Dr. Sunil Jalalpure is the recipient of the “Awards for Research Publications (ARP)”, Best Teacher Award, Best Young Scientist Award, Best Scientist Award, ISP Eminence Award, STARS Award (Excellence in Academic Research).
He has received financial support from various funding agencies like UGC, AICTE, DST and ICMR for research projects and for organizing conferences/workshops. He is member of several pharmacy professional societies and has chaired several scientific sessions at national and international conferences. He has worked as organizing secretary for several national and international conventions. He has been invited to visit Australia, Thailand, Malaysia and South Africa to attend and present research papers at conferences.
Prof. Jalalpure has published over 140 scientific papers in national and international journals. He has 5 intellectual property rights to his credit. He has successfully guided 48 M. 18 Ph.D. students and 1 Post Doc fellow.
EDUCATION
1) B. Pharm. from KLES’s College of Pharmacy, Belagavi, Karnataka University, Dharwad in 1996.
2) M. Pharm. from KLES’s College of Pharmacy, Belagavi, Rajiv Gandhi University of Health Sciences, Bangalore in1998
3) Ph.D. from KLES’s College of Pharmacy, Belagavi, Rajiv Gandhi University of Health Sciences, Bangalore in 2006.
4) Post-Doctoral Studies from School of Pharmacy, BRI Lab. Rhodes University, Grahamstown, South Africa in 2010.
RESEARCH INTERESTS
isolation/ characterization of active principles from medicinal plants and their pharmacological screening for various biological activities. He is recently involved in nanoparticle drug delivery system of herbal actives and green nanotechnology.
149
Scopus Publications
Scopus Publications
Molecular docking and dynamic simulation of marine natural products from soft coral-derived microbes against SARS-CoV-2 main protease and spike protein Naga Venkata Anusha Anthikapalli, Vishal S. Patil, Phaniendra Alugoju, Vishwambhar V. Bhandare, Ankush Prasad, Sunil S. Jalalpure Scientific Reports, 2026 Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Two key therapeutic target proteins of SARS-CoV-2, the Spike (S) protein and the main protease (Mpro), facilitate the entry of virus and its replication inside the host cell, respectively. Notably, several pointmutations in the receptor-binding domain (RBD) of the S-protein have led to the origin of different SARS-CoV-2 Variants of Concern (VOCs) including Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2), Gamma (P.1), and Omicron (B.1.1.529). The low efficacy of currently available antiviral drugs against these VOCs highlights the need for screening and discovery of novel natural compounds against COVID-19. This study performed molecular docking of marine natural products from soft coral-derived microbes against the Mpro and the RBD of the S-protein from wild type (WT) and five VOCs. Many of the test compounds [e.g., Cottoquinazoline B and D (CQB/D), Tetraorcinol A (TOA), Versicoloritide A and C (VCA/C), Fumiquinazoline K, and Pencillanthranin A) showed stronger binding affinities compared to control antiviral drugs (nelfinavir and remdesivir) and formed favorable interactions with both Mpro and the RBD of S-protein. ADMET analysis revealed that most of the best-docked compounds obey Lipinski rule of five. Molecular dynamics (MD) simulation (200 ns) analysis further revealed stable binding conformations of the top docked complexes of (1) CQB with Mpro, (2) CQB with the RBD of WT S-protein, (3) TOA with the RBD of S-protein from beta variant (4) TOA with the RBD of S-protein from Omicron variant, (5) TOA with the RBD of S-protein from Delta variant, (6) TOA with the RBD of S-protein from Gamma variant, and (7) VCA with the RBD of alpha variant. However, future in vitro and in vivo studies are still required to validate efficacy of these compounds.
Flavonoids of Andrographis paniculata regulate hepatitis B virus replication and hepatocellular carcinoma progression: evidence from computational and experimental studies Vishal S. Patil, Darasaguppe R. Harish, Rajitha Charla, Vishwambhar Vishnu Bhandare, Swarup S. Gujarathi, Faizan A. Beerwala, Priyanka P. Patil, Sunil S. Jalalpure, Harsha V. Hegde, Subarna Roy BMC Complementary Medicine and Therapies, 2025 The HBx protein of hepatitis B virus (HBV) plays a crucial role in HBV pathogenesis, yet current treatments like HIV reverse transcriptase (RT) inhibitors, which target HBV RT due to similar active sites, have severe side effects, risk of drug resistance, and high costs. The present study investigates the anti-hepatitis B virus (HBV) properties of Andrographis paniculata (AP) and Thespesia populnea (TP) on HBV expressing HepG2.2.15 cells and by computational analysis. In vitro cytotoxicity, reverse transcriptase inhibitory, DNA and pgRNA quantification by qRT-PCR, time course analysis of HBsAg and HBeAg, and HBX-HBXIP interaction inhibition studies were conducted. The interaction of HBX with HBXIP, and phytocompounds’ interaction with HBx was analyzed through molecular docking and dynamics studies. AP exhibits lower cytotoxicity (CC50 = 832.915 µg/mL) than TP (CC50 = 593.122 µg/mL) after 24 h, with Tenofovir disoproxil fumarate (TDF) showing minimal cytotoxicity (CC50 > 500 µM). Both AP and TP significantly decreased intracellular HBV DNA with a > 25 fold reduction at higher concentrations (125–500 µg/mL) but had no significant effect on pgRNA level. AP and TP 500 µg/mL effectively inhibited HBsAg secretion (95% and 80% inhibition, respectively), over 120 h. AP also showed inhibition of HBeAg secretion (75–82%), while TP exhibited a higher inhibition of 90% at 24 h. TDF showed consistent but lower inhibitory effects on HBsAg and HBeAg. The HBx-HBXIP interaction inhibition assay showed AP’s greater inhibitory capacity (IC50 < 62.5 µg/mL) compared to TP (IC50 = 806.69 µg/mL). Computational studies further validated these findings, showing stable binding interactions of AP compounds (flavonoids) with HBx protein (with Arg138 and His139, Lys140, and Trp141 residues participating in the interaction with HBXIP), corroborating their potential in disrupting HBV replication. Molecular dynamics simulations confirmed the stability of these interactions over 100ns. AP exhibits potent anti-HBV activities, making it a promising candidate for further therapeutic development.
In Silico and In Vivo Pharmacological Study of Acmella paniculata Flowers for Anti-Inflammatory and Antiarthritic Potential Akshay Shamnewadi, Banappa S. Unger, Partha Palit, Shamanand P. Mallapur, Vishal S. Patil, Harish Darasaguppe Ramachandra, Abu Md Ashif Ikbal, Sunil S. Jalalpure Chemistry and Biodiversity, 2025 Acmella paniculata has been traditionally used in folklore medicine to alleviate pain and manage articular rheumatism. This study explores its potential anti‐inflammatory and antiarthritic effects through in silico and in vivo approaches. A. paniculata bioactives' antiarthritic mechanisms were elucidated using computational techniques, namely, gene set enrichment analysis, network pharmacology, molecular docking, and molecular dynamics (MD) simulations using KEGG pathway analysis, PyRx, Discovery Studio, and GROMACS tools. A. paniculata hydroalcoholic extract (APE) and the ethyl acetate fraction (APF) were analyzed via LC‒MS for phytochemical profiling. In vivo studies assessed anti‐inflammatory and antiarthritic potential in carrageenan‐induced paw edema and complete Freund's adjuvant (CFA)‐induced arthritis models in Wistar rats. Ferulic acid, isoferulic acid, and acetyl aleuritolic acid were identified as bioactives that targeted RELA, a key NF‐κB component. Stable interactions were confirmed through docking and MD simulations. LC‒MS verified these compounds in APE and APF. In vivo study revealed significant reductions in paw volume, arthritis scores, and inflammatory markers (CRP, RF, IL‐6, and TNF‐α) and improved histopathological outcomes in the APE and APF‐treated groups compared to the CFA. These findings highlight the anti‐inflammatory and antiarthritic potential of A. paniculata via multi‐protein modulation, particularly NF‐κB signaling, and it can be utilized as a promising therapeutic for rheumatoid arthritis.
Analytical standardization of Piccha basti using Physicochemical and Phytochemical Parameters. Savita Bhosale, Prashanth G Jadar, B S Prasad, Sunil S Jalalpure, Indrajit S Shinde Journal of Ayurveda and Holistic Medicine, 2025 Background: The standardization of Piccha Basti (therapeutic enema procedure) used in ulcerative colitis involves integrating organoleptic, physicochemical and phytochemical analysis to ensure its consistency, safety, and effectiveness. By employing modern analytical methods, it becomes possible to optimize quality control, ensuring that each batch of Piccha basti maintains the same therapeutic value and is free from contaminants. Method: The standardization of Piccha basti was conducted using three samples prepared in different time with same method and analyzed to ensure standard values along with quality and consistency. Organoleptic evaluation assessed sensory characteristics such as color, odor, taste, appearance, and texture. Result: Physicochemical analysis revealed that the pH levels were near to neutral lies in between 6.05 to 6.24. Specific Gravity values ranged from 1.047 to 1.072, whereas viscosity ranges between 276 cP (centipoise) – 380.6 cP. The Refractive Index was consistent at 1.290 – 1.362, reflecting uniform optical properties. The total solid content varied slightly, from 1.577 gm. to 1.667 gm. and total ash 5.383 % to 6.024 %. Acid insoluble ash 1.135 % to 1.794 % whereas water soluble ash varies from 4.166 % to 4.771 %, water soluble extract varies from 47.514 % to 50.741 % whereas acid soluble extract 46.783 % to 56.4 %. Centrifugation test varies from 46.2 sec to 50.26 sec and creaming test all shows upward movements. Phytochemical analysis provided for each sample, confirming the presence of essential phytochemical compounds. Conclusion: The results demonstrated a high degree of uniformity across all samples, ensuring reproducibility and reliability in the formulation of Piccha Basti. These findings support the standard values for reference, therapeutic use of the standardized formulation in clinical settings.
Network Pharmacology Based Anti-inflammatory Activity of Datura (Datura metel L.): An In-Silico Study Sreeja V Kaimal, Rajeshwari V Kamat, Sunil S Jalalpure, Amal S Chandran Journal of Ayurveda and Holistic Medicine, 2025 Background: Rheumatoid arthritis (RA), is a chronic autoimmune disease, which is having the symptoms joint pain, swelling, and gradual joint destruction by refractory joint inflammation. Even though the current available treatments are effective in managing and reducing the progression of the disease but these interventions are associated with severe complications. Datura metel L., is a shrub which is known for its therapeutic potential in Ayurveda for the treatment of a variety of inflammatory conditions like arthritis. Objective: A network pharmacology-based study was planned to validate Ayurveda knowledge and to understand the mechanism of action of Datura in inflammation. Materials and Methods: The databases like Dr. Dukes, PubChem, Gene Cards and IMPPAT were utilised to identify the potential targets and related pathways. The open-source databases revealed 14 phytocompounds in Datura and the Swiss target Prediction Server predicted 79 target protein molecules. The STRING 10.5, KEGG Pathway database and Cytoscape 3.7.2 were utilised in the network pharmacology study for identifying protein targets, potential interactions, pathway analysis and for the construction of the network. Results: 14 phytocompounds identified in Datura which were expected to be targeting 79 inflammatory proteins. The gene enrichment analysis identified 27 targets among which The MAPK signaling pathway acts as the key hub. The majority of compounds fulfilled acceptable standards in drug-likeness screening. The phytocompounds Atropine (1.39) and Hyoscyamine (1.29) shows high score according to drug-likeness screening which predicts the suitability of the compounds as a drug in the disease. Conclusion: The study concludes that the phytocompounds like hyoscyamine, deoxywithastramonolide, fastusic acid, scopolamine, and tigloidine have major action on TNF, IL6, COX, APK14, and other proteins through P38 MAPK signalling pathway and the Rheumatoid arthritis pathway. The network pharmacology study validates the anti-inflammatory potential of Datura metel.
Validation of new liquid chromatographic method for naturally isolated quercetin and its commercial application to Ayurvedic formulation Indian Drugs, 2019
Pharmacognostical assessment and anticonvulsant activity of whole plant of Cassia occidentalis Linn International Journal of Pharmacognosy and Phytochemical Research, 2016
Pharmacognostical evaluation and anticonvulsant activity of stem of abutilon indicum linn sweet International Journal of Pharmacy and Pharmaceutical Sciences, 2016
Preparation and evaluation of Amavatvidhvansa rasa- A herbomineral formulation International Journal of Drug Development and Research, 2014
Smedds formulation: Demonstration of enhanced bioavailability of pioglitazone in rats International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Invitro anthelmintic activity of bark of Azadirachta indica against Ascardi galli and Eudrilus eugeniae Journal of Natural Remedies, 2014
Studies on antimicrobial potentials of Aerva lanata fractions International Journal of Pharmaceutical Research, 2013
Comparative efficacy of root extracts of Curcuma zedoaria Rosc on behavioural and radiological changes in arthritic rats International Journal of Pharmaceutical Research, 2012
Antiinflammatory efficacy of Curcuma zedoaria rosc root extracts Asian Journal of Pharmaceutical and Clinical Research, 2011
Evaluation of anti-inflammatory effect of ethnolic and aqueous extracts of curcuma zedoaria Rosc root International Journal of Drug Development and Research, 2011
In-vitro immunomodulatory activity of extracts of Bauhinia vareigata Linn stem bark on human neutrophils Iranian Journal of Pharmacology and Therapeutics, 2010
Evaluation of antidiabetic activity of Cassia glauca lam. Leaf in streptozotocin induced diabetic rats Iranian Journal of Pharmacology and Therapeutics, 2010
Comparative hypoglycemic effects of cassia glauca Lam. in streptozotocin- induced diabetic rats Internet Journal of Pharmacology, 2010
Anticonvulsant activity of whole plant of Solanum surattense burm against mes and PTZ induced seizures in rats Pharmacologyonline, 2010
Wound healing activity of the roots of Eclipta alba Linn. Indian Drugs, 2004
Antiinflammatory activity of the leaves of Anacardium occidentale linn Indian Journal of Pharmaceutical Sciences, 2003
Hepatoprotective activity of the fruits of Piper longum Linn Indian Journal of Pharmaceutical Sciences, 2003
Effect of Lawsonia alba leaf extracts on carbon tetrachloride-induced hepatic damage in albino rats Journal of Natural Remedies, 2003
Analgesic and antipyretic activity of Pergularia extensa in rats Indian Journal of Pharmaceutical Sciences, 2002
Wound healing activity of the galls of Quercus infectoria olivier Journal of Natural Remedies, 2002
Preliminary phytochemical investigation and wound healing activity of the leaves of Argemone mexicana linn. (papaveraceae) Indian Drugs, 2001
GRANT DETAILS
Ongoing Projects:
1. Funding Agency: Government of India, Ministry of Science and
Technology, Department of Biotechnology
Title of Project: Development and Establishment of Genetic Markers for ‘Jivanti’ – An Ayurvedic Medicinal Material
Amount Rs.: 40,06,000/-
Date of sanction and Duration: 31st May 2018 (3 Years)
2. Funding Agency: Government of India, All India Council for Technical Education
Title of Project: Development and evaluation of quercetin loaded nanostructured liquid crystalline dispersion for targeting
skin cancer
Amount: 16,47,058/-
Date Sanctioned and Duration: 22ndNov. 2019 (3 Years)
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Patents/ Intellectual Property Rights:
Title of the invention : Diuretic and antiurolithiatic herbal
composition and use thereof.
Names of the inventers : Gadage Navneet and Jalalpure Sunil
Application Number : 2209/MUM/2010
Date of filing of application : 04/08/2010
Date of publication : 01/10/2010
Title of the invention : A method of extraction and purification of
phytoconstituents from botanical materials.
Names of the inventers : Gadage Navneet and Jalalpure Sunil
Application Number : 2524/MUM/2010
Date of filing of Application : 14/09/2010
Date of Publication : 29/04/2011
Title of the invention : An improved method for quantitative
determination of Adenosine in Adenosine
Solution for Injection
Names of the inventers : Chandrawadan Panchal, Jalalpure Sunil et al
Application Number : 201721004362A
Date of filing of Application : 07.02.2017
Date of Publication : 17.02.2017
Title of the invention : Nanostructured Lipid Carriers (NLCs) Based
Transdermal Patches of Colchicine.
Names of the inventers : JOSHI S.A. & JALALPURE S. S.
Application Number : 201821015784 A
Date of filing of application : 26/04/2018
Date of publication : 22/06/2018
International classification : A61K31/353
Industry, Institute, or Organisation Collaboration
Collaborative Research Project ongoing:
1. In vitro anticancer potential of curcumin based analogues, Reva University, Bengaluru.
2. AMS-OIL; A WONDER OIL : Pharmacological and cellular analyses for its extensive therapeutic effects, Amsar Private Limited, Goa.