Alessia Filippone
@unime.it
University of Messina
Scopus Publications
- Impact of Spheroid Use for Identifying Hepatocellular Carcinoma Features: Involvement of Kinase-Mediated Molecular Pathways
Nicoletta Palermo, Giuseppe Pantò, Antonio Catalfamo, Alessia Filippone, Emanuela Esposito
Frontiers in Bioscience Landmark, 2026
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, owing to its molecular complexity and limited therapeutic options. Three-dimensional (3D) in vitro models more accurately recapitulate in vivo conditions than traditional two-dimensional (2D) models, due to their ability to accurately reproduce the tumor microenvironment (TME). Among these models, HepG2 cell-derived spheroids have become an important tool for drug screening, toxicity assessment, and liver cancer research. This review highlights the advantages and limitations of currently available 3D culture systems. In particular, special attention is given to the multifaceted role of leucine-rich repeat kinase 2 (LRRK2), a gene traditionally associated with neurological disorders but increasingly implicated in cancer, a kinase, which emerges as a promising therapeutic target in HCC since it regulates oxidative stress, lipid metabolism, and treatment responses, all of which contribute to tumor progression. Finally, we explore future directions, including organ-on-chip technologies and co-culture systems, which hold considerable promise for improving precision medicine and translational research in HCC. - Pharmacological Inhibition of EZH2 by GSK-343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury
Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici, Bulzomì Maria, Ahmed Hasan, Antonio Catalfamo, Jia Yang, Marika Lanza, Alessia Filippone
Journal of Neuroscience Research, 2026
Spinal cord injury (SCI) is a devastating condition with limited therapeutic options and a strong neuroinflammatory component that exacerbates tissue damage and impairs functional recovery. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and core component of the Polycomb Repressive Complex 2 (PRC2), has emerged as a key regulator of epigenetic modifications involved in neuroinflammation. In this study, we investigated the potential neuroprotective effects of GSK‐343, a selective EZH2 inhibitor, in a murine model of SCI induced by extradural compression. Female adult CD1 mice received intraperitoneal injections of GSK‐343 (1, 5, or 10 mg/kg) at 1‐ and 6‐h post‐injury. After 24 h, spinal cord tissues were collected and analyzed. GSK‐343 treatment significantly reduced histological damage, neuronal demyelination, and the expression of pro‐inflammatory markers, likely through modulation of the TRAF6/NF‐κB signaling pathway. Moreover, EZH2 inhibition attenuated innate immune responses, as evidenced by the reduction in mast cell infiltration, microglial activation, and MCP‐1 levels. These findings support the therapeutic potential of EZH2 inhibition as a novel epigenetic strategy to counteract neuroinflammation and promote early neuroprotection following SCI. - A Topical Combination of Xyloglucan and Pea Protein Effectively Manages Oral Ulcers In Vivo
Alessia Filippone, Giovanna Casili, Marika Lanza, Michela Campolo, Irene Paterniti, Laura Cucinotta, Rossella Basilotta, Alessio Ardizzone, Emanuela Esposito
Journal of Oral Pathology and Medicine, 2025
BackgroundAphthous stomatitis (AS) is a common idiopathic condition that affects approximately 5% to 25% of the general population. AS is characterized by recurrent painful aphthous ulcers on non‐keratinized oral mucous membranes. Lifestyle modifications and topical treatments are often used to manage symptoms, but no definitive cure exists. This study aims to evaluate the ability of a topical gel containing xyloglucan and pea protein (TXP), two mucoprotective substances, to restore the integrity of oral epithelial cells and manage inflammation associated with AS.MethodsIn this study, oral ulcers were induced in rats by applying a phenol solution for 60 s to the mucosa of the left cheek. Following the formation of the lesion (24 h later) topical treatment with TXP was carried out for 2, 4, and 5 days. The healing properties of TXP were assessed by histopathological examination of the oral mucosa through the evaluation of morphological criteria such as hyperemia, edema, and presence of neutrophilic infiltration and by measuring the expression levels of inflammatory markers such as TNF‐α and IL‐2.ResultsResults demonstrated that TXP was able to effectively treat oral ulcers by reducing the degree of hyperemia and edema in cheek tissue already at day 4. Moreover, TXP significantly decreased the levels of IL‐2 and TNF‐α after 4 days of gel application.ConclusionsThis study demonstrates that TXP possesses a significant ulcer repairing ability in vivo, as it effectively restores the integrity of oral mucosal tissue, thus helping to reduce inflammation. - Casein Kinase 2 Inhibitor, CX-4945, Induces Apoptosis and Restores Blood-Brain Barrier Homeostasis in In Vitro and In Vivo Models of Glioblastoma
Valentina Bova, Deborah Mannino, Ayomide E. Salako, Emanuela Esposito, Alessia Filippone, Sarah A. Scuderi
Cancers, 2024
Background: In oncology, casein kinase 2 (CK2), a serine/threonine kinase, has a dual action, regulating cellular processes and acting as an oncogenic promoter. Methods: This study examined the effect of CX-4945, a selective CK2 inhibitor, in a human U-87 glioblastoma (GBM) cell line, treated with CX-4945 (5, 10, and 15 μM) for 24 h. Similarly, the hCMEC/D3 cell line was used to mimic the blood–brain barrier (BBB), examining the ability of CX-4945 to restore BBB homeostasis, after stimulation with lipopolysaccharide (LPS) and then treated with CX-4945 (5, 10, and 15 μM). Results: We reported that CX-4945 reduced the proliferative activity and modulated the main pathways involved in tumor progression including apoptosis. Furthermore, in confirmation of the in vitro study, performing a xenograft model, we demonstrated that CX-4945 exerted promising antiproliferative effects, also restoring the tight junctions’ expression. Conclusions: These new insights into the molecular signaling of CK2 in GBM and BBB demonstrate that CX-4945 could be a promising approach for future GBM therapy, not only in the tumor microenvironment but also at the BBB level. - CK and LRRK2 Involvement in Neurodegenerative Diseases
Valentina Bova, Deborah Mannino, Anna Paola Capra, Marika Lanza, Nicoletta Palermo, Alessia Filippone, Emanuela Esposito
International Journal of Molecular Sciences, 2024
Neurodegenerative diseases (NDDs) are currently the most widespread neuronal pathologies in the world. Among these, the most widespread are Alzheimer’s disease (AD), dementia, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD)—all characterized by a progressive loss of neurons in specific regions of the brain leading to varied clinical symptoms. At the basis of neurodegenerative diseases, an emerging role is played by genetic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene that cause increased LRRK2 activity with consequent alteration of neuronal autophagy pathways. LRRK2 kinase activity requires GTPase activity which functions independently of kinase activity and is required for neurotoxicity and to potentiate neuronal death. Important in the neurodegeneration process is the upregulation of casein kinase (CK), which causes the alteration of the AMPK pathway by enhancing the phosphorylation of α-synuclein and huntingtin proteins, known to be involved in PD and HD, and increasing the accumulation of the amyloid-β protein (Aβ) for AD. Recent research has identified CK of the kinases upstream of LRRK2 as a regulator of the stability of the LRRK2 protein. Based on this evidence, this review aims to understand the direct involvement of individual kinases in NDDs and how their crosstalk may impact the pathogenesis and early onset of neurodegenerative diseases. - Rebalance of mitophagy by inhibiting LRRK2 improves colon alterations in an MPTP in vivo model
Alessia Filippone, Deborah Mannino, Laura Cucinotta, Fabrizio Calapai, Lelio Crupi, Irene Paterniti, Emanuela Esposito
Iscience, 2024
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are common genetic causes of Parkinson's disease (PD). Studies demonstrated that variants in LRRK2 genetically link intestinal disorders to PD. We aimed to evaluate whether the selective inhibitor of LRRK2, PF-06447475 (PF-475), attenuates the PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in central nervous system (CNS) and in the gastrointestinal system. CD1 mice received four intraperitoneal injections of MPTP (20 mg/kg, total dose of 80 mg/kg) at 2 h intervals (day 1). After 24 h PF-475 was administered intraperitoneally at the doses of 2.5, 5, and 10 mg/kg for seven days. LRRK2 inhibition reduced brain α-synuclein and modulated mitophagy pathway and reduced pro-inflammatory markers and α-synuclein aggregates in colonic tissues through the modulation of mitophagy proteins. LRRK2 inhibition suppressed MPTP-induced enteric dopaminergic neuronal injury and protected tight junction in the colon. Results suggested that PF-475 may attenuate gastrointestinal dysfunction associated to PD. - Benzyl isothiocyanate suppresses development of thyroid carcinoma by regulating both autophagy and apoptosis pathway
Rossella Basilotta, Giovanna Casili, Deborah Mannino, Alessia Filippone, Marika Lanza, Anna Paola Capra, Domenico Giosa, Stefano Forte, Lorenzo Colarossi, Dorotea Sciacca, Emanuela Esposito, Irene Paterniti
Iscience, 2024
Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer, characterized by rapid growth and invasion and poor prognosis. Due to its rarity and aggressive nature, ATC is a difficult condition to treat, thus knowledge of the mechanisms underlying its progression represents important research challenges. Benzyl isothiocyanate (BITC) is a natural compound that has shown promising anticancer properties. The aim of this study was to evaluate the antitumor effect of BITC in ATC, highlighting signaling pathways involved in BITC mechanism of action. This work included <i>in vitro</i> and <i>in vivo</i> studies. Results obtained indicate that BITC, both <i>in vitro</i> and <i>in vivo</i>, has the potential to slow the progression of ATC through interactions with autophagy, reduction in epithelial-mesenchymal transition (EMT) and attenuation of inflammation. In conclusion, this study identifies BITC as a compound worth further investigation for the development of new treatment strategies for this aggressive form of thyroid cancer. - EZH2 Inhibition to Counteract Oral Cancer Progression through Wnt/β-Catenin Pathway Modulation
Michela Campolo, Sarah Adriana Scuderi, Alessia Filippone, Valentina Bova, Sofia Paola Lombardo, Lorenzo Colarossi, Serena Sava, Anna Paola Capra, Federica De Gaetano, Marco Portelli, Angela Militi, Emanuela Esposito, Irene Paterniti
Pharmaceuticals, 2024
Oral squamous cell carcinoma (OSCC) is one of the most common human malignancies worldwide. The molecular mechanisms of OSCC pathogenesis are still unknown; however, in recent years, several reports have focused on the role of enhancer of zeste homolog 2 (EZH2) in OSCC. Therefore, in this study we aimed to investigate the effects of GSK343, a selective EZH2 inhibitor, and its impact on the signaling pathways in OSCC, using an in vitro and in vivo orthotopic model. In the in vitro model, GSK343 (1, 10, and 25 μM) significantly decreased OSCC cell viability and cell migration through EZH2 inhibition, modulating NF-κB/IκBα pathway activation and eNOS, VEGF, and TGFβ expression, important markers of angiogenesis. In the in vivo model, GSK343 (5 mg/kg and 10 mg/kg) restored tongue tissue architecture and reduced tumor progression through EZH2 inhibition and Wnt/β-catenin signaling pathway modulation. Moreover, GSK343 reduced the expression of inflammatory mediators; eNOS and TGFβ, markers of angiogenesis; and CD31 and CD34, markers of micro vessel density, respectively. In conclusion, our data demonstrate that GSK343 counteracts oral cancer progression through EZH2/Wnt/β-catenin pathway modulation, suggesting that it could be a promising therapeutic approach for OSCC management. - The Protective Role of Troxerutin (Trox) in Counteracting Anaplastic Thyroid Carcinoma (ATC) Progression
Valentina Bova, Rossella Basilotta, Giovanna Casili, Marika Lanza, Alessia Filippone, Michela Campolo, Anna Paola Capra, Giulia Vitale, Giulia Chisari, Cristina Colarossi, Dario Giuffrida, Irene Paterniti, Emanuela Esposito
Biomedicines, 2024
Anaplastic thyroid carcinoma (ATC) is a rare thyroid neoplasm characterized by aggressiveness and a high mortality rate. Troxerutin (Trox) is a bioflavonoid widely found in various fruits and vegetables with numerous protective effects, including anticancer activities. To evaluate the anti-oxidant and anti-inflammatory effect of Trox, in vitro and in vivo studies were conducted in a model of ATC. Human ATC 8305C cell lines were treated with increasing concentrations of Trox (10 μg/mL, 30 μg/mL, 100 μg/mL, 300 μg/mL), and our results revealed that Trox treatment was able to reduce the viability of ATC cells and migratory capacity, reducing the expression of anti-apoptotic factors, such as B-cell lymphoma (bcl-2), and increasing the expression of pro-apoptotic factors, such as Caspase-3 and BID, activating oxidative stress mediators, such as manganese superoxide dismutase (MnSOD), heme oxygenase-1 (HO-1), glutathione (GSH) and reactive oxygen species modulator 1 (ROMO-1). Furthermore, Trox modulates NF-κB pathway markers, such as NIK and TRAF-6. Further confirmation was obtained through in vivo studies, in which Trox treatment, at doses of 12.5, 25 and 50 mg/kg, reduced morphological alteration, decreasing mast cell accumulation. Therefore, the use of Trox could be considered a promising strategy to counteract the progression of ATC. - Efficacy of an oral suspension containing xyloglucan and pea proteins on a murine model of gastroesophageal reflux disease
Alessio Ardizzone, Deborah Mannino, Giovanna Casili, Michela Campolo, Irene Paterniti, et al.
Phytotherapy Research, 2024
Gastroesophageal reflux disease (GERD) is the most common foregut disease, affecting about 20% of the adult population. Esophageal epithelial barrier plays a fundamental role in the pathophysiology of GERD; however, pharmacological therapies mainly aim to reduce the acidity of the gastroesophageal environment rather than to protect esophageal tissue integrity. This study aims to evaluate the efficacy of an oral solution containing xyloglucan and pea proteins (XP) in reestablishing gastroesophageal tissue integrity and biochemical markers. To induce GERD, C57BL/6 mice were alternatively overfed and fasted for 56 days and then treated with XP, sodium alginate, omeprazole, or omeprazole+XP twice daily for 7 days. Gastric pain and inflammatory markers were evaluated after 3 and 7 days of treatment. After sacrifice, the esophagi and stomachs were surgically removed for macroscopic and histological examination. Gastric pain was significantly reduced at days 3 and 7 by XP, omeprazole, and omeprazole+XP, while alginates were ineffective at day 3. XP was able to diminish gastric macroscopic damage and demonstrated the same efficacy as omeprazole in reducing esophageal damage. XP significantly reduced histological damage, with an efficacy comparable to that of omeprazole, but superior to alginates. Inflammatory markers were significantly reduced by XP, with superior efficacy compared with alginates at day 7. Interestingly, XP was also able to significantly increase gastric pH. This study demonstrated that XP restored gastric homeostasis, improved esophageal integrity, and decreased inflammation and pain with a similar efficacy to omeprazole and greater than alginates. - Correction to: Therapeutic Potential of BAY-117082, a Selective NLRP3 Inflammasome Inhibitor, on Metastatic Evolution in Human Oral Squamous Cell Carcinoma (OSCC) (Cancers, (2023), 15, 10, (2796), 10.3390/cancers15102796)
Giovanna Casili, Sarah Adriana Scuderi, Marika Lanza, Alessia Filippone, Deborah Mannino, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Anna Paola Capra, Federica De Gaetano, Marco Portelli, Angela Militi, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Cancers, 2024 - The role of autophagy in Parkinson’s disease: a gender difference overview
Laura Cucinotta, Deborah Mannino, Alessia Filippone, Adele Romano, Emanuela Esposito, Irene Paterniti
Frontiers in Pharmacology, 2024 - Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis
Marika Lanza, Sarah Adriana Scuderi, Anna Paola Capra, Giovanna Casili, Alessia Filippone, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Scientific Reports, 2023 - Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Deborah Mannino, Sarah Adriana Scuderi, Giovanna Casili, Valentina Bova, Laura Cucinotta, Marika Lanza, Alessia Filippone, Emanuela Esposito, Irene Paterniti
Journal of Neuroinflammation, 2023 - bFGF-like Activity Supported Tissue Regeneration, Modulated Neuroinflammation, and Rebalanced Ca2+ Homeostasis following Spinal Cord Injury
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alessia Filippone, Marika Lanza, Alberto Repici, Emanuela Esposito, Irene Paterniti
International Journal of Molecular Sciences, 2023 - Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential
Alberto Repici, Alessio Ardizzone, Alessia Filippone, Cristina Colarossi, Marzia Mare, Gabriele Raciti, Deborah Mannino, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Cells, 2023 - The Transcription Factor Nrf2 Mediates the Effects of Antrodia camphorata Extract on Neuropathological Changes in a Mouse Model of Parkinson’s Disease
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2023 - New Insights into the Mechanism of Ulva pertusa on Colitis in Mice: Modulation of the Pain and Immune System
Alessio Ardizzone, Deborah Mannino, Anna Paola Capra, Alberto Repici, Alessia Filippone, Emanuela Esposito, Michela Campolo
Marine Drugs, 2023 - Trehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Cellular and Molecular Neurobiology, 2023 - Therapeutic Potential of BAY-117082, a Selective NLRP3 Inflammasome Inhibitor, on Metastatic Evolution in Human Oral Squamous Cell Carcinoma (OSCC)
Giovanna Casili, Sarah Adriana Scuderi, Marika Lanza, Alessia Filippone, Deborah Mannino, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Anna Paola Capra, Federica De Gaetano, Marco Portelli, Angela Militi, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Cancers, 2023 - Inhibition of LRRK2 Attenuates Depression-Related Symptoms in Mice with Moderate Traumatic Brain Injury
Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza, Giovanna Casili, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Cells, 2023 - Recent Emerging Immunological Treatments for Primary Brain Tumors: Focus on Chemokine-Targeting Immunotherapies
Alessio Ardizzone, Rossella Basilotta, Alessia Filippone, Lelio Crupi, Marika Lanza, Sofia Paola Lombardo, Cristina Colarossi, Dorotea Sciacca, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Cells, 2023 - Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis
Alessia Filippone, Giovanna Casili, Marika Lanza, Sarah Adriana Scuderi, Alessio Ardizzone, Anna Paola Capra, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2023 - Therapeutic Potential of Dimethyl Fumarate in Counteract Oral Squamous Cell Carcinoma Progression by Modulating Apoptosis, Oxidative Stress and Epithelial–Mesenchymal Transition
Rossella Basilotta, Marika Lanza, Alessia Filippone, Giovanna Casili, Deborah Mannino, Federica De Gaetano, Giulia Chisari, Lorenzo Colarossi, Gianmarco Motta, Michela Campolo, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
International Journal of Molecular Sciences, 2023 - Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling
Alessia Filippone, Giovanna Casili, Sarah Adriana Scuderi, Deborah Mannino, Marika Lanza, Michela Campolo, Irene Paterniti, Anna Paola Capra, Cristina Colarossi, Annalisa Bonasera, Sofia Paola Lombardo, Salvatore Cuzzocrea, Emanuela Esposito
Cancers, 2023 - A New Approach for the Treatment of Recurrent Vulvovaginal Candidiasis with a Combination of Pea Protein, Grape Seed Extract, and Lactic Acid Assessed In Vivo
Irene Paterniti, Giovanna Casili, Alessia Filippone, Marika Lanza, Alessio Ardizzone, Anna Paola Capra, Michela Campolo, Emanuela Esposito
Journal of Fungi, 2022 - BAY-117082-driven NLRP3 inflammasome inhibition resolves nitro-glycerine (NTG) neuronal damage in in vivo model of migraine
Alessia Filippone, Sarah Adriana Scuderi, Rossella Basilotta, Marika Lanza, Giovanna Casili, Valentina Bova, Irene Paterniti, Emanuela Esposito
Biomedicine and Pharmacotherapy, 2022 - SUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alessia Filippone, Michela Campolo, Marika Lanza, Emanuela Esposito, Irene Paterniti
Journal of Neuroinflammation, 2022 - A Combination of Xyloglucan, Pea Protein and Chia Seed Ameliorates Intestinal Barrier Integrity and Mucosa Functionality in a Rat Model of Constipation-Predominant Irritable Bowel Syndrome
Alessia Filippone, Alessio Ardizzone, Valentina Bova, Marika Lanza, Giovanna Casili, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo, Irene Paterniti
Journal of Clinical Medicine, 2022 - Overview on Common Genes Involved in the Onset of Glioma and on the Role of Migraine as Risk Factor: Predictive Biomarkers or Therapeutic Targets?
Giovanna Casili, Marika Lanza, Alessia Filippone, Maria Caffo, Irene Paterniti, Michela Campolo, Lorenzo Colarossi, Dorotea Sciacca, Sofia Paola Lombardo, Salvatore Cuzzocrea, Emanuela Esposito
Journal of Personalized Medicine, 2022 - Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management
Alessia Filippone, Deborah Mannino, Giovanna Casili, Marika Lanza, Irene Paterniti, Salvatore Cuzzocrea, Anna Paola Capra, Lorenzo Colarossi, Dario Giuffrida, Sofia Paola Lombardo, Emanuela Esposito
International Journal of Molecular Sciences, 2022 - The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors
Laura Cucinotta, Alessia Filippone, Giovanna Casili, Marika Lanza, Valentina Bova, Anna Paola Capra, Raffaella Giuffrida, Cristina Colarossi, Dorotea Sciacca, Irene Paterniti, Salvatore Cuzzocrea, Michela Campolo, Emanuela Esposito
International Journal of Molecular Sciences, 2022 - GSK343, an Inhibitor of Enhancer of Zeste Homolog 2, Reduces Glioblastoma Progression through Inflammatory Process Modulation: Focus on Canonical and Non-Canonical NF-κB/IκBα Pathways
Sarah Adriana Scuderi, Alessia Filippone, Rossella Basilotta, Deborah Mannino, Giovanna Casili, Anna Paola Capra, Giulia Chisari, Lorenzo Colarossi, Serena Sava, Michela Campolo, Emanuela Esposito, Irene Paterniti
International Journal of Molecular Sciences, 2022 - The contribution of altered neuronal autophagy to neurodegeneration
Alessia Filippone, Emanuela Esposito, Deborah Mannino, Nicholas Lyssenko, Domenico Praticò
Pharmacology and Therapeutics, 2022 - LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma
Alessia Filippone, Deborah Mannino, Laura Cucinotta, Irene Paterniti, Emanuela Esposito, Michela Campolo
Antioxidants, 2022 - PD1/PD-L1 immune checkpoint as a potential target for preventing brain tumor progression
A. Filippone, M. Lanza, D. Mannino, G. Raciti, C. Colarossi, D. Sciacca, S. Cuzzocrea, I. Paterniti
Cancer Immunology Immunotherapy, 2022 - Dimethyl Fumarate (DMF) Alleviated Post-Operative (PO) Pain through the N-Methyl-d-Aspartate (NMDA) Receptors
Giovanna Casili, Marika Lanza, Alessia Filippone, Laura Cucinotta, Irene Paterniti, Alberto Repici, Anna Paola Capra, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Antioxidants, 2022 - Ulva pertusa, a Marine Green Alga, Attenuates DNBS-Induced Colitis Damage via NF-κB/Nrf2/SIRT1 Signaling Pathways
Alessio Ardizzone, Alessia Filippone, Deborah Mannino, Sarah Adriana Scuderi, Giovanna Casili, Marika Lanza, Laura Cucinotta, Michela Campolo, Emanuela Esposito
Journal of Clinical Medicine, 2022 - Adenosine Targeting as a New Strategy to Decrease Glioblastoma Aggressiveness
Valentina Bova, Alessia Filippone, Giovanna Casili, Marika Lanza, Michela Campolo, Anna Paola Capra, Alberto Repici, Lelio Crupi, Gianmarco Motta, Cristina Colarossi, Giulia Chisari, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Cancers, 2022 - Neurofibromatosis: New Clinical Challenges in the Era of COVID-19
Alessio Ardizzone, Anna Paola Capra, Michela Campolo, Alessia Filippone, Emanuela Esposito, Silvana Briuglia
Biomedicines, 2022 - Supplementation with SCFAs Re‐Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG‐Induced Migraine
Marika Lanza, Alessia Filippone, Giovanna Casili, Letterio Giuffrè, Sarah Adriana Scuderi, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2022 - Evaluation of a Gel Containing a Propionibacterium Extract in an In Vivo Model of Wound Healing
Campolo M., Gallo G., Roviello F., Ardizzone A., La Torre M., Filippone A., Lanza M., Cuzzocrea S., Siroli L., Esposito E.
International Journal of Molecular Sciences, 2022 - Effect of Melatonin on Psoriatic Phenotype in Human Reconstructed Skin Model
Sarah Adriana Scuderi, Laura Cucinotta, Alessia Filippone, Marika Lanza, Michela Campolo, Irene Paterniti, Emanuela Esposito
Biomedicines, 2022 - Beneficial effect of KYP-2047, a propyl-oligopeptidase inhibitor, on oral squamous cell carcinoma
Sarah Adriana Scuderi, Giovanna Casili, Alessia Filippone, Marika Lanza, Rossella Basilotta, Raffaella Giuffrida, Stefania Munaò, Lorenzo Colarossi, Anna Paola Capra, Emanuela Esposito, Irene Paterniti
Oncotarget, 2021 - The protective role of prolyl oligopeptidase (Pop) inhibition in kidney injury induced by renal ischemia–reperfusion
Giovanna Casili, Alessio Ardizzone, Rossella Basilotta, Marika Lanza, Alessia Filippone, Irene Paterniti, Emanuela Esposito, Michela Campolo
International Journal of Molecular Sciences, 2021 - Nlrp3 inflammasome inhibitor bay-117082 reduces oral squamous cell carcinoma progression
Sarah Adriana Scuderi, Giovanna Casili, Rossella Basilotta, Marika Lanza, Alessia Filippone, Gabriele Raciti, Ivana Puliafito, Lorenzo Colarossi, Emanuela Esposito, Irene Paterniti
International Journal of Molecular Sciences, 2021 - Evaluating the protective properties of a xyloglucan-based nasal spray in a mouse model of allergic rhinitis
Marika Lanza, Giovanna Casili, Alessia Filippone, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2021 - SCFA treatment alleviates pathological signs of migraine and related intestinal alterations in a mouse model of NTG-induced migraine
Marika Lanza, Alessia Filippone, Alessio Ardizzone, Giovanna Casili, Irene Paterniti, Emanuela Esposito, Michela Campolo
Cells, 2021 - Inhibition of prolyl oligopeptidase prevents consequences of reperfusion following intestinal ischemia
Alessia Filippone, Giovanna Casili, Alessio Ardizzone, Marika Lanza, Deborah Mannino, Irene Paterniti, Emanuela Esposito, Michela Campolo
Biomedicines, 2021 - The protective role of prolyl oligopeptidase (pop) inhibition in acute lung injury induced by intestinal ischemia-reperfusion
Giovanna Casili, Sarah Adriana Scuderi, Marika Lanza, Alessia Filippone, Rossella Basilotta, Deborah Mannino, Michela Campolo, Emanuela Esposito, Irene Paterniti
Oncotarget, 2021 - The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury
Michela Campolo, Giovanna Casili, Marika Lanza, Alessia Filippone, Marika Cordaro, Alessio Ardizzone, Sarah Adriana Scuderi, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Journal of Cellular and Molecular Medicine, 2021 - Endosome Dysregulation in Down Syndrome: A Potential Contributor to Alzheimer Disease Pathology
Alessia Filippone, Domenico Praticò
Annals of Neurology, 2021 - Role of calixarene in chemotherapy delivery strategies
Rossella Basilotta, Deborah Mannino, Alessia Filippone, Giovanna Casili, Angela Prestifilippo, Lorenzo Colarossi, Gabriele Raciti, Emanuela Esposito, Michela Campolo
Molecules, 2021 - Role of mirna-19a in cancer diagnosis and poor prognosis
Alessio Ardizzone, Giovanna Calabrese, Michela Campolo, Alessia Filippone, Dario Giuffrida, Francesca Esposito, Cristina Colarossi, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
International Journal of Molecular Sciences, 2021 - Pea-oxa mitigates oxaliplatin-induced painful neuropathy through nf-κb/nrf-2 axis
Michela Campolo, Marika Lanza, Irene Paterniti, Alessia Filippone, Alessio Ardizzone, Giovanna Casili, Sarah A. Scuderi, Caterina Puglisi, Marzia Mare, Lorenzo Memeo, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2021 - Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency
Giovanna Casili, Marika Lanza, Michela Campolo, Salvatore Messina, Sarah Scuderi, Alessio Ardizzone, Alessia Filippone, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Vascular Pharmacology, 2021 - Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau
Alessia Filippone, Tiffany Smith, Domenico Pratico
Journal of Inflammation Research, 2021 - VPS35 Downregulation Alters Degradation Pathways in Neuronal Cells
Alessia Filippone, Jian-Guo Li, Domenico Praticò
Journal of Alzheimer S Disease, 2021 - TAK1 inhibitor enhances the therapeutic treatment for glioblastoma
Michela Campolo, Marika Lanza, Giovanna Casili, Irene Paterniti, Alessia Filippone, Maria Caffo, Salvatore M. Cardali, Ivana Puliafito, Cristina Colarossi, Gabriele Raciti, Salvatore Cuzzocrea, Emanuela Esposito
Cancers, 2021 - Tlr7/8 in the pathogenesis of parkinson’s disease
Michela Campolo, Alessia Filippone, Carmelo Biondo, Giuseppe Mancuso, Giovanna Casili, Marika Lanza, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
International Journal of Molecular Sciences, 2020 - Efficacy of Xyloglucan against Escherichia coli Extraintestinal Urinary Tract Infection: An in vivo Study
Emanuela Esposito, Michela Campolo, Giovanna Casili, Marika Lanza, Domenico Franco, Enza Fazio, Alessia Filippone, Irene Paterniti, Salvatore Cuzzocrea
Microbial Physiology, 2020 - Modulation of nlrp3 inflammasome attenuated inflammatory response associated to diarrhea-predominant irritable bowel syndrome
Sarah Adriana Scuderi, Giovanna Casili, Marika Lanza, Alessia Filippone, Irene Paterniti, Emanuela Esposito, Michela Campolo
Biomedicines, 2020 - Role of ABT888, a Novel Poly(ADP-Ribose) Polymerase (PARP) Inhibitor in Countering Autophagy and Apoptotic Processes Associated to Spinal Cord Injury
Giovanna Casili, Michela Campolo, Marika Lanza, Alessia Filippone, Sarah Scuderi, Salvatore Messina, Alessio Ardizzone, Emanuela Esposito, Irene Paterniti
Molecular Neurobiology, 2020 - Evaluation of a Product Containing Xyloglucan and Pea Protein on Skin Barrier Permeability
Michela Campolo, Marika Lanza, Alessia Filippone, Irene Paterniti, Giovanna Casili, Sarah A. Scuderi, Alessio Ardizzone, Salvatore Cuzzocrea, Emanuela Esposito
Skin Pharmacology and Physiology, 2020 - Topical delivery of curcumin by choline-calix[4]arene-based nanohydrogel improves its therapeutic effect on a psoriasis mouse model
Alessia Filippone, Grazia M. L. Consoli, Giuseppe Granata, Giovanna Casili, Marika Lanza, Alessio Ardizzone, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
International Journal of Molecular Sciences, 2020 - Effect of a product containing xyloglucan and pea protein on a murine model of atopic dermatitis
Michela Campolo, Giovanna Casili, Irene Paterniti, Alessia Filippone, Marika Lanza, Alessio Ardizzone, Sarah A Scuderi, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2020 - The anti-inflammatory and antioxidant effects of sodium propionate
Alessia Filippone, Marika Lanza, Michela Campolo, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
International Journal of Molecular Sciences, 2020 - Protective effect of sodium propionate in Aβ1-42 -induced neurotoxicity and spinal cord trauma
A. Filippone, M. Lanza, M. Campolo, G. Casili, I. Paterniti, S. Cuzzocrea, E. Esposito
Neuropharmacology, 2020 - Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
Giovanna Casili, Marika Lanza, Alessia Filippone, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Journal of Neuroinflammation, 2020 - Sodium Butyrate Exerts Neuroprotective Effects in Spinal Cord Injury
M. Lanza, M. Campolo, G. Casili, A. Filippone, I. Paterniti, S. Cuzzocrea, Emanuela Esposito
Molecular Neurobiology, 2019 - TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model
Michela Campolo, Irene Paterniti, Rosalba Siracusa, Alessia Filippone, Emanuela Esposito, Salvatore Cuzzocrea
Brain Behavior and Immunity, 2019 - The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice
Michela Campolo, Rosalba Siracusa, Marika Cordaro, Alessia Filippone, Enrico Gugliandolo, Alessio F. Peritore, Daniela Impellizzeri, Rosalia Crupi, Irene Paterniti, Salvatore Cuzzocrea
Plos One, 2019 - TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas
Giovanna Casili, Maria Caffo, Michela Campolo, Valeria Barresi, Gerardo Caruso, Salvatore M. Cardali, Marika Lanza, Raffaella Mallamace, Alessia Filippone, Alfredo Conti, Antonino Germanò, Salvatore Cuzzocrea, Emanuela Esposito
Oncotarget, 2018 - Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis
Emanuela Esposito, Michela Campolo, Giovanna Casili, Marika Lanza, Alessia Filippone, Alessio F Peritore, Salvatore Cuzzocrea
Future Microbiology, 2018 - Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury
Giovanna Casili, Michela Campolo, Irene Paterniti, Marika Lanza, Alessia Filippone, Salvatore Cuzzocrea, Emanuela Esposito
Journal of Neurotrauma, 2018 - Protective effects of xyloglucan in association with the polysaccharide gelose in an experimental model of gastroenteritis and urinary tract infections
Emanuela Esposito, Michela Campolo, Giovanna Casili, Marika Lanza, Domenico Franco, Alessia Filippone, Alessio F. Peritore, Salvatore Cuzzocrea
International Journal of Molecular Sciences, 2018 - Multiple mechanisms of dimethyl fumarate in amyloid β-induced neurotoxicity in human neuronal cells
Michela Campolo, Giovanna Casili, Marika Lanza, Alessia Filippone, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Journal of Cellular and Molecular Medicine, 2018
