Cabotegravir-loaded polymeric micelles: a promising strategy for improved solubility and therapeutic outcomes Siddharth Vernekar, Archana S. Patil, Yadishma A. Gaude, Rajashree S. Masareddy Drug Development and Industrial Pharmacy, 2026 OBJECTIVE: To design and optimize a d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-stabilized polymeric micellar system for cabotegravir (CAB), strategically addressing its dissolution-rate and permeability constraints to potentiate oral bioavailability and maximize antiretroviral therapeutic outcomes. SIGNIFICANCE: CAB, a potent HIV-1 integrase strand transfer inhibitor, suffers from dissolution-rate limitations and P-glycoprotein efflux, restricting oral utility. Incorporation of TPGS enables superior solubilization, enhances intestinal translocation, and circumvents efflux transporters, offering a transformative, noninvasive alternative to parenteral antiretroviral regimens while reinforcing patient adherence and therapeutic efficacy. METHODS: pharmacokinetic profiling in Wistar rats. RESULTS: The optimized micellar system demonstrated a mean PS of 95.16 ± 0.12 nm, PDI of 0.411 ± 0.24, ZP of -4.72 ± 1.05 mV, and an exceptional encapsulation efficiency of 96.26 ± 1.21%. Compared to conventional CAB suspension, the TPGS-based micelles exhibited markedly enhanced dissolution kinetics and a 236.75 ± 0.74% increase in relative oral bioavailability, accompanied by prolonged systemic circulation. CONCLUSION: TPGS-enabled micellar encapsulation significantly enhances the oral delivery profile of CAB, offering a promising, noninvasive, and patient-compliant alternative to parenteral antiretroviral regimens, potentially improving therapeutic outcomes in HIV management.
Gastroretentive microballoons of olmesartan medoxomil: formulation and in vitro-in vivo evaluation Archana S. Patil, Shweta Aloshi, Yadishma Gaude, Rajashree S. Masareddy Therapeutic Delivery, 2025 BACKGROUND Olmesartan medoxomil, classified as BCS class II due to its poor water solubility, exhibits a low oral bioavailability of 28.6%. MATERIALS AND METHODS Microballoons of Olmesartan medoxomil were formulated using the ionotropic gelation technique and subjected to various evaluation parameters. RESULTS The particles were found to be in the range of 85.11 to 312.6 µm. The prepared microballoons remained buSSoyant for more than 12 hours and showed percentage of cumulative drug release between 56.32-83.62%. In vivo studies showed significant reduction in Systolic blood pressure (SBP) in optimized formulation (OF). CONCLUSION The formulated microballoons (hollow microspheres) emerged as a promising option for an oral gastro retentive controlled drug delivery system for Olmesartan medoxomil.
Advancements in hyperpigmentation management: exploring conventional methods, phytoconstituents, novel approaches, and instrumental techniques Arpana S Patil, Archana S. Patil, Pratik Ugare, Esha Jain, Rajashree S. Masareddy Journal of Cosmetic and Laser Therapy, 2025 Hyperpigmentation is a common dermatological condition characterized by the darkening of patches of skin compared to the surrounding areas. It can occur in individuals of all skin types and ethnicities, and is caused by an overproduction or accumulation of melanin, the pigment responsible for the color of our skin, hair, and eyes. This comprehensive overview aims to delve into the various types, causes, risk factors, clinical manifestations, diagnosis, and treatment options for hyperpigmentation. Additionally, it explores the global and national prevalence of hyperpigmentation, its etiology, pathophysiology and diagnosis and treatment strategies. Furthermore, examines the formulations and dosage forms used to treat hyperpigmentation, including their side effects. It also discusses combination drugs and their associated side effects, as well as novel drug delivery systems and nanocarriers employed in the treatment of hyperpigmentation, providing insight into future prospects in this field.
Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH-Sensitive Gel Systems for Biomedical Applications Ruturaj R. Patil, Arpana S. Patil, Krutuja Chougule, Archana S. Patil, Pratik Ugare, Rajashree S. Masareddy Macromolecular Symposia, 2024 In situ gel systems have emerged as promising drug delivery platforms due to their numerous benefits, including increased patient compliance and decreased administration frequency. The potential of in situ gel extends beyond its formulation benefits, with the ability to transform medical treatment by enhancing drug delivery, offering personalized therapies, and introducing innovative approaches. Ongoing research and the efforts of pharmaceutical companies are dedicated to exploring the vast opportunities presented by in situ gel, pushing the limits of innovation in the field of drug delivery. The selection of suitable polymers is critical for the development of in situ gel formulations. Additionally, consideration of drug‐polymer compatibility ensures the stability and efficacy of the drug within the gel matrix. Formulation considerations play a pivotal role in the development of effective in situ gel systems. They have shown great potential in drug delivery systems, tissue engineering, and regenerative medicine. The ability to prolong gastric retention time, targeted delivery, and localized drug release are among the advantages offered by in situ gels. Although in situ gel technology has shown significant advancements, challenges remain, including stability and shelf‐life issues, biocompatibility and safety concerns, and the need for further research and development. Future directions focus on overcoming these challenges and exploring new applications and advancements in the field. In conclusion, in situ gel systems provide a versatile and promising drug delivery and tissue engineering platform. However, further research and development are essential to address the challenges and fully harness the potential of this innovative technology.
Fabrication, Optimization, and Evaluation of Transdermal Patch: As an Alternative and Effective Transdermal Delivery System for Nebivolol HCl Archana S. Patil, Shraja Birkodi, Rajashree S. Masareddy, Manisha Rajpurohit Pharmaceutical Nanotechnology, 2024 Background: Nebivolol HCl is a unique third-generation beta blocker that has less oral bioavailability and exhibits various adverse effects like gastrointestinal disturbance and abdominal pain. Objective: This study aimed to formulate and evaluate nebivolol HCl transferosomal transdermal patches to reduce the problems associated with oral delivery of the drug and enhancement of drug permeation through the skin. Methodds: Nebivolol HCl loaded transferosomes were prepared by thin film hydration method. Eight formulations were prepared based on the two independent variables, type of surfactant (Tween 80 and Span 80) and Phospholipid: Edge activator ratio and were evaluated for their vesicle size, PDI, and entrapment efficiency. The optimized formulations were incorporated into transdermal patches, which were evaluated for physicochemical properties, in-vitro and ex-vivo permeation, skin irritancy, and stability studies. Results: The vesicle size of the transferosomes ranged from 49nm to 93nm, and EE% varied from 39% to 79%. Vesicles formed with Span 80 as an edge activator showed smaller vesicle size and greater EE% as compared to Tween 80. Based on the results, TW4 and SP4 were selected as the optimized formulations for further incorporation into the transdermal patches. In-vitro and ex-vivo permeation studies showed permeation in the order F2 > F3 > F1, indicating that transferosomal formulations showed superior permeation of the drug compared to plain Nebivolol HCl patches. Span 80 transferosomes showed a slightly better permeation than Tween 80. Stability studies showed that transferosomes and the transdermal patches demonstrated good stability under proper storage conditions. Conclusion: The study concluded that transferosomal patches of Nebivolol HCl could be used as a potential approach with effective transdermal delivery for the management of hypertension.
Exploring magnesium myristate for its dual functionality as a binder and lubricant in the formulation of tablet Rachana Pockle, Rajashree Masareddy, Vijay Bambulkar, Rishabh Desai, Sai Kiran Therapeutic Delivery, 2024 Purpose: To explore ‘magnesium myristate’ for its dual functionality as a lubricant and binder in the formulation of tablets. Methods: Using (DoE), tablet formulations using magnesium myristate and conventional excipients (magnesium stearate and PVP K30) were developed by wet granulation technique. The prepared granules and formulated tablets were evaluated for pre- and post-compression parameters, respectively. Results: Magnesium myristate exhibited excellent flow properties. The optimized formulations containing magnesium myristate exhibited increased hardness and in vitro drug release in comparison to conventional excipients. f2 similarity index for in vitro drug release showed no significant variations with optimized formulations and with the marketed formulations. Conclusion: Magnesium myristate shows a promising replacement for conventional excipients as both a lubricant and binder in tablet formulation.
Intranasal administration of innovative triamcinolone acetonide encapsulated cubosomal in situ gel: formulation and characterization Ruturaj Patil, Archana S. Patil, Krutuja Chougule, Yadishma Gaude, Rajashree S. Masareddy Drug Development and Industrial Pharmacy, 2024 Aim: The primary objective of the research was to develop a cubosomal in situ gel encapsulated with Triamcinolone acetonide (TCA) in order to enhance its penetration through the blood-brain barrier (BBB) when administered via the intranasal route, thus enabling efficient and rapid action.Method: Cubosomes were formulated by top-down approach using glyceryl monooleate (GMO), using pluronics127 (PF127) and polyvinyl alcohol (PVA) in varying proportions based on the Box-Behnken design. High resolution transmission electron microscopy (HR-TEM) analysis confirmed the morphology of the cubosomes. The in situ gel was formulated and optimized. Experiments involving ex vivo permeation and histopathology analyses were undertaken to evaluate drug permeation and tissue effects.Results: The cubosomes exhibited a particle size (PS) of 197.9 nm, zeta potential (ZP) of -31.11 mV, and entrapment efficacy (EE) of 84.31%, with low deviation. Batch F4 (19% PF127) showed favorable results. In vitro and ex vivo permeation studies revealed drug release of 78.59% and 76.65%, respectively, after 8 h. Drug release followed the Hixson Crowell model of release kinetics. The histopathological examination revealed no signs of toxicity or adverse effects on the nasal mucosa of the sheep. The formulation exhibited short-term stability, maintaining its integrity and properties when stored at room temperature.Conclusion: The utilization of an intranasal cubosomal in situ gel encapsulated with TCA was anticipated to lower intracranial pressure and improve patient adherence by offering effective relief for individuals suffering from Brain edema. This efficacy is attributed to its rapid onset of action and its safe and well-tolerated dosage form.
Effect of polymers as matrix system in formulation of sustained release Theophylline matrix tablet International Journal of Pharmacy and Pharmaceutical Sciences, 2012
Development and characterization of Diltiazem hydrochloride pulsatile drug delivery system for chronomodulated therapy Asian Journal of Pharmaceutical and Clinical Research, 2011
Hydrodynamically balanced tablets of clarithromycin: An approach to prolong and increase the local action by gastric retention Research Journal of Pharmaceutical Biological and Chemical Sciences, 2010
Development and evaluation of floating matrix tablets of Riboflavin International Journal of Pharmtech Research, 2010
Formulation and evaluation of piroxicam dispersible tablets using natural disintegrants Journal of Pharmaceutical Sciences and Research, 2009
Development and characterization of ornidazole gels using natural polymers for local treatment of periodontitis Indian Drugs, 2009
Cabotegravir-loaded polymeric micelles: a promising strategy for improved solubility and therapeutic outcomes S Vernekar, AS Patil, YA Gaude, RS Masareddy Drug Development and Industrial Pharmacy 52 (5), 977-989 , 2026 2026
Development of Bimatoprost-Loaded Nano Spanlastic In-Situ Gel for Ophthalmic Drug Delivery: A Box-Behnken Optimization Approach with In Vitro and Ex Vivo Characterization R Masareddy, P Patted, AS Patil, KR Chougule Journal of Pharmaceutical Innovation 20 (4), 130 , 2025 2025
Host Immune Modulation: A Strategy to Enhance the Efficacy of Antifungal Therapy S Bilagi, R Masareddy, AS Patil, Y Gaude IJSAT-International Journal on Science and Technology 16 (2) , 2025 2025 Citations: 1
A Review on Pathophysiology and Current Treatment Trends of Rosacea M Attimarad, R Masareddy, A Patil Journal of Pharma Insights and Research 3 (2), 185-193 , 2025 2025
Optimizing Torasemide Gastroretentive In Situ Gel: Integration Of Central Composite Design AS Patil, S Teli, AP Gadad, Y Gaude, RS Masareddy Journal of Pharmaceutical Innovation 20 (2), 54 , 2025 2025 Citations: 1
Gastroretentive microballoons of olmesartan medoxomil: formulation and in vitro-in vivo evaluation AS Patil, S Aloshi, Y Gaude, RS Masareddy Therapeutic Delivery 16 (3), 227-236 , 2025 2025 Citations: 1
Advancements in hyperpigmentation management: exploring conventional methods, phytoconstituents, novel approaches, and instrumental techniques AS Patil, AS Patil, P Ugare, E Jain, RS Masareddy Journal of Cosmetic and Laser Therapy 27 (1-2), 1-16 , 2025 2025 Citations: 2
Omega-3 fatty acids: a comprehensive scientific review of their sources, functions and health benefits PG Patted, RS Masareddy, AS Patil, RR Kanabargi, CT Bhat Future Journal of Pharmaceutical Sciences 10 (1), 94 , 2024 2024 Citations: 102
Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications RR Patil, AS Patil, K Chougule, AS Patil, P Ugare, RS Masareddy Macromolecular Symposia 413 (2), 2300153 , 2024 2024 Citations: 8
Exploring magnesium myristate for its dual functionality as a binder and lubricant in the formulation of tablet R Pockle, R Masareddy, V Bambulkar, R Desai, S Kiran Therapeutic Delivery 15 (4), 253-266 , 2024 2024 Citations: 1
Formulation and evaluation of itraconazole-loaded nanoemulgel for efficient topical delivery to treat fungal infections AS Patil, SS Chougale, U Kokatanr, S Hulyalkar, RD Hiremath, V Japti, ... Therapeutic Delivery 15 (3), 165-179 , 2024 2024 Citations: 5
Fabrication, optimization, and evaluation of transdermal patch: as an alternative and effective transdermal delivery system for nebivolol HCl AS Patil, S Birkodi, RS Masareddy, M Rajpurohit Pharmaceutical Nanotechnology 12 (1), 79-89 , 2024 2024 Citations: 4
Intranasal administration of innovative triamcinolone acetonide encapsulated cubosomal in situ gel: formulation and characterization R Patil, AS Patil, K Chougule, Y Gaude, RS Masareddy Drug Development and Industrial Pharmacy 50 (1), 68-77 , 2024 2024 Citations: 9
SOLUBILITY ENHANCEMENT OF GEMFIBROZIL USING OMEGA 3 OIL FOR A POTENTIAL ANTIHYPERLIPIDEMIC ACTIVITY PG PATTED, R MASAREDDY, R KANABARAGI, CH BHAT JOURNAL OF CURRENT PHARMA RESEARCH Учредители: Human Journals 20 (9), 25-35 , 2024 2024
In Situ Gastric Floating Gel of Atazanavir Sulphate for Sustained Release: formulation, Optimization and Evaluation R Masareddy, P Sandure, A Patil, Y Gaude, A Patil Therapeutic Delivery 14 (10), 619-633 , 2023 2023 Citations: 3
Flexibility in the Design of Nanomedicine Using Biomimetic Immunomodulatory AS Patil, RS Masareddy, PP Patil Nanovaccinology: Clinical Application of Nanostructured Materials Research … , 2023 2023 Citations: 2
Preparation of Liquid Foundation Using Magnesium Myristate P Patil, R Masareddy, V Bambulkar, R Desai, R Pockle, D Patil Journal of Cosmetic Science 74 (4), 241-254 , 2023 2023
A comprehensive review on pharmaceutical excipients RD Pockle, RS Masareddy, AS Patil, PD Patil Therapeutic delivery 14 (7), 443-458 , 2023 2023 Citations: 41
Fabrication of polyisobutene based matrix patches for transdermal delivery of atenolol AS Patil, SS Kamat, SU Birkodi, U Kokatanur, RS Masareddy, ... Research Journal of Pharmacy and Technology 16 (5), 2085-2090 , 2023 2023 Citations: 2
Current novel drug deliveries for oral cancer: A chronotherapeutic approach KP Sutar, NS Shirkoli, PS Sutar, BK Kurangi, PM Dandagi, R Masareddy Current Drug Delivery 20 (3), 237-249 , 2023 2023 Citations: 5
MOST CITED SCHOLAR PUBLICATIONS
Omega-3 fatty acids: a comprehensive scientific review of their sources, functions and health benefits PG Patted, RS Masareddy, AS Patil, RR Kanabargi, CT Bhat Future Journal of Pharmaceutical Sciences 10 (1), 94 , 2024 2024 Citations: 102
Dissofilm: a novel approach for delivery of phenobarbital; design and characterization SK Yellanki, S Jagtap, R Masareddy Journal of Young Pharmacists 3 (3), 181-188 , 2011 2011 Citations: 87
Development of mouth dissolving tablets of clozapine using two different techniques RS Masareddy, RV Kadia, FV Manvi Indian journal of pharmaceutical sciences 70 (4), 526 , 2008 2008 Citations: 64
A comprehensive review on pharmaceutical excipients RD Pockle, RS Masareddy, AS Patil, PD Patil Therapeutic delivery 14 (7), 443-458 , 2023 2023 Citations: 41
Exploring the solvent-anti-solvent method of nanosuspension for enhanced oral bioavailability of lovastatin AS Patil, R Hegde, AP Gadad, PM Dandagi, R Masareddy, U Bolmal Turkish Journal of Pharmaceutical Sciences 18 (5), 541 , 2021 2021 Citations: 40
Development of orodispersible tizanidine HCl tablets using spray dried coprocessed exipient bases R Masareddy, A Kokate, V Shah Indian journal of pharmaceutical sciences 73 (4), 392 , 2011 2011 Citations: 27
Development and evaluation of floating matrix tablets of riboflavin R Masareddy, SK Yellanki, BR Patil, FV Manvi Int J PharmTech Res 2 (2), 1439-45 , 2010 2010 Citations: 22
Preparation and evaluation of periodontal gel of ornidazole using natural polymers V Shukla, M Vasudha, V Bhardwaj, RS Masareddy, FV Manvi Der Pharmacia Lettre 2 (1), 61-69 , 2010 2010 Citations: 19
Metformin HCl loaded sodium alginate floating microspheres prepared by ionotropic gelation technique: Formulation, evaluation and optimization RS Masareddy, UB Bolmal, BR Patil, V Shah Indian Journal of Novel Drug Delivery 3 (2), 125-133 , 2011 2011 Citations: 18
Influence of β-Cyclodextrin complexation on ketoprofen release from matrix formulation V Shukla, R Masareddy, A Anghore, FV Manvi Int J Pharma Sci Drug Res 1, 195-202 , 2009 2009 Citations: 17
Microsponge gel approach to increase the stability and efficacy of avobenzone as a sun-protective agent A Patil, RS Masareddy, AS Patil, PSR Dwivedi Journal of Pharmaceutical Innovation 17 (4), 1347-1359 , 2022 2022 Citations: 12
Development and evaluation of nanosuspension incorporated in situ gel of brimonidine tartarate for ocular drug delivery V Hanagandi, AS Patil, RS Masareddy, PM Dandagi, UB Bolmal Indian J. Pharm. Educ. Res 56, 94-102 , 2022 2022 Citations: 12
Nanostructured lipid carrier: a potential system for enhanced oral bioavailability of felodipine AS Patil, V Jaknoor, AP Gadad, RS Masareddy, PM Danadagi, U Bolmal Indian Journal of Pharmaceutical Education and Research 56 (1), 77-85 , 2022 2022 Citations: 11
Formulation and evaluation of natamycin solid dispersion incorporated ophthalmic films L Bhandari, AS Patil, U Bolmal, R Masareddy, P Dandagi Indian J Pharm Educ Res 56 (4) , 2022 2022 Citations: 11
Development of budesonide oral colon specific drug delivery system using interpolymer Complexation method P Ramgonda, RS Masareddy, A Patil, U Bolmal Indian Journal of Pharmaceutical Education and Research 55 (1), 164-175 , 2021 2021 Citations: 11
Intranasal administration of innovative triamcinolone acetonide encapsulated cubosomal in situ gel: formulation and characterization R Patil, AS Patil, K Chougule, Y Gaude, RS Masareddy Drug Development and Industrial Pharmacy 50 (1), 68-77 , 2024 2024 Citations: 9
Nasal drug delivery–a review T Deshpande, R Masareddy, A Patil RGUHS J Pharm Sci 2 (1), 24-37 , 2012 2012 Citations: 9
Preparation and characterization of rabeprazole gastroretentive drug delivery system by ionotropic gelation technique RS Masareddy, SD Rananaware, BR Patil Research Journal of Pharmacy and Technology 3 (2), 526-529 , 2010 2010 Citations: 9
Formulation and evaluation of piroxicam dispersible tablets using natural disintegrants V Shukla, MS Rajashree, UB Bolmal, FV Manvi The Indian Pharmacist 6 (66), 85-88 , 2007 2007 Citations: 9
Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications RR Patil, AS Patil, K Chougule, AS Patil, P Ugare, RS Masareddy Macromolecular Symposia 413 (2), 2300153 , 2024 2024 Citations: 8
