Basanagouda Patil

Scopus Publications

In silico profiling of Cynodon dactylon L. Bioactives: Targeting Alzheimer’s pathways through network pharmacology, molecular docking and ADMET analysis
Laxmi Pattanashetti, Vishal S. Patil, Basanagouda M. Patil
Indian Journal of Physiology and Pharmacology, 2025
Objectives: The present study aims to investigate the therapeutic potential of Cynodon dactylon in alleviating memory deficits associated with Alzheimer’s disease (AD). Specifically, we seek to explore its antioxidant properties and evaluate its potential as an acetylcholinesterase (AChE) inhibitor, with the ultimate goal of identifying C. dactylon bioactives as lead molecules for the management of AD. Materials and Methods: We performed an in silico analysis incorporating in silico studies, namely network pharmacology, docking and ADMET profile, to discover the potential effect of C. dactylon L. bioactives against AD targets. Results: The present study identified eight bioactive compounds with favourable drug-likeness scores, predicted to target 122 genes involved in crucial pathways. These key targets were involved in 7 pathways with targets such as AChE, butyrylcholinesterase, adenosine receptors A2A, monoamine oxidase (MAO) A, MAOB regulating protein binding, protein dimerisation and serine hydrolase activity. Notably, molecular docking simulations revealed quercetin, kaempferol and luteolin; active ingredients of C. dactylon and exhibited significant binding affinity with AChE. Conclusion: These computational insights provide a foundation for further investigation and highlight C. dactylon bioactives as potential candidates for modulating memory deficit in AD, offering new prospects for therapeutic interventions.
Multifaceted targets of cannabidiol in epilepsy: Modulating glutamate signaling and beyond
Pukar Khanal, Vishal S. Patil, Kunal Bhattacharya, B.M. Patil
Computers in Biology and Medicine, 2024
Alzheimer’s Disease: Epidemiology, Neuropathology, and Neurochemistry
Raushan Kumar Chaudhary, Uday Venkat Mateti, Pukar Khanal, Kala Bahadur Rawal, Praneetha Jain, Vishal S Patil, Amit Kumar Shrivastava, B M Patil
Computational and Experimental Studies in Alzheimers Disease, 2024
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterized by a decline in memory and cognition, resulting in an inability of an individual to function alone. The trend of increasing elderly populations due to increased life expectancy has surged the Alzheimer’s population globally, i.e., around 50 million. The etiopathology and neurochemistry of AD are complex and incompletely understood to date. However, it has been reported that age, gender, race, environmental factors, air pollution, infection, genetics, comorbidities (cardiovascular, obesity, and diabetes), and lifestyle are potential risk factors associated with Alzheimer’s. Based on the cut-off of age 65, AD is categorized as early or late onset. The neuropathology of Alzheimer’s has been linked with the formation and deposition of β-amyloid plaque and neurofibrillary tangles; this deposition results in immunological reactions and amyloid angiopathy. Further, altered neurochemistry is one of the factors associated with AD pathogenesis. The altered concentration of neurotransmitters such as acetylcholine, dopamine, serotonin, nor-adrenaline, glutamate, and GABA in the brain and any pathological changes in their respective neurons and corresponding receptors contribute to the development of psychiatric illnesses, including AD. The pathogenesis of AD makes it difficult to treat, resulting in poor prognosis of patients, which corresponds with a huge disease burden, poor quality of life, and high economic burden.
Computational Modelling of BACE-1, AChE, and Phosphodiesterase Inhibitors as Anti-Alzheimer’s Agents
Vishal S. Patil, Jagadeesh Dodakallanavar, Pukar Khanal, B M Patil, Raushan Kumar Chaudhary, Amit Kumar Shrivastava, Nongmaithem Randhoni Chanu, Darasaguppe R. Harish, Uday Venkat Mateti
Computational and Experimental Studies in Alzheimers Disease, 2024
Coumarins belong to the family of benzopyrone and have a variety of biological activities, including the management of Alzheimer’s disease (AD). Inhibition of beta-secretase-I (BACE1), acetylcholinesterase (ACHE), and phosphodiesterase-4D (PDE4D) is important for the management of AD progression. The present study is framed to identify coumarin analogous as potent antagonists of ACHE, BACE1, and PDE4D by stringent in silico checkpoints. A list of coumarin derivatives was collated from the ChEBI database. The pkCSM database was used to predict the ability of compounds to cross the blood–brain barrier. Molecular docking of prioritized compounds was screened against BACE1, ACHE, and PDE4D protein targets using AutoDock vina via using POAP pipeline. Lead hit compounds molecular dynamics for 150 ns were performed by GROMACS. Binding free energy, per residue energy contribution, and principal component analysis of the complexes were performed for MD trajectories. Finally, gene set pathway enrichment and network analysis of BACE1, ACHE, and PDE4D inhibitors were performed by the KEGG database and Cytoscape software, respectively. Out of 379 coumarins shortlisted, 69 were found to act on the central nervous system. The study provided 3 important coumarin derivatives (decursin, farnesiferol A, and 2-Acetamido-6H-dibenzo[b,d]pyran-6-one) as potent lead molecules against BACE1, ACHE, and PDE4D) for the management of \ AD. Along with these 3 molecules, 11, 21, and 16 compounds were predicted to inhibit BACE1, ACHE, and PDE4D, respectively. Additionally, these compounds found to regulate neuroactive ligand-receptor interaction; GABAergic synapse; serotonergic synapse; phenylalanine, tyrosine, glycine, serine, and threonine metabolism; cGMP-PKG, calcium signalling pathway, etc. that are directly linked to AD pathogenesis. The resulting list of coumarins represented in this study needs wet lab research for novel candidate development against AD.
The marijuana-schizophrenia multifaceted nexus: Connections and conundrums towards neurophysiology
Pukar Khanal, Vishal S. Patil, B.M. Patil, Kunal Bhattacharya, Amit Kumar Shrivastava, Raushan K. Chaudhary, Lokjan Singh, Prarambh SR Dwivedi, Darasaguppe R. Harish, Subarna Roy
Computational Biology and Chemistry, 2023
Systems and in vitro pharmacology profiling of diosgenin against breast cancer
Pukar Khanal, Vishal S. Patil, Vishwambhar V. Bhandare, Priyanka P. Patil, B. M. Patil, Prarambh S. R. Dwivedi, Kunal Bhattacharya, Darasaguppe R. Harish, Subarna Roy
Frontiers in Pharmacology, 2023
Aim: The purpose of this study was to establish a mode of action for diosgenin against breast cancer employing a range of system biology tools and to corroborate its results with experimental facts.Methodology: The diosgenin-regulated domains implicated in breast cancer were enriched in the Kyoto Encyclopedia of Genes and Genomes database to establish diosgenin-protein(s)-pathway(s) associations. Later, molecular docking and the lead complexes were considered for molecular dynamics simulations, MMPBSA, principal component, and dynamics cross-correlation matrix analysis using GROMACS v2021. Furthermore, survival analysis was carried out for the diosgenin-regulated proteins that were anticipated to be involved in breast cancer. For gene expression analyses, the top three targets with the highest binding affinity for diosgenin and tumor expression were examined. Furthermore, the effect of diosgenin on cell proliferation, cytotoxicity, and the partial Warburg effect was tested to validate the computational findings using functional outputs of the lead targets.Results: The protein-protein interaction had 57 edges, an average node degree of 5.43, and a p-value of 3.83e-14. Furthermore, enrichment analysis showed 36 KEGG pathways, 12 cellular components, 27 molecular functions, and 307 biological processes. In network analysis, three hub proteins were notably modulated: IGF1R, MDM2, and SRC, diosgenin with the highest binding affinity with IGF1R (binding energy −8.6 kcal/mol). Furthermore, during the 150 ns molecular dynamics (MD) projection run, diosgenin exhibited robust intermolecular interactions and had the least free binding energy with IGF1R (−35.143 kcal/mol) compared to MDM2 (−34.619 kcal/mol), and SRC (-17.944 kcal/mol). Diosgenin exhibited the highest cytotoxicity against MCF7 cell lines (IC50 12.05 ± 1.33) µg/ml. Furthermore, in H2O2-induced oxidative stress, the inhibitory constant (IC50 7.68 ± 0.51) µg/ml of diosgenin was lowest in MCF7 cell lines. However, the reversal of the Warburg effect by diosgenin seemed to be maximum in non-cancer Vero cell lines (EC50 15.27 ± 0.95) µg/ml compared to the rest. Furthermore, diosgenin inhibited cell proliferation in SKBR3 cell lines more though.Conclusion: The current study demonstrated that diosgenin impacts a series of signaling pathways, involved in the advancement of breast cancer, including FoxO, PI3K-Akt, p53, Ras, and MAPK signaling. Additionally, diosgenin established a persistent diosgenin-protein complex and had a significant binding affinity towards IGF1R, MDM2, and SRC. It is possible that this slowed down cell growth, countered the Warburg phenomenon, and showed the cytotoxicity towards breast cancer cells.
Procyanidin Dimer from the Stem Bark of Moringa oleifera (Lam.) Attenuates Insulin Resistance in Rats
Hasanpasha N. Sholapur, Basanagouda M. Patil, Fatima Sanjeri Dasankoppa
Journal of Biologically Active Products from Nature, 2023
AbstractAlcoholic extract and its ethyl acetate fraction of Moringa oleifera (Lam.) (MO), (Moringaceae) bark are experimentally claimed to possess insulin-sensitizing potentials. The present study aimed to isolate and characterize the phytochemical(s) responsible for insulin sensitization in dexamethasone-induced acute and chronic rat models for insulin resistance (IR). The reported ethyl acetate fraction from the alcoholic extract of the bark of MO was prepared and subjected to bioactivity-guided sub-fractionation and isolation of phytochemicals. A component responsible for improving insulin sensitivity in rat models for IR was isolated and reported for the first time from the bark of MO and its structure was characterized as a procyanidin dimer type of polyphenol by spectroscopic techniques.Keywords: DexamethasoneInsulin resistanceMoringa oleiferaOral glucose tolerance testProcyanidin
Computational and experimental pharmacology to decode the efficacy of Theobroma cacao L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice
Priyanka P. Patil, Pranjal Kumar, Pukar Khanal, Vishal S. Patil, Harish R. Darasaguppe, Vishwambhar Vishnu Bhandare, Arati Bhatkande, Sudhanshu Shukla, Rajesh K. Joshi, Basanagouda M. Patil, Subarna Roy
Frontiers in Pharmacology, 2023
Background and objective: Doxorubicin is extensively utilized chemotherapeutic drug, and it causes damage to the heart, liver, and kidneys through oxidative stress. Theobroma cacao L (cocoa) is reported to possess protective effects against several chemical-induced organ damages and also acts as an anticancer agent. The study aimed to determine whether the administration of cocoa bean extract reduces doxorubicin-induced organ damage in mice with Ehrlich ascites carcinoma (EAC) without compromising doxorubicin efficacy.Methodology: Multiple in vitro methods such as cell proliferation, colony formation, chemo-sensitivity, and scratch assay were carried out on cancer as well as normal cell lines to document the effect of cocoa extract (COE) on cellular physiology, followed by in vivo mouse survival analysis, and the organ-protective effect of COE on DOX-treated animals with EAC-induced solid tumors was then investigated. In silico studies were conducted on cocoa compounds with lipoxygenase and xanthine oxidase to provide possible molecular explanations for the experimental observations.Results:In vitro studies revealed potent selective cytotoxicity of COE on cancer cells compared to normal. Interestingly, COE enhanced DOX potency when used in combination. The in vivo results revealed reduction in EAC and DOX-induced toxicities in mice treated with COE, which also improved the mouse survival time; percentage of lifespan; antioxidant defense system; renal, hepatic, and cardiac function biomarkers; and also oxidative stress markers. COE reduced DOX-induced histopathological alterations. Through molecular docking and MD simulations, we observed chlorogenic acid and 8′8 methylenebiscatechin, present in cocoa, to have the highest binding affinity with lipoxygenase and xanthine oxidase, which lends support to their potential in ameliorating oxidative stress.Conclusion: The COE reduced DOX-induced organ damage in the EAC-induced tumor model and exhibited powerful anticancer and antioxidant effects. Therefore, COE might be useful as an adjuvant nutritional supplement in cancer therapy.
Duranta repens Linn reverses hepatic and peripheral insulin resistance in fructose-induced hyperinsulinaemic rats – Experimental and computational findings
Pukar Khanal, BM Patil
South African Journal of Botany, 2022
The present study investigated the effect of hydroalcoholic extract of Duranta repens Linn over gluconeogenesis, glycolysis, glycogenesis, leptin, and dipeptidyl peptidase-4 regulation in fructose-induced insulin-resistant rats. Initially, hyperinsulinemia was induced by supplementing fructose in drinking water for fifty-four days. Glucose intolerance was confirmed using oral glucose tolerance test and subjected for extract treatment for next thirty days. After thirty days of treatment, animals fasted and an oral glucose tolerance test was performed followed by an insulin tolerance test. After that, animals were overdosed with anesthetic ether, blood was collected to separate plasma and serum. Further, multiple biochemical parameters i.e. lipid profile, hepatic enzymes, enzymatic and non-enzymatic antioxidant biomarkers, glycogen content, leptin, and the glucagon-like peptide-1 level were quantified. Additionally, the glucose uptake in rat hemidiaphragm and hepatic histology were performed. Further, molecular docking was performed using AutoDock Vina and the ligand pose with minimum binding energy was chosen to visualize the ligand-protein interaction. After the thirty days of treatment with extract, it was observed to ameliorate the fructose-induced alterations in body weight, food intake, and water intake. Further, it improved glucose tolerance. This was confirmed via the quantification of the total triglycerides and assessing oral glucose and insulin tolerance test. Additionally, it also improved the level of hepatic enzymes involved in gluconeogenesis and glycolysis. Also, it upregulated the leptin pathway; however, did not influence the dipeptidyl peptidase-4-glucagon-like peptide-1. Similarly, a docking study predicted scutellarein, pseudo-ginsenoside-RT1, repennoside, and durantanin I as probable lead hits from Duranta repens as prime regulators of gluconeogenesis. Additionally, molecular docking revealed scutellarein, pseudo-ginsenoside-RT1, repennoside, and durantanin I as the probable lead hits in regulating the enzymes involved in hepatic glucose catabolism and anabolism. Treatment with the hydroalcoholic extract of Duranta repens extract ameliorated fructose-induced gluconeogenesis, glycolysis, glycogenesis, and leptin regulation; however, did not influence the dipeptidyl-peptidase 4- glucagon-like peptide-1 pathway.
Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compounds
Pukar Khanal, Vishal S. Patil, Vishwambhar V. Bhandare, Prarambh S.R. Dwivedi, C.S. Shastry, B.M. Patil, Shailendra S. Gurav, Darasaguppe R. Harish, Subarna Roy
Computers in Biology and Medicine, 2022
Ficus benghalensis promotes the glucose uptake- Evidence with in silico and in vitro
Vaishnavi Shankar Madiwalar, Prarambh S. R. Dwivedi, Ashwini Patil, Soham M. N. Gaonkar, Vrunda J. Kumbhar, Pukar Khanal, B. M. Patil
Journal of Diabetes and Metabolic Disorders, 2022
GLUT-2 mediated glucose uptake analysis of Duranta repens: In-silico and In-vitro approach
Ashwini Patil, Prarambh S. R. Dwivedi, Soham Naik Gaonkar, Vrunda Kumbhar, Vaishnavi Shankar Madiwalar, Pukar Khanal, B. M. Patil
Journal of Diabetes and Metabolic Disorders, 2022
Effect of Theobroma cacao L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma
Priyanka P. Patil, Pukar Khanal, Vishal S. Patil, Rajitha Charla, Darasaguppe R. Harish, Basanagouda M. Patil, Subarna Roy
Antioxidants, 2022
Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival
Priyanka P. Patil, Vishal S. Patil, Pukar Khanal, Harish R. Darasaguppe, Rajitha Charla, Arati Bhatkande, Basanagouda M. Patil, Subarna Roy
Plos One, 2022
System biology-based investigation of Silymarin to trace hepatoprotective effect
Prarambh S.R. Dwivedi, Vishal S. Patil, Pukar Khanal, Vishwambhar V. Bhandare, Shailendra Gurav, Darasaguppe R. Harish, B.M. Patil, Subarna Roy
Computers in Biology and Medicine, 2022
Reversal of insulin resistance by Ficus benghalensis bark in fructose-induced insulin-resistant rats
Pukar Khanal, B.M. Patil
Journal of Ethnopharmacology, 2022
Cyperus rotundus L. reverses the olanzapine-induced weight gain and metabolic changes-outcomes from network and experimental pharmacology
Shivprakash Nagaraj Kanagali, B.M. Patil, Pukar Khanal, Banappa S. Unger
Computers in Biology and Medicine, 2022
Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19
Pukar Khanal, Taaza Duyu, B.M. Patil, Yadu Nandan Dey, Ismail Pasha, Manish Wanjari, Shailendra S. Gurav, Arindam Maity
Journal of Ayurveda and Integrative Medicine, 2022
Withanolides from Withania somnifera as an immunity booster and their therapeutic options against COVID-19
Pukar Khanal, Rupesh Chikhale, Yadu Nandan Dey, Ismail Pasha, Sharad Chand, Nilambari Gurav, Muniappan Ayyanar, B. M. Patil, Shailendra Gurav
Journal of Biomolecular Structure and Dynamics, 2022
Beneficial effect of Zingiber officinale on olanzapine-induced weight gain and metabolic changes
Mrityunjaya B. Ullagaddi, B. M. Patil, Pukar Khanal
Journal of Diabetes and Metabolic Disorders, 2021
Consolidation of network and experimental pharmacology to divulge the antidiabetic action of Ficus benghalensis L. bark
Pukar Khanal, B. M. Patil
3 Biotech, 2021
Hydroethanolic extract of Sida rhombifolia L. ameliorates scopolamine-induced cognitive dysfunction in rats
Pattanashetti Laxmi A., Patil Basanagouda M., Hegde Harsha V., Kangle Ranjit
Journal of Applied Pharmaceutical Science, 2021
Screening of JAK-STAT modulators from the antiviral plants of Indian traditional system of medicine with the potential to inhibit 2019 novel coronavirus using network pharmacology
Pukar Khanal, Taaza Duyu, B. M. Patil, Yadu Nandan Dey, Ismail Pasha, Rohini S. Kavalapure, Sharad Chand, Shailendra Gurav
3 Biotech, 2021
Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19
Pukar Khanal, Yadu Nandan Dey, Rajesh Patil, Rupesh Chikhale, Manish M. Wanjari, Shailendra S. Gurav, B. M. Patil, Bhavana Srivastava, Sudesh N. Gaidhani
Rsc Advances, 2021
Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.
Pukar Khanal, Basanagouda M. Patil
Journal of Integrative Medicine, 2021
Potential ameliorative effect of Cynodon dactylon (L.) pers on scopolamine-induced amnesia in rats: Restoration of cholinergic and antioxidant pathways
LaxmiA Pattanashetti, BasanagoudaM Patil, HarshaV Hegde, RanjitP Kangle
Indian Journal of Pharmacology, 2021
Gene ontology enrichment analysis of α-amylase inhibitors from Duranta repens in diabetes mellitus
Pukar Khanal, B. M. Patil
Journal of Diabetes and Metabolic Disorders, 2020
Integration of in silico, in vitro and ex vivo pharmacology to decode the anti-diabetic action of Ficus benghalensis L. bark
Pukar Khanal, B. M. Patil
Journal of Diabetes and Metabolic Disorders, 2020
In vitro and in silico anti-oxidant, cytotoxicity and biological activities of Ficus benghalensis and Duranta repens
Pukar Khanal, Basanagouda M. Patil
Chinese Herbal Medicines, 2020
Anthraquinone Derivatives as an Immune Booster and their Therapeutic Option Against COVID-19
Pukar Khanal, B. M. Patil, Jagdish Chand, Yasmin Naaz
Natural Products and Bioprospecting, 2020
α-Glucosidase inhibitors from Duranta repens modulate p53 signaling pathway in diabetes mellitus
Pukar Khanal, B. M. Patil
Advances in Traditional Medicine, 2020
Mimosa pudica modulates neuroactive ligand-receptor interaction in parkinson’s disease
Taaza Duyu, Pukar Khanal, Nayeem Ashrafali Khatib, Basanagouda Mahadevagouda Patil
Indian Journal of Pharmaceutical Education and Research, 2020
Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis
Pukar Khanal, BM Patil
Asian Pacific Journal of Tropical Biomedicine, 2019
In silico docking study of limonoids from Azadirachta indica with pfpk5: A novel target for Plasmodium falciparum
P Khanal, B. K Mandar, Priyanka Magadum, B. M Patil, K. K Hullatti
Indian Journal of Pharmaceutical Sciences, 2019
In silico antidiabetic screening of borapetoside C, cordifolioside A and magnoflorine
P Khanal, B. K Mandar, B. M Patil, K. K Hullatti
Indian Journal of Pharmaceutical Sciences, 2019
Effect of fractions of alcoholic extract of Moringa oleifera lam. Bark on dexamethasone induced insulin resistance in rats
Hasanpasha N Sholapur, Basanagouda M Patil
Journal of Young Pharmacists, 2017
Effect of Moringa oleifera Bark Extracts on Dexamethasone-induced Insulin Resistance in Rats
H. Sholapur, B. Patil
Drug Research, 2013
Pharmacognostic and phytochemical investigations on the bark of Moringa oleifera Lam.
Indian Journal of Natural Products and Resources, 2013
Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol
Mahamad Yunnus A. Mahat, Nagaraj M. Kulkarni, Santosh L. Vishwakarma, Farhin R. Khan, B.S. Thippeswamy, Vijay Hebballi, Anjana A. Adhyapak, Vijay S. Benade, Saudagar Mohammad Ashfaque, Suraj Tubachi, Basangouda M. Patil
European Journal of Pharmacology, 2010
Synthesis of novel 1-benzhydryl-4-(3-(piperidin-4-yl)propyl) piperidine sulfonamides as anticonvulsant agents
K. Vinaya, B. Veeresh, C. Ananda Kumar, D. Prasanna, S. Ranganatha, S. Benaka Prasad, B. Patil, K. Rangappa
Letters in Drug Design and Discovery, 2010
Effect of phyllanthus fraternus on fructose induced insulin resistance in rats
A.S. Kushwah, B.M. Patil, B.S. Thippeswam
International Journal of Pharmacology, 2010
Apocynin improves endothelial function and prevents the development of hypertension in fructose fed rat
BasangoudaM Patil, BanappaS Unger
Indian Journal of Pharmacology, 2009
Involvement of nitric oxide in 5-HT3 receptor agonist-induced fluid accumulation in jejunum and colon of anesthetized rats
BasanagoudaM Patil, B Veeresh, SV Veeresh Babu, NeelakanthM Jeedi, BanappaS Unger
Indian Journal of Pharmacology, 2009
Synthesis and biological activities of indole-3-propionic acids
Indian Journal of Heterocyclic Chemistry, 2008
Synthesis and evaluation of in vivo antiinflammatory activity of indole -3-acetic acids
Indian Journal of Heterocyclic Chemistry, 2007
Insulin resistance and changes in chronotropic responses to adrenergic and cholinergic agonists in isolated rat atria
BasanagoudaM Patil, ThippeswamyS Boreddy
Indian Journal of Pharmacology, 2007
Evaluation of antiinflammatory activity of methanol extract of Phyllanthus amarus in experimental animal models
BM Patil, MA Mahat
Indian Journal of Pharmaceutical Sciences, 2007
Elevation of systolic blood pressure in an animal model of olanzapine induced weight gain
Basanagouda M. Patil, Nagaraj M. Kulkarni, Banappa S. Unger
European Journal of Pharmacology, 2006
Antipyretic and wound healing activities of Moringa oleifera Lam. in rats
VI Hukkeri, CV Nagathan, RV Karadi, BS Patil
Indian Journal of Pharmaceutical Sciences, 2006
L-arginine-nitric oxide pathway modulates morphine-induced inhibition of gall bladder emptying in mice
Indian Journal of Pharmacology, 2004
Effect of vitamin E on the impaired gastrointestinal activity of streptozotocin-induced diabetic rats
Indian Journal of Pharmacology, 2003
Possible role of nitric oxide in 5-HT-induced intestinal fluid and electrolyte secretion, in rats
Indian Journal of Pharmaceutical Sciences, 2002
Role of nitric oxide in 5-HT-induced intestinal motility and diarrhea
Indian Journal of Pharmaceutical Sciences, 2001
Inhibition of nitric oxide synthase by (N)ω-nitro-L-arginine overcomes delayed intestinal transit in streptozotocin -induced diabetic mice
Indian Journal of Pharmacology, 1999
Glibenclamide antagonizes the inhibitory effect of morphine on gall bladder emptying
B M Patil, P R Thakker
Journal of Pharmacy and Pharmacology, 1996
Effect of hyperglycemia on loperamide induced inhibition of gastrointestinal transit in rats
Indian Journal of Pharmacology, 1995
Synthesis and analgesic evaluation of 3-aryl 1-4-(4-formyl-1-phenylpyrazol-3-yl) sydnones
Indian Drugs, 1995
Screening of some substituted thiadiazolyl sydnones for diuretic activity in albino rats
Indian Drugs, 1992

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