Prof. Devaraju K S

Scopus Publications

Methanol extract of Smritisagara Rasa attenuates neurobehavior, neurochemical and stress indicators in rotenone-induced Drosophila model of Parkinson's disease
G Gopinath, Ramesha Hanumanthappa, Raifa Abdul Aziz, P.C. Kiran, Hemalatha Nanjaiah, Iranna B. Kotturshetty, Shamprasad Varija Raghu, Manjunath Ajanal, Devaraju Kuramkote Shivanna
Advances in Biomarker Sciences and Technology, 2026
Smritisagara Rasa (SSR), a traditional Ayurvedic herbo-mineral formulation, has long been prescribed for the treatment of Parkinson’s disease (PD) since ancient times. Nevertheless, the underlying molecular mechanisms and treatment strategies remain unclear due to a lack of adequate experimental data. This study focused on formulating SSR and extracting its components using different solvent systems, including water and methanol. SSR, along with its water extract (SSR-WEX) and methanol extract (SSR-MEX), was tested for efficacy in mitigating PD phenotypes using a Rotenone (ROT)-induced Drosophila melanogaster PD model. SSR was prepared according to the Ayurvedic Formulary of India and subsequently characterized, followed by solvent extraction and phytoconstituent profiling. Different concentrations of SSR, SSR-WEX, and SSR-MEX were administered to control flies to evaluate their potential toxicity. Flies were then co-exposed to 500 μM ROT and 75 mg/kg diet of SSR, SSR-WEX, and SSR-MEX for seven days. Behavioral, neurochemical, and oxidative stress parameters were assessed, with pramipexole (PPX) used as a positive control. ROT exposure markedly impaired climbing ability, reduced dopamine and acetylcholinesterase (AChE) activity, and elevated oxidative stress markers, including malondialdehyde (MDA), protein carbonyl content (PCC), hydrogen peroxide, and nitric oxide. Co-treatment with SSR and its extracts significantly restored locomotor function, dopamine, and AChE levels, while enhancing antioxidant enzymes (glutathione-S-transferase and catalase) and reducing oxidative damage indices. Among the formulations, SSR-MEX demonstrated superior neuroprotective and antioxidative efficacy, comparable to the standard drug pramipexole. This effect is likely due to its enriched profile of flavonoids, coumarins, and phenolic acids. These findings substantiate traditional claims regarding SSR’s role in mitigating neurodegenerative symptoms and highlight SSR-MEX as a promising phytopharmaceutical candidate for managing PD-like pathologies through attenuation of oxidative stress and restoration of dopaminergic and cholinergic systems. Graphical abstract illustrates that preparation of herbo-mineral preparation of SSR and its extracts attenuates neurobehavior, neurochemical and stress indicators in ROT-induced Drosophila model of PD. • Smritisagara Rasa (SSR), a classical Ayurvedic herbo-mineral formulation, demonstrates promising neuroprotective potential in PD; however, its molecular mechanism remains largely unexplored due to limited experimental evidence. • SSR was formulated and characterized as per the Ayurvedic Formulary of India (AFI) and compared with its water (SSR-WEX) and methanol (SSR-MEX) extracts for efficacy using a rotenone (ROT)-induced Drosophila melanogaster model of PD. • Toxicity screening confirmed that SSR, SSR-WEX, and SSR-MEX were non-toxic at concentrations up to 75 mg/kg diet, ensuring the extracts safety for subsequent neurobehavioral and biochemical assays. • ROT-induced PD flies treated with SSR, SSR-WEX, SSR-MEX, and pramipexole (PPX) exhibited significant restoration of locomotor activity, DA levels, AChE, GST, and catalase enzyme activities, along with reduced oxidative stress markers such as MDA, PCC, H 2 O 2 , and NO. • Among all treatments, SSR-MEX showed the most pronounced therapeutic effect, exhibiting neurochemical and antioxidant restoration comparable to PPX, suggesting that its rich composition of bioactive phytochemicals synergistically counteracts dopaminergic degeneration and oxidative imbalance in PD. • The results scientifically validate the traditional Ayurvedic use of Smritisagara Rasa in neurological disorders, identifying SSR-MEX as a promising candidate for future drug development or adjunct therapy in PD management.
Chemotherapy-induced cognitive impairment (CICI): Cisplatin's effects on neurotransmitter regulation and oxidative stress in Drosophila melanogaster
Raifa Abdul Aziz, Deepa Mugudthi Venugopal, Avinash Kundadka Kudva, Ramesha Hanumanthappa, Mohammed S. Mustak, KuramkoteShivanna Devaraju, Manjeshwar Shrinath Baliga, Shamprasad Varija Raghu
Neurotoxicology, 2026
Application of TXRF for exploring the concentration levels of multi-trace elements in human diabetes blood: A comparative analysis with a chemometric approach
Manjunatha, A.S. Bennal, Ramesha Hanumanthappa, K.S. Devaraju, S.S. Kulkarni, P.B. Gai
Spectrochimica Acta Part B Atomic Spectroscopy, 2025
A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model
Ramesha Hanumanthappa, Sumit Ramesh Naik, Sahana Prakash Nayak, Asmatanzeem Bepari, Hanan Nasser Altamimi, Mujeeb Ahmed Shaikh, Fahd A. Nasr, Farha M. Shaikh, P. C. Nethravathi, Hemalatha Nanjaiah, D. Suresh, Raghu S. V., Kuramkote Shivanna Devaraju
Nanoscale Advances, 2025
A multifunctional nanocarrier of lactoferrin-functionalized Pluronic F-127 capped dopamine-loaded mesoporous silica nanocomposite (Lf-DA-MSN-PF127), was designed for targeted drug delivery across the blood–brain barrier (BBB) via intranasal.
A Levodopa-Encapsulated Poly-ϵ-Caprolactone Nanocomposite Improves the Motor Symptoms and Neurochemical Changes in a Rotenone-Induced Mouse Model of Parkinson’s Disease
Ramesha Hanumanthappa, Geetha B. Heggannavar, Aishwarya Banakar, Divya D. Achari, Vijaykumar Ramesh Karoshi, B. R. Radha Krushna, Asmatanzeem Bepari, Rasha Assad Assiri, Hanan Nasser Altamimi, Hemalatha Nanjaiah, Devaraja Sannaningaiah, Shamprasad Varija Raghu, Vishwas Kaveeshwar, H. Nagabhushana, Kuramkote Shivanna Devaraju
ACS Omega, 2025
Parkinson's disease (PD) is the most common neurodegenerative disorder; in this condition, patients lose dopamine (DA), which leads to abnormal motor functions. Levodopa (LD) is the most effective drug used for the treatment of PD; however, LD shows poor plasma bioavailability and limited brain uptake and induces peripheral side effects. Due to its poor brain availability and short half-life, prolonged treatment must be repeated with a dosing schedule, which leads to long-term side effects, including dyskinesia, stomatitis, anxiety, and depression. An LD-encapsulated polymer nanocomposite has been reported to overcome these problems. The present study aims to improve the bioavailability and efficiency of LD to an effective treatment strategy for PD. Herein, we report the newly synthesized LD-encapsulated poly-ε-caprolactone (PCL) nanocomposite (LD-PCL-PVA NC), and its chemical and physical properties were analyzed. The LD-PCL-PVA NC exhibits no toxicity on the SH-SY5Y cell line and shows improved bioavailability of the LD in mouse plasma. Furthermore, we found that LD-PCL-PVA NC showed a significant improvement in motor symptoms in the rotenone (RT)-induced PD mouse model compared to the LD treatment. In addition, LD-PCL-PVA NC significantly increased the DA and homovanillic acid compared to LD and restored the total glutathione level and malonaldehyde and catalase activity in mouse brain. The histopathology studies reveal that LD-PCL-PVA NC did not exhibit toxicity in treated mice. The study suggested that LD-PCL-PVA NC can be used for the effective and promising treatment of PD.
Phytoconstituents of Cassia auriculata Linn Inhibits the Pro-Inflammatory Cytokines: An In Silico Study to Identify Multi-Target Drug Candidates
Letters in Applied Nanobioscience, 2025
Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence
Manjunatha, A. S. Bennal, Ramesha Hanumanthappa, S. S. Kulkarni, K. S. Devaraju, U. R. Hallikeri, N. M. Badiger, P. B. Gai
Biological Trace Element Research, 2025
Red emitting SnO2:Eu3+ hierarchical structures for multifunctional applications: Thermal sensing, w-LEDs, latent fingerprint detection and biomedical applications
B. Krushna, I.S. Pruthviraj, S.C. Sharma, Subhashree Ray, S.T. Elayakumar, I. Jaiganesh, K.V. Archana, K. Manjunatha, Sheng Yun Wu, H. Ramesha, K. S. Devaraju, H. Nagabhushana
Journal of Alloys and Compounds, 2025
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles
Ramesha Hanumanthappa, Aravind Parthasarathy, Geetha B. Heggannavar, Kiran PC, Hemalatha Nanjaiah, Ramhari Kumbhar, Kuramkote Shivanna Devaraju
Neuroprotection, 2024
The blood‐brain barrier (BBB), which protects the brain from foreign molecules, makes delivery of drugs to the central nervous system is challenging. Nanoparticles (NPs) have been used over the past decade as drug delivery systems for the treatment of many disorders with great results. However, the effectiveness of NPs in delivering drugs to the brain for the treatment of Alzheimer's disease (AD) and Parkinson's disease (PD) is limited by the BBB. A recent breakthrough in nanotechnology delivery systems involves the use of surface‐modified polymer NPs that enhance drug absorption and transport across the BBB; however, the technology still has some limitations. Studies conducted over the past few years have demonstrated that NPs modified with peptides or proteins can effectively cross the BBB via specific receptors, thus enhancing their delivery efficiency. In this review, we explore the use of polymer NPs combined with peptides and proteins for the treatment of AD and PD. This discussion focuses on the pathophysiology of these diseases, the BBB, and the potential of therapeutics based on co‐modifying NPs with peptides and proteins. Additionally, we outline future directions for the use of polymer NPs conjugated with these biomolecules.
Eco-friendly synthesis of CQDs from Pistachio shells: Versatile applications in anti-counterfeiting, flexible films, latent fingerprints and potential anti-cancer activity
D.H. Sandeep, B.R. Radha Krushna, S.C. Sharma, Pratheesh Ravindran, R. Sivayogana, H. Ramesha, N. Hemalatha, H. Rashmi, K.S. Devaraju, C. Krithika, Bikash kar, K. Manjunatha, Sheng Yun Wu, H. Nagabhushana
Journal of Alloys and Compounds, 2024
E5-((3-phenoxyphenyl)diazenyl)quinolin-8-ol (PPDQ): A Novel Promising Anticorrosive for Mild Steel in Acid Media, and a Pharmacologically Potent Antidiabetic, Antioxidant Azo Dye
Pruthviraj K, Chethan B. S, Ramesh H., Lokanath N. K., Kiran Poral P. C., Devaraju K. S., Narayana Hebbar N., Sunil K.
Orbital, 2024
Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus
Aravind Parthasarathy, Ramesha Hanumanthappa, Sarojini R. Bulbule, Kiran P.C., Hemalatha Nanjaiah, Gopinath G., Siddaiah B.M., David Muniswamy, Devaraju Kuramkote Shivanna
Neuroprotection, 2024
Ultrasound-driven facile fabrication of Pd doped SnO2 hierarchical superstructures: Structural, growth mechanism, dermatoglyphics, and anti-cancer activity
B.R. Radha Krushna, K. Manjunatha, Sheng Yun Wu, D. Sivaganesh, S.C. Sharma, C. Sridhar, Fr. Deepu Joy, H. Ramesha, Nagarjun Prakash Dalbanjan, K.S. Devaraju, H. Nagabhushana
Biomaterials Advances, 2024
Synthesis, Antioxidant, and Electrochemical Behavior Studies of 2-Amino-4H-Chromene Derivatives Catalyzed by WEOFPA: Green Protocol
Krishnappa B. Badiger, Kantharaju Kamanna, Ramesha Hanumanthappa, K. S. Devaraju, G. Giddaerappa, Lokesh Koodlur Sannegowda
Polycyclic Aromatic Compounds, 2024
Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a Drosophila Parkinson’s Disease Model
Ramesha Hanumanthappa, Deepa Mugudthi Venugopal, Nethravathi P C, Ahesanulla Shaikh, Siddaiah B.M, Geetha B. Heggannavar, Akshay A. Patil, Hemalatha Nanjaiah, D. Suresh, Mahadevappa Y. Kariduraganavar, Shamprasad Varija Raghu, Kuramkote Shivanna Devaraju
ACS Omega, 2023
Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice
Sophiya Pundalik, Krishna Ram Hanumappa, Aladahalli S Giresha, Deepadarshan Urs, Sharath Rajashekarappa, Narayanappa Muniyappa, Manjunatha Jamballi G, Devaraju Kuaramkote Shivanna, Rajkumar S Meti, Sathisha Anekere Dasappa Setty, Prabhakar Bettadathunga Thippegowda, Dharmappa Kattepura Krishnappa
Journal of Inflammation Research, 2022
Pharmacological and therapeutic approaches in the treatment of epilepsy
Shampa Ghosh, Jitendra Kumar Sinha, Tarab Khan, Kuramkote Shivanna Devaraju, Prabhakar Singh, Kumar Vaibhav, Pankaj Gaur
Biomedicines, 2021
Elevation of gene expression of calcineurin, calmodulin and calsyntenin in oxidative stress induced PC12 cells
P. Aravind, Sarojini R. Bulbule, N. Hemalatha, R.L. Babu, K.S. Devaraju
Genes and Diseases, 2021
Molecular docking studies of phytochemicals against trehalose–6–phosphate phosphatases of pathogenic microbes
H. R. Umesh, K. V. Ramesh, K. S. Devaraju
Beni Suef University Journal of Basic and Applied Sciences, 2020
Elevation of gene expression of Btg2, Gadd 153, and antioxidant markers in RONS-induced PC12 cells
Aravind P, Sarojini R. Bulbule, Hemalatha N, Anushree G, Babu R.L, Devaraju K.S
Beni Suef University Journal of Basic and Applied Sciences, 2020
Peroxynitrite-induced conformational changes in DNA that lead to cell death: UV, CD spectral, molecular dynamics simulation and FACS analysis
G. Anushree, P. Aravind, D. Vinod, N. Hemalatha, S. T. Girisha, K. S. Devaraju
Nucleosides Nucleotides and Nucleic Acids, 2020
Modeling, Synthesis and Characterization of Phospho–Penta–Peptide derived from PKA RII Sub Unit: A Candidate Substrate for CaN Assay
Sarojini R. Bulbule, P. Aravind, N. Hemalatha, K. S. Devaraju
International Journal of Peptide Research and Therapeutics, 2019
Forskolin and Phorbol 12-myristate 13-acetate modulates the expression pattern of AP-1 factors and cell cycle regulators in estrogen-responsive MCF-7 cells
R.L. Babu, M. Naveen Kumar, Rajeshwari H. Patil, K.M. Kiran Kumar, K.S. Devaraju, Govindarajan T. Ramesh, S. Chidananda Sharma
Genes and Diseases, 2019
Single Lysis-Salting Out Method of Genomic DNA Extraction From Dried Blood Spots
Muntaj Shaik, Devaraju Kuramkote Shivanna, Mahesh Kamate, Vedamurthy AB, Kruthika‐Vinod TP
Journal of Clinical Laboratory Analysis, 2016
Discovery of a latent calcineurin inhibitory peptide from its autoinhibitory domain by docking, dynamic simulation, and in vitro methods
B. M. Harish, R. Saraswathi, D. Vinod, K. S. Devaraju
Journal of Biomolecular Structure and Dynamics, 2016
A novel assay method for calcium calmodulin dependent phosphatase from bovine brain extract
Indian Journal of Experimental Biology, 2014
Spectrophotometric estimation of nitro tyrosine by azo-coupling reaction
International Journal of Pharma and Bio Sciences, 2014
Biosorption of chromium(VI) and lead(II): Role of spirulina platensis in the treatment of industrial effluent
R. L. Babu, E. Vijayalakshmi, M. Naveen Kumar, Rajeshwari H. Patil, K. S. Devaraju, S. Chidananda Sharma
Bioremediation Journal, 2013
In silico binding affinity study of calcineurin inhibitors to calcineurin and its close associates
Indian Journal of Biotechnology, 2013
Effect of estrogen and tamoxifen on the expression pattern of AP-1 factors in MCF-7 cells: Role of c-Jun, c-Fos, and Fra-1 in cell cycle regulation
R. L. Babu, M. Naveen Kumar, Rajeshwari H. Patil, K. S. Devaraju, Govindarajan T. Ramesh, S. Chidananda Sharma
Molecular and Cellular Biochemistry, 2013
Bioimaging of peroxynitrite in MCF-7 Cells by a new fluorescent probe rhodamine b phenyl hydrazide
Gopi Ambikapathi, Suresh Kumar Kempahanumakkagari, Babu Ramappa Lamani, Devaraju Kuramkote Shivanna, Harish Bodagur Maregowda, Anushree Gupta, Pandurangappa Malingappa
Journal of Fluorescence, 2013
2,7-dichlorofluorescein hydrazide as a new fluorescent probe for mercury quantification: Application to industrial effluents and polluted water samples
Sureshkumar Kempahanumakkagari, Pandurangappa Malingappa, Gopi Ambikapathi, Devaraju Kuramkote Shivanna
Journal of Spectroscopy, 2013
Syntheses, characterizations, and antimicrobial activities of binuclear ruthenium(III) complexes containing 2-substituted benzimidazole derivatives
B. Roopashree, V. Gayathri, A. Gopi, K.S. Devaraju
Journal of Coordination Chemistry, 2012
Synthesis and biological evaluation of novel pyrazole derivatives as urease inhibitors
Der Pharma Chemica, 2011
Synthesis, In- vivo and In-silico anti-inflammatory studies of substituted fluoro pyrazole
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2011
In silico and pharmacokinetics of para-nitrophenylphosphate substrate for calcineurin
International Conference on Bioinformatics Computational Biology Genomics and Chemoinformatics 2010 Bcbgc 2010, 2010
A sensitive assay for ornithine amino transferase in rat brain mitochondria by ninhydrin method
H. Ravi Kumar, S. Ananda, K. S. Devaraju, B. M. Prakash, S. Sampath Kumar, S. V. Suresh Babu, N. Ramachandraswamy, H. P. Puttaraju
Indian Journal of Clinical Biochemistry, 2009
Effect of pH on spectral characteristics of P5C-ninhydrin derivative: Application in the assay of ornithine amino transferase activity from tissue lysate
H. Ravikumar, K. S. Devaraju, K. Taranath Shetty
Indian Journal of Clinical Biochemistry, 2008
Synthesis of a modified peptide fragment analog Val-Tyr (P)-Val-Ala-Ala-OH of cAMP protein kinase regulatory sub unit type II employing Fmoc chemistry
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2006

RECENT SCHOLAR PUBLICATIONS

Dietary lutein protects against Emamectin benzoate induced neurotoxicity by restoring oxidative and calcium balance in Drosophila melanogaster
PC Kiran, P Kumar, KVH Prashanth, KS Devaraju
Food Bioscience, 108564 , 2026
2026
Chemotherapy-Induced Cognitive Impairment (CICI): Cisplatin’s Effects on Neurotransmitter Regulation and Oxidative Stress in Drosophila melanogaster
RA Aziz, DM Venugopal, AK Kudva, R Hanumanthappa, MS Mustak, ...
NeuroToxicology, 103365 , 2025
2025
Citations: 1
Application of TXRF for exploring the concentration levels of multi-trace elements in human diabetes blood: A comparative analysis with a chemometric approach
AS Bennal, R Hanumanthappa, KS Devaraju, SS Kulkarni, PB Gai
Spectrochimica Acta Part B: Atomic Spectroscopy, 107275 , 2025
2025
Citations: 2
A Levodopa-Encapsulated Poly-ε-Caprolactone Nanocomposite Improves the Motor Symptoms and Neurochemical Changes in a Rotenone-Induced Mouse Model of Parkinson’s Disease
R Hanumanthappa, GB Heggannavar, A Banakar, DD Achari, ...
ACS omega 10 (19), 19682-19696 , 2025
2025
Citations: 4
Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence
Manjunatha, AS Bennal, R Hanumanthappa, SS Kulkarni, KS Devaraju, ...
Biological Trace Element Research 203 (3), 1277-1286 , 2025
2025
Citations: 6
Red emitting SnO2: Eu3+ hierarchical structures for multifunctional applications: Thermal sensing, w-LEDs, latent fingerprint detection and biomedical applications
BRR Krushna, IS Pruthviraj, SC Sharma, S Ray, ST Elayakumar, ...
Journal of Alloys and Compounds 1013, 178496 , 2025
2025
Citations: 17
A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model
R Hanumanthappa, SR Naik, SP Nayak, A Bepari, HN Altamimi, ...
Nanoscale Advances 7 (19), 6017-6031 , 2025
2025
Citations: 3
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles
R Hanumanthappa, A Parthasarathy, GB Heggannavar, PC Kiran, ...
Neuroprotection 2 (04), 255-275 , 2024
2024
Citations: 12
E5-((3-phenoxyphenyl) diazenyl) quinolin-8-ol (PPDQ): A Novel Promising Anticorrosive for Mild Steel in Acid Media, and a Pharmacologically Potent Antidiabetic, Antioxidant Azo Dye
K Pruthviraj, H Ramesh, NK Lokanath, PC Kiran Poral, KS Devaraju, ...
Orbital: The Electronic Journal of Chemistry, 198-204 , 2024
2024
Eco-friendly synthesis of CQDs from Pistachio shells: Versatile applications in anti-counterfeiting, flexible films, latent fingerprints and potential anti-cancer activity
DH Sandeep, BRR Krushna, SC Sharma, P Ravindran, R Sivayogana, ...
Journal of Alloys and Compounds 991, 174311 , 2024
2024
Citations: 30
Ultrasound-driven facile fabrication of Pd doped SnO2 hierarchical superstructures: Structural, growth mechanism, dermatoglyphics, and anti-cancer activity
BRR Krushna, K Manjunatha, SY Wu, D Sivaganesh, SC Sharma, ...
Biomaterials Advances 160, 213855 , 2024
2024
Citations: 36
Synthesis, Antioxidant, and Electrochemical Behavior Studies of 2-Amino-4 H -Chromene Derivatives Catalyzed by WEOFPA: Green Protocol
KB Badiger, K Kamanna, R Hanumanthappa, KS Devaraju, ...
Polycyclic Aromatic Compounds 44 (1), 333-360 , 2024
2024
Citations: 12
Phytoconstituents of Cassia auriculata Linn Inhibits the Pro-Inflammatory Cytokines: An In Silico Study to Identify Multi-Target Drug Candidates
RH Tejaswini, S Biradar, SJ Shreedevi, KS Devaraju, RL Babu
2024
Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a Drosophila Parkinson’s …
R Hanumanthappa, DM Venugopal, N PC, A Shaikh, S BM, ...
ACS omega 8 (50), 47482-47495 , 2023
2023
Citations: 15
Does Protein Kinases exhibit Binding Affinity with Antipsychotic Drugs? A Molecular Docking Approach
DKS Kiran.P.C, Sarojini.R.Bulbule, Ramesha Hanumanthappa, Hemalatha Nanjaiah
Journal of Applied Bioinformatics & Computational Biology 12 (3) , 2023
2023
In silico Binding Affinity Studies of Antipsychotic Drugs with Protein Phosphatases by Molecular Docking
SRBPA Devaraju KS*
J Appl Bioinforma Comput Biol 12 (1), 1-5 , 2023
2023
Corosolic Acid Inhibits Secretory Phospholipase A 2 IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice
S Pundalik, KR Hanumappa, AS Giresha, D Urs, S Rajashekarappa, ...
Journal of Inflammation Research, 6905-6921 , 2022
2022
Citations: 14
Binding affinity studies of trifluoperazine with protein kinases.
S Bulbule, P Aravind, KS Devaraju
Indian Journal of Clinical Biochemistry 33 (S1), S82-S82 , 2022
2022
Large-scale Extraction of DNA by Using Salting-out Principle for Dried Blood Spots to Screen Multiple Mutations in GCDH Gene
M Shaik, A Alladi, AB Vedamurthy, KS Devaraju, M Kamate, ...
Iranian Journal of Science and Technology, Transactions A: Science 46 (1), 33-40 , 2022
2022
Citations: 1
Pharmacological and therapeutic approaches in the treatment of epilepsy
S Ghosh, JK Sinha, T Khan, KS Devaraju, P Singh, K Vaibhav, P Gaur
Biomedicines 9 (5), 470 , 2021
2021
Citations: 127

MOST CITED SCHOLAR PUBLICATIONS

Pharmacological and therapeutic approaches in the treatment of epilepsy
S Ghosh, JK Sinha, T Khan, KS Devaraju, P Singh, K Vaibhav, P Gaur
Biomedicines 9 (5), 470 , 2021
2021
Citations: 127
Molecular docking studies of phytochemicals against trehalose–6–phosphate phosphatases of pathogenic microbes
HR Umesh, KV Ramesh, KS Devaraju
Beni-Suef University Journal of Basic and Applied Sciences 9 (1), 5 , 2020
2020
Citations: 66
Effect of estrogen and tamoxifen on the expression pattern of AP-1 factors in MCF-7 cells: role of c-Jun, c-Fos, and Fra-1 in cell cycle regulation
RL Babu, M Naveen Kumar, RH Patil, KS Devaraju, GT Ramesh, ...
Molecular and cellular biochemistry 380 (1), 143-151 , 2013
2013
Citations: 63
Bioimaging of peroxynitrite in MCF-7 cells by a new fluorescent probe rhodamine B phenyl hydrazide
G Ambikapathi, SK Kempahanumakkagari, B Ramappa Lamani, ...
Journal of fluorescence 23 (4), 705-712 , 2013
2013
Citations: 37
Ultrasound-driven facile fabrication of Pd doped SnO2 hierarchical superstructures: Structural, growth mechanism, dermatoglyphics, and anti-cancer activity
BRR Krushna, K Manjunatha, SY Wu, D Sivaganesh, SC Sharma, ...
Biomaterials Advances 160, 213855 , 2024
2024
Citations: 36
Eco-friendly synthesis of CQDs from Pistachio shells: Versatile applications in anti-counterfeiting, flexible films, latent fingerprints and potential anti-cancer activity
DH Sandeep, BRR Krushna, SC Sharma, P Ravindran, R Sivayogana, ...
Journal of Alloys and Compounds 991, 174311 , 2024
2024
Citations: 30
Prediction of kabaddi playing ability from selected anthropometrical and physical variables among college level players
K Devaraju, R Kalidasan
Asian Journal of Information Technology 11 (4), 131-134 , 2012
2012
Citations: 29
Prediction of playing ability in Kabaddi from Selected anthropometrical, physical, Physiological and psychological variables among college level players
K Devaraju, A Needhiraja
International Journal of Management 3 (2), 150-157 , 2012
2012
Citations: 25
In silico binding affinity study of calcineurin inhibitors to calcineurin and its close associates
BM Harish, KS Devaraju, A Gopi, R Saraswathi, RL Babu, ...
Indian Journal of Biotechnology 12, 213-217 , 2013
2013
Citations: 23
Syntheses, characterizations, and antimicrobial activities of binuclear ruthenium (III) complexes containing 2-substituted benzimidazole derivatives
B Roopashree, V Gayathri, A Gopi, KS Devaraju
Journal of Coordination Chemistry 65 (22), 4023-4040 , 2012
2012
Citations: 23
Red emitting SnO2: Eu3+ hierarchical structures for multifunctional applications: Thermal sensing, w-LEDs, latent fingerprint detection and biomedical applications
BRR Krushna, IS Pruthviraj, SC Sharma, S Ray, ST Elayakumar, ...
Journal of Alloys and Compounds 1013, 178496 , 2025
2025
Citations: 17
Elevation of gene expression of calcineurin, calmodulin and calsyntenin in oxidative stress induced PC12 cells
P Aravind, SR Bulbule, N Hemalatha, RL Babu, KS Devaraju
Genes & Diseases 8 (1), 87-93 , 2021
2021
Citations: 16
Biosorption of Chromium(VI) and Lead(II): Role of Spirulina platensis in the Treatment of Industrial Effluent
RL Babu, E Vijayalakshmi, MN Kumar, RH Patil, KS Devaraju, SC Sharma
Bioremediation journal 17 (4), 231-239 , 2013
2013
Citations: 16
Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a Drosophila Parkinson’s …
R Hanumanthappa, DM Venugopal, N PC, A Shaikh, S BM, ...
ACS omega 8 (50), 47482-47495 , 2023
2023
Citations: 15
Corosolic Acid Inhibits Secretory Phospholipase A 2 IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice
S Pundalik, KR Hanumappa, AS Giresha, D Urs, S Rajashekarappa, ...
Journal of Inflammation Research, 6905-6921 , 2022
2022
Citations: 14
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles
R Hanumanthappa, A Parthasarathy, GB Heggannavar, PC Kiran, ...
Neuroprotection 2 (04), 255-275 , 2024
2024
Citations: 12
Synthesis, Antioxidant, and Electrochemical Behavior Studies of 2-Amino-4 H -Chromene Derivatives Catalyzed by WEOFPA: Green Protocol
KB Badiger, K Kamanna, R Hanumanthappa, KS Devaraju, ...
Polycyclic Aromatic Compounds 44 (1), 333-360 , 2024
2024
Citations: 12
Genetic screening of selected disease-causing mutations in glutaryl-CoA dehydrogenase gene among Indian patients with glutaric aciduria type I
TP Kruthika-Vinod, S Muntaj, KS Devaraju, M Kamate, AB Vedamurthy
Journal of Pediatric Genetics 6 (03), 142-148 , 2017
2017
Citations: 8
Discovery of a latent calcineurin inhibitory peptide from its autoinhibitory domain by docking, dynamic simulation, and in vitro methods
BM Harish, R Saraswathi, D Vinod, KS Devaraju
Journal of Biomolecular Structure and Dynamics 34 (5), 983-992 , 2016
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