C. Janani

Gender : Female
Marital status : Married
Date of Birth : 23.08.1987
Languages Known : English, Tamil
Nationality : Indian
Religion : Hindu, Kantharvakottai Kallar

EDUCATION

M.Sc., Ph.D. Biotechnology

RESEARCH, TEACHING, or OTHER INTERESTS

Biotechnology, Plant Science, Agricultural and Biological Sciences, Biochemistry, Genetics and Molecular Biology

Scopus Publications

Piperine’s potential in treating polycystic ovarian syndrome explored through in-silico docking
Rahul Francis, Ramanathan Kalyanaraman, Vasuki Boominathan, Sudharsan Parthasarathy, Ashajyothi Chavaan, Irfan Aamer Ansari, Siddique Akber Ansari, Hamad M Alkahtani, Janani Chandran, Siva Vijayakumar Tharumasivam
Scientific Reports, 2024
Polycystic Ovarian Syndrome (PCOS) is a multifaceted metabolic and hormonal condition that impacts women in their procreative ages, identified by ovarian dysfunction, hyperandrogenaemia overweight and insulin insensitivity. The piperine, an important alkaloid compound of black pepper has shown promise in modulating various physiological processes. In this work, employed computational docking studies to explore the potential of piperine as a treatment for PCOS. Utilizing computational methods, we analyzed the binding interactions between piperine and key molecular targets implicated in PCOS pathogenesis, including hyperandrogenism, and “oligomenorrhea. The network pharmacology analysis report found 988 PCOS-related genes, 108 hyperandrogenism-related genes, and 377 oligomenorrhea-related genes, and we finally shortlisted 5 common genes in PCOS, hyperandrogenism, and “oligomenorrhea”: NR3C1, PPARG, FOS, CYP17A1, and H6PD. Our results reveal favorable binding affinities with PPARG (-8.34 Kcal/mol) and H6PD (-8.70 Kcal/mol) and interaction patterns, suggesting the potential of piperine to modulate these targets. Moreover, the reliability of the piperine-target interactions was revealed by molecular simulations studies. These findings support further experimental investigations to validate the therapeutic efficacy of piperine in PCOS management. The integration of computational approaches with experimental studies has the potential to lay the groundwork for the creation of new therapies specifically targeting PCOS and related endocrine disorders.
Photocatalytic Degradation of Textile Dye Using Green Synthesized Nanoparticles
Adaikalasamy Joicy, Ramasamy Selvamani, Chandran Janani, C P Balasubramanian, K. Prabhu, et al.
Letters in Applied Nanobioscience, 2023
In recent years, plants have been used as reducing agents for the synthesis of nanoparticles in a short time, and it consists of low cost, and there is no harmful effect on the environment; In this study, silver nanoparticles are synthesized from AgNO3 using leaf extract of Solena amplexicaulis (Lam.) Gandhi. The leaf extract is mixed with AgNO3 solution, and color change occurs from whitish-yellow to dark brown at room temperature within a few minutes. After incubation, the suspension was centrifuged, and particles were separated and dried. The green synthesized AgNPs were characterized by UV-visible spectroscopy in a maximum wavelength of 393 nm, FTIR, SEM, EDAX, DLS, XRD, and ZETA POTENTIAL; Photocatalytic degradation of Victoria blue or basic blue dye was investigated by green synthesized Ag nanoparticles with solar irradiation technique by biometrically at different time intervals. The UV-visible characteristic peak absorption of Victoria blue solution was 250 nm. The photocatalytic activity at different time intervals [control, treated controls, 30 min, (1, 2, 3, 5, 8, 12, 24, 48, 60, 72) hrs] was collected and decreased the peak intensity and was measured using UV-visible spectroscopy and Fourier Transform Infrared Spectroscopy. Green synthesized Ag nanoparticles effectively degraded the Victoria blue dye solution in total exposure time.
Environmental and biomedical applications in the synthesis and structural, optical, elemental characterizations of Mg doped ZnO nanoparticles using Coleus aromaticus leaf extract
S. M. Fathima Khyrun, Z. Mohamed Riyas, Vaishnavi Raja, Sulthana Sabura Sarbudeen, Vinothini Natesan, K. Velsankar, S. Sudhahar, M.Ramesh Prabhu, Mydhili Govindarasu, Muthu Thiruvengadam, Baskar Venkidasamy, Chandran Janani, Thevasundari Selvaraj
South African Journal of Botany, 2022
Green nanotechnology is critical in the development of novel and successful treatment techniques for wide range of diseases. Biological production of metal nanoparticles has traditionally been recognized as an effective replacement to current chemical methodologies. The green production of Magnesium doped Zinc oxide nanoparticles (Mg-ZnO NPs) was produced using Coleus aromaticus leaves extract. The crystalline structure was observed in the X-ray diffraction pattern, with an approximate crystalline size of 30nm. The metal oxygen bonding in the prepared sample is clearly visible in the FTIR spectrum. The UV-Visible analysis confirms the SPR band at 371nm and the band gap energy is found to be 3.38 eV. The particle size analyzer (DLS) reveals the Mg-ZnO NPs size range between 40-60 nm. The photoluminescence spectrum represented emission peak in the visible region (627 nm). FESEM images portrayed hexagonal and spherical shaped Mg-ZnO NPs. The existence of Mg, Zn, and O revealed the formation of homogeneous Mg-ZnO NPs in the EDAX spectrum and tracing. The antimicrobial assay depicted good toxicity against bacterial and fungal strains. The antioxidant assay expressed potential free radical scavenging compared to the standard ascorbic acid. High anti-diabetic behavior was achieved in anti-diabetic α–glucosidase inhibition assay. Our results revealed that Mg-ZnO NPs produced from C. aromaticus leaf extract might be a safe and efficacious resource of UV protective, anti‒bacterial, and anti‒diabetic compounds.
Impact of Piper betle L. bioactive compounds in larvicidal activity against Culex quinquefasciatus
K. Prabhu, P. Sudharsan, P. Ganesh Kumar, B. Chitra, C. Janani
Journal of Natural Pesticide Research, 2022
Mosquitoes are the powerful vectors causing various lethal diseases across the world. Everyone is expecting an alternative better product to the existing mosquito repellent technologies. Herbal mediated vector control is expanding its wide range due to nontoxic and ecofriendly nature. Bioactive compounds present in the plants plays its effective role against mosquitoes. Piper betle L. is an indigenous plant of India found to have potential presence of various bioactive compounds for various biological activities such as alpha-cubebene, 4,7- methanoazulene, Cyclohexane, Benzene, Caryophyllene, 1H-Cyclopropa(a)naphthalene, 2H- 2,4a-Methanonaphthalene, alpha-caryophyllene, 1H-Cycloprop(e) azulene, 1,6-Cyclodecadiene were confirmed by GC MS analysis. The aqueous and ethanolic extract of P. betle L. showed highest antibacterial activity against E. coli, Staphylococcus aureus, Pseudomonous and Klebsiella. In the larvicidal study, the ethanolic extract of P. betle L. showed 100% of mortality compared to aqueous extract against Culex quinquefasciatus. Utilisation of the P. betle L. ethanolic extract in the mosquito will help to reduce the mosquito population.
Construction and transformation of peroxisome proliferator activated receptor gamma (RnPPARγ) gene using Agrobacterium tumefaciens into Glycine max L. Merr.
C. Janani, B. Sundararajan, B.D. Ranjitha Kumari
Gene Reports, 2019
The PPARγ gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) nuclear receptors subfamily which forms heterodimers with retinoid X receptors (RXRs) and they regulate transcription of various genes. In the present study, the binary vector of pBI121 was constructed with RnPPARγ gene (1428 bp) of Rattus norvegicus under CaMV35s promoter and also kanamycin resistance gene available for selecting the transforms. Transformation of soybean was conducted for half seed explants of JS335 variety using strain EHA105 harboring pBI121- RnPPARγ. Transformation conditions were standardized for soybean, and the results demonstrate that L-Cysteine (1 mM) has improved the regeneration of transformants. The combination of TDZ (10 μM) and L-Cysteine (1 mM) induced a maximum of 80% shooting, whereas IBA (15 μM) and L-Cysteine (1 mM) combination induced a maximum of 83% rooting frequency. PCR and Southern Blotting techniques confirmed the transgene integration. These study findings suggest that L-Cysteine (1 mM) involvement increased the transfer of T-DNA during transformation and the gene delivered under the suitable condition for regeneration and also enhanced the transformation efficiency in soybean through direct (1.6%), indirect (1.2%) and in planta (2.0%) method of transformation.
PPAR gamma gene - A review
C. Janani, B.D. Ranjitha Kumari
Diabetes and Metabolic Syndrome Clinical Research and Reviews, 2015
Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes. There have been described three PPAR isotypes α, δ and γ which have an integrated role in controlling the expression of genes playing key roles in the storage and mobilization of lipids, in glucose metabolism, in morphogenesis and inflammatory response. Recent advances include the discovery of novel genes that are regulated by PPARγ, which helps to explain how activation of this adipocyte predominant transcription factor regulates glucose and lipid homeostasis. Increased levels of circulating free fatty acids and lipid accumulation in non-adipose tissue have been implicated in the development of insulin resistance. This situation is improved by PPARγ ligands, which promotes fatty acid storage in fat deposits and regulates the expression of adipocyte-secreted hormones that impacts on glucose homeostasis. So the net result of the pleiotropic effects of PPARγ ligands is improvement of insulin sensitivity. This review highlights the roles that PPAR gamma play in the regulation of gene expression of multiple diseases including obesity, diabetes and cancer and highlights the gene isolation transformation role. Further studies are needed for the transformation of PPAR gamma gene in plants and evaluate in animals for the treatment of type 2 diabetes.

RECENT SCHOLAR PUBLICATIONS

Unlocking nature’s secrets: a review on the pharmacokinetics of plant-based medicines and herbal remedies
S Parthasarathy, SH Aly, SV Tharumasivam, B Giridharan, J Chandran, ...
Natural product research, 1-25 , 2025
2025
Citations: 27
In silico Investigations of Al2O3 and NiO Nanoparticles Interactions with Antioxidant Enzymes of Fresh Water Fish O. mossambicus
SVT Vasuki Boominathan, Ramanathan Kalyanaraman, Rahul Francis, Janani Chandran
UTTAR PRADESH JOURNAL OF ZOOLOGY 45 (18), 525-536 , 2024
2024
Citations: 2
EXPLORING POTENTIAL ANTIAGING COMPOUNDS FROM MEDICINAL PLANTS AND BINDING AFFINITY OF RESVERATROL FROM VITIS VINIFERA WITH hTERT GENE.
R Kalyanaraman, V Boominathan, R Francis, J Chandran, ...
Biochemical & Cellular Archives 24 (1) , 2024
2024
Citations: 14
TOXICITY ASSESSMENT ON HAEMATOLOGY AND ENZYMOLOGICAL ALTERATIONS OF AL 2 O 3 NANOPARTICLES EXPOSED FRESHWATER FISH …
V Boominathan, R Kalyanaraman, R Francis, J Chandran, ...
Biochemical & Cellular Archives 24 (1) , 2024
2024
COMPUTATIONAL ANALYSIS OF THERAPEUTIC POTENTIAL AND ANTI-ALZHEIMER'S EFFICACY OF MYRISTICIN FROM NUTMEG (MYRISTICA FRAGRANS).
S Thamaraiselvan, SR Arockiaraj, JM Jeyaseelan, JVR Antony Samy, ...
Biochemical & Cellular Archives 24 (1) , 2024
2024
Citations: 1
In vivo Molecular Functional Aging and Gradual Senescence with hTERT Gene as Antiaging Interventions in Danio rerio
SVT R Kalyanaraman, V Boominathan, R Francis, S Parthasarathy, J Chandran
Uttar Pradesh Journal Of Zoology 45 (18), 371-389 , 2024
2024
Citations: 11
Piperine’s potential in treating polycystic ovarian syndrome explored through in-silico docking
R Francis, R Kalyanaraman, V Boominathan, S Parthasarathy, A Chavaan, ...
Scientific Reports 14, 21834 , 2024
2024
Citations: 40
PPAR gamma Agonists–Plant Compounds
AK Moola, G Shobana, C Janani
Journal of Stress Physiology & Biochemistry 19 (4), 163-177 , 2023
2023
Citations: 2
Environmental and biomedical applications in the synthesis and structural, optical, elemental characterizations of Mg doped ZnO nanoparticles using Coleus aromaticus leaf extract
SMF Khyrun, ZM Riyas, V Raja, SS Sarbudeen, V Natesan, K Velsankar, ...
South African Journal of Botany 151, 290-300 , 2022
2022
Citations: 17
马齿苋叶提取物对致倦库蚊和斯氏按蚊幼虫组织结构的影响
P Sudharsan, D Siva, K Prabhu, C Janani
浙江中医药大学 , 2022
2022
Impact of Piper betle L. bioactive compounds in larvicidal activity against Culex quinquefasciatus
K Prabhu, P Sudharsan, PG Kumar, B Chitra, C Janani
Journal of natural pesticide research 2, 100013 , 2022
2022
Citations: 23
Photocatalytic degradation of textile dye using green synthesized nanoparticles
AA Joicy, R Selvamani, C Janani, C Balasubramanian, K Prabhu, ...
Lett. Appl. NanoBioScience 12, 102 , 2022
2022
Citations: 11
The influence of Portulaca oleracea L. leaves extracts on the histoarchitecture of Culex quinquefasciatus and Anopheles stephensi larvae
P Sudharsan, D Siva, K Prabhu, C Janani
Clinical Complementary Medicine and Pharmacology 2 (3), 100053 , 2022
2022
Citations: 11
Effect of Salinity and Alleviating Role of Gibberellic Acid (GA3) for Improving the Morphological and Biochemical Aspects of Vigna radiata L.
C Janani, B Sundararajan, BD Nagamala and Ranjitha Kumari
The Journal of Plant Science Research 38 (1), 315–325 , 2022
2022
Citations: 1
Larvicidal Activity of Aqueous Extract of Solanum trilobatum L. Leaves and Stem against Aedes aegypti
DS P Dhossaradhan, C Janani
Indian Journal of Natural Sciences (IJONS) 12 (65), 29598 - 29603 , 2021
2021
Citations: 4
Assessment of Histoarchitecture Antioxidant and Anti-Cholinesterase Activity of Methanolic Extract from Nigella Sativa Linn.
S Sudha, C Janani, B Chitra, SA Nisha
2021
Citations: 2
Antidiabetic activity of methanolic leaves extract of transformed soybean plantlets in streptozotocin (STZ) induced diabetic rats
C Janani, B Sundararajan, AK Moola, BDR Kumari
Journal of Stress Physiology & Biochemistry 17 (2), 66-78 , 2021
2021
Citations: 5
Construction and transformation of peroxisome proliferator activated receptor gamma (RnPPARγ) gene using Agrobacterium tumefaciens into Glycine max L. Merr.
C Janani, B Sundararajan, BDR Kumari
Gene Reports 16, 100427 , 2019
2019
Citations: 3
Enumeration of Sodium Chloride Illness on Regeneration by Ethyl Methane Sulphonate (EMS) Treatment in Arabidopsis thaliana (L.).
C Janani, BD Ranjitha Kumari
Journal of Information and Computational Science 9 (11), 1364-1372 , 2019
2019
Antidiabetic activity of methanolic leaves extracts of transformed soybean in 3T3-L1 preadipocytes cell line
C Janani, BDR Kumari
Int J Pharm Sci Res 1 (8), 11 , 2017
2017
Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

PPAR gamma gene–a review
C Janani, BDR Kumari
Diabetes & Metabolic Syndrome: Clinical Research & Reviews 9 (1), 46-50 , 2015
2015.0
Citations: 934
Piperine’s potential in treating polycystic ovarian syndrome explored through in-silico docking
R Francis, R Kalyanaraman, V Boominathan, S Parthasarathy, A Chavaan, ...
Scientific Reports 14, 21834 , 2024
2024.0
Citations: 40
Unlocking nature’s secrets: a review on the pharmacokinetics of plant-based medicines and herbal remedies
S Parthasarathy, SH Aly, SV Tharumasivam, B Giridharan, J Chandran, ...
Natural product research, 1-25 , 2025
2025.0
Citations: 27
Impact of Piper betle L. bioactive compounds in larvicidal activity against Culex quinquefasciatus
K Prabhu, P Sudharsan, PG Kumar, B Chitra, C Janani
Journal of natural pesticide research 2, 100013 , 2022
2022.0
Citations: 23
Environmental and biomedical applications in the synthesis and structural, optical, elemental characterizations of Mg doped ZnO nanoparticles using Coleus aromaticus leaf extract
SMF Khyrun, ZM Riyas, V Raja, SS Sarbudeen, V Natesan, K Velsankar, ...
South African Journal of Botany 151, 290-300 , 2022
2022.0
Citations: 17
EXPLORING POTENTIAL ANTIAGING COMPOUNDS FROM MEDICINAL PLANTS AND BINDING AFFINITY OF RESVERATROL FROM VITIS VINIFERA WITH hTERT GENE.
R Kalyanaraman, V Boominathan, R Francis, J Chandran, ...
Biochemical & Cellular Archives 24 (1) , 2024
2024.0
Citations: 14
In vivo Molecular Functional Aging and Gradual Senescence with hTERT Gene as Antiaging Interventions in Danio rerio
SVT R Kalyanaraman, V Boominathan, R Francis, S Parthasarathy, J Chandran
Uttar Pradesh Journal Of Zoology 45 (18), 371-389 , 2024
2024.0
Citations: 11
Photocatalytic degradation of textile dye using green synthesized nanoparticles
AA Joicy, R Selvamani, C Janani, C Balasubramanian, K Prabhu, ...
Lett. Appl. NanoBioScience 12, 102 , 2022
2022.0
Citations: 11
The influence of Portulaca oleracea L. leaves extracts on the histoarchitecture of Culex quinquefasciatus and Anopheles stephensi larvae
P Sudharsan, D Siva, K Prabhu, C Janani
Clinical Complementary Medicine and Pharmacology 2 (3), 100053 , 2022
2022.0
Citations: 11
In vitro culture and Agrobacterium-mediated transformation in high altitude tomato (Lycopersicon esculentum Mill.) cultivar Shalimar
C Janani, S Girija, BD Ranjitha Kumari
Int. J. Pharm. Teach. Pract 4, 483-488 , 2013
2013.0
Citations: 7
Antidiabetic activity of methanolic leaves extract of transformed soybean plantlets in streptozotocin (STZ) induced diabetic rats
C Janani, B Sundararajan, AK Moola, BDR Kumari
Journal of Stress Physiology & Biochemistry 17 (2), 66-78 , 2021
2021.0
Citations: 5
In vitro plant regeneration from cotyledonary node and half seed explants of Glycine max L. (JS335)
RKBD Janani C
Annals of Biological Research 4 (11), 60-66 , 2013
2013.0
Citations: 5
Larvicidal Activity of Aqueous Extract of Solanum trilobatum L. Leaves and Stem against Aedes aegypti
DS P Dhossaradhan, C Janani
Indian Journal of Natural Sciences (IJONS) 12 (65), 29598 - 29603 , 2021
2021.0
Citations: 4
Construction and transformation of peroxisome proliferator activated receptor gamma (RnPPARγ) gene using Agrobacterium tumefaciens into Glycine max L. Merr.
C Janani, B Sundararajan, BDR Kumari
Gene Reports 16, 100427 , 2019
2019.0
Citations: 3
In silico Investigations of Al2O3 and NiO Nanoparticles Interactions with Antioxidant Enzymes of Fresh Water Fish O. mossambicus
SVT Vasuki Boominathan, Ramanathan Kalyanaraman, Rahul Francis, Janani Chandran
UTTAR PRADESH JOURNAL OF ZOOLOGY 45 (18), 525-536 , 2024
2024.0
Citations: 2
PPAR gamma Agonists–Plant Compounds
AK Moola, G Shobana, C Janani
Journal of Stress Physiology & Biochemistry 19 (4), 163-177 , 2023
2023.0
Citations: 2
Assessment of Histoarchitecture Antioxidant and Anti-Cholinesterase Activity of Methanolic Extract from Nigella Sativa Linn.
S Sudha, C Janani, B Chitra, SA Nisha
2021.0
Citations: 2
Antidiabetic activity of methanolic leaves extracts of transformed soybean in 3T3-L1 preadipocytes cell line
C Janani, BDR Kumari
Int J Pharm Sci Res 1 (8), 11 , 2017
2017.0
Citations: 2
In vitro Regeneration and Biohardening of Soybean (JS335) Variety
C Janani, BDR Kumari
International Journal of Science and Research 5 (5), 1653 - 1656 , 2016
2016.0
Citations: 2
Evaluation of Phytochemical Compounds, In-vitro Antioxidant Properties, and Toxicity of Essential Oil from Myristica fragrans Houtt (Nutmeg) Using Danio rerio (Zebrafish)
S Thamaraiselvan, JM Jeyaseelan, JVRA Samy, R Govindhan, ...
UTTAR PRADESH JOURNAL OF ZOOLOGY 44 (23), 155-169 , 0
Citations: 2

Publications

• Janani C, Girija S. and Ranjitha Kumari B. D. In vitro Culture and Agrobacterium Mediated Transformation in High Altitude Tomato (Lycopersicon esculentum Mill.) Cultivar Shalimar. International Journal of Pharmacy Teaching & Practices, 2013, 4, 1, 483-488. (Citations 6).
• Janani C and Ranjitha Kumari B.D. In vitro plant regeneration from cotyledonary node and half seed explants of Glycine max L. (JS335). Annals of Biological Research. 2013, 4 (11). 60-66. (Citations 5).
• Janani C and Ranjitha Kumari B.D. PPAR Gamma Gene - A Review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2015. 46–50. (Citations 588).
• Janani C and Ranjitha Kumari B.D. In vitro Regeneration and Biohardening of Soybean (JS335) Variety. International Journal of Science and Research. 2016. 5:5, 1653-1656.
• Janani C., Ranjitha Kumari B.D. Antidiabetic Activity of Methanolic Leaves Extracts of Transformed Soybean in 3T3-L1 Pre-Adipocytes Cell Line. International Journal of Pharmaceutical Sciences and Research. 2017. 8(11): 4732-4744. (Citation 1)
• Janani C., Sundararajan B., Ranjitha Kumari B.D. Construction and transformation of peroxisome proliferator activated receptor gamma (RnPPARγ) gene using Agrobacterium tumefaciens into Glycine max L. Merr. Gene Reports. 2019. 100427.
• Janani C., and Ranjitha Kumari B.D. Enumeration of Sodium Chloride Illness on Regeneration by Ethyl Methane Sulphonate (EMS) T