Evaluation of Analgesic activity of Schiff base Coumarins with metal complex S. K. Nimbal, Manjunath Patil, Pradeep Ronad, Pradeep Kumar MR Research Journal of Pharmacy and Technology, 2023 Purpose: The metal complexes of schiff bases have essential task during the field of chemistry and possess diverse pharmacological activities. Coumarin containing synthesized derivatives or plant extract may show analgesic effects Objective: Evaluating the analgesic activity of schiff base coumarins with metal complex. Materials and Methods: The study was conducted using Wister rats (150-250g) in both central and peripheral screening models of analgesics such as hot plate method, tail flick method (central) and writhing test (peripheral). The rats were pre administered with different derivatives of coumarins such as copper complex of schiff base of 2,5-dimethoxybenzaldehyde (Compound I), copper complex of schiff base of 4-dimethylaminobenzaldehyde (Compound II) and copper complex of the schiff base of 3-nitrobenzaldehyde (Compound III) for 14 days orally at the dose of 200mg/kg. Body weight, food and water consumption were continuously noted in chronic model. After the fourteen days rats were subjected to different screening models of pain and noted the reaction time. Gastro intestinal (GI) histopathological study was carried out to evaluate the GI toxicity. Results: Pretreatment with the different coumarin derivatives showed analgesic effect by increasing the reaction time to pain. In hot plate method, Compound II and III exhibited significant analgesic activity compared to Compound I whereas all three compounds showed significant increase in reaction time for tail flick method. In writhing test all compounds showed significant activity by reducing the pain perception induced by acetic acid. In histopathological study all compounds showed protective effect by reducing the ulceration and congestion of gastric mucosa. Conclusion: The screening model results and histopathological data evidently substantiate the analgesic effect of schiff base coumarins with metal complex.
Analgesic and anti-inflammatory investigation of 1,2,4- triazole derivatives in rats Neelakanth M Jeedi, Sandeep Bajji, Pradeepkumar M Ronad, Shrishail K Nimbal, Santosh B Patil Journal of Medical Pharmaceutical and Allied Sciences, 2023 Pain and inflammation are the major devastating health problems commonly treated with NSAIDs. NSAIDs are regularly employed to relieve pain and inflammation. However, the 1,2,4-triazole derivatives have been scientifically evaluated for their use in relieving pain and inflammation. The current research plan is to explore the analgesic and anti-inflammatory properties of 1,2,4-triazole derivatives. 1,2,4-triazoles was tested for their anti-inflammatory properties using carrageenan and formalin-induced paw oedema, acetic acid-induced writhing investigation, while its peripheral and central analgesic actions were assessed using the hot plate method and Carrageenan induced Air Pouch model respectively. The test compounds were administrated at dose of 55 mg/Kg. The standard Diclofenac drug was administrated at dose of 10 mg/Kg for Acetic acid induced writhing investigation, Anti-inflammatory activity and 10 mg/Kg dose of pentazocine was administrated for hot plate method. Rats given with distilled water (10 mL/kg) were designated as the negative controls. Oral administration of all treatments was used. Evaluation of the analgesic and anti-inflammatory investigation showed that the second compound (5-(4-nitrophenyl)-1-phenyl-1H-1,2,4-triazole-3-(2H)–one declines the number of abdominal cramps caused by 1�etic acid and increases the time of response in hot plate method and decreased the edema induced by carrageenan, formalin also decreased volume of exudates in air pouch model. The results of the research indicate that compound 5-(4-nitrophenyl)-1-phenyl-1H-1,2,4-triazole-3-(2H)-one has shown more effective analgesic and Anti-inflammatory properties than the other two compounds.
Novel series of phenylalanine analogs endowed with promising anti-inflammatory activity: Synthesis, pharmacological evaluation, and computational insights Mahesh B. Palkar, D. M. Praveen, Pradeepkumar M. Ronad, A. H. M. Viswanathswamy, Rajesh A. Rane, Harun M. Patel, Mahamadhanif S. Shaikh, Girish A. Hampannavar, Kavita S. Jain, Rajshekhar Karpoormath Medicinal Chemistry Research, 2015 A novel series of methyl-2-(substituted benzylideneamino)-3-phenyl propionate (2a–j) derivatives have been synthesized. The title compounds (2a–j) were screened for in vivo acute anti-inflammatory and analgesic activities at a dose of 200 mg/kg b.w. Compound 2e exhibited the most promising and significant anti-inflammatory profile while compounds 2b, 2h, 2i, and 2j showed moderate to good inhibitory activity at 2nd and 4th h, respectively. These compounds were also found to have considerable analgesic activity (acetic acid-induced writhing model) and antipyretic activity (yeast-induced pyrexia model). In addition, the tested compounds were also found to possess less degree of ulcerogenic potential as compared to the standard NSAIDs. The synthesized compounds were further evaluated for their inhibitory activity against cyclooxygenase enzyme (COX-1/COX-2), by in vitro colorimetric COX (ovine) inhibitor screening assay method. The results revealed that the compounds 2b, 2e, 2h, 2i, and 2j exhibited selective and effective inhibition against COX-2. In an attempt to understand the ligand–protein interactions in terms of their binding affinity, docking studies were also performed using Molegro Virtual Docker (MVD-2013, 6.0) for the title compounds. It was observed that the binding affinities calculated were in agreement with the experimental IC50 values.Graphical Abstract
Synthesis, anti-inflammatory and analgesic activity of 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1,2,4-triazol-3-yl thio] acetic acid derivatives R.D. Hunashal, P.M. Ronad, V.S. Maddi, D. Satyanarayana, M.A. Kamadod Arabian Journal of Chemistry, 2014 The title compounds 3a–l have been synthesized by the reaction of thiocarbohydrazide with substituted phenoxy acetic acid to obtained substituted 1,2,4-triazoles (1). Compound 1 was treated with various substituted aromatic aldehydes which results in 4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-2H-1,2,4-triazol-3(4H)-thiones (2a–g), further 2a–g is converted to 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1,2,4-triazol-3-yl thio] acetic acid (3a–l) derivatives by the reaction with chloroacetic acid. All the newly synthesized compounds were evaluated for in vivo anti-inflammatory and analgesic activities. Among the series 2-[4-(2,4-dichlorobenzylideneamino)-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl thio] acetic acid (3d), 2-[4-(4-dichlorobenzylideneamino)-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl thio] acetic acid (3e), 2-[4-(2,4-dichlorobenzylideneamino)-5-[(2,4-dichlorophenoxy)methyl]-4H-1,2,4-triazol-3-yl thio] acetic acid (3j) and 2-[5-[(2,4-dichlorophenoxy)methyl)]-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazol-3-yl thio] acetic acid (3k) showed significant anti-inflammatory activity with P < 0.001 (63.4%, 62.0%, 64.1% and 62.5% edema inhibition, respectively), as compared to the standard drug diclofenac (67.0%) after third hour respectively and also compounds 3j, 3k exhibited significant analgesic activity with P < 0.001 (55.9% and 54.9% protection, respectively) and less ulcerogenic activity as compared with standard drug aspirin (57.8%).
Coumarinyl pyrazole derivatives of INH: Promising antimycobacterial agents Prashant Aragade, Mahesh Palkar, Pradeepkumar Ronad, Darbhamulla Satyanarayana Medicinal Chemistry Research, 2013 The purpose of this study was to evaluate the antimycobacterial activity of various pyrazole derivatives derived from the isoniazid pharmacophore along with coumarin scaffold. The synthesized title compounds (4a–4k) were investigated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using Resazurin MIC assay. The synthesized compounds exhibited MIC ranging from 0.625 to 2.50 μg/ml. Among the series tested, compound 3-[3-(4-fluorophenyl)-1-isonicotinoyl-1H-pyrazol-5-yl]-2H-chromen-2-one 4i was found to be the most active with MIC of 0.625 μg/ml.Graphical AbstractSynthesis, spectral studies and antimycobacterial screening of a series of 11 new 2-pyrazole derivatives containing coumarin nucleus are described.
Synthesis and evaluation of anti-inflammatory and analgesic activity of 3-[(5-substituted-1,3,4-oxadiazol-2-yl-thio)acetyl]-2H-chromen-2-ones Nista Ingale, Veeresh Maddi, Mahesh Palkar, Pradeepkumar Ronad, Shivalingrao Mamledesai, A. H. M. Vishwanathswamy, Darbhamulla Satyanarayana Medicinal Chemistry Research, 2012 A novel series of 3-[(5-substituted-1,3,4-oxadiazol-2-yl-thio)acetyl]-2H-chromen-2-one (7a–i) were synthesized by the condensation between the appropriately substituted 5-substituted-1,3,4-oxadiazolyl-2-thione (4a–i) derived from various existing NSAIDs and 3-(2-bromoacetyl)-2H-chromen-2-one (6) under reflux in the presence of sodium ethoxide. Structure of the synthesized compounds was established on the basis of physicochemical, elemental analysis, and spectral data. The title compounds were screened for in vivo acute anti-inflammatory and analgesic activities at a dose of 200 mg/kg bw. Among the series, four compounds 7c, 7e, 7f, and 7h were found to possess a significant anti-inflammatory and analgesic activity profile. In addition, these compounds were also found to possess a less degree of ulcerogenic potential as compared to standard NSAIDs.
SYNTHESIS OF METAL COMPLEXES OF COUMARIN DERIVATIVES AND EVALUATION OF THEIR PHARMACOLOGICAL ACTIVITY AGAINST LUNG CANCER. PM Ronad, AA Ankalikar, A Menasinkai, P Gouda, T Sheikh Biochemical & Cellular Archives 25 (2) , 2025 2025
EVALUATION OF THE HEPATOPROTECTIVE AND ANTIOXIDANT POTENTIAL OF MURRAYA PANICULATA METHANOLIC EXTRACT AGAINST LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS AND HEPATIC INJURY IN … AA Ankalikar, PM Ronad, AS Menasinakai, AK Singh, L Babu, R Kumar, ... Journal of Experimental Zoology India 28 (2) , 2025 2025
Effect of Hydroalcoholic Extracts of Leaves of Vitex trifolia Linn. on Chronic Inflammation and Tuberculosis. AA Ankalikar, AH Viswanathswamy, P Ronad Journal of Young Pharmacists 15 (4) , 2023 2023 Citations: 1
Evaluation of analgesic activity of schiff base coumarins with metal complex SK Nimbal, M Patil, P Ronad, MRP Kumar Research Journal of Pharmacy and Technology 16 (7), 3092-3098 , 2023 2023 Citations: 3
Analgesic and anti-inflammatory investigation of 1, 2, 4-triazole derivatives in rats NM Jeedi, S Bajji, PM Ronad, SK Nimbal, SB Patil J Med Pharm Allied Sci 12 (3), 5850-8 , 2023 2023 Citations: 5
Simultaneous detection and quantification of bronchodilators in pure form and from in-vitro drug release of a novel combinational formulation PMR Sheena M. Raj, Vilas G. Jamakandi, Sunil S. Jalalpure Journal of Applied Pharmaceutical Science 10 (8), 131-138 , 2020 2020 Citations: 5
Synthesis and pharmacological evaluation of schiff bases of 7-amino-4-methyl coumarins as novel anti-inflammatory agents PCG R. Jaya Krishna, Abhishek Pandagale, P. M. Ronad, S. S. Honnalli, Bhrigu ... Asian Journal of Pharmacy and Pharmacology 5 (4), 693-700 , 2019 2019 Citations: 9
Novel series of phenylalanine analogs endowed with promising anti-inflammatory activity: synthesis, pharmacological evaluation, and computational insights MB Palkar, DM Praveen, PM Ronad, AHM Viswanathswamy, RA Rane, ... Medicinal Chemistry Research 24 (5), 1988-2004 , 2015 2015 Citations: 8
Synthesis, anti-inflammatory and analgesic activity of 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1, 2, 4-triazol-3-yl thio] acetic acid derivatives RD Hunashal, PM Ronad, VS Maddi, D Satyanarayana, MA Kamadod Arabian Journal of Chemistry 7 (6), 1070-1078 , 2014 2014 Citations: 66
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents MB Palkar, AS Singhai, PM Ronad, AHM Vishwanathswamy, TS Boreddy, ... Bioorganic & medicinal chemistry 22 (10), 2855-2866 , 2014 2014 Citations: 89
Coumarinyl pyrazole derivatives of INH: promising antimycobacterial agents P Aragade, M Palkar, P Ronad, D Satyanarayana Medicinal Chemistry Research 22 (5), 2279-2283 , 2013 2013 Citations: 41
Synthesis and evaluation of anti-inflammatory and analgesic activity of 3-[(5-substituted-1, 3, 4-oxadiazol-2-yl-thio) acetyl]-2H-chromen-2-ones N Ingale, V Maddi, M Palkar, P Ronad, S Mamledesai, ... Medicinal Chemistry Research 21 (1), 16-26 , 2012 2012 Citations: 63
Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats AHMV Swamy, U Wangikar, BC Koti, AHM Thippeswamy, PM Ronad, ... Indian journal of pharmacology 43 (5), 507-511 , 2011 2011 Citations: 151
Indian Journal of Novel Drug Delivery PM RONAD, VS MADDI, BC KOTI, YV KURHE, A SWAMY, A SWAMY, ... Indian Journal of Novel Drug delivery 2 (4), 158-161 , 2010 2010
Synthesis and biological activities of N-(4-(substituted benzylideneamino)-3-(2, 4-dichlorophenoxymethyl)-1, 2, 4-triazole-5yl))-isonicontinyl hydrazides RH Hunashal, PP Ronad, V Maddi, S Darbhamulla, M Kamdod Int. J. Drug Des. Discov 1, 107-113 , 2010 2010 Citations: 7
Evaluation of anticonvulsant activity of novel series of benzopyran-2-one derivatives by PTZ induced seizure model in mice PM Ronad, VS Maddi, BC Koti, YV Kurhe, A Swamy, A Swamy, MS Jaji Indian J Novel Drug Delivery 2 (4), 158-61 , 2010 2010 Citations: 10
Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives PM Ronad, MN Noolvi, S Sapkal, S Dharbhamulla, VS Maddi European journal of medicinal chemistry 45 (1), 85-89 , 2010 2010 Citations: 159
Synthesis and antimycobacterial activity of a novel series of isonicotinylhydrazide derivatives S Jaju, M Palkar, V Maddi, P Ronad, S Mamledesai, D Satyanarayana, ... Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal … , 2009 2009 Citations: 58
Synthesis and Antibacterial Activity of a New Series of 3‐[3‐(Substituted Phenyl)‐1‐Isonicotinoyl‐1 H ‐Pyrazol‐5‐yl]‐2 H ‐Chromen‐2‐one Derivatives P Aragade, V Maddi, S Khode, M Palkar, P Ronad, S Mamledesai, ... Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal … , 2009 2009 Citations: 36
Synthesis and pharmacological evaluation of a novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents S Khode, V Maddi, P Aragade, M Palkar, PK Ronad, S Mamledesai, ... European journal of medicinal chemistry 44 (4), 1682-1688 , 2009 2009 Citations: 262
MOST CITED SCHOLAR PUBLICATIONS
Synthesis and pharmacological evaluation of a novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents S Khode, V Maddi, P Aragade, M Palkar, PK Ronad, S Mamledesai, ... European journal of medicinal chemistry 44 (4), 1682-1688 , 2009 2009 Citations: 262
Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives PM Ronad, MN Noolvi, S Sapkal, S Dharbhamulla, VS Maddi European journal of medicinal chemistry 45 (1), 85-89 , 2010 2010 Citations: 159
Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats AHMV Swamy, U Wangikar, BC Koti, AHM Thippeswamy, PM Ronad, ... Indian journal of pharmacology 43 (5), 507-511 , 2011 2011 Citations: 151
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents MB Palkar, AS Singhai, PM Ronad, AHM Vishwanathswamy, TS Boreddy, ... Bioorganic & medicinal chemistry 22 (10), 2855-2866 , 2014 2014 Citations: 89
Synthesis, anti-inflammatory and analgesic activity of 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1, 2, 4-triazol-3-yl thio] acetic acid derivatives RD Hunashal, PM Ronad, VS Maddi, D Satyanarayana, MA Kamadod Arabian Journal of Chemistry 7 (6), 1070-1078 , 2014 2014 Citations: 66
Synthesis and evaluation of anti-inflammatory and analgesic activity of 3-[(5-substituted-1, 3, 4-oxadiazol-2-yl-thio) acetyl]-2H-chromen-2-ones N Ingale, V Maddi, M Palkar, P Ronad, S Mamledesai, ... Medicinal Chemistry Research 21 (1), 16-26 , 2012 2012 Citations: 63
Synthesis and antimycobacterial activity of a novel series of isonicotinylhydrazide derivatives S Jaju, M Palkar, V Maddi, P Ronad, S Mamledesai, D Satyanarayana, ... Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal … , 2009 2009 Citations: 58
Synthesis of Novel Substituted 7‐(Benzylideneamino)‐4‐Methyl‐2 H ‐Chromen‐2‐one Derivatives as Anti‐inflammatory and Analgesic Agents P Ronad, S Dharbamalla, R Hunshal, V Maddi Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal … , 2008 2008 Citations: 52
Coumarinyl pyrazole derivatives of INH: promising antimycobacterial agents P Aragade, M Palkar, P Ronad, D Satyanarayana Medicinal Chemistry Research 22 (5), 2279-2283 , 2013 2013 Citations: 41
Synthesis and Antibacterial Activity of a New Series of 3‐[3‐(Substituted Phenyl)‐1‐Isonicotinoyl‐1 H ‐Pyrazol‐5‐yl]‐2 H ‐Chromen‐2‐one Derivatives P Aragade, V Maddi, S Khode, M Palkar, P Ronad, S Mamledesai, ... Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal … , 2009 2009 Citations: 36
Synthesis and Evaluation of Antiinflammatory and Analgesic Activities of a Novel Series of Substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides PM Ronad, RD Hunashal, S Darbhamalla, VS Maddi Arzneimittelforschung 58 (12), 641-646 , 2008 2008 Citations: 18
Evaluation of anticonvulsant activity of novel series of benzopyran-2-one derivatives by PTZ induced seizure model in mice PM Ronad, VS Maddi, BC Koti, YV Kurhe, A Swamy, A Swamy, MS Jaji Indian J Novel Drug Delivery 2 (4), 158-61 , 2010 2010 Citations: 10
Synthesis and pharmacological evaluation of schiff bases of 7-amino-4-methyl coumarins as novel anti-inflammatory agents PCG R. Jaya Krishna, Abhishek Pandagale, P. M. Ronad, S. S. Honnalli, Bhrigu ... Asian Journal of Pharmacy and Pharmacology 5 (4), 693-700 , 2019 2019 Citations: 9
Novel series of phenylalanine analogs endowed with promising anti-inflammatory activity: synthesis, pharmacological evaluation, and computational insights MB Palkar, DM Praveen, PM Ronad, AHM Viswanathswamy, RA Rane, ... Medicinal Chemistry Research 24 (5), 1988-2004 , 2015 2015 Citations: 8
Synthesis and biological activities of N-(4-(substituted benzylideneamino)-3-(2, 4-dichlorophenoxymethyl)-1, 2, 4-triazole-5yl))-isonicontinyl hydrazides RH Hunashal, PP Ronad, V Maddi, S Darbhamulla, M Kamdod Int. J. Drug Des. Discov 1, 107-113 , 2010 2010 Citations: 7
Physico-chemical and pharmacological characteristics of minor seed oils. KR Alagawadi, PM Ronad, RD Hunshal, TM Shah, AK Ashif 2000 Citations: 6
Analgesic and anti-inflammatory investigation of 1, 2, 4-triazole derivatives in rats NM Jeedi, S Bajji, PM Ronad, SK Nimbal, SB Patil J Med Pharm Allied Sci 12 (3), 5850-8 , 2023 2023 Citations: 5
Simultaneous detection and quantification of bronchodilators in pure form and from in-vitro drug release of a novel combinational formulation PMR Sheena M. Raj, Vilas G. Jamakandi, Sunil S. Jalalpure Journal of Applied Pharmaceutical Science 10 (8), 131-138 , 2020 2020 Citations: 5
Synthesis and antimicrobial activity of some 2, 5-disubstituted 1, 3, 4-oxadiazoles SS Honnalli, PM Ronad, K Vijaybhasker, VI Hukkeri, R Kumar Heterocyclic Communications 11 (6), 505 , 2005 2005 Citations: 5
Evaluation of analgesic activity of schiff base coumarins with metal complex SK Nimbal, M Patil, P Ronad, MRP Kumar Research Journal of Pharmacy and Technology 16 (7), 3092-3098 , 2023 2023 Citations: 3