VINAYKUMAR KANCHUPALLI

Scopus Publications

Metal-organic frameworks as therapeutic chameleons: revolutionizing the cancer therapy employing novel nanoarchitectonics
Sajja Bhanu Prasad, Akshay Shinde, Dadi A. Srinivasrao, Paras Famta, Saurabh Shah, Tejaswini Kolipaka, Giriraj Pandey, Deelip Gaonker, Ganesh Vambhurkar, Pooja Khairnar, Rahul Kumar, Amol G. Dikundwar, Vinaykumar Kanchupalli, Saurabh Srivastava
Asian Journal of Pharmaceutical Sciences, 2025
Cancer is one of the most complex diseases and the second leading cause of mortality worldwide. Due to its poor prognosis and challenges in diagnosis, eradicating cancer remains highly difficult. The limitations associated with conventional therapies have led to the emergence of copious therapeutic strategies such as chemotherapy, phototherapy, starvation therapy, radiotherapy and immunotherapy; however, limited therapeutic efficacy, poor tumor cell selectivity and substantial adverse effects remain significant concern. Attributed to the expeditious advancement of nanotechnology, the amalgamation of nanomaterials with therapeutic approaches provides an opportunity to address the shortcomings of conventional chemotherapy. Metal-organic frameworks (MOFs), which consist of bridging ligands and ions/clusters connected by coordination bonds, have been widely used in cancer therapy to address the limitations of currently therapeutic interventions, such as poor efficacy, low stability and severe side effects. This potential arises from their tuneable porosities, high specific surface area-to-volume ratio, tailorable diameters, tractable morphologies, variegated compositions, biocompatibility and facile functionalization. We summarized the role of MOF-based nanoplatforms along with mechanistic insights into emerging avenues-such as cuproptosis, ferroptosis, cell-penetrating and biomimetic MOFs, and tumor microenvironment-responsive MOFs- alongside recent advancements in mono- and multifunctional cancer therapeutics. Theragnostic and imaging functionalities, as well as regulatory considerations and future prospects of MOF-based nanoplatforms utilized in cancer treatment, are also discussed.
Quality-by-Design-Assisted Laboratory Scale-Up of Lipid Nanoparticles of Stearic Acid-Raloxifene Hydrochloride Conjugate: A Pathway for Enhanced Oral Bioavailability via Lymphatic Uptake
Atul Mourya, Sanjeev Kumar, Saurabh Shah, Paras Famta, Vinaykumar Kanchupalli, Saurabh Srivastava, Jitender Madan
Molecular Pharmaceutics, 2025
Despite exhibiting promising efficacy in managing postmenopausal osteoporosis, hormonal therapy, and breast cancer prevention, the usage of raloxifene hydrochloride (RLX) is limited in clinical settings due to its low aqueous solubility (345.2 ± 15.6 μg/mL) and 2% oral bioavailability. Oral administration of RLX results in the formation of an inactive glucuronide conjugate at free hydroxyl groups in the presence of hepatic and extrahepatic UDP-glucuronosyltransferases (UGTs). To circumvent RLX transformation, lipid-drug-conjugate-based lymphatic targeting may offer a suitable alternative. Therefore, we synthesized a stearic acid-raloxifene hydrochloride (SRC) conjugate and confirmed it using ATR-FT-IR, 1H NMR, and HR-MS spectral techniques. Further, SRC was amalgamated with optimized lipid nanoparticles (SRC@LNPs4) to improve its stability under simulated physiological conditions. SRC@LNPs4 demonstrated remarkably improved stability of SRC compared to SRC alone when incubated with SGF, SIF, porcine lipoprotein lipase, and lipase-simulated plasma. Furthermore, biocompatibility analysis conducted with HT-29 cells ensured its safety for oral administration. Micrographic evaluation of rat intestines incubated with C6@LNPs indicated improved uptake of LNPs into enteric epithelia. Female Wistar rats orally administered with SRC@LNPs4 (∼10 mg/kg of RLX) exhibited a hike (unpaired t-test, p < 0.05) of 1.87-fold in the AUC0-t of SRC@LNPs4 (43.04 ± 0.50 h·μg/mL) compared to RLX (22.95 ± 4.30 h·μg/mL) Furthermore, the notable changes observed in the pharmacokinetic parameters of SRC@LNPs4 in rats previously injected with cycloheximide (CHX; 3 mg/kg) suggest that the drug is primarily absorbed into systemic circulation through lymphatic uptake. In conclusion, SRC@LNPs4 presents a valuable strategy to augment oral absorption and bioavailability via lymphatic targeting.
Microwave-Assisted Copper-Catalyzed Electrophilic Amination of Arylboronic Acids: A Rapid Approach to Arylhydrazides
Bhargav Desai, Akshay Bharodiya, Shruti Seshathre, Raj N. Patel, Bharatkumar Dholakiya, Piyushkumar Satani, Vinaykumar Kanchupalli, Togati Naveen
Synlett, 2025
We present a copper-catalyzed rapid and efficient method for the electrophilic amination of arylboronic acids with azodicarboxylates under microwave irradiation to synthesize aryl-substituted hydrazines. This transformation encompasses a wide range of substituted boronic acids and azodicarboxylates to provide the corresponding products in good to excellent yields. The key features of this reaction are its broad substrate scope, high functional-group tolerance, good to excellent yields, and short reaction time.
Rh(III)-Catalyzed Regioselective [3+2]-Annulation of Indoles with 1,3-Enynes to Access 3H-pyrrolo[1,2-a]indol-3-ones
Sanjeev Kumar, Pradeep Girase, Sayali Pradeep Jadhav, Bhargav Desai, Togati Naveen, Vinaykumar Kanchupalli
Asian Journal of Organic Chemistry, 2025
Herein, we present a novel and highly efficient strategy for the synthesis of synthetically valuable 3H‐pyrrolo[1,2‐a]indol‐3‐ones via a Rh(III)‐catalyzed regioselective [3+2] annulation strategy. The protocol ensures precise regioselective insertion of substituted 1,3‐enynes at the less sterically hindered site, while offering a broad substrate scope, excellent functional group compatibility, and mild reaction conditions. Moreover, the methodology is amenable to gram‐scale synthesis and demonstrates the successful application of terbinafine as a substrate within this transformation.
Site-Selective Direct γ-Difunctionalization of Diazoenals: Application to the Synthesis of Enal-Functionalized Allenes and Furans
Jagadeesh Kalepu, Bapurao Sudam Lad, Pratap Kumar Mandal, Vinaykumar Kanchupalli, Durjay Roy, Sreenivas Katukojvala
Chemistry an Asian Journal, 2025
A new approach for the synthetically important γ‐functionalized enals has been developed. The strategy involves rhodium‐catalyzed direct C−C & C−S bond forming site‐selective γ‐difunctionalization of diazoenals with aryl propargyl sulfides via sulfur ylide [2,3] sigmatropic rearrangement, resulting in the highly functionalized γ‐allenyl(sulfanyl)enals in excellent yield at ambient temperature. This highly versatile approach constitutes a viable alternative to the remote carbonyl‐directed γ‐functionalization of unmodified enals which suffer from competitive side reactions. The synthetic utility of the γ‐allenyl(sulfanyl)enals was demonstrated by the InCl3‐catalyzed cycloisomerization to the trisubstituted furanyl‐enals via an unusual 1,4‐sulfanyl migration. In addition, an operationally simple and efficient one‐pot [3+2] annulation of diazoenals and propargyl sulfides, involving combined γ‐difunctionalization and cycloisomerization was successfully developed for the diverse enal‐functionalized furans.
Radical Denitrogenative Transformations of Polynitrogen Heterocycles
Sanjeev Kumar, Vinaykumar Kanchupalli
Denitrogenative Transformation of Nitrogen Heterocycles Synthesis Reactions and Applications, 2025
Poly-nitrogen heterocycles are important organic scaffolds that feature unique physical and chemical properties. They are not only a key component in diverse biologically active natural products but also act as versatile synthons for various denitrogenative transformations to access synthetically challenging high-value N -heterocycles. In view of the importance of N -scaffolds in modern science, there has been significant growth recently in the development of denitrogenative reactions with diverse poly-nitrogen heterocycles. Notably, pioneering discoveries have led to the development of denitrogenative reactions through an ionic mechanistic pathway. In contrast to traditional approaches, radical denitrogenative transformations of poly-nitrogen heterocycles have gained significant attention in recent years, as these methods allow for mild and efficient conditions in a controlled manner. Particularly, this chapter focuses on the recent advances in radical denitrogenative transformations of poly-nitrogen heterocycles and their applications, and key mechanistic studies are also briefly described.
Separation and characterization of degradation impurities of upadacitinib by liquid chromatography and high resolution mass spectrometry
Sowmya Chaganti, Chagnya Nelapati, Drishti Jain, K.R. Roshitha, Vinaykumar Kanchupalli, Gananadhamu Samanthula
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2024
Synthesis of Oxaspirocyclohexadienones via Lewis-Acid Catalyzed [2+3]-Annulations of p-Quinone Methides and Iodonium Ylides
Mohd. Mujahid, Sanjeev Kumar, Nitin Pal Kalia, Vinaykumar Kanchupalli
Advanced Synthesis and Catalysis, 2024
Herein, we report a mild method for the synthesis of oxaspirocyclohexadienones by using a combination of Lewis acid‐HFIP mediated [2+3]‐annulation of p‐quinone methides (p‐QMs) and iodonium ylides. The proposed mechanism proceeds through a one‐pot sequence of carbonyl activation/cyclopropyl formation/Cloke‐Wilson rearrangement to provide a broad range of oxaspirocyclohexadienones in moderate to high yields. Interestingly, the spiro‐annulated products were further converted to tetrahydroxanthane derivatives via BF3.OEt2 mediated dienone‐phenol rearrangement pathway. Moreover, the spiro‐annulated derivatives also showed a moderate anti‐tuberculosis activity against Mycobacterium tuberculosis H37Ra ATCC25177.
Synthesis of γ-Spirolactams via Rh(III)-Catalyzed C-H Activation/Directing Group Migration/Dearomatization/Spiroannulation of Indoles with 1,3-Enynes
Sanjeev Kumar, Vinaykumar Kanchupalli
Organic Letters, 2024
1,3-Enynes are valuable coupling partners in transition-metal-catalyzed C-H functionalizations. Certainly, aliphatic-substituted 1,3-enynes have been thoroughly investigated in C-H functionalizations, whereas aromatic-substituted 1,3-enynes remain underexplored. Herein, we report the realization of this goal, where we achieve an atom-economical protocol for the synthesis of γ-spirolactams via Rh(III)-catalyzed C-H functionalization of N-carbamoylindoles with 1,3-enynes. The reaction proceeds through a unique cascade strategy, such as C-H activation/directing group (DG) migration/indole dearomatization/spiroannulation, to access novel and synthetically challenging spiro[indoline-2,2'-pyrrolidin]-5'-one scaffolds. Moreover, the isolation of intermediate and mechanistic and ESI-HRMS studies further provide valuable insights into the proposed catalytic cycle.
Structural characterization and in silico toxicity prediction of degradation impurities of roxadustat
Rupali Mahajan, Sanjeev Kumar, Ramulu Parupalli, Rahul Khemchandani, Vinaykumar Kanchupalli, Srinivas Nanduri, Gananadhamu Samanthula, Amit Asthana
Journal of Pharmaceutical and Biomedical Analysis, 2023
Rh(III)-Catalyzed C−H Annulation of Sulfoxonium Ylides and 1,3-Diynes: A Rapid Access to Alkynyl-1-Naphthol Derivatives
Sanjeev Kumar, Vaishnavi Borkar, Saiprasad Nunewar, Shashank Yadav, Vinaykumar Kanchupalli
Chemistry an Asian Journal, 2023
1,3-Diynes: A Versatile Precursor in Transition-Metal Catalyzed (Mediated) C−H Functionalizations
Sanjeev Kumar, Tharun Kumar Sabbi, Rasika Pingale, Pradeep Girase, Vinaykumar Kanchupalli
Chemical Record, 2023
Structural characterization of novel hydrolytic and oxidative degradation products of acalabrutinib by LC-Q-TOF-MS, H/D exchange and NMR
Bhoopendra Singh Kushwah, Hara Prasad Padhy, Rahul Khemchandani, Vijaya Madhyanapu Golla, Vinay Kumar Kanchupalli, Rajesh Sonti, Gananadhamu Samanthula
Journal of Pharmaceutical and Biomedical Analysis, 2022
Iodonium ylides: an emerging and alternative carbene precursor for C-H functionalizations
Sanjeev Kumar, Vaishnavi Borkar, Mohd. Mujahid, Saiprasad Nunewar, Vinaykumar Kanchupalli
Organic and Biomolecular Chemistry, 2022
Ru(II)-Catalyzed C-H Functionalization of 2-Arylbenzimidazoles with Iodonium Ylides: A Straightforward Access to Bridgehead Polycyclic N-Heterocycles
Saiprasad Nunewar, Sanjeev Kumar, Akhilesh Waman Meshram, Vinaykumar Kanchupalli
Journal of Organic Chemistry, 2022
A comprehensive review on potential therapeutic inhibitors of nosocomial Acinetobacter baumannii superbugs
Danaboina Srikanth, Swanand Vinayak Joshi, Mahammad Ghouse Shaik, Gaurav Pawar, Sushmitha Bujji, Vinaykumar Kanchupalli, Sidharth Chopra, Srinivas Nanduri
Bioorganic Chemistry, 2022
Rhodium-Catalyzed Enal Transfer with N-Methoxypyridazinium Salts
Vinaykumar Kanchupalli, Laxman Anandrao Thorbole, Jagadeesh Kalepu, Desna Joseph, Mohammad Arshad, Sreenivas Katukojvala
Organic Letters, 2022
Synthesis of Indenone Derivatives by Rh(III)-Catalyzed C−H Functionalization of Sulfoxonium Ylides with 1,3-Diynes
Sanjeev Kumar, Saiprasad Nunewar, Tharun Kumar Sabbi, Vinaykumar Kanchupalli
Organic Letters, 2022
The solvent-controlled Rh(iii)-catalyzed switchable [4+2] annulation of 2-arylIndoles with iodonium ylides
Saiprasad Nunewar, Sanjeev Kumar, Pendam Priyanka, Pradeep Girase, Vinaykumar Kanchupalli
Chemical Communications, 2022
Rh(III)-Catalyzed Cross-Coupling/Annulation of Two Carbene Precursors: Construction of Dihydrobenzo[c]chromen-6-one Scaffolds and Application in the Total Synthesis of Cannabinol
Sanjeev Kumar, Saiprasad Nunewar, Vinaykumar Kanchupalli
Asian Journal of Organic Chemistry, 2022
Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2
Shashi Chandrama Singh, Dharmendra Kumar Khatri, Kulbhaskar Singh, Vinay Kumar Kanchupalli, Jitender Madan, Shashi Bala Singh, Harshpal Singh
Heliyon, 2021
Rh(III)-Catalyzed Chemodivergent Annulations between Indoles and Iodonium Carbenes: A Rapid Access to Tricyclic and Tetracyclic N-Heterocylces
Saiprasad Nunewar, Sanjeev Kumar, Harishchandra Pandhare, Srinivas Nanduri, Vinaykumar Kanchupalli
Organic Letters, 2021
Rh(III)-Catalyzed [3+2] Annulation and C−H Alkenylation of Indoles with 1,3-Diynes by C−H Activation
Sanjeev Kumar, Saiprasad Nunewar, Khan Mohammad Usama, Vinaykumar Kanchupalli
European Journal of Organic Chemistry, 2021
Co(III), Rh(III) & Ir(III)-Catalyzed Direct C−H Alkylation/Alkenylation/Arylation with Carbene Precursors
Saiprasad Nunewar, Sanjeev Kumar, Srilakshmi Talakola, Srinivas Nanduri, Vinaykumar Kanchupalli
Chemistry an Asian Journal, 2021
Recent advances in Rh(iii)/Ir(iii)-catalyzed C-H functionalization/annulationviacarbene migratory insertion
Sanjeev Kumar, Saiprasad Nunewar, Srilekha Oluguttula, Srinivas Nanduri, Vinaykumar Kanchupalli
Organic and Biomolecular Chemistry, 2021
Rh(III)-Catalyzed Redox-Neutral Cascade Annulation of Benzamides with p-Quinone Methides
Vinaykumar Kanchupalli, Rahul K. Shukla, Anurag Singh, Chandra M. R. Volla
European Journal of Organic Chemistry, 2020
[1+1+3] Annulation of Diazoenals and Vinyl Azides: Direct Synthesis of Functionalized 1-Pyrrolines through Olefination
Vinaykumar Kanchupalli, Sreenivas Katukojvala
Angewandte Chemie International Edition, 2018
Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles
Vinaykumar Kanchupalli, Desna Joseph, Sreenivas Katukojvala
Organic Letters, 2015
Synergistic rhodium(II) carboxylate and Brønsted acid catalyzed multicomponent reactions of enalcarbenoids: Direct synthesis of α-pyrrolylbenzylamines
Sudam Ganpat Dawande, Vinaykumar Kanchupalli, Bapurao Sudam Lad, Jyoti Rai, Sreenivas Katukojvala
Organic Letters, 2014
Rhodium enalcarbenoids: Direct synthesis of indoles by rhodium(II)- catalyzed [4+2] benzannulation of pyrroles
Sudam Ganpat Dawande, Vinaykumar Kanchupalli, Jagadeesh Kalepu, Haribabu Chennamsetti, Bapurao Sudam Lad, Sreenivas Katukojvala
Angewandte Chemie International Edition, 2014

RECENT SCHOLAR PUBLICATIONS

Metal-organic frameworks as therapeutic chameleons: revolutionizing the cancer therapy employing novel nanoarchitectonics
SB Prasad, A Shinde, DA Srinivasrao, P Famta, S Shah, T Kolipaka, ...
Asian Journal of Pharmaceutical Sciences 20 (5), 101054 , 2025
2025
Citations: 8
Quality-by-Design-Assisted Laboratory Scale-Up of Lipid Nanoparticles of Stearic Acid–Raloxifene Hydrochloride Conjugate: A Pathway for Enhanced Oral Bioavailability via …
A Mourya, S Kumar, S Shah, P Famta, V Kanchupalli, S Srivastava, ...
Molecular Pharmaceutics 22 (7), 3868-3884 , 2025
2025
Citations: 2
Microwave-Assisted Copper-Catalyzed Electrophilic Amination of Arylboronic Acids: A Rapid Approach to Arylhydrazides
B Desai, A Bharodiya, S Seshathre, RN Patel, B Dholakiya, P Satani, ...
Synlett 36 (09), 1252-1256 , 2025
2025
Rh(III)‐Catalyzed Regioselective [3+2]‐Annulation of Indoles with 1,3‐Enynes to Access 3 H ‐pyrrolo[1,2‐ a ]indol‐3‐ones
S Kumar, P Girase, SP Jadhav, B Desai, T Naveen, V Kanchupalli
Asian Journal of Organic Chemistry 14 (5), e202400810 , 2025
2025
Radical Denitrogenative Transformations of Polynitrogen Heterocycles
S Kumar, V Kanchupalli
Denitrogenative Transformation of Nitrogen Heterocycles, 447-483 , 2025
2025
Site‐Selective Direct γ ‐Difunctionalization of Diazoenals: Application to the Synthesis of Enal‐Functionalized Allenes and Furans
J Kalepu, B Sudam Lad, P Kumar Mandal, V Kanchupalli, D Roy, ...
Chemistry–An Asian Journal 20 (1), e202401081 , 2025
2025
Citations: 1
Microwave-Assisted Copper-Catalyzed Electrophilic Amination of Arylboronic Acids: A Rapid Approach to Arylhydrazides B. Desai, A. Bharodiy, S. Seshathre, RN Patel, B. Dholakiya …
V Kanchupalli, T Naveen
Synlett 36, 1103-1110 , 2025
2025
Separation and characterization of degradation impurities of upadacitinib by liquid chromatography and high resolution mass spectrometry
S Chaganti, C Nelapati, D Jain, KR Roshitha, V Kanchupalli, ...
Journal of Chromatography B 1247, 124319 , 2024
2024
Citations: 7
Synthesis of γ-Spirolactams via Rh (III)-Catalyzed C–H Activation/Directing Group Migration/Dearomatization/Spiroannulation of Indoles with 1, 3-Enynes
S Kumar, V Kanchupalli
Organic Letters 26 (42), 8975-8981 , 2024
2024
Citations: 6
Synthesis of Oxaspirocyclohexadienones via Lewis‐Acid Catalyzed [2+3]‐Annulations of p‐ Quinone Methides and Iodonium Ylides
M Mujahid, S Kumar, N Pal Kalia, V Kanchupalli
Advanced Synthesis & Catalysis 366 (15), 3283-3289 , 2024
2024
Citations: 6
Rh-Catalyzed Functionalization of N-Heterocycles Through C–H Activation
S Kumar, V Kanchupalli
Functionalisation of Heterocycles through Transition Metal Catalyzed CH … , 2024
2024
Citations: 1
Structural characterization and in silico toxicity prediction of degradation impurities of roxadustat
R Mahajan, S Kumar, R Parupalli, R Khemchandani, V Kanchupalli, ...
Journal of Pharmaceutical and Biomedical Analysis 234, 115517 , 2023
2023
Citations: 11
Rh (III)‐Catalyzed C− H Annulation of Sulfoxonium Ylides and 1, 3‐Diynes: A Rapid Access to Alkynyl‐1‐Naphthol Derivatives
S Kumar, V Borkar, S Nunewar, S Yadav, V Kanchupalli
Chemistry–An Asian Journal, e202201201 , 2023
2023
Citations: 7
Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations
S Kumar, V Borkar, M Mujahid, S Nunewar, V Kanchupalli
Organic & Biomolecular Chemistry 21 (1), 24-38 , 2023
2023
Citations: 61
Structural characterization of novel hydrolytic and oxidative degradation products of acalabrutinib by LC-Q-TOF-MS, H/D exchange and NMR
BS Kushwah, HP Padhy, R Khemchandani, VM Golla, VK Kanchupalli, ...
Journal of Pharmaceutical and Biomedical Analysis 221, 115077 , 2022
2022
Citations: 9
Ru (II)-Catalyzed C–H Functionalization of 2-Arylbenzimidazoles with Iodonium Ylides: A Straightforward Access to Bridgehead Polycyclic N-Heterocycles
S Nunewar, S Kumar, AW Meshram, V Kanchupalli
The Journal of Organic Chemistry 87 (21), 13757-13762 , 2022
2022
Citations: 18
A comprehensive review on potential therapeutic inhibitors of nosocomial Acinetobacter baumannii superbugs
D Srikanth, SV Joshi, MG Shaik, G Pawar, S Bujji, V Kanchupalli, ...
Bioorganic Chemistry 124, 105849 , 2022
2022
Citations: 17
Rhodium-Catalyzed Enal Transfer with N -Methoxypyridazinium Salts
V Kanchupalli, LA Thorbole, J Kalepu, D Joseph, M Arshad, S Katukojvala
Organic letters 24 (21), 3850-3854 , 2022
2022
Citations: 10
Synthesis of indenone derivatives by Rh (III)-catalyzed C–H functionalization of sulfoxonium ylides with 1, 3-diynes
S Kumar, S Nunewar, TK Sabbi, V Kanchupalli
Organic Letters 24 (18), 3395-3400 , 2022
2022
Citations: 32
1, 3‐Diynes: A Versatile Precursor in Transition‐Metal Catalyzed (Mediated) C− H Functionalizations
S Kumar, T Kumar Sabbi, R Pingale, P Girase, V Kanchupalli
The Chemical Record, e202200228 , 2022
2022
Citations: 19

MOST CITED SCHOLAR PUBLICATIONS

Rhodium Enalcarbenoids: Direct Synthesis of Indoles by Rhodium (II)‐Catalyzed [4+ 2] Benzannulation of Pyrroles
SG Dawande, V Kanchupalli, J Kalepu, H Chennamsetti, BS Lad, ...
Angewandte Chemie International Edition 53 (16), 4076-4080 , 2014
2014
Citations: 112
Recent advances in Rh (iii)/Ir (iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion
S Kumar, S Nunewar, S Oluguttula, V Nanduri, S., Kanchupalli
Organic & Biomolecular Chemistry , 2021
2021
Citations: 107
Co (III), Rh (III) & Ir (III)‐Catalyzed Direct C–H Alkylation/Alkenylation/Arylation with carbene precursors
S Nunewar, S Kumar, S Talakola, V Nanduri, S., Kanchupalli
Chemistry–An Asian Journal , 2021
2021
Citations: 84
Rh(III)-Catalyzed Chemodivergent Annulations between Indoles and Iodonium Carbenes: A Rapid Access to Tricyclic and Tetracyclic N -Heterocylces
S Nunewar, S Kumar, H Pandhare, S Nanduri, V Kanchupalli
Organic letters 23 (11), 4233-4238 , 2021
2021
Citations: 74
Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations
S Kumar, V Borkar, M Mujahid, S Nunewar, V Kanchupalli
Organic & Biomolecular Chemistry 21 (1), 24-38 , 2023
2023
Citations: 61
[1+ 1+ 3] Annulation of Diazoenals and Vinyl Azides: Direct Synthesis of Functionalized 1‐Pyrrolines through Olefination
V Kanchupalli, S Katukojvala
Angew. Chem. Int. Ed. 2018, 57, 5433 130 (19), 5531-5535 , 2018
2018
Citations: 52
Pyridazine N -Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles
V Kanchupalli, D Joseph, S Katukojvala
Organic Letters 17 (23), 5878-5881 , 2015
2015
Citations: 52
The solvent-controlled Rh (III)-catalyzed switchable [4+ 2] annulation of 2-arylIndoles with iodonium ylides
S Nunewar, S Kumar, P Priyanka, P Girase, V Kanchupalli
Chemical Communications 58 (41), 6140-6143 , 2022
2022
Citations: 42
Synergistic Rhodium (II) carboxylate and Brønsted acid catalyzed multicomponent reactions of enalcarbenoids: Direct synthesis of α-pyrrolylbenzylamines
SG Dawande, V Kanchupalli, BS Lad, J Rai, S Katukojvala
Organic Letters 16 (14), 3700-3703 , 2014
2014
Citations: 40
Synthesis of indenone derivatives by Rh (III)-catalyzed C–H functionalization of sulfoxonium ylides with 1, 3-diynes
S Kumar, S Nunewar, TK Sabbi, V Kanchupalli
Organic Letters 24 (18), 3395-3400 , 2022
2022
Citations: 32
Rh(III)‐Catalyzed Cross‐Coupling/Annulation of Two Carbene Precursors: Construction of Dihydrobenzo[ c ]chromen‐6‐one Scaffolds and Application in the Total …
S Kumar, S Nunewar, V Kanchupalli
Asian Journal of Organic Chemistry 11 (1), e202100689 , 2022
2022
Citations: 28
Rh (III)‐Catalyzed [3+ 2] Annulation and C− H Alkenylation of Indoles with 1, 3‐Diynes by C− H Activation
S Kumar, S Nunewar, KM Usama, V Kanchupalli
European Journal of Organic Chemistry 2021 (15), 2223-2229 , 2021
2021
Citations: 22
1, 3‐Diynes: A Versatile Precursor in Transition‐Metal Catalyzed (Mediated) C− H Functionalizations
S Kumar, T Kumar Sabbi, R Pingale, P Girase, V Kanchupalli
The Chemical Record, e202200228 , 2022
2022
Citations: 19
Ru (II)-Catalyzed C–H Functionalization of 2-Arylbenzimidazoles with Iodonium Ylides: A Straightforward Access to Bridgehead Polycyclic N-Heterocycles
S Nunewar, S Kumar, AW Meshram, V Kanchupalli
The Journal of Organic Chemistry 87 (21), 13757-13762 , 2022
2022
Citations: 18
A comprehensive review on potential therapeutic inhibitors of nosocomial Acinetobacter baumannii superbugs
D Srikanth, SV Joshi, MG Shaik, G Pawar, S Bujji, V Kanchupalli, ...
Bioorganic Chemistry 124, 105849 , 2022
2022
Citations: 17
Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis …
SC Singh, DK Khatri, K Singh, VK Kanchupalli, J Madan, SB Singh, ...
Heliyon 7 (8) , 2021
2021
Citations: 17
Rh(III)‐Catalyzed Redox‐Neutral Cascade Annulation of Benzamides with p ‐Quinone Methides
V Kanchupalli, RK Shukla, A Singh, CMR Volla
European Journal of Organic Chemistry 2020 (29), 4494-4498 , 2020
2020
Citations: 13
Structural characterization and in silico toxicity prediction of degradation impurities of roxadustat
R Mahajan, S Kumar, R Parupalli, R Khemchandani, V Kanchupalli, ...
Journal of Pharmaceutical and Biomedical Analysis 234, 115517 , 2023
2023
Citations: 11
Rhodium-Catalyzed Enal Transfer with N -Methoxypyridazinium Salts
V Kanchupalli, LA Thorbole, J Kalepu, D Joseph, M Arshad, S Katukojvala
Organic letters 24 (21), 3850-3854 , 2022
2022
Citations: 10
Structural characterization of novel hydrolytic and oxidative degradation products of acalabrutinib by LC-Q-TOF-MS, H/D exchange and NMR
BS Kushwah, HP Padhy, R Khemchandani, VM Golla, VK Kanchupalli, ...
Journal of Pharmaceutical and Biomedical Analysis 221, 115077 , 2022
2022
Citations: 9

VINAYKUMAR KANCHUPALLI

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS