germ) agglutinin and for three toxic lectins (abrin-a, ricin and mistletoe toxic lectin-I)
Albert M. Wu, Winifred M. Watkins, Chie-Pein Chen, Shuh-Chyung Song, Lu-Ping Chow, Jung-Yaw Lin
FEBS Letters, 1995
Crystal structure of abrin-a at 2.14 Å
Tahir H. Tahirov, Tian-Huey Lu, Yen-Chywan Liaw, Yung-Liang Chen, Jung-Yaw Lin
Journal of Molecular Biology, 1995
A sheep hydatid cyst glycoprotein as receptors for three toxic lectins, as well as Abrus precatorius and Ricinus communis agglutinins
A Wu
Bba General Subjects, 1995
Amino acid sequences of trypsin inhibitors from the melon Cucumis melo
Chi-Fang Lee, Jung-Yaw Lin
Journal of Biochemistry, 1995
A New Fungal Immunomodulatory Protein, FIP‐fve Isolated from the Edible Mushroom, Flammulina velutipes and its Complete Amino Acid Sequence
Jiunn-Liang Ko, Chyong-Ing Hsu, Rong-Hwa Lin, Chuan-Liang Kao, Jung-Yaw Lin
European Journal of Biochemistry, 1995
Corrigendum: Crystal structure of Abrin-a at 2.14 Å (Journal of Molecular Biology (1995) 250 (354-367))
Tahir H. Tahirov, Tian-Huey Lu, Yen-Chywan Liaw, Yung-Lian Chen, Jung-Yaw Lin
Journal of Molecular Biology, 1995
Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix
C CHANG, M LIN, S LEE, K LIU, F HSU, J LIN
Antiviral Research, 1995
Inactivation of Acacia confusa trypsin inhibitor by site-specific mutagenesis
Chih-Hung Hung, Ming-Chih Lee, Jung-Yaw Lin
FEBS Letters, 1994
Inhibitory effects of polyphenolic catechins from Chinese green tea on HIV reverse transcriptase activity
C. W. Chang, F. L. Hsu, J. Y. Lin
Journal of Biomedical Science, 1994
A new crystal form of abrin-a from the seeds of Abrus precatorius
Tahir Haji oglu Tahirov, Tian-Huey Lu, Yen-Chywan Liaw, Shu-Chen Chu, Jung-Yaw Lin
Journal of Molecular Biology, 1994
Antitumor protein: Abrin
J. Y. Lin
Toxin Reviews, 1994
Cloning and expression of three abrin A‐chains and their mutants derived by site‐specific mutagenesisin Escherichia coli
Chih‐Hung HUNG, Ming‐Chih LEE, Jeen‐Kuan CHEN, Jung‐Yaw LIN
European Journal of Biochemistry, 1994
Cloning and expression of the gene encoding Acacia confusa trypsin inhibitor that is active without post-translational proteolysis
Hung Chih-Hung, Lee Ming-Chih, Lin Ming-Tay, Lin Jung-Yaw
Gene, 1993
Primary structure of three distinct isoabrins determined by cDNA sequencing: Conservation and significance
Chih-Hung Hung, Ming-Chih Lee, Te-Chang Lee, Jung-Yaw Lin
Journal of Molecular Biology, 1993
The complete amino acid sequence of a kunitz family trypsin inhibitor from seeds of acacia confusa
Han-Chung Wu, Jung-Yaw Lin
Journal of Biochemistry, 1993
Defining the carbohydrate specificities of Abrus precatorius agglutinin as T (Galβ1→3GalNAc) > I/II (Galβ1→3/4GlcNAc)
Journal of Biological Chemistry, 1992
The complete primary structure of abrin-a B chain
Yung-Liang Chen, Lu-Ping Chow, Akira Tsugita, Jung-Yaw Lin
FEBS Letters, 1992
Nucleotide sequence of cDNA for Acacia confusa trypsin inhibitor and implication of post-translation processing
Chih-Hung Hung, Ming-chih Lee, Jung-Yaw Lin
Biochemical and Biophysical Research Communications, 1992
Inhibition of angiotensin-i-converting enzyme by tetrahydroxyxanthones isolated from tripterospermum lanceolatum
Chin-Hsiung Chen, Jung-Yaw Lin, Chun-Nan Lin, Shin-Yuan Hsu
Journal of Natural Products, 1992
Inhibitory effects of flavonoids on moloney murine leukemia virus reverse transcriptase activity
Shu-Chen Chu, Yih-Shou Hsieh, Jung-Yaw Lin
Journal of Natural Products, 1992
Analysis of mutations in trfA, the replication initiation gene of the broad-host-range plasmid RK2
J Lin, D R Helinski
Journal of Bacteriology, 1992
Inhibition of Moloney murine leukemia virus reverse transcriptase activity by tetrahydroxyxanthones isolated from the Chinese herb, Tripterospermum lanceolatum (Hyata)
Chia-Che Chang, Chun-Nan Lin, Jung-Yaw Lin
Antiviral Research, 1992
Trypsin inhibitor from the seeds of Acacia confusa
Jung-Yaw Lin, Shu-Chen Chu, Han-Chung Wu, Yih-Shou Hsieh
Journal of Biochemistry, 1991
Chimeric protein: abrin B chain-trypsin inhibitor conjugate as a new antitumor agent.
Biochemistry International, 1989
Thyroxine may decrease serum thyroxine-binding globulin levels
Journal of the Formosan Medical Association, 1989
Antimutagenic activity of extracts from anticancer drugs in Chinese medicine
Huei Lee, Jung-Yaw Lin
Mutation Research Genetic Toxicology, 1988
The detection of mycobacterial DNA sequences in uncultured clinical specimens with cloned Mycobacterium tuberculosis DNA as probes
Chia C. Pao, Shyh-Shyan Lin, Shaw-Yun Wu, Whei-Meih Juang, Chau-Hsiung Chang, Jung-Yaw Lin
Tubercle, 1988
The isolation and purification of pre-S2 containing hepatitis B virus surface antigen by chemical affinity chromatography
Jung-Yaw Lin, Yih-Shou Hsieh, Shu-Chen Chu
Applied Biochemistry and Biotechnology, 1987
Deoxyribonucleic acid hybridization analysis for the detection of urogenital Chlamydia trachomatis infections in women
Chia C. Pao, Shyh-Shyan Lin, Tsyr-En Yang, Yung-Kuei Soong, Pai-Shun Lee, Jung-Yaw Lin
American Journal of Obstetrics and Gynecology, 1987
Studies on the antitumor lectins isolated from the seeds of Ricinus communis (castor bean)
Jung-Yaw Lin, Su-Ying Liu
Toxicon, 1986
Studies on Ricinus communis lectin--carbohydrate interaction by means of affinity electrophoresis.
Proceedings of the National Science Council Republic of China Part B Life Sciences, 1986
Antitumor lectin-trypsin inhibitor conjugate1, 2
Jung‐Yaw Lin, Lihua Lin
Journal of the National Cancer Institute, 1985
Isolation and characterization of a lectin from edible mushroom, Volvariella volvacea
Jung-Yaw LIN, Tze-Bin CHOU
Journal of Biochemistry, 1984
Effects of caloric intake on amino acid metabolism in parenteral nutrition: With special reference to the plasma amino acid profile
Journal of Surgical Association Republic of China, 1983
Induction of Antitumor Immunity by Tumor Cells Treated with Abrin
Cancer Research, 1982
Formation of mutagens in boiled pork extract
J.-Y. Lin, H. Lee, H.-I. Huang
Food and Chemical Toxicology, 1982
Inhibitory effects of four isoabrins on the growth of sarcoma 180 cells
Cancer Research, 1982
Detection of mutagens in boiled pork extract
Journal of the Chinese Biochemical Society, 1981
Lectin Derivatives of Methotrexate and Chlorambucil as Chemotherapeutic Agents
Jung‐Yaw Lin, Jiann-Shyong Li, Ta‐Cheng Tung
Journal of the National Cancer Institute, 1981
Isolation of four isotoxic proteins and one agglutinin from jequiriti bean (Abrus precatorius)
Jung-Yaw Lin, Te-Chang Lee, Su-Tieng Hu, Ta-Cheng Tung
Toxicon, 1981
The growth inhibition of S-180 sarcoma cells by Abrus agglutinin treatment in vivo (author's transl)
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1981
Mutagenicity of Chinese wine treated with nitrite
J.-Y. Lin, M.-W. Tai
Food and Cosmetics Toxicology, 1980
The mutagenicity of Chinese food and herb
Toxicology Letters, 1980
Tumor immunity induction in inbred balb/c mice by abrus agglutinin treated Meth-A fibrosarcoma cells
Journal of the Formosan Medical Association, 1979
Antigenicity of abrus agglutinin-treated meth-A tumor cells in inbred BALB/C mice
Journal of the Formosan Medical Association, 1979
Total parenteral nutrition employing fat emulsion--a clinical and experimental study.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1979
The mutagenicity of soy bean sauce
J.Y. Lin, H.-I. Wang, Y.-C. Yeh
Food and Cosmetics Toxicology, 1979
Inhibition of S-180 sarcoma growth by treatment with abrus agglutinin
Journal of the Formosan Medical Association, 1979
Immunoelectron microscopic localization of abrin in tumor cells
Toxicon, 1979
Effects of the caloric intake on amino acid metabolism in parenteral nutrition
Journal of the Formosan Medical Association, 1978
Effect of abrin on the outgrowth of neurites and fibroblasts from dorsal root ganglia in tissue culture
Journal of the Formosan Medical Association, 1978
ISOLATION OF ANTITUMOR PROTEINS ABRIN‐A AND ABRIN‐B FROM ABRUS PRECATORIUS*
Jung‐Yaw Lin, Te‐Chang Lee, Ta‐Cheng Tung
International Journal of Peptide and Protein Research, 1978
Isolation of toxic and non-toxic lectins from the bitter pear melon Momordica charantia Linn
Jung-Yaw Lin, Mei-Jane Hou, Yon-Chang Chen
Toxicon, 1978
Syngeneic tumor immunity induction in Swiss mice by abrus agglutinin treated S 180 sarcoma cells
Journal of the Formosan Medical Association, 1976
Studies on the analgesic effects of Abrin and Ricin
J Formosan MED Ass, 1976
The effect of ricin on the growth of chick embryo spinal ganglia in tissue culture
J Formosan MED Ass, 1976
Study on anti cancer activity of abrin: effects of abrin on leukocyte and lymphocyte in peripheral blood of rats (Chinese)
J Formosan MED Ass, 1975
Effects of abrin and ricin on mammalian cells in tissue culture
J Formosan MED Ass, 1975
Amino-terminal sequences of the anti-tumor lectin ricin A- and B-chains
Steven Shoei-lung Li, Chin Hsuan Wei, Jung-Yaw Lin, Ta-Cheng Tung
Biochemical and Biophysical Research Communications, 1975
Studies on a new cardiotoxin isolated from the edible mushroom, Volvariella volvaceae and Flammulina velutipes
Toxicon, 1975
Studies on abrin
Toxicon, 1975
Some aspects on mechanism of anti cancer activity of abrin
Toxicon, 1975
Toxicity of the cardiotoxic protein, flammutoxin, isolated from the edible mushroom Flammunlina velutipes
Jung-Yaw Lin, Hua-Lin Wu, Guey-Yueh Shi
Toxicon, 1975
The mechanism of the anti cancer activities of abrin and ricin
J Formosan MED Ass, 1974
Further report on therapeutic effect of Abrin and Ricin on human cancers
J Formosan MED Ass, 1974
Cardiotoxic protein from edible mushrooms
JUNG-YAW LIN, YIE-JANE LIN, CHENG-CHUNG CHEN, HUA-LIN WU, GUEY-YUEH SHI, TZYY-WEN JENG
Nature, 1974
A micromethod for the determination of 5-(adenosine 5'-pyrophosphoryl)-D-ribose (adenosine diphosphoribose-(5)) in biological extracts.
Carbohydrate Research, 1974
Isolation of a new cardiotoxic protein from the edible mushroom, volvariella volvacea
JUNG-YAW LIN, TZYY-WEN JENG, CHENG-CHUNG CHEN, GUEY-YUEH SHI, TA-CHENG TUNG
Nature, 1973
The cytotoxic effects of abrin and ricin on Ehrlich ascites tumor cells
Jung-Yaw Lin, Yuang-Chi Chang, Liu-Yuh Huang, Ta-Cheng Tung
Toxicon, 1973
The Binding of Abrin and Ricin by Ehrlich Ascites Tumor Cells
Cancer Research, 1973
Polyribosome Disaggregation in Rat Liver Following Administration of the Phytotoxic Proteins, Abrin and Ricin1
Cancer Research, 1972
Effect of crystalline ricin on the biosynthesis of protein, RNA, and DNA in experimental tumor cells.
Cancer Research, 1971
Studies on the active principle from Abrus precatorius L. Leguminosae seed kernels
Jung-Yaw Lin, Yon-Shong Shaw, Ta-Cheng Tung
Toxicon, 1971
Amino acid analysis of the coat protein of the filamentous bacterial virus xf from Xanthomonas oryzae
Jung-Yaw Lin, Chu-Ching Wu, Tsong-Teh Kue
Virology, 1971
Carbohydrate in abrin
Jung-Yaw Lin, Yon-Ch'ang Cheng, Kang Liu, Ta-Cheng Tung
Toxicon, 1971
Abrin and ricin: New anti-tumour substances
JUNG-YAW LIN, KOU-YI TSERNG, CHI-CHING CHEN, LEE-TZU LIN, TA-CHENG TUNG
Nature, 1970
Study on the effect of tryptic digestion on the toxicity of abrin.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1970
Purification of ricin from Ricinus communis.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1970
The inhibitory effect of crystalline ricin in Ehrlich ascites tumor.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1970
Distribution of I131-labeled abrin in vivo
Jung-Yaw Lin, Shyr-Te Ju, Yon-Shong Shaw, Ta-Cheng Tung
Toxicon, 1970
Effect of Crystalline Abrin on the Biosynthesis of Protein, RNA, and DNA in Experimental Tumors
Cancer Research, 1970
Antineoplastic activity of abrin.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1969
Purification of abrin from Abrus precatorius L. Leguminosae.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1969
Inhibitory effect of abrin on Ehrlich ascites tumor.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1969
N-and C-terminal residues in crystalline abrin.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1969
Studies on the toxic action of abrin.
Taiwan Yi Xue Hui Za Zhi Journal of the Formosan Medical Association, 1969
Demonstration of Further Differences between in Vitro and in Vivo Synthesized MS2 Coat Protein
Jung-Yaw Lin, H. Fraenkel-Conrat
Biochemistry, 1967
The coat protein of the RNA bacteriophage MS2
Jung-Yaw Lin, Chung M. Tsung, H. Fraenkel-Conrat
Journal of Molecular Biology, 1967
Studies on favism. 3. Studies on the physiological activites of vicine in vitro.
Journal of the Formosan Medical Association Taiwan Yi Zhi, 1962
Studies on favism. I. Isolation of an active principle from faba beans (Vicia faba).
Journal of the Formosan Medical Association Taiwan Yi Zhi, 1962
Studies on favism. 2. Studies on the physiological activities of vicine in vivo.
Journal of the Formosan Medical Association Taiwan Yi Zhi, 1962
Studies on free amino acids in the seeds of Leucaena glauca Benth. III. Biological study on mimosine.
Journal of the Formosan Medical Association Taiwan Yi Zhi, 1961
Studies on free amino acids in the seeds of Leucaena glauca Benth. I. Isolation and identification of mimosine.
Journal of the Formosan Medical Association Taiwan Yi Zhi, 1961

Jung-Yaw Lin

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