Green Synthetic Chemistry ,Activity studies and Solar cell application
75
Scopus Publications
793
Scholar Citations
16
Scholar h-index
23
Scholar i10-index
Scopus Publications
QUALITY BY DESIGN-GUIDED WHITE AND GREEN HPLC METHOD FOR THE DETERMINATION OF PROCESS-RELATED IMPURITIES OF ELACESTRANT IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS VENKATA SAI SURESH KUMAR SISTA, ANJALI JHA, VLNSH HARI HARAN A. International Journal of Applied Pharmaceutics, 2026 Objective: The quality by design (QbD) guided, robust, and environmentally sustainable HPLC method was developed for the simultaneous quantification of elacestrant and its process-related impurities. Methods: The method optimisation uses organic solvent composition, mobile phase pH, and flow rate as critical method parameters. Based on structural features and pKa values of the analytes, separation was achieved on a hypersilgold C18 (250 × 4.6 mm, 5 µm) column using a green mobile phase of ethanol and 0.1% aqueous formic acid (65:35, v/v) at pH 3.4 at a 0.7 mL/min flow rate,achieving baseline resolution between elacestrant and its close eluting dihydrochloride impurity ( = 3.1) with good symmetry (tailing factor ~1.1) and a total run time of 13 min. Results: The method validation demonstrates excellent linearity (r² > 0.999), accuracy (recoveries 99–101%), precision (RSD < 1.5%), and sensitivity (LOQs 0.1–0.2 µg/mL for impurities). The sustainability assessment confirms the strong environmental and operational profile of the method. The AGREE evaluation yields a score of 0.78, whereas the GAPI pictogram displays predominantly green fields,confirming the strong alignment of the proposed method with green analytical chemistry principles. Further, the RGB12 model demonstrates favourable scoresof 73.2% (redness), 75.8%(greenness), and 86.7% (blueness) with an integrated whiteness score of 78.3%. These results classify the proposed method as awhite analytical procedure. Conclusion: Collectively, these outcomes confirm that the developed method was not only analytically reliable but also environmentally responsible and economically feasible. Hence, the method was highly suitable for routine impurity profiling and sustainable quality control of elacestrant in pharmaceutical formulations.
An eco-friendly triple quadrupole mass spectrometry approach for the simultaneous screening of N-nitroso-desethyl lidocaine and N-nitroso lidocaine EP impurity E in lidocaine drug substance and injectable solutions Sreekanth Batna, Anjali Jha, Mukthinuthalapati Mathrusri Annapurna European Journal of Mass Spectrometry, 2026 N-nitrosamine compounds have been recognized for their carcinogenic properties. Compounds containing secondary and tertiary amine moieties in their chemical structure, including drugs, intermediates, or solvents, are susceptible to the formation of nitrosamine impurities when they react with residual nitrite and nitrate reagents. Lidocaine (LDC) features a tertiary amine moiety, while lidocaine EP impurity E (LEE) includes a secondary amine moiety in its chemical structure. This structural characteristic makes it susceptible to the formation of N-nitroso-desethyl lidocaine (NDL) and N-nitroso lidocaine EP impurity E (NLE) during the synthesis of the LDC drug substance or the manufacturing of the LDC drug product. In this study, we developed and validated a triple quadrupole mass spectrometer (TQ-MS) method for the quantification of NDL and NLE in both the LDC drug substance and the LDC injectable formulation. This method employed a Zorbax Eclipse XDB-C18 column, utilizing an eluent composed of methanol and formic acid in water (0.1% v/v). This method enables the quantification of both NDL and NLE at a lower concentration of 0.0165 ng/mL. The method demonstrates a linear, precise, and accurate performance within the range of 0.0165 to 2.5 ng/mL for NDL and from 0.0165 to 5 ng/mL for NLE. Furthermore, the degradation pathways for both NDL and NEL impurities were discussed. In addition, the environmental impact from the TQ-MS approach using GAC tools like BAGI and AGREE was evaluated.
A ROBUST AND VALIDATED HEADSPACE GC METHOD FOR SENSITIVE DETERMINATION OF RESIDUAL SOLVENTS IN SUNITINIB CYCLAMATE SALT Venkata Sai Suresh Kumar Sista, Anjali Jha, V. L. H. HaranA., G.V. S. Prasad Rasayan Journal of Chemistry, 2026 This research outlines the development and validation of a reliable analytical method for determining residual solvents—methanol, acetone, dichloromethane (DCM), and toluene—in Sunitinib Cyclamate, a newsalt formof theanticancer drug Sunitinib. This method employs headspace gas chromatography (GC-HS), a precise and efficient technique for analysing volatile organic impurities. Validation followed ICH Q2(R1) guidelines, covering essential parameters such as specificity, accuracy, precision, linearity, range, robustness, ruggedness, and solution stability. The results demonstrated excellent specificity, with no interference from the drug matrix or excipients. Systemsuitability parameters, including resolution and %RSD, consistently satisfied the acceptance limits. The methodshowed high precision (%RSD < 2%), satisfactory recovery (85–115%), and strong linearity (R² ≥ 0.996) across thetested concentration range. Moreover, the procedure-maintained robustness under intentional variations in analytical conditions and showed consistent ruggedness among different analysts and instruments. Overall, the validatedGC- HS method provides a sensitive, accurate, and regulatory-compliant approach for residual solvent determinationinSunitinib Cyclamate, supporting its dependable use in routine quality control and pharmaceutical batch release.
FORCED DEGRADATION AND STABILITY STUDY OF LENALIDOMIDE: IMPURITY PROFILING AND METHOD DEVELOPMENT USING HPLC Venkata Sai Suresh Kumar Sista, Anjali Jha, Vlnsh Hari Haran A, R. S. K. Sharma, Anindita Chatterjee, G. V. Siva Prasad, K. Satyam Naidu, D. Ravi Kumar Rasayan Journal of Chemistry, 2025 Lenalidomide is an immunomodulatory drug that plays a significant role in treating hematological conditions, including multiple myeloma and myelodysplastic syndromes. The stability of lenalidomide is crucial for maintaining its safety and effectiveness throughout its shelf life. Environmental factors such as light, heat, moisture, and changes in pH can lead to the degradation of lenalidomide, resulting in harmful impurities that may compromise its therapeutic potency. This research presents a novel approach to studying the stability of lenalidomide under various stress conditions using a High-Performance Liquid Chromatography method. The method is designed to investigate degradation pathways and impurity profiling. It incorporates a dynamic gradient system and optimizes the mobile phase composition to enhance the separation of degradation products with improved precision and reproducibility. The research also integrates green chemistry principles, minimizing the use of harmful solvents and reducing the environmental impact. Forced degradation studies were conducted under various stress conditions, such as ultraviolet light, heat, acidic, alkaline, and oxidative conditions, revealing previously unknown degradation products. The results of these studies offer essential insights into the stability of lenalidomide, providing valuable recommendations for improving formulation and storage conditions. This validated High-Performance Liquid Chromatography method proves to be a reliable, eco-friendly, and efficient tool for routine quality control and stability testing, ensuring the safety and effectiveness of lenalidomide.
Sonochemical Synthesis of Schiff Base of Substituted Benzoxazolone: A Quantum Chemical, Antibacterial Evaluation and Molecular Docking Study Maria Sundari A. C., Anjali Jha Chemistryselect, 2025 The derivatives of benzoxazolone (BOA) have attracted a lot of interest because of their diverse pharmacological potential as therapeutic agents. In this work, we report an environmentally friendly synthetic method based on ultrasonication(US) as well as conventional method to prepare new BOA derivatives (M1–M4). Furthermore, the BOA derivatives were reacted with p‐nitro, p‐chloro, and p‐hydroxy anilines to get Schiff bases compounds (M5–M16). The results demonstrated that, in comparison to traditional approaches, the ultrasonication method had higher reaction kinetics and energy efficiency. Additionally, quantum chemical calculations and molecular docking studies were performed to understand the reaction mechanisms and evaluate the antibacterial potential of the synthesized compounds. The presence of electron‐withdrawing group at the para position of substituted anilines follows the trend ─NO2 > ─Cl > ─OH, leading to higher formation energies of the corresponding products as reflected in the progression of the reactions in the mechanistic studies. Further, the presence of a methyl group in benzoxazolone (BOA) enhances the binding interaction affinity with Escherichia coli, however on the basis of docking scores of nitro group containing (M5, M8, M11, and M14) compounds exhibited stronger interactions with the protein of E. coli, compared to the chlorine and hydroxyl groups. The docking results were also found consistent with in vitro results.
Structural characterization and evaluation of antioxidant activity of isolated phenolic compounds from Talinum fruticosum leaves International Journal of Pharmaceutical Sciences Review and Research, 2016
Ultrasonic synthesis, antimicrobial and brine shrimp lethality assay of novel thiadiazole-imidazole derivatives Research Journal of Pharmaceutical Biological and Chemical Sciences, 2016
Effect of C-glycosyl flavone from Urginea Indica on antibiotic induced microbial cell death International Journal of Pharmacy and Pharmaceutical Sciences, 2016
Synthesis, characterization and bioactivity of transition metal complexes of new 3-methyl-5-mercapto-4-triazole schiff bases Research Journal of Pharmaceutical Biological and Chemical Sciences, 2015
Design, synthesis and antimicrobial evaluation of some mannich base derivative of 2-(subtituted)-5-amino-thiadiazoles International Journal of Pharmacy and Pharmaceutical Sciences, 2015
An innovative green synthesis of some schiffbases and their antimicrobial activity International Journal of Pharma and Bio Sciences, 2013
Antitumour, anti-HIV and antifungal studies of transition metal complexes of azolo-2,4-pentanediones and their derivatives Indian Journal of Chemistry Section A Inorganic Physical Theoretical and Analytical Chemistry, 1998
Complexes of Nickel-, Zinc-, Palladium- And Cadmium(II) with some Furan-2-thiohydrazones Journal of the Indian Chemical Society, 1997
trans-Dihalo-tetrakis Complexes of Rhodium(III) with some Imidazole Derivatives Journal of the Indian Chemical Society, 1997
Synthetic and spectral studies of nickel(II), copper(II) and palladium(II) complexes with triazolo-malononitrile/ethyl-cyanoacetate Indian Journal of Chemistry Section A Inorganic Physical Theoretical and Analytical Chemistry, 1996
An eco-friendly triple quadrupole mass spectrometry approach for the simultaneous screening of N-nitroso-desethyl lidocaine and N-nitroso lidocaine EP impurity E in lidocaine … S Batna, A Jha, MM Annapurna European Journal of Mass Spectrometry, 14690667261453520 , 2026 2026
Structural and Mechanistic Heterogeneity of the Phase Separation and Aggregation of Full-Length TDP-43 is Governed by Environmental Conditions AA Doke, MS Kirmire, A Jha, SK Jha ACS Chemical Neuroscience 17 (7), 1362-1374 , 2026 2026
Toxicity and antiproliferative activity assessment of a novel compound Zr I isolated from Zingiber roseum Rosc A Jha, SPD Ponamgi, S Kumari, S Peela Naunyn-Schmiedeberg's Archives of Pharmacology 399 (2), 2155-2173 , 2026 2026
Second harmonic generation and electro-optical properties of Schiff base compounds CRS Kumar, A Jha, M Rabari, BR Kumar The European Physical Journal Plus 140 (12), 1163 , 2025 2025
Experiences of Respectful Maternity Care among postnatal women at a tertiary care hospital in new Delhi I Mandal, MM Singh, B Banerjee, N Bhatnagar, S Tyagi, A Jha BMC Pregnancy and Childbirth 25 (1), 1023 , 2025 2025
Can dual donor with an azo group as a π-spacer enhance the dye-sensitized solar cell performance? AD Vasarla, PN Sahu, A Jha, A Sen Chemical Physics Letters, 142434 , 2025 2025 Citations: 1
The gut-bone axis: gut microbiota dysbiosis and dental implant failures–Is there a link?-A systematic review A Jha, G Krishnamoorthy, A I Narayana F1000Research 14, 929 , 2025 2025
Design and Ultrasonic Synthesis of hydrazine clubbed oxazoles/oxazolidin-4-ones-hybrid derivatives for potent urease inhibitors: molecular docking and in-vitro anti-urease … BGG KrishnamRaju, A Jha, N Shivshetty, KR Amperayani Journal of Molecular Structure, 143621 , 2025 2025
Strategies with spectroscopic and optical insights for optoelectronic applications of novel synthesized Schiff base: impact of nitro group A Jha, BR Kumar, RSK Ch Structural Chemistry 36 (4), 1355-1368 , 2025 2025 Citations: 4
Occurrence of postnatal depression and its risk factors in a rural area of northern India: A prospective cohort study R Raghavan, B Banerjee, P Sharma, N Bhatnagar, M Kapoor, R Kumar, ... Indian Journal of Psychiatry 67 (7), 693-699 , 2025 2025
Sonochemical synthesis of Schiff base of substituted benzoxazolone: A quantum chemical, antibacterial evaluation and molecular docking study M Sundari AC, A Jha ChemistrySelect 10 (5), e202404442 , 2025 2025 Citations: 3
Design, ultrasonic synthesis, antimicrobial activity and molecular docking studies of pyridine-2, 6-dithiazole/dioxazole analogues MS AC, A Jha, KR Amperayani, VM Chand Journal of Molecular Structure 1316, 139063 , 2024 2024 Citations: 6
DNA-mediated formation of phase-separated coacervates of the nucleic acid-binding domain of TAR DNA-binding protein (TDP-43) prevents its amyloid-like misfolding D Patni, AD Patil, MS Kirmire, A Jha, SK Jha ACS Chemical Neuroscience 15 (22), 4105-4122 , 2024 2024 Citations: 5
Eco-friendly Synthesis of Indole Conjugated Chromeno [d] Pyrimidines as Anti-cancer Agents and their Molecular Modelling Studies VRKR Datla, A Jha Current Green Chemistry 11 (3), 221-228 , 2024 2024 Citations: 2
New benzothiazole and benzoxazole picolinamide conjugates as potential anti-cancer agents: Design, synthesis, molecular docking and anticancer studies VRK Raju, A Jha Journal of Molecular Structure 1309, 138153 , 2024 2024 Citations: 5
Design and Synthesis of 2‐Phenylindolizine Acetamides: Molecular Docking, in Vitro Antimicrobial and Anticancer Activity Evaluation S Kumar Gandham, A Jha, AA Kudale Chemistry & Biodiversity 21 (5), e202400075 , 2024 2024 Citations: 2
Structural, electronic and optical properties of synthesized schiff base compound-validation with a computational method CRS Kumar, M Prasanti, A Jha, BR Kumar Physica Scripta 99 (2), 025932 , 2024 2024 Citations: 2
New indazole–1, 2, 3–triazoles as potent antimicrobial agents: Design, synthesis, molecular modeling and in silico ADME profiles SK Gandham, AA Kudale, TR Allaka, K Chepuri, A Jha Journal of Molecular Structure 1295, 136714 , 2024 2024 Citations: 52
Structural Aspects and Characterization of Synthesized Novel Schiff Base of 4-Hydroxybenzaldehyde with Anilines for Optoelectronic Properties M Prasanti, A Jha, BR Kumar, RSK Ch 2023
New tetrazolopyrrolidine-1, 2, 3-triazole analogues as potent anticancer agents: design, synthesis and molecular docking studies SK Gandham, AA Kudale, TR Allaka, K Chepuri, A Jha Molecular Diversity, 1-17 , 2023 2023 Citations: 9
MOST CITED SCHOLAR PUBLICATIONS
Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (m pro ): a molecular docking, molecular dynamics and structure … VN Badavath, A Kumar, PK Samanta, S Maji, A Das, G Blum, A Jha, A Sen Journal of Biomolecular Structure and Dynamics 40 (7), 3110-3128 , 2022 2022 Citations: 66
Synthesis, spectroscopic and antifungal studies of transition metal trinuclear/polynuclear complexes with azolo-2, 4-pentanedione: Part III L Mishra, A Jha, AK Yadaw Transition Metal Chemistry 22 (4), 406-410 , 1997 1997 Citations: 54
New indazole–1, 2, 3–triazoles as potent antimicrobial agents: Design, synthesis, molecular modeling and in silico ADME profiles SK Gandham, AA Kudale, TR Allaka, K Chepuri, A Jha Journal of Molecular Structure 1295, 136714 , 2024 2024 Citations: 52
Inhibition of β-amyloid aggregation through a designed β-hairpin peptide A Jha, MG Kumar, HN Gopi, KM Paknikar Langmuir 34 (4), 1591-1600 , 2018 2018 Citations: 49
Design and synthesis of 1, 3, 4-thiadiazole derivatives as novel anticancer and antitubercular agents D Chandra Sekhar, DV Venkata Rao, A Tejeswara Rao, U Lav Kumar, ... Russian Journal of General Chemistry 89 (4), 770-779 , 2019 2019 Citations: 44
Screening donor and acceptor groups for organic azo-based dyes for dye sensitized solar cells D Biswal, A Jha, A Sen Journal of Molecular Structure 1228, 129776 , 2021 2021 Citations: 36
Design, Synthesis and Antimicrobial Evaluation of some Mannich base derivative of 2-(subtituted)-5-amino-thiadiazoles AJ K Balaji, Priyanka Bhatt, D. Mallika International Journal of Pharmacy and Pharmaceutical Sciences 7 (10), 145-149 , 2015 2015 Citations: 35
Microwave assisted synthesis of organic compounds and nanomaterials A Jha Nanofibers-Synthesis, Properties and Applications , 2021 2021 Citations: 25
Design, synthesis and anticancer evaluation of oxa/thiadiazolylhydrazones of barbituric and thiobarbituric acid: A collective in vitro and in silico approach P Bhatt, M Kumar, A Jha ChemistrySelect 3 (25), 7060-7065 , 2018 2018 Citations: 23
Synthesis and spectroscopic studies of transition metal dinuclear/polynuclear complexes with azolo-2, 4-pentanedione L Mishra, A Jha Transition Metal Chemistry 18 (6), 559-563 , 1993 1993 Citations: 23
Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid β (1–42) peptide MS Said, GR Navale, A Yadav, N Khonde, SS Shinde, A Jha Biophysical Chemistry 267, 106480 , 2020 2020 Citations: 22
Synthesis, characterization, and antimicrobial activity of some new 2-diazo-benzimidazole derivatives and their Ni (II), Cu (II), and Ag (I) complexes YLN Murthy, G Durga, A Jha Medicinal Chemistry Research 22 (5), 2266-2272 , 2013 2013 Citations: 22
Rapid synthesis, characterization, anticancer and antimicrobial activity studies of substituted thiadiazoles and their dinucleating ligand metal complexes A Jha, YLN Murthy, U Sanyal, G Durga Medicinal Chemistry Research 21 (9), 2548-2556 , 2012 2012 Citations: 20
Design and Synthesis of Benzoxepine–Based 1, 2, 3‐Triazoles: Molecular Docking and In Vitro Antimicrobial Activity Evaluation SK Gandham, AA Kudale, T Rao Allaka, A Jha ChemistrySelect 7 (21), e202200683 , 2022 2022 Citations: 17
Synthesis and biological evaluation of chalcone fused quinoline derivatives as anticancer agents L Kumar, A Jha, G Sridhar Chemical Data Collections 22, 100236 , 2019 2019 Citations: 17
Effect of polyamines on mechanical and structural properties of Bombyx mori silk A Yerra, DK Mysarla, P Siripurapu, A Jha, SV Valluri, A Mamillapalli Biopolymers 107 (1), 20-27 , 2017 2017 Citations: 16
Synthesis, docking and anticancer activity of azo-linked hybrids of 1, 3, 4-thia-/oxadiazoles with cyclic imides P Bhatt, M Kumar, A Jha Molecular Diversity 22 (4), 827-840 , 2018 2018 Citations: 15
Induced crystal G phase of liquid crystalline amide through inter molecular hydrogen bonding CRS Kumar, A Jha, SS Sastry Journal of non-crystalline solids 356 (6-8), 334-339 , 2010 2010 Citations: 15
Microwave‐Assisted Synthesis of 3, 5‐Dibenzyl‐4‐amino‐1, 2, 4‐triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity A Jha, YLN Murthy, G Durga, TT Sundari Journal of Chemistry 7 (4), 1571-1577 , 2010 2010 Citations: 15
Synthesis and characterization of nickel (II), copper (II), palladium (II) and platinum (II and IV) complexes with azolo 2, 4-pentanedione-PartzyxwvutsrqponmlkjihgfedcbaZYXW Il! L Mishra, A Jha Indian Journal of Chemistry 33 (J1l1y1994), 638-643 , 1994 1994 Citations: 13
