Diabetic foot ulcer: A systematic review of risk factors Andreas M Lazaris, Katerina Angeli-Doulami, Adriane E Napp, Günther Silbernagel, Mihai Ionac, Nikolaos Doulamis, Anastasios Doulamis, Eftychios Protopapadakis, Michael A Lazaris, Georgios Pappas, Vaia Lampadiari, Panagiotis Halvatsiotis, Maria-Erofili S Lazari, George Geroulakos Journal of Wound Care, 2026 Background: This study used a systematic analysis to identify risk factors that may be used to predict which patients with diabetes will develop a foot ulcer. Methods: A systematic review of the literature was conducted, which included observational cohort studies that followed patients with diabetes to see whether they developed a diabetic foot ulcer (DFU). A random-effect meta-analysis was performed, and odds ratios were used for nominal data or mean differences for continuous data. This study was registered at PROSPERO (CRD42020182527). Results: The analysis included eight studies. From 4914 patients, 607 developed a DFU (12%) within a median of 30 months follow-up, indicating a 4.8% annual rate. The following parameters were found to be related to DFU development: a history of DFUs; cerebrovascular accident; peripheral arterial disease and lower extremity amputation; duration of diabetes; glycated haemoglobin; use of insulin; visual impairment; claudication; altered monofilament sensitivity; foot deformity; onychomycosis; foot oedema; and local hyperkeratosis. The quality of evidence for most of the factors was either low or very low. Conclusion: The development of DFUs may be associated with various factors, including: a history of previous DFUs; amputation or clinical atherosclerosis syndrome, such as peripheral arterial and cerebrovascular disease; the severity of diabetes; and various clinical signs regarding the patient's foot. The low certainty of evidence for most of these factors indicates that there is still a gap in knowledge regarding the early detection of foot ulcers in people with diabetes. A large prospective study could identify more precisely which factors are the most significant. Contemporary technology could use such data to create devices that would be able to predict DFUs so they can be prevented or treated earlier, which would reduce the possibility of lower limb amputation.
A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol Franz Förster, Katrin Horn, Janne Pott, Graciela E. Delgado, Marcus E. Kleber, Winfried März, Angela Patricia Moissl-Blanke, Günther Silbernagel, Melanie Waldenberger, Harald Grallert, Annette Peters, Christian Gieger, Ronny Baber, Holger Kirsten, Markus Loeffler, Berend Isermann, Joachim Thiery, Peter Kovacs, Anke Tönjes, Michael Stumvoll, Helena Gylling, Mika Kähönen, Terho Lehtimäki, Pashupati Prasad Mishra, Olli Raitakari, Uta Ceglarek, Markus Scholz Ebiomedicine, 2026 BACKGROUND: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis. METHODS: We conducted a genome-wide association meta-analysis, combining data from KORA, LIFE-Heart, LIFE-Adult, LURIC, the Sorbs study, and YFS, resulting in up to 10,519 individuals. We investigated 14 traits related to serum concentrations of lanosterol, desmosterol, and cholesterol. Direct and indirect effects of lanosterol on CAD were investigated with a Mendelian randomisation mediation analysis. FINDINGS: ) associations not previously reported in the GWAS catalogue. These include two loci without prior connection to cholesterol, associated with lanosterol (7q21.2, CYP51A1) and free cholesterol (11q14.1), and two associations with lanosterol at loci previously reported for cholesterol (5q13.3, HMGCR; 11q23.3, APO cluster). We also replicated eight loci previously reported for associations with cholesterol-related traits. Lanosterol exhibited significant total and indirect effects on CAD, but its direct effect was not significant. INTERPRETATION: We demonstrate that the investigation of intermediate phenotypes can help to functionally fine map previously reported associations for cholesterol, improving our understanding of genetic regulation of cholesterol concentrations. Further, the effect of lanosterol on CAD is probably fully mediated by total cholesterol. FUNDING: This investigation was primarily funded by the ministry for science and health of the Rhineland-Palatinate through the CoAGE graduate programme. A complete list of funding organisations is provided in the acknowledgements.
Arterial thromboembolic events in testicular cancer patients: short- and long-term incidence, risk factors, and impact on mortality Florian Moik, Angelika Terbuch, Ariane Sprakel, Georg Pichler, Dominik A. Barth, Renate Pichler, Peter Rainer, Günther Silbernagel, Sebastian Mannweiler, Philipp J. Jost, Sascha A. Ahyai, Thomas Bauernhofer, Georg C. Hutterer, Martin Pichler Journal of Thrombosis and Haemostasis, 2025 BACKGROUND: Patients with testicular germ cell tumors (TGCT) have a high cancer-specific survival rate. OBJECTIVES: We aimed to determine the short- and long-term risk of arterial thromboembolic events (ATE), their impact on mortality, and risk factors for ATE in TGCT patients. METHODS: Patients with TGCT treated between 1994 and 2020 were included in a single-center retrospective cohort study. The primary outcome was ATE (ie, acute coronary syndrome, ischemic stroke, and acute peripheral arterial occlusion). Cumulative incidences were obtained in competing risk analysis. The impact of ATE on mortality was analyzed in a multistate model. Cox regression was used to explore short- and long-term ATE risk factors. RESULTS: Overall, 1277 patients were included (median age, 35 years; seminoma: 56%; 44% cisplatin-based chemotherapy). Cumulative ATE incidences at 1, 10, and 25 years were 0.6% (95% CI, 0.3%-1.1%), 2.6% (95% CI, 1.8%-3.7%), and 12.0% (95% CI, 8.7%-15.9%), respectively. ATE diagnosis was independently associated with increased all-cause mortality (age-adjusted transition hazard ratio, 4.61; [95% CI, 2.40-8.85]; P < .001). Cisplatin-based chemotherapy was associated with ATE risk within 1 year after TGCT diagnosis (1.4% vs 0%, P < .001), whereas no differences were observed thereafter. Regarding long-term ATE risk, a point-based risk score was derived (age ≥ 35, smoking, and lactate dehydrogenase ≥ 250 IU/L), which efficiently stratified ATE risk (Harrel's C, 0.71 [95% CI, 0.63-0.78]), with cumulative ATE incidences in low-, intermediate-, and high-risk patients of 3.9%, 11.4%, and 22.7%, respectively. CONCLUSION: ATE represents a common complication in TGCT survivors and is associated with increased mortality. A simple point-based score efficiently stratifies long-term ATE risk, whereas cisplatin-based chemotherapy increases short-term ATE risk.
The impact of statins on pulmonary embolism severity—a retrospective data analysis Paul Gressenberger, Bettina Wachmann, Andrea Borenich, Gudrun Pregartner, Lisa Moser, Nikolaus Schreiber, Johannes Schmid, Ewald Kolesnik, Günther Silbernagel, Reinhard B. Raggam, Marianne Brodmann, Thomas Gary Research and Practice in Thrombosis and Haemostasis, 2025 Background: Recent studies have demonstrated decreased rates of venous thrombotic events, including pulmonary embolism (PE), in patients taking statins. It, however, remains elusive whether statins could also impact PE severity. Objectives: To investigate a potential association between statin use and the severity of PE in a retrospective cohort. Methods: We performed a retrospective data analysis of patients with PE confirmed by computed tomography pulmonary angiography between January 1, 2010, and December 31, 2019, at the University Hospital Graz, Austria. PE severity was assessed based on the 2019 European Society of Cardiology guidelines. Results: ), no significant differences in PE severity were found. Conclusion: Statin use was not associated with PE severity. The smaller proportion of low-risk PE in statin users is likely attributable to their older age, higher BMI, and comorbidities.
Endothelial function and vascular events in patients with limited cutaneous systemic sclerosis (EFVELSS): a prospective observational study Philipp Jud, Philipp Douschan, Teresa Sassmann, Günther Silbernagel, Katharina Gütl, Reinhard B. Raggam, Peter Rief, Leyla Schweiger, Nikolaus John, Gerald Seinost, Vasile Foris, Gabor Kovacs, Thomas Gary, Viktoria Nemecz, Andreas Meinitzer, Heimo Strohmaier, Balazs Odler, Florentine Moazedi-Fürst, Marianne Brodmann, Franz Hafner Rheumatology International, 2025 Evaluating the predictive role of endothelial dysfunction in the development of vasculopathy-mediated complications in patients with limited cutaneous systemic sclerosis (lcSSc). 38 patients with lcSSc who were naïve for vasculopathy-mediated complications, defined as absent pre-existing digital ulcers (DU), pulmonary hypertension (PH) and symptomatic atherosclerotic cardiovascular diseases, were prospectively observed during a 3-years follow-up period. At study enrolment, functional and laboratory parameters of endothelial dysfunction were assessed. Microvascular events, defined as the development of DU and PH, macrovascular events, defined as newly symptomatic atherosclerotic cardiovascular diseases, and clinical events, defined as additional interstitial lung disease (ILD), renal crisis and esophageal dysfunction, were recorded annually. 33 patients (86.8%) completed all follow-up study visits. During the follow-up period, DU, PH, carotid and vertebral artery disease and ILD occurred in eight (24.2%), one (3.0%), one (3.0%) and two patients (6.1%), respectively, without recorded renal crisis and esophageal dysfunction. Number of pathologic FMD, NMD and/or PWV values was significantly associated with the development of clinical events (p = 0.035), but was not a significant predictor for microvascular events. Number of pathologic FMD, NMD and/or PWV values was a significant predictor for disease activity assessed by EUSTAR index ≥ 2.5 at last study visit (OR 5.47 [95% CI 1.01–29.03], p = 0.049). Distinct endothelial dysfunction may promote the development of disease complications and disease activity in patients with lcSSc.
Two-dimensional vessel wall diffusion anisotropy of human carotids – A novel measure of vascular ageing? Stefan L. Leber, Felix Gunzer, Eva Maria Hassler, Peter Opriessnig, Thomas Metzner, Günther Silbernagel, Hannes Deutschmann, Gernot Reishofer Computers in Biology and Medicine, 2025 BACKGROUND: Magnetic resonance (MR) diffusion tensor imaging (DTI) is a new, non-invasive method to investigate arterial vessel walls. High resolution diffusion weighted imaging (DWI) in combination with a two-dimensional (2D) diffusion gradient sampling scheme has recently been demonstrated as feasible for evaluating diffusivity in the vessel wall of human carotids. We aimed to identify associations of altered diffusivity in human carotids with presence or absence of cardiovascular disease, body mass index (BMI), sex and age in a clinical setting. METHODS: In this single center case-control study we used DWI in combination with a 2D gradient in a 3 T MRI scanner to evaluate diffusivity parameters in carotid vessel walls of clinical patients with known cardiovascular disease (n = 17) and healthy controls (n = 21). We used a read-out segmented EPI (rs-EPI) sequence for DWI. RESULTS: A group comparison showed significantly decreased fractional anisotropy (FA) in patients older than 60 years (p < 0.001) and in patients with a BMI higher than 25 (p = 0.019). Patients with cardiovascular disease had higher values for mean diffusivity (p = 0.005) than patients without cardiovascular disease. A multiple linear regression analysis showed age and sex to be associated with FA. CONCLUSION: Two-dimensional vessel wall DTI of human carotids is feasible for clinical research. Besides patient age, we identified Sex, BMI, or the presence of cardiovascular disease as relevant factors for carotid vessel wall diffusivity. Decreased FA values might indicate early-stage atherosclerosis and vascular ageing.
Associations of Circulating ANGPTL3, C-Terminal Domain-Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality Günther Silbernagel, Yan Q. Chen, Hongxia Li, Deven Lemen, Yi Wen, Eugene Y. Zhen, Martin Rief, Marcus E. Kleber, Graciela Delgado, Mark A. Sarzynski, Yue-Wei Qian, Boerge Schmidt, Raimund Erbel, Ulrike Trampisch, Angela P. Moissl, Henrik Rudolf, Heribert Schunkert, Andreas Stang, Winfried März, Hans J. Trampisch, Hubert Scharnagl, Robert J. Konrad Circulation, 2025 BACKGROUND: ANGPTL3/4/8 (angiopoietin-like proteins 3, 4, and 8) are important regulators of LPL (lipoprotein lipase). ANGPTL8 forms complexes with ANGPTL3 and ANGPTL4. ANGPTL4/8 complex formation converts ANGPTL4 from a furin substrate to a plasmin substrate, and both cleavages generate similar C-terminal domain–containing (CD)—ANGPTL4 fragments. Whereas several studies have investigated associations of free ANGPTL proteins with cardiovascular risk, there are no data describing associations of the complexes and CD-ANGPTL4 with outcomes or describing the effects of the complexes on LPL bound to GPIHBP1 (glycosylphosphatidylinositol HDL-binding protein 1). METHODS: Recombinant protein assays were used to study ANGPTL protein and complex effects on GPIHBP1-LPL activity. ANGPTL3/8, ANGPTL3, ANGPTL4/8, and CD-ANGPTL4 were measured with dedicated immunoassays in 2394 LURIC (Ludwigshafen Risk and Cardiovascular Health) study participants undergoing coronary angiography and 6188 getABI study (German Epidemiological Trial on Ankle Brachial Index) participants undergoing ankle brachial index measurement. There was a follow-up for cardiovascular death with a median (interquartile range) duration of 9.80 (8.75–10.40) years in the LURIC study and 7.06 (7.00–7.14) years in the getABI study. RESULTS: ANGPTL3/8 potently inhibited GPIHBP1-LPL activity and showed positive associations with LDL-C (low-density lipoprotein cholesterol) and triglycerides (both P <0.001). However, in neither study did ANGPTL3/8 correlate with cardiovascular death. Free ANGPTL3 was positively associated with cardiovascular death in the getABI study but not the LURIC study. ANGPTL4/8 and especially CD-ANGPTL4 were positively associated with the prevalence of diabetes, CRP (C-reactive protein; all P <0.001), and cardiovascular death in both studies. In the LURIC and getABI studies, respective hazard ratios for cardiovascular mortality comparing the third with the first ANGPTL4/8 tertile were 1.47 (1.15–1.88) and 1.68 (1.25–2.27) when adjusted for sex, age, body mass index, and diabetes. For CD-ANGPTL4, these hazard ratios were 2.44 (1.86–3.20) and 2.76 (2.00–3.82). CONCLUSIONS: ANGPTL3/8 potently inhibited GPIHBP1-LPL enzymatic activity, consistent with its positive association with serum lipids. However, ANGPTL3/8, LDL-C, and triglyceride levels were not associated with cardiovascular death in the LURIC and getABI cohorts. In contrast, concentrations of ANGPTL4/8 and particularly CD-ANGPTL4 were positively associated with inflammation, the prevalence of diabetes, and cardiovascular mortality.
Support of Home-Based Structured Walking Training and Prediction of the 6-Minute Walk Test Distance in Patients With Peripheral Arterial Disease Based on Telehealth Data: Prospective Cohort Study Fabian Wiesmüller, Andreas Prenner, Andreas Ziegl, Gihan El-Moazen, Robert Modre-Osprian, Martin Baumgartner, Marianne Brodmann, Gerald Seinost, Günther Silbernagel, Günter Schreier, Dieter Hayn Jmir Formative Research, 2025 Background Telehealth has been effective in managing cardiovascular diseases like stroke and heart failure and has shown promising results in managing patients with peripheral arterial disease. However, more work is needed to fully understand the effect of telehealth-based predictive modeling on the physical fitness of patients with peripheral arterial disease. Objective For this work, data from the Keep Pace study were analyzed in depth to gain insights on temporal developments of patients’ conditions and to develop models to predict the patients’ total walking distance at the study end. This could help to determine patients who are likely to benefit from the telehealth program and to continuously provide estimations to the patients as a motivating factor. Methods This work analyzes continuous patient-reported telehealth data, in combination with in-clinic data from 19 Fontaine stage II patients with peripheral arterial disease who underwent a 12-week telehealth-based walking program. This analysis granted insights into the increase of the total walking distance of the 6-minute walk tests (6MWT) as a measure for physical fitness, the steady decrease in the patients’ pain, and the positive correlation between well-being and the total walking distance measured by the 6MWT. Results This work analyzed trends of and correlations between continuous patient-generated data. Findings of this study include a significant decrease of the patients’ pain sensation over time (P=.006), a low but highly significant correlation between pain sensation and steps taken on the same day (r=−0.11; P<.001) and the walking distance of the independently performed 6MWTs (r=−0.39; P<.001). Despite the reported pain, adherence to the 6MWT measurement protocol was high (85.53%). Additionally, patients significantly improved their timed-up-and-go test times during the study (P=.002). Predicting the total walking distance at the study end measured by the 6MWT worked well at study baseline (root mean squared error of 30 meters; 7.04% of the mean total walking distance at the study end of 425 meters) and continuously improved by adding further telehealth data. Future work should validate these findings in a larger cohort and in a prospective setting based on a clinical outcome. Conclusions We conclude that the prototypical trend estimation has great potential for an integration in the telehealth system to be used in future work to provide tailored patient-specific advice based on these predictions. Continuous data from the telehealth system grant a deeper insight and a better understanding of the patients’ status concerning well-being and level of pain as well as their current physical fitness level and the progress toward reaching set goals.
Laboratory diagnostics of lipid metabolism disorders Winfried März, Hubert Scharnagl, Marcus Kleber, Günther Silbernagel, Matthias Nauck, Dirk Müller-Wieland, Arnold von Eckardstein Deutsche Medizinische Wochenschrift, 2023
Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Rafael Kramann, Christina Körbel, Emmanuel Ampofo, Matthias W. Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Gaul, Günther Silbernagel, Martina Sester, Urban Sester, Gunter Aßmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D. Menger, Lucia Rohrer, Winfried März, Michael Böhm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A. Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer Nature Immunology, 2023
Lipoprotein(a) and Pulmonary Embolism Severity-A Retrospective Data Analysis Paul Gressenberger, Florian Posch, Moritz Pechtold, Katharina Gütl, Viktoria Muster, Philipp Jud, Jakob Riedl, Günther Silbernagel, Ewald Kolesnik, Johannes Schmid, Reinhard B. Raggam, Marianne Brodmann, Thomas Gary Frontiers in Cardiovascular Medicine, 2022
J-shaped association between circulating apoC-III and cardiovascular mortality Günther Silbernagel, Hubert Scharnagl, Marcus E Kleber, Michael M Hoffmann, Graciela E Delgado, Tatjana Stojakovic, Thomas Gary, Lingyao Zeng, Andreas Ritsch, Stephen Zewinger, Thimoteus Speer, Heribert Schunkert, Ulf Landmesser, Winfried März, Tanja B Grammer European Journal of Preventive Cardiology, 2022
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9) Vasiliki Lagou, , Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May E. Montasser, Jeff R. O’Connell, Lawrence F. Bielak, Rebecca J. Webster, Richa Saxena, Jeanette M. Stafford, Beate St Pourcain, Nicholas J. Timpson, Perttu Salo, So-Youn Shin, Najaf Amin, Albert V. Smith, Guo Li, Niek Verweij, Anuj Goel, Ian Ford, Paul C. D. Johnson, Toby Johnson, Karen Kapur, Gudmar Thorleifsson, Rona J. Strawbridge, Laura J. Rasmussen-Torvik, Tõnu Esko, Evelin Mihailov, Tove Fall, Ross M. Fraser, Anubha Mahajan, Stavroula Kanoni, Vilmantas Giedraitis, Marcus E. Kleber, Günther Silbernagel, Julia Meyer, Martina Müller-Nurasyid, Andrea Ganna, Antti-Pekka Sarin, Loic Yengo, Dmitry Shungin, Jian’an Luan, Momoko Horikoshi, Ping An, Serena Sanna, Yvonne Boettcher, N. William Rayner, Ilja M. Nolte, Tatijana Zemunik, Erik van Iperen, Peter Kovacs, Nicholas D. Hastie, Sarah H. Wild, Stela McLachlan, Susan Campbell, Ozren Polasek, Olga Carlson, Josephine Egan, Wieland Kiess, Gonneke Willemsen, Johanna Kuusisto, Markku Laakso, Maria Dimitriou, Andrew A. Hicks, Rainer Rauramaa, Stefania Bandinelli, Barbara Thorand, Yongmei Liu, Iva Miljkovic, Lars Lind, Alex Doney, Markus Perola, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Amanda J. Bennett, Christopher J. Groves, Christian Herder, Heikki A. Koistinen, Leena Kinnunen, Ulf de Faire, Stephan J. L. Bakker, Matti Uusitupa, Colin N. A. Palmer, J. Wouter Jukema, Naveed Sattar, Anneli Pouta, Harold Snieder, Eric Boerwinkle, James S. Pankow, Patrik K. Magnusson, Ulrika Krus, Chiara Scapoli, Eco J. C. N. de Geus, Matthias Blüher, Bruce H. R. Wolffenbuttel, Michael A. Province, Goncalo R. Abecasis, James B. Meigs, G. Kees Hovingh, Jaana Lindström, James F. Wilson, Alan F. Wright, George V. Dedoussis, Stefan R. Bornstein, Peter E. H. Schwarz, Anke Tönjes, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März, Andres Metspalu, Jackie F. Price, Panos Deloukas, Antje Körner, Timo A. Lakka, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Richard N. Bergman, Jaakko Tuomilehto, Nicholas J. Wareham, Claudia Langenberg, Satu Männistö, Paul W. Franks, Caroline Hayward, Veronique Vitart, Jaakko Kaprio, Sophie Visvikis-Siest, Beverley Balkau, David Altshuler, Igor Rudan, Michael Stumvoll, Harry Campbell, Cornelia M. van Duijn, Christian Gieger, Thomas Illig, Luigi Ferrucci, Nancy L. Pedersen, Peter P. Pramstaller, Michael Boehnke, Timothy M. Frayling, Alan R. Shuldiner, Patricia A. Peyser, Sharon L. R. Kardia, Lyle J. Palmer, Brenda W. Penninx, Pierre Meneton, Tamara B. Harris, Gerjan Navis, Pim van der Harst, George Davey Smith, Nita G. Forouhi, Ruth J. F. Loos, Veikko Salomaa, Nicole Soranzo, Dorret I. Boomsma, Leif Groop, Tiinamaija Tuomi, Albert Hofman, Patricia B. Munroe, Vilmundur Gudnason, David S. Siscovick, Hugh Watkins, Cecile Lecoeur, Peter Vollenweider, Anders Franco-Cereceda, Per Eriksson, Marjo-Riitta Jarvelin, Kari Stefansson, Anders Hamsten, George Nicholson, Fredrik Karpe, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Mark I. McCarthy, Philippe Froguel, Marika A. Kaakinen, Valeriya Lyssenko, Richard M. Watanabe, Erik Ingelsson, Jose C. Florez, Josée Dupuis, Inês Barroso, Andrew P. Morris, Inga Prokopenko Nature Communications, 2021
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Vasiliki Lagou, , Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May E. Montasser, Jeff R. O’Connell, Lawrence F. Bielak, Rebecca J. Webster, Richa Saxena, Jeanette M. Stafford, Beate St Pourcain, Nicholas J. Timpson, Perttu Salo, So-Youn Shin, Najaf Amin, Albert V. Smith, Guo Li, Niek Verweij, Anuj Goel, Ian Ford, Paul C. D. Johnson, Toby Johnson, Karen Kapur, Gudmar Thorleifsson, Rona J. Strawbridge, Laura J. Rasmussen-Torvik, Tõnu Esko, Evelin Mihailov, Tove Fall, Ross M. Fraser, Anubha Mahajan, Stavroula Kanoni, Vilmantas Giedraitis, Marcus E. Kleber, Günther Silbernagel, Julia Meyer, Martina Müller-Nurasyid, Andrea Ganna, Antti-Pekka Sarin, Loic Yengo, Dmitry Shungin, Jian’an Luan, Momoko Horikoshi, Ping An, Serena Sanna, Yvonne Boettcher, N. William Rayner, Ilja M. Nolte, Tatijana Zemunik, Erik van Iperen, Peter Kovacs, Nicholas D. Hastie, Sarah H. Wild, Stela McLachlan, Susan Campbell, Ozren Polasek, Olga Carlson, Josephine Egan, Wieland Kiess, Gonneke Willemsen, Johanna Kuusisto, Markku Laakso, Maria Dimitriou, Andrew A. Hicks, Rainer Rauramaa, Stefania Bandinelli, Barbara Thorand, Yongmei Liu, Iva Miljkovic, Lars Lind, Alex Doney, Markus Perola, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Amanda J. Bennett, Christopher J. Groves, Christian Herder, Heikki A. Koistinen, Leena Kinnunen, Ulf de Faire, Stephan J. L. Bakker, Matti Uusitupa, Colin N. A. Palmer, J. Wouter Jukema, Naveed Sattar, Anneli Pouta, Harold Snieder, Eric Boerwinkle, James S. Pankow, Patrik K. Magnusson, Ulrika Krus, Chiara Scapoli, Eco J. C. N. de Geus, Matthias Blüher, Bruce H. R. Wolffenbuttel, Michael A. Province, Goncalo R. Abecasis, James B. Meigs, G. Kees Hovingh, Jaana Lindström, James F. Wilson, Alan F. Wright, George V. Dedoussis, Stefan R. Bornstein, Peter E. H. Schwarz, Anke Tönjes, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März, Andres Metspalu, Jackie F. Price, Panos Deloukas, Antje Körner, Timo A. Lakka, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Richard N. Bergman, Jaakko Tuomilehto, Nicholas J. Wareham, Claudia Langenberg, Satu Männistö, Paul W. Franks, Caroline Hayward, Veronique Vitart, Jaakko Kaprio, Sophie Visvikis-Siest, Beverley Balkau, David Altshuler, Igor Rudan, Michael Stumvoll, Harry Campbell, Cornelia M. van Duijn, Christian Gieger, Thomas Illig, Luigi Ferrucci, Nancy L. Pedersen, Peter P. Pramstaller, Michael Boehnke, Timothy M. Frayling, Alan R. Shuldiner, Patricia A. Peyser, Sharon L. R. Kardia, Lyle J. Palmer, Brenda W. Penninx, Pierre Meneton, Tamara B. Harris, Gerjan Navis, Pim van der Harst, George Davey Smith, Nita G. Forouhi, Ruth J. F. Loos, Veikko Salomaa, Nicole Soranzo, Dorret I. Boomsma, Leif Groop, Tiinamaija Tuomi, Albert Hofman, Patricia B. Munroe, Vilmundur Gudnason, David S. Siscovick, Hugh Watkins, Cecile Lecoeur, Peter Vollenweider, Anders Franco-Cereceda, Per Eriksson, Marjo-Riitta Jarvelin, Kari Stefansson, Anders Hamsten, George Nicholson, Fredrik Karpe, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Mark I. McCarthy, Philippe Froguel, Marika A. Kaakinen, Valeriya Lyssenko, Richard M. Watanabe, Erik Ingelsson, Jose C. Florez, Josée Dupuis, Inês Barroso, Andrew P. Morris, Inga Prokopenko Nature Communications, 2021
Practical realization of ESC-Guidelines to reduce LDL-cholesterol Zeitschrift Fur Gefassmedizin, 2020
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Rafael Kramann, Christina Körbel, Emmanuel Ampofo, Matthias W. Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Schuster, Günther Silbernagel, Martina Sester, Urban Sester, Gunter Aßmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D. Menger, Lucia Rohrer, Winfried März, Michael Böhm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A. Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer Nature Immunology, 2020
The role of red yeast rice (RYR) supplementation in plasma cholesterol control: A review and expert opinion Maciej Banach, Eric Bruckert, Olivier S. Descamps, Lars Ellegård, Marat Ezhov, Bernhard Föger, Zlatko Fras, Petri T. Kovanen, Gustavs Latkovskis, Winfried März, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Angela Pirillo, Andrea Poli, Željko Reiner, Günter Silbernagel, Margus Viigimaa, Michal Vrablík, Alberico L. Catapano Atherosclerosis Supplements, 2019
The interrelations between PCSK9 metabolism and cholesterol synthesis and absorption Günther Silbernagel, Lars K. Steiner, Tim Hollstein, Günter Fauler, Hubert Scharnagl, Tatjana Stojakovic, Friederike Schumann, Bediha Bölükbasi, Winfried März, Elisabeth Steinhagen-Thiessen, Ulrich Laufs, Ursula Kassner Journal of Lipid Research, 2019
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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, Luting Xue, Tsegaselassie Workalemahu, Nancy L. Heard-Costa, Marcel den Hoed, Tarunveer S. Ahluwalia, Qibin Qi, Julius S. Ngwa, Frida Renström, Lydia Quaye, John D. Eicher, James E. Hayes, Marilyn Cornelis, Zoltan Kutalik, Elise Lim, Jian’an Luan, Jennifer E. Huffman, Weihua Zhang, Wei Zhao, Paula J. Griffin, Toomas Haller, Shafqat Ahmad, Pedro M. Marques-Vidal, Stephanie Bien, Loic Yengo, Alexander Teumer, Albert Vernon Smith, Meena Kumari, Marie Neergaard Harder, Johanne Marie Justesen, Marcus E. Kleber, Mette Hollensted, Kurt Lohman, Natalia V. Rivera, John B. Whitfield, Jing Hua Zhao, Heather M. Stringham, Leo-Pekka Lyytikäinen, Charlotte Huppertz, Gonneke Willemsen, Wouter J. Peyrot, Ying Wu, Kati Kristiansson, Ayse Demirkan, Myriam Fornage, Maija Hassinen, Lawrence F. Bielak, Gemma Cadby, Toshiko Tanaka, Reedik Mägi, Peter J. van der Most, Anne U. Jackson, Jennifer L. Bragg-Gresham, Veronique Vitart, Jonathan Marten, Pau Navarro, Claire Bellis, Dorota Pasko, Åsa Johansson, Søren Snitker, Yu-Ching Cheng, Joel Eriksson, Unhee Lim, Mette Aadahl, Linda S. Adair, Najaf Amin, Beverley Balkau, Juha Auvinen, John Beilby, Richard N. Bergman, Sven Bergmann, Alain G. Bertoni, John Blangero, Amélie Bonnefond, Lori L. Bonnycastle, Judith B. Borja, Søren Brage, Fabio Busonero, Steve Buyske, Harry Campbell, Peter S. Chines, Francis S. Collins, Tanguy Corre, George Davey Smith, Graciela E. Delgado, Nicole Dueker, Marcus Dörr, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Jessica D. Faul, Mao Fu, Kristine Færch, Christian Gieger, Sven Gläser, Jian Gong, Penny Gordon-Larsen, Harald Grallert, Tanja B. Grammer, Niels Grarup, Gerard van Grootheest, Kennet Harald, Nicholas D. Hastie, Aki S. Havulinna, Dena Hernandez, Lucia Hindorff, Lynne J. Hocking, Oddgeir L. Holmens, Christina Holzapfel, Jouke Jan Hottenga, Jie Huang, Tao Huang, Jennie Hui, Cornelia Huth, Nina Hutri-Kähönen, Alan L. James, John-Olov Jansson, Min A. Jhun, Markus Juonala, Leena Kinnunen, Heikki A. Koistinen, Ivana Kolcic, Pirjo Komulainen, Johanna Kuusisto, Kirsti Kvaløy, Mika Kähönen, Timo A. Lakka, Lenore J. Launer, Benjamin Lehne, Cecilia M. Lindgren, Mattias Lorentzon, Robert Luben, Michel Marre, Yuri Milaneschi, Keri L. Monda, Grant W. Montgomery, Marleen H. M. De Moor, Antonella Mulas, Martina Müller-Nurasyid, A. W. Musk, Reija Männikkö, Satu Männistö, Narisu Narisu, Matthias Nauck, Jennifer A. Nettleton, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Lavinia Paternoster, Jeremiah Perez, Markus Perola, Annette Peters, Ulrike Peters, Patricia A. Peyser, Inga Prokopenko, Hannu Puolijoki, Olli T. Raitakari, Tuomo Rankinen, Laura J. Rasmussen-Torvik, Rajesh Rawal, Paul M. Ridker, Lynda M. Rose, Igor Rudan, Cinzia Sarti, Mark A. Sarzynski, Kai Savonen, William R. Scott, Serena Sanna, Alan R. Shuldiner, Steve Sidney, Günther Silbernagel, Blair H. Smith, Jennifer A. Smith, Harold Snieder, Alena Stančáková, Barbara Sternfeld, Amy J. Swift, Tuija Tammelin, Sian-Tsung Tan, Barbara Thorand, Dorothée Thuillier, Liesbeth Vandenput, Henrik Vestergaard, Jana V. van Vliet-Ostaptchouk, Marie-Claude Vohl, Uwe Völker, Gérard Waeber, Mark Walker, Sarah Wild, Andrew Wong, Alan F. Wright, M. Carola Zillikens, Niha Zubair, Christopher A. Haiman, Loic Lemarchand, Ulf Gyllensten, Claes Ohlsson, Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden, Louis Pérusse, James F. Wilson, Caroline Hayward, Ozren Polasek, Francesco Cucca, Kristian Hveem, Catharina A. Hartman, Anke Tönjes, Stefania Bandinelli, Lyle J. Palmer, Sharon L. R. Kardia, Rainer Rauramaa, Thorkild I. A. Sørensen, Jaakko Tuomilehto, Veikko Salomaa, Brenda W. J. H. Penninx, Eco J. C. de Geus, Dorret I. Boomsma, Terho Lehtimäki, Massimo Mangino, Markku Laakso, Claude Bouchard, Nicholas G. Martin, Diana Kuh, Yongmei Liu, Allan Linneberg, Winfried März, Konstantin Strauch, Mika Kivimäki, Tamara B. Harris, Vilmundur Gudnason, Henry Völzke, Lu Qi, Marjo-Riitta Järvelin, John C. Chambers, Jaspal S. Kooner, Philippe Froguel, Charles Kooperberg, Peter Vollenweider, Göran Hallmans, Torben Hansen, Oluf Pedersen, Andres Metspalu, Nicholas J. Wareham, Claudia Langenberg, David R. Weir, David J. Porteous, Eric Boerwinkle, Daniel I. Chasman, CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium, Gonçalo R. Abecasis, Inês Barroso, Mark I. McCarthy, Timothy M. Frayling, Jeffrey R. O’Connell, Cornelia M. van Duijn, Michael Boehnke, Iris M. Heid, Karen L. Mohlke, David P. Strachan, Caroline S. Fox, Ching-Ti Liu, Joel N. Hirschhorn, Robert J. Klein, Andrew D. Johnson, Ingrid B. Borecki, Paul W. Franks, Kari E. North, L. Adrienne Cupples, Ruth J. F. Loos, Tuomas O. Kilpeläinen Plos Genetics, 2017
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher, Kristin Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley, Julius S. Ngwa, Tarunveer S. Ahluwalia, Audrey Y. Chu, Nancy L. Heard-Costa, Elise Lim, Jeremiah Perez, John D. Eicher, Zoltán Kutalik, Luting Xue, Anubha Mahajan, Frida Renström, Joseph Wu, Qibin Qi, Shafqat Ahmad, Tamuno Alfred, Najaf Amin, Lawrence F. Bielak, Amelie Bonnefond, Jennifer Bragg, Gemma Cadby, Martina Chittani, Scott Coggeshall, Tanguy Corre, Nese Direk, Joel Eriksson, Krista Fischer, Mathias Gorski, Marie Neergaard Harder, Momoko Horikoshi, Tao Huang, Jennifer E. Huffman, Anne U. Jackson, Johanne Marie Justesen, Stavroula Kanoni, Leena Kinnunen, Marcus E. Kleber, Pirjo Komulainen, Meena Kumari, Unhee Lim, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Jonathan Marten, Rita P. S. Middelberg, Martina Müller-Nurasyid, Pau Navarro, Louis Pérusse, Natalia Pervjakova, Cinzia Sarti, Albert Vernon Smith, Jennifer A. Smith, Alena Stančáková, Rona J. Strawbridge, Heather M. Stringham, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Peter J. van der Most, Jana V. Van Vliet-Ostaptchouk, Sailaja L. Vedantam, Niek Verweij, Jacqueline M. Vink, Veronique Vitart, Ying Wu, Loic Yengo, Weihua Zhang, Jing Hua Zhao, Martina E. Zimmermann, Niha Zubair, Gonçalo R. Abecasis, Linda S. Adair, Saima Afaq, Uzma Afzal, Stephan J. L. Bakker, Traci M. Bartz, John Beilby, Richard N. Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Daniele Braga, Brendan M. Buckley, Steve Buyske, Harry Campbell, John C. Chambers, Francis S. Collins, Joanne E. Curran, Gert J. de Borst, Anton J. M. de Craen, Eco J. C. de Geus, George Dedoussis, Graciela E. Delgado, Hester M. den Ruijter, Gudny Eiriksdottir, Anna L. Eriksson, Tõnu Esko, Jessica D. Faul, Ian Ford, Terrence Forrester, Karl Gertow, Bruna Gigante, Nicola Glorioso, Jian Gong, Harald Grallert, Tanja B. Grammer, Niels Grarup, Saskia Haitjema, Göran Hallmans, Anders Hamsten, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas D. Hastie, Andrew C. Heath, Dena Hernandez, Lucia Hindorff, Lynne J. Hocking, Mette Hollensted, Oddgeir L. Holmen, Georg Homuth, Jouke Jan Hottenga, Jie Huang, Joseph Hung, Nina Hutri-Kähönen, Erik Ingelsson, Alan L. James, John-Olov Jansson, Marjo-Riitta Jarvelin, Min A. Jhun, Marit E. Jørgensen, Markus Juonala, Mika Kähönen, Magnus Karlsson, Heikki A. Koistinen, Ivana Kolcic, Genovefa Kolovou, Charles Kooperberg, Bernhard K. Krämer, Johanna Kuusisto, Kirsti Kvaløy, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Karin Leander, Nanette R. Lee, Lars Lind, Cecilia M. Lindgren, Allan Linneberg, Stephane Lobbens, Marie Loh, Mattias Lorentzon, Robert Luben, Gitta Lubke, Anja Ludolph-Donislawski, Sara Lupoli, Pamela A. F. Madden, Reija Männikkö, Pedro Marques-Vidal, Nicholas G. Martin, Colin A. McKenzie, Barbara McKnight, Dan Mellström, Cristina Menni, Grant W. Montgomery, AW Musk, Narisu Narisu, Matthias Nauck, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Patricia A. Peyser, Charlotta Pisinger, David J. Porteous, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Laura J. Rasmussen-Torvik, Rajesh Rawal, Treva Rice, Paul M. Ridker, Lynda M. Rose, Stephanie A. Bien, Igor Rudan, Serena Sanna, Mark A. Sarzynski, Naveed Sattar, Kai Savonen, David Schlessinger, Salome Scholtens, Claudia Schurmann, Robert A. Scott, Bengt Sennblad, Marten A. Siemelink, Günther Silbernagel, P Eline Slagboom, Harold Snieder, Jan A. Staessen, David J. Stott, Morris A. Swertz, Amy J. Swift, Kent D. Taylor, Bamidele O. Tayo, Barbara Thorand, Dorothee Thuillier, Jaakko Tuomilehto, Andre G. Uitterlinden, Liesbeth Vandenput, Marie-Claude Vohl, Henry Völzke, Judith M. Vonk, Gérard Waeber, Melanie Waldenberger, R. G. J. Westendorp, Sarah Wild, Gonneke Willemsen, Bruce H. R. Wolffenbuttel, Andrew Wong, Alan F. Wright, Wei Zhao, M Carola Zillikens, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Carsten A. Böger, Dorret I. Boomsma, Claude Bouchard, Marcel Bruinenberg, Daniel I. Chasman, Yii-DerIda Chen, Peter S. Chines, Richard S. Cooper, Francesco Cucca, Daniele Cusi, Ulf de Faire, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Penny Gordon-Larsen, Hans- Jörgen Grabe, Vilmundur Gudnason, Christopher A. Haiman, Caroline Hayward, Kristian Hveem, Andrew D. Johnson, J Wouter Jukema, Sharon L. R. Kardia, Mika Kivimaki, Jaspal S. Kooner, Diana Kuh, Markku Laakso, Terho Lehtimäki, Loic Le Marchand, Winfried März, Mark I. McCarthy, Andres Metspalu, Andrew P. Morris, Claes Ohlsson, Lyle J. Palmer, Gerard Pasterkamp, Oluf Pedersen, Annette Peters, Ulrike Peters, Ozren Polasek, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Blair H. Smith, Thorkild I. A. Sørensen, Konstantin Strauch, Henning Tiemeier, Elena Tremoli, Pim van der Harst, Henrik Vestergaard, Peter Vollenweider, Nicholas J. Wareham, David R. Weir, John B. Whitfield, James F. Wilson, Jessica Tyrrell, Timothy M. Frayling, Inês Barroso, Michael Boehnke, Panagiotis Deloukas, Caroline S. Fox, Joel N. Hirschhorn, David J. Hunter, Tim D. Spector, David P. Strachan, Cornelia M. van Duijn, Iris M. Heid, Karen L. Mohlke, Jonathan Marchini, Ruth J. F. Loos, Tuomas O. Kilpeläinen, Ching-Ti Liu, Ingrid B. Borecki, Kari E. North, L Adrienne Cupples Nature Communications, 2017
LDL-Cholesterol: Standards of Treatment 2016: A German Perspective Winfried März, Hubert Scharnagl, Ioanna Gouni-Berthold, Günther Silbernagel, Alexander Dressel, Tanja B. Grammer, Ulf Landmesser, Hans Dieplinger, Eberhard Windler, Ulrich Laufs American Journal of Cardiovascular Drugs, 2016
Genome-wide association study of the modified stumvoll insulin sensitivity index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci Geoffrey A. Walford, Stefan Gustafsson, Denis Rybin, Alena Stančáková, Han Chen, Ching-Ti Liu, Jaeyoung Hong, Richard A. Jensen, Ken Rice, Andrew P. Morris, Reedik Mägi, Anke Tönjes, Inga Prokopenko, Marcus E. Kleber, Graciela Delgado, Günther Silbernagel, Anne U. Jackson, Emil V. Appel, Niels Grarup, Joshua P. Lewis, May E. Montasser, Claes Landenvall, Harald Staiger, Jian’an Luan, Timothy M. Frayling, Michael N. Weedon, Weijia Xie, Sonsoles Morcillo, María Teresa Martínez-Larrad, Mary L. Biggs, Yii-Der Ida Chen, Arturo Corbaton-Anchuelo, Kristine Færch, Juan Miguel Gómez-Zumaquero, Mark O. Goodarzi, Jorge R. Kizer, Heikki A. Koistinen, Aaron Leong, Lars Lind, Cecilia Lindgren, Fausto Machicao, Alisa K. Manning, Gracia María Martín-Núñez, Gemma Rojo-Martínez, Jerome I. Rotter, David S. Siscovick, Joseph M. Zmuda, Zhongyang Zhang, Manuel Serrano-Rios, Ulf Smith, Federico Soriguer, Torben Hansen, Torben J. Jørgensen, Allan Linnenberg, Oluf Pedersen, Mark Walker, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan, Leif Groop, Jeff R. O’Connell, Michael Boehnke, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Winfried März, Peter Kovacs, Michael Stumvoll, Bruce M. Psaty, Johanna Kuusisto, Markku Laakso, James B. Meigs, Josée Dupuis, Erik Ingelsson, Jose C. Florez Diabetes, 2016
Serum amyloid A: High-density lipoproteins interaction and cardiovascular risk Stephen Zewinger, Christiane Drechsler, Marcus E. Kleber, Alexander Dressel, Julia Riffel, Sarah Triem, Marlene Lehmann, Chantal Kopecky, Marcus D. Säemann, Philipp M. Lepper, Günther Silbernagel, Hubert Scharnagl, Andreas Ritsch, Barbara Thorand, Tonia de las Heras Gala, Stefan Wagenpfeil, Wolfgang Koenig, Annette Peters, Ulrich Laufs, Christoph Wanner, Danilo Fliser, Thimoteus Speer, Winfried März European Heart Journal, 2015
Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese Steven A. Lubitz, Kathryn L. Lunetta, Honghuang Lin, Dan E. Arking, Stella Trompet, Guo Li, Bouwe P. Krijthe, Daniel I. Chasman, John Barnard, Marcus E. Kleber, Marcus Dörr, Kouichi Ozaki, Albert V. Smith, Martina Müller-Nurasyid, Stefan Walter, Sunil K. Agarwal, Joshua C. Bis, Jennifer A. Brody, Lin Y. Chen, Brendan M. Everett, Ian Ford, Oscar H. Franco, Tamara B. Harris, Albert Hofman, Stefan Kääb, Saagar Mahida, Sekar Kathiresan, Michiaki Kubo, Lenore J. Launer, Peter W. Macfarlane, Jared W. Magnani, Barbara McKnight, David D. McManus, Annette Peters, Bruce M. Psaty, Lynda M. Rose, Jerome I. Rotter, Guenther Silbernagel, Jonathan D. Smith, Nona Sotoodehnia, David J. Stott, Kent D. Taylor, Andreas Tomaschitz, Tatsuhiko Tsunoda, Andre G. Uitterlinden, David R. Van Wagoner, Uwe Völker, Henry Völzke, Joanne M. Murabito, Moritz F. Sinner, Vilmundur Gudnason, Stephan B. Felix, Winfried März, Mina Chung, Christine M. Albert, Bruno H. Stricker, Toshihiro Tanaka, Susan R. Heckbert, J. Wouter Jukema, Alvaro Alonso, Emelia J. Benjamin, Patrick T. Ellinor Journal of the American College of Cardiology, 2014
Reply: Intestinal cholesterol absorption and cardiovascular risk Günther Silbernagel, M. John Chapman, Bernd Genser, Marcus E. Kleber, Günter Fauler, Hubert Scharnagl, Tanja B. Grammer, Kari-Matti Mäkelä, Mika Kähönen, Rafael Carmena, Ernst R. Rietzschel, Eric Bruckert, John E. Deanfield, Olli T. Raitakari, Terho Lehtimäki, Winfried März Journal of the American College of Cardiology, 2014
Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease Helena Gylling, Jogchum Plat, Stephen Turley, Henry N. Ginsberg, Lars Ellegård, Wendy Jessup, Peter J. Jones, Dieter Lütjohann, Winfried Maerz, Luis Masana, Günther Silbernagel, Bart Staels, Jan Borén, Alberico L. Catapano, Guy De Backer, John Deanfield, Olivier S. Descamps, Petri T. Kovanen, Gabriele Riccardi, Lale Tokgözoglu, M. John Chapman Atherosclerosis, 2014
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2 Jie Huang, Jennifer E. Huffman, Munekazu Yamakuchi, Stella Trompet, Folkert W. Asselbergs, Maria Sabater-Lleal, David-Alexandre Trégouët, Wei-Min Chen, Nicholas L. Smith, Marcus E. Kleber, So-Youn Shin, Diane M. Becker, Weihong Tang, Abbas Dehghan, Andrew D. Johnson, Vinh Truong, Lasse Folkersen, Qiong Yang, Tiphaine Oudot-Mellkah, Brendan M. Buckley, Jason H. Moore, Frances M.K. Williams, Harry Campbell, Günther Silbernagel, Veronique Vitart, Igor Rudan, Geoffrey H. Tofler, Gerjan J. Navis, Anita DeStefano, Alan F. Wright, Ming-Huei Chen, Anton J.M. de Craen, Bradford B. Worrall, Alicja R. Rudnicka, Ann Rumley, Ebony B. Bookman, Bruce M. Psaty, Fang Chen, Keith L. Keene, Oscar H. Franco, Bernhard O. Böhm, Andre G. Uitterlinden, Angela M. Carter, J. Wouter Jukema, Naveed Sattar, Joshua C. Bis, Mohammad A. Ikram, Michèle M. Sale, Barbara McKnight, Myriam Fornage, Ian Ford, Kent Taylor, P. Eline Slagboom, Wendy L. McArdle, Fang-Chi Hsu, Anders Franco-Cereceda, Alison H. Goodall, Lisa R. Yanek, Karen L. Furie, Mary Cushman, Albert Hofman, Jacqueline C.M. Witteman, Aaron R. Folsom, Saonli Basu, Nena Matijevic, Wiek H. van Gilst, James F. Wilson, Rudi G.J. Westendorp, Sekar Kathiresan, Muredach P. Reilly, Russell P. Tracy, Ozren Polasek, Bernhard R. Winkelmann, Peter J. Grant, Hans L. Hillege, Francois Cambien, David J. Stott, Gordon D. Lowe, Timothy D. Spector, James B. Meigs, Winfried Marz, Per Eriksson, Lewis C. Becker, Pierre-Emmanuel Morange, Nicole Soranzo, Scott M. Williams, Caroline Hayward, Pim van der Harst, Anders Hamsten, Charles J. Lowenstein, David P. Strachan, Christopher J. O’Donnell Arteriosclerosis Thrombosis and Vascular Biology, 2014
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation Jie Huang, Maria Sabater-Lleal, Folkert W. Asselbergs, David Tregouet, So-Youn Shin, Jingzhong Ding, Jens Baumert, Tiphaine Oudot-Mellakh, Lasse Folkersen, Andrew D. Johnson, Nicholas L. Smith, Scott M. Williams, Mohammad A. Ikram, Marcus E. Kleber, Diane M. Becker, Vinh Truong, Josyf C. Mychaleckyj, Weihong Tang, Qiong Yang, Bengt Sennblad, Jason H. Moore, Frances M. K. Williams, Abbas Dehghan, Günther Silbernagel, Elisabeth M. C. Schrijvers, Shelly Smith, Mahir Karakas, Geoffrey H. Tofler, Angela Silveira, Gerjan J. Navis, Kurt Lohman, Ming-Huei Chen, Annette Peters, Anuj Goel, Jemma C. Hopewell, John C. Chambers, Danish Saleheen, Per Lundmark, Bruce M. Psaty, Rona J. Strawbridge, Bernhard O. Boehm, Angela M. Carter, Christa Meisinger, John F. Peden, Joshua C. Bis, Barbara McKnight, John Öhrvik, Kent Taylor, Maria Grazia Franzosi, Udo Seedorf, Rory Collins, Anders Franco-Cereceda, Ann-Christine Syvänen, Alison H. Goodall, Lisa R. Yanek, Mary Cushman, Martina Müller-Nurasyid, Aaron R. Folsom, Saonli Basu, Nena Matijevic, Wiek H. van Gilst, Jaspal S. Kooner, Albert Hofman, John Danesh, Robert Clarke, James B. Meigs, DIAGRAM Consortium, Sekar Kathiresan, Muredach P. Reilly, CARDIoGRAM Consortium, Norman Klopp, Tamara B. Harris, Bernhard R. Winkelmann, Peter J. Grant, Hans L. Hillege, Hugh Watkins, C4D Consortium, Timothy D. Spector, Lewis C. Becker, Russell P. Tracy, Winfried März, Andre G. Uitterlinden, Per Eriksson, Francois Cambien, CARDIOGENICS Consortium, Pierre-Emmanuel Morange, Wolfgang Koenig, Nicole Soranzo, Pim van der Harst, Yongmei Liu, Christopher J. O'Donnell, Anders Hamsten Blood, 2012
Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)) Richa Saxena, Clara C. Elbers, Yiran Guo, Inga Peter, Tom R. Gaunt, Jessica L. Mega, Matthew B. Lanktree, Archana Tare, Berta Almoguera Castillo, Yun R. Li, Toby Johnson, Marcel Bruinenberg, Diane Gilbert-Diamond, Ramakrishnan Rajagopalan, Benjamin F. Voight, Ashok Balasubramanyam, John Barnard, Florianne Bauer, Jens Baumert, Tushar Bhangale, Bernhard O. Böhm, Peter S. Braund, Paul R. Burton, Hareesh R. Chandrupatla, Robert Clarke, Rhonda M. Cooper-DeHoff, Errol D. Crook, George Davey-Smith, Ian N. Day, Anthonius de Boer, Mark C.H. de Groot, Fotios Drenos, Jane Ferguson, Caroline S. Fox, Clement E. Furlong, Quince Gibson, Christian Gieger, Lisa A. Gilhuijs-Pederson, Joseph T. Glessner, Anuj Goel, Yan Gong, Struan F.A. Grant, Diederick E. Grobbee, Claire Hastie, Steve E. Humphries, Cecilia E. Kim, Mika Kivimaki, Marcus Kleber, Christa Meisinger, Meena Kumari, Taimour Y. Langaee, Debbie A. Lawlor, Mingyao Li, Maximilian T. Lobmeyer, Anke-Hilse Maitland-van der Zee, Matthijs F.L. Meijs, Cliona M. Molony, David A. Morrow, Gurunathan Murugesan, Solomon K. Musani, Christopher P. Nelson, Stephen J. Newhouse, Jeffery R. O'Connell, Sandosh Padmanabhan, Jutta Palmen, Sanjey R. Patel, Carl J. Pepine, Mary Pettinger, Thomas S. Price, Suzanne Rafelt, Jane Ranchalis, Asif Rasheed, Elisabeth Rosenthal, Ingo Ruczinski, Sonia Shah, Haiqing Shen, Günther Silbernagel, Erin N. Smith, Annemieke W.M. Spijkerman, Alice Stanton, Michael W. Steffes, Barbara Thorand, Mieke Trip, Pim van der Harst, Daphne L. van der A, Erik P.A. van Iperen, Jessica van Setten, Jana V. van Vliet-Ostaptchouk, Niek Verweij, Bruce H.R. Wolffenbuttel, Taylor Young, M. Hadi Zafarmand, Joseph M. Zmuda, Michael Boehnke, David Altshuler, Mark McCarthy, W.H. Linda Kao, James S. Pankow, Thomas P. Cappola, Peter Sever, Neil Poulter, Mark Caulfield, Anna Dominiczak, Denis C. Shields, Deepak L. Bhatt, Li Zhang, Sean P. Curtis, John Danesh, Juan P. Casas, Yvonne T. van der Schouw, N. Charlotte Onland-Moret, Pieter A. Doevendans, Gerald W. Dorn, Martin Farrall, Garret A. FitzGerald, Anders Hamsten Robert Hegele, Aroon D. Hingorani, Marten H. Hofker, Gordon S. Huggins, Thomas Illig, Gail P. Jarvik, Julie A. Johnson, Olaf H. Klungel, William C. Knowler, Wolfgang Koenig, Winfried März, James B. Meigs, Olle Melander, Patricia B. Munroe, Braxton D. Mitchell, Susan J. Bielinski, Daniel J. Rader, Muredach P. Reilly, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Nilesh J. Samani, Eric E. Schadt, Alan R. Shuldiner, Roy Silverstein, Kandice Kottke-Marchant, Philippa J. Talmud, Hugh Watkins, Folkert W. Asselbergs, Paul I.W. de Bakker, Jeanne McCaffery, Cisca Wijmenga, Marc S. Sabatine, James G. Wilson, Alex Reiner, Donald W. Bowden, Hakon Hakonarson, David S. Siscovick, Brendan J. Keating American Journal of Human Genetics, 2012
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci Richa Saxena, Clara C. Elbers, Yiran Guo, Inga Peter, Tom R. Gaunt, Jessica L. Mega, Matthew B. Lanktree, Archana Tare, Berta Almoguera Castillo, Yun R. Li, Toby Johnson, Marcel Bruinenberg, Diane Gilbert-Diamond, Ramakrishnan Rajagopalan, Benjamin F. Voight, Ashok Balasubramanyam, John Barnard, Florianne Bauer, Jens Baumert, Tushar Bhangale, Bernhard O. Böhm, Peter S. Braund, Paul R. Burton, Hareesh R. Chandrupatla, Robert Clarke, Rhonda M. Cooper-DeHoff, Errol D. Crook, George Davey-Smith, Ian N. Day, Anthonius de Boer, Mark C.H. de Groot, Fotios Drenos, Jane Ferguson, Caroline S. Fox, Clement E. Furlong, Quince Gibson, Christian Gieger, Lisa A. Gilhuijs-Pederson, Joseph T. Glessner, Anuj Goel, Yan Gong, Struan F.A. Grant, Diederick E. Grobbee, Claire Hastie, Steve E. Humphries, Cecilia E. Kim, Mika Kivimaki, Marcus Kleber, Christa Meisinger, Meena Kumari, Taimour Y. Langaee, Debbie A. Lawlor, Mingyao Li, Maximilian T. Lobmeyer, Anke-Hilse Maitland-van der Zee, Matthijs F.L. Meijs, Cliona M. Molony, David A. Morrow, Gurunathan Murugesan, Solomon K. Musani, Christopher P. Nelson, Stephen J. Newhouse, Jeffery R. O'Connell, Sandosh Padmanabhan, Jutta Palmen, Sanjey R. Patel, Carl J. Pepine, Mary Pettinger, Thomas S. Price, Suzanne Rafelt, Jane Ranchalis, Asif Rasheed, Elisabeth Rosenthal, Ingo Ruczinski, Sonia Shah, Haiqing Shen, Günther Silbernagel, Erin N. Smith, Annemieke W.M. Spijkerman, Alice Stanton, Michael W. Steffes, Barbara Thorand, Mieke Trip, Pim van der Harst, Daphne L. van der A, Erik P.A. van Iperen, Jessica van Setten, Jana V. van Vliet-Ostaptchouk, Niek Verweij, Bruce H.R. Wolffenbuttel, Taylor Young, M. Hadi Zafarmand, Joseph M. Zmuda, Michael Boehnke, David Altshuler, Mark McCarthy, W.H. Linda Kao, James S. Pankow, Thomas P. Cappola, Peter Sever, Neil Poulter, Mark Caulfield, Anna Dominiczak, Denis C. Shields, Deepak L. Bhatt, Li Zhang, Sean P. Curtis, John Danesh, Juan P. Casas, Yvonne T. van der Schouw, N. Charlotte Onland-Moret, Pieter A. Doevendans, Gerald W. Dorn, Martin Farrall, Garret A. FitzGerald, Anders Hamsten, Robert Hegele, Aroon D. Hingorani, Marten H. Hofker, Gordon S. Huggins, Thomas Illig, Gail P. Jarvik, Julie A. Johnson, Olaf H. Klungel, William C. Knowler, Wolfgang Koenig, Winfried März, James B. Meigs, Olle Melander, Patricia B. Munroe, Braxton D. Mitchell, Susan J. Bielinski, Daniel J. Rader, Muredach P. Reilly, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Nilesh J. Samani, Eric E. Schadt, Alan R. Shuldiner, Roy Silverstein, Kandice Kottke-Marchant, Philippa J. Talmud, Hugh Watkins, Folkert W. Asselbergs, Paul I.W. de Bakker, Jeanne McCaffery, Cisca Wijmenga, Marc S. Sabatine, James G. Wilson, Alex Reiner, Donald W. Bowden, Hakon Hakonarson, David S. Siscovick, Brendan J. Keating American Journal of Human Genetics, 2012
Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children Tuomas O. Kilpeläinen, Lu Qi, Soren Brage, Stephen J. Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, Samia Mora, Marika Kaakinen, Camilla Helene Sandholt, Christina Holzapfel, Christine S. Autenrieth, Elina Hyppönen, Stéphane Cauchi, Meian He, Zoltan Kutalik, Meena Kumari, Alena Stančáková, Karina Meidtner, Beverley Balkau, Jonathan T. Tan, Massimo Mangino, Nicholas J. Timpson, Yiqing Song, M. Carola Zillikens, Kathleen A. Jablonski, Melissa E. Garcia, Stefan Johansson, Jennifer L. Bragg-Gresham, Ying Wu, Jana V. van Vliet-Ostaptchouk, N. Charlotte Onland-Moret, Esther Zimmermann, Natalia V. Rivera, Toshiko Tanaka, Heather M. Stringham, Günther Silbernagel, Stavroula Kanoni, Mary F. Feitosa, Soren Snitker, Jonatan R. Ruiz, Jeffery Metter, Maria Teresa Martinez Larrad, Mustafa Atalay, Maarit Hakanen, Najaf Amin, Christine Cavalcanti-Proença, Anders Grøntved, Göran Hallmans, John-Olov Jansson, Johanna Kuusisto, Mika Kähönen, Pamela L. Lutsey, John J. Nolan, Luigi Palla, Oluf Pedersen, Louis Pérusse, Frida Renström, Robert A. Scott, Dmitry Shungin, Ulla Sovio, Tuija H. Tammelin, Tapani Rönnemaa, Timo A. Lakka, Matti Uusitupa, Manuel Serrano Rios, Luigi Ferrucci, Claude Bouchard, Aline Meirhaeghe, Mao Fu, Mark Walker, Ingrid B. Borecki, George V. Dedoussis, Andreas Fritsche, Claes Ohlsson, Michael Boehnke, Stefania Bandinelli, Cornelia M. van Duijn, Shah Ebrahim, Debbie A. Lawlor, Vilmundur Gudnason, Tamara B. Harris, Thorkild I. A. Sørensen, Karen L. Mohlke, Albert Hofman, André G. Uitterlinden, Jaakko Tuomilehto, Terho Lehtimäki, Olli Raitakari, Bo Isomaa, Pål R. Njølstad, Jose C. Florez, Simin Liu, Andy Ness, Timothy D. Spector, E. Shyong Tai, Philippe Froguel, Heiner Boeing, Markku Laakso, Michael Marmot, Sven Bergmann, Chris Power, Kay-Tee Khaw, Daniel Chasman, Paul Ridker, Torben Hansen, Keri L. Monda, Thomas Illig, Marjo-Riitta Järvelin, Nicholas J. Wareham, Frank B. Hu, Leif C. Groop, Marju Orho-Melander, Ulf Ekelund, Paul W. Franks, Ruth J. F. Loos Plos Medicine, 2011
