Natural Product Chemistry, Pharmacology, Chemistry, Toxicology and Pharmaceutical, Medicine
18
Scopus Publications
340
Scholar Citations
10
Scholar h-index
10
Scholar i10-index
Scopus Publications
Anti-cholesterol Potential of Indonesian Lantana camara L.: In Vitro and Molecular Docking Analysis Magie M. Kapojos, Mario Walean, Natalia Godiman, Fitje Losung, Delfly B. Abdjul Tropical Journal of Natural Product Research, 2026 Cardiovascular diseases remain a major global health burden, with hypercholesterolemia as a key contributor to atherosclerotic disorders. Limitations and adverse effects associated with existing lipid-lowering therapies underscore the urgent need for safer, more effective anti-cholesterol agents. This study aimed to evaluate the anti-cholesterol potential of fractions derived from the aerial parts of Indonesian Lantana camara L. through in vitro assay and molecular docking analysis. The ethanol extract was subjected to ODS column chromatography, and the resulting fractions were tested for the anti-cholesterol activity by following the photometric method based on the reaction of the Liebermann-Burchard reagent with cholesterol. Molecular docking analysis was conducted on triterpenoids isolated from this plant, collected at the same location, using human HMG-CoA reductase as the target receptor. Fractions 4 (70% CH3OH) and 5 (85% CH3OH) showed the strongest anti-cholesterol activity at 100 µg/mL with inhibition values of 59.9% and 64.2%, respectively, higher than the positive control, simvastatin (53.6%, conc. 10 µg/mL). Moreover, molecular docking analysis suggested that camaric acid, lantadene A, and lantadene D are promising anti-cholesterol agents due to these compounds exhibiting the most favorable binding affinity value compared with the native ligand (compactin) and positive control (simvastatin and atorvastatin). This result indicates that Lantana camara L. collected at North Sulawesi, Indonesia, had potential anti-cholesterol agents.
PTP1B Inhibitors from Indonesian Plants and Its Structure-Activity Relationship: A Review Magie M. Kapojos, Mario Walean, Delfly B. Abdjul Tropical Journal of Natural Product Research, 2024 Diabetes is still a world health problem because of the large number of sufferers and from year to year shows a trend of increasing the number. Type 2 diabetes is the most common type found as well as the largest contributor to diabetes cases, with a percentage of more than 90%. To overcome this problem, more potent and efficient type 2 diabetes drugs are urgently needed. Protein tyrosine phosphatase 1B (PTP1B) is one of the enzyme targets in the discovery of new drugs for type 2 diabetes because it has an important contribution as a negative regulator in the blood sugar transport mechanism, especially in the insulin and leptin signaling pathways. Based on this role, compounds that can act as PTP1B inhibitors have great potential to be developed as new drug candidates for type 2 diabetes. Natural products derived from plants with extraordinary structural diversity are expected to provide potential PTP1B inhibitor scaffolds for developing type 2 diabetes drugs. This review focuses on the structure-activity relationship (SAR) of compounds derived from Indonesian plants that have shown PTP1B inhibitory activity to provide information about the correlation between chemical structures and PTP1B activity that can be useful for the selection of potential scaffolds for type 2 diabetes drug development.
Antimicrobial and FAD synthetases modulating activities of leporins A-C isolated from the sponge-associated fungus Trichoderma sp. Fitje Losung, Elvy Like Ginting, Delfly B. Abdjul, Magie M. Kapojos, Wilmar Maarisit, et al. Biodiversitas, 2023 Abstract. Losung F, Ginting EL, Abdjul B, Kapojos MM, Maarisit W, Mentang F, Sumilat DA, Balansa W, Mangindaan REP. 2023. Antimicrobial and FAD synthetases modulating activities of leporins A-C isolated from the sponge-associated fungus Trichoderma sp. Biodiversitas 24: 6502-6515. The emergence of microbial resistance poses a formidable threat to human health, requiring the discovery of new antibiotics. In this study, we investigated the antimicrobial potential and molecular structures of the metabolites produced by a sponge's symbiont fungal species, Trichoderma sp., in vitro against S. aureus IAM 12544T and Candida albicans IFM 4954 and in-silico against the emerging antibacterial target, prokaryotic bifunctional synthetases (FADS). The molecular structures were determined using spectroscopic techniques (1D, 2D NMR, HRESIMS), while the assessment of biological activities, physicochemical properties, and molecular modifications was performed through a slightly modified disk agar diffusion method, molecular docking, SwissAdme and pkCMS tools, and bioisosterism, respectively. The analysis of spectroscopic data supported the identification of leporins A-C (1-3) as the metabolites, which exhibited strong binding affinities against the 2X0K protein target (-8.9 to -9.4 kcal/mol). Despite their being slightly weaker than known FADS modulators such as compounds 4 (-10.5 kcal/mol) and 5 (-10.5 kcal/mol), leporins A-C demonstrated a stronger binding affinity than compound 6 (-9.6 to -10.5 kcal/mol). Notably, substituting a methyl group with a fluorine atom in 1-3 resulted in lepofluorins A-C (1a-3a), which exhibited enhanced binding affinities and improved physicochemical properties compared to the existing FADS modulators. These findings suggest that leporins A-C (1-3), particularly lepofluorins A-C (1a-3a), have potential as putative novel modulators of FADS. This study provides valuable insights into the design and development of new antibiotics to combat microbial resistance.
Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation Satoshi Ohte, Hiroyuki Yamazaki, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Huiping Zhang, Fumiaki Hayashi, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida Bioorganic and Medicinal Chemistry Letters, 2021 A new unique sesquiterpene lactone, bicyclolamellolactone A (1), was isolated together with two known monocyclofarnesol-type sesquiterpenes, lamellolactones A (2) and B (3), from the Indonesian marine sponge Lamellodysidea sp. (cf. L. herbacea). The planar structure of 1 was assigned based on its spectroscopic data (1D and 2D NMR, HRESIMS, UV, and IR spectra). The relative and absolute configuration of 1 was determined by comparison of its calculated and experimental electronic circular dichroism spectra in combination with NOESY correlations. Compounds 1-3 inhibited bone morphogenic protein (BMP)-induced alkaline phosphatase activity in mutant BMP receptor-carrying C2C12 cells with IC50 values of 51, 4.6, and 20 μM, respectively.
Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates Hiroyuki Yamazaki, Satoshi Ohte, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida Marine Drugs, 2020 Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder with heterotopic ossification (HO) in soft tissues. The abnormal activation of bone morphogenetic protein (BMP) signaling by a mutant activin receptor-like kinase-2 (ALK2) leads to the development of HO in FOP patients, and, thus, BMP signaling inhibitors are promising therapeutic applications for FOP. In the present study, we screened extracts of 188 Indonesian marine invertebrates for small molecular inhibitors of BMP-induced alkaline phosphatase (ALP) activity, a marker of osteoblastic differentiation in a C2C12 cell line stably expressing ALK2(R206H) (C2C12(R206H) cells), and identified five marine sponges with potent ALP inhibitory activities. The activity-guided purification of an EtOH extract of marine sponge Dysidea sp. (No. 256) resulted in the isolation of dysidenin (1), herbasterol (2), and stellettasterol (3) as active components. Compounds 1–3 inhibited ALP activity in C2C12(R206H) cells with IC50 values of 2.3, 4.3, and 4.2 µM, respectively, without any cytotoxicity, even at 18.4–21.4 µM. The direct effects of BMP signaling examined using the Id1WT4F-luciferase reporter assay showed that compounds 1–3 did not decrease the reporter activity, suggesting that they inhibit the downstream of the Smad transcriptional step in BMP signaling.
Screening of Indonesian edible plants for bioactive constituents and a new protein tyrosine phosphatase 1b inhibitory acylbenzene derivative from leaves of Indonesian syzygium polyanthum Magie Melanie Kapojos, Delfly Booby Abdjul, Hiroyuki Yamazaki, Akiho Yagi, Ryuji Uchida Chemical and Pharmaceutical Bulletin, 2020 Bioassay screening using Indonesian plants, such as traditional foods (vegetables, spices, and tea) and folk medicinal herbs, identified eight protein tyrosine phosphatase (PTP) 1B inhibitory and two antibacterial plants. The leaves of Syzygium polyanthum (Wight) Walp. were examined in more detail to define PTP1B inhibitory components, resulting in the isolation of a new active acylbenzene (1) along with four related congeners of 1 (2-5) and four oleanane triterpenes (6-9). The structure of 1 was elucidated as 12-oxo-12-(2,3,5-trihydroxy-4-methylphenyl)dodecanoic acid based on its spectroscopic data. The acylbenzenes 1 and 3-5 inhibited PTP1B activity with IC50 values ranging between 9.5 and 14 µM, whereas the triterpenes 7-9 also suppressed this activity with IC50 values of 3.3-5.7 µM.
Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. Magie M. Kapojos, Delfly B. Abdjul, Hiroyuki Yamazaki, Taichi Ohshiro, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Hiroshi Tomoda, Michio Namikoshi, Ryuji Uchida Bioorganic and Medicinal Chemistry Letters, 2018 Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data. Compounds 1-3 inhibited both of the SOAT isozymes, SOAT1 and SOAT2, in cell-based and enzyme-based assays.
Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata Delfly B. Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Ryota Kirikoshi, Ohgi Takahashi, Fitje Losung, Magie M. Kapojos, Michio Namikoshi Phytochemistry Letters, 2018 Research on protein tyrosine phosphatase (PTP) 1B inhibitors from terrestrial and marine natural resources identified N-isobutyl-2E-decenamide (1) and 3,4,5-tri-O-caffeoylquinic acid (2) as PTP1B inhibitory substances together with a new N-alkylamide (3) and two known congeners (4 and 5) from the aerial parts of Indonesian Spilanthes paniculata. The structure of 3 was elucidated as (2E, 7Z)-6,9-endoperoxy-N-2-methylbutyl-2,7-decadienamide based on its spectroscopic data. Compound 3 is a rare N-alkylamide derivative with an endoperoxide bridge, and only three natural products have been reported in this class. Compound 1 inhibited PTP1B activity with an IC50 value of 24 μM, whereas compound 2 exerted an inhibitory effect of 35% at 15 μM. This is the first study to report the inhibitory effects of an N-alkylamide derivative (1) on PTP1B activity.
Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea Magie M. Kapojos, Delfly B. Abdjul, Hiroyuki Yamazaki, Ryota Kirikoshi, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Kazuyo Ukai, Michio Namikoshi Phytochemistry Letters, 2018 Three known polybromobiphenyl ether derivatives, 2-(2′,4′-dibromophenoxy)-3,5-dibromophenol (1), 2-(2′,4′-dibromophenoxy)-4,6-dibromophenol (2), and 2-(2′-dibromophenoxy)-3,4,5,6-tetrabromophenol (3), were identified as PTP1B inhibitors from the Indonesian marine sponge Lamellodysidea sp. (cf. L. herbacea) together with two new monocyclofarnesol-derived sesquiterpenes, lamellolactones A (4) and B (5). The structures of 4 and 5 were elucidated based on their spectroscopic data and comparisons with those for related compounds. Compounds 1–3 inhibited PTP1B activity with IC50 values of 5.3, 7.8, and 5.3 μM, respectively, while compounds 4 and 5 were not active at 38–40 μM. The selective activities of 1–3 against PTP1B over the other PTPs (T-cell PTP, CD45 tyrosine phosphatase, and vaccinia H-1-related phosphatase) showed that the position and/or number of Br atoms affected their inhibitory activities.
Absolute structures of wedelolide derivatives and structure–activity relationships of protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of wedelia spp. collected in Indonesia and Japan Delfly Booby Abdjul, Hiroyuki Yamazaki, Syu-ichi Kanno, Ryota Kirikoshi, Ayako Tomizawa, Ohgi Takahashi, Wilmar Maarisit, Fitje Losung, Henki Rotinsulu, Defny Silvia Wewengkang, Deiske Adeliene Sumilat, Magie Melanie Kapojos, Michio Namikoshi Chemical and Pharmaceutical Bulletin, 2018 Two sesquiterpene lactones with the (9R)-eudesman-9,12-olide framework, wedelolides I and J, have been isolated together with five eudesmanolide sesquiterpenes and twelve ent-kaurene diterpenes from the aerial parts of Indonesian Wedelia prostrata. The absolute configurations of wedelolides I and J, proposed in the previous communication, were proven by comparing their experimental Electronic Circular Dichroism (ECD) spectra with the calculated ECD spectrum of wedelolide I. The phytochemical study on the aerial parts of Okinawan Wedelia chinensis led to the isolation of three other eudesmanolide sesquiterpenes in addition to the three sesquiterpenes and eleven diterpenes isolated from the Indonesian W. prostrata as above. However, the wedelolide derivatives found in the Indonesian plant were not detected. Among these compounds, most of the diterpenes inhibited protein tyrosine phosphatase (PTP) 1B activity, and a structure-activity relationship study revealed that the cinnamoyl group enhanced inhibitory activity. Therefore, two ent-kaurene derivatives with and without a cinnamoyl group were examined for the ability to accumulate phosphorylated-Akt (p-Akt) because PTP1B dephosphorylates signal transduction from the insulin receptor such as phosphorylated Akt, a key downstream effector. However, neither compound enhanced insulin-stimulated p-Akt levels in two human hepatoma cell lines (Huh-7 and HepG2) at non-cytotoxic doses.
Lobohedleolide induces interleukin-8 production in LPS-stimulated human monocytic cell line THP-1 International Journal of Applied Research in Natural Products, 2011
PTP1B Inhibitors from Indonesian plants and its structure-activity relationship: A Review MM Kapojos, M Walean, DB Abdjul Tropical Journal of Natural Product Research 8 (3), 6480-6486 , 2024 2024 Citations: 2
Skrining aktivitas antimikobakteri ekstrak etanol spons dari Perairan Malalayang Sulawesi Utara M Kapojos, D Abdjul Pharmacy Research Journal 1 (01), 32-35 , 2024 2024
Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation S Ohte, H Yamazaki, O Takahashi, H Rotinsulu, DS Wewengkang, ... Bioorganic & Medicinal Chemistry Letters 35, 127783 , 2021 2021 Citations: 12
Tropical Journal of Natural Product Research BI Amro, MNA Hajleh, F Afifi 2021 Citations: 1
Screening for small molecule inhibitors of BMP-induced osteoblastic differentiation from Indonesian marine invertebrates H Yamazaki, S Ohte, H Rotinsulu, DS Wewengkang, DA Sumilat, ... Marine drugs 18 (12), 606 , 2020 2020 Citations: 9
Screening of Indonesian edible plants for bioactive constituents and a new protein tyrosine phosphatase 1B inhibitory acylbenzene derivative from leaves of Indonesian Syzygium … MM Kapojos, DB Abdjul, H Yamazaki, A Yagi, R Uchida Chemical and Pharmaceutical Bulletin 68 (9), 903-906 , 2020 2020 Citations: 4
MINI REVIEW: SENYAWA ANTIMIKOBAKTERI YANG DIISOLASI DARI SPONS SULAWESI UTARA DAN OKINAWA DB Abdjul, MM Kapojos Prosiding Seminar Nasional Pakar, 1.14. 1-1.14. 6 , 2019 2019 Citations: 1
Absolute structures of wedelolide derivatives and structure–activity relationships of protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of … DB Abdjul, H Yamazaki, S Kanno, R Kirikoshi, A Tomizawa, O Takahashi, ... Chemical and Pharmaceutical Bulletin 66 (6), 682-687 , 2018 2018 Citations: 5
Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. MM Kapojos, DB Abdjul, H Yamazaki, T Ohshiro, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 28 (10), 1911-1914 , 2018 2018 Citations: 26
Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea MM Kapojos, DB Abdjul, H Yamazaki, R Kirikoshi, O Takahashi, ... Phytochemistry Letters 24, 10-14 , 2018 2018 Citations: 20
Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata DB Abdjul, H Yamazaki, W Maarisit, R Kirikoshi, O Takahashi, F Losung, ... Phytochemistry Letters 24, 71-74 , 2018 2018 Citations: 6
Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan DB Abdjul, H Yamazaki, W Maarisit, H Rotinsulu, DS Wewengkang, ... Phytochemistry 144, 106-112 , 2017 2017 Citations: 31
Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp. W Maarisit, DB Abdjul, H Yamazaki, H Kato, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 27 (15), 3503-3506 , 2017 2017 Citations: 43
An anti-mycobacterial bisfunctionalized sphingolipid and new bromopyrrole alkaloid from the Indonesian marine sponge Agelas sp. DB Abdjul, H Yamazaki, S Kanno, A Tomizawa, H Rotinsulu, ... Journal of Natural medicines 71 (3), 531-536 , 2017 2017 Citations: 35
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp. DB Abdjul, H Yamazaki, S Kanno, DS Wewengkang, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 27 (5), 1159-1161 , 2017 2017 Citations: 37
A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp. W Maarisit, H Yamazaki, S Kanno, A Tomizawa, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 27 (4), 999-1002 , 2017 2017 Citations: 17
Aktivitas antimitotik dari ekstrak karang lunak genus Sinularia WA Tanod, REP Mangindaan, M Kapojos Omni-Akuatika 11 (2), 40-48 , 2015 2015 Citations: 7
Hubungan antara Pola Makan dengan Kejadian Hipertensi di Puskesmas Airmadidi FG Mamengko, S Timah, MM Kapojos Journal Of Community and Emergency 3 (1), 7-7 , 2015 2015
Antimitotic activity from soft coral genus Sinularia extracts WA Tanod, RE Mangindaan, M Kapojos OmniAkuatika 11 (2), 41-49 , 2015 2015 Citations: 5
Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp. W Maarisit, DB Abdjul, H Yamazaki, H Kato, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 27 (15), 3503-3506 , 2017 2017 Citations: 43
Two unprecedented cembrene-type terpenes from an indonesian soft coral sarcophyton sp. MM Kapojos, JS Lee, T Oda, T Nakazawa, O Takahashi, K Ukai, ... Tetrahedron 66 (3), 641-645 , 2010 2010 Citations: 39
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp. DB Abdjul, H Yamazaki, S Kanno, DS Wewengkang, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 27 (5), 1159-1161 , 2017 2017 Citations: 37
An anti-mycobacterial bisfunctionalized sphingolipid and new bromopyrrole alkaloid from the Indonesian marine sponge Agelas sp. DB Abdjul, H Yamazaki, S Kanno, A Tomizawa, H Rotinsulu, ... Journal of Natural medicines 71 (3), 531-536 , 2017 2017 Citations: 35
Three new nardosinane type sesquiterpenes from an Indonesian soft coral Nephthea sp. MM Kapojos, REP Mangindaan, T Nakazawa, T Oda, K Ukai, ... Chemical and Pharmaceutical Bulletin 56 (3), 332-334 , 2008 2008 Citations: 32
Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan DB Abdjul, H Yamazaki, W Maarisit, H Rotinsulu, DS Wewengkang, ... Phytochemistry 144, 106-112 , 2017 2017 Citations: 31
Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. MM Kapojos, DB Abdjul, H Yamazaki, T Ohshiro, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 28 (10), 1911-1914 , 2018 2018 Citations: 26
Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea MM Kapojos, DB Abdjul, H Yamazaki, R Kirikoshi, O Takahashi, ... Phytochemistry Letters 24, 10-14 , 2018 2018 Citations: 20
A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp. W Maarisit, H Yamazaki, S Kanno, A Tomizawa, H Rotinsulu, ... Bioorganic & Medicinal Chemistry Letters 27 (4), 999-1002 , 2017 2017 Citations: 17
Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation S Ohte, H Yamazaki, O Takahashi, H Rotinsulu, DS Wewengkang, ... Bioorganic & Medicinal Chemistry Letters 35, 127783 , 2021 2021 Citations: 12
Screening for small molecule inhibitors of BMP-induced osteoblastic differentiation from Indonesian marine invertebrates H Yamazaki, S Ohte, H Rotinsulu, DS Wewengkang, DA Sumilat, ... Marine drugs 18 (12), 606 , 2020 2020 Citations: 9
Aktivitas antimitotik dari ekstrak karang lunak genus Sinularia WA Tanod, REP Mangindaan, M Kapojos Omni-Akuatika 11 (2), 40-48 , 2015 2015 Citations: 7
Lobohedleolide induces interleukin-8 production in LPS-stimulated human monocytic cell line THP-1 T Oda, DS Wewengkang, MM Kapojos, REP Mangindaan, JS Lee, ... International Journal of Applied Research in Natural Products 4 (3), 16-21 , 2011 2011 Citations: 7
Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata DB Abdjul, H Yamazaki, W Maarisit, R Kirikoshi, O Takahashi, F Losung, ... Phytochemistry Letters 24, 71-74 , 2018 2018 Citations: 6
Absolute structures of wedelolide derivatives and structure–activity relationships of protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of … DB Abdjul, H Yamazaki, S Kanno, R Kirikoshi, A Tomizawa, O Takahashi, ... Chemical and Pharmaceutical Bulletin 66 (6), 682-687 , 2018 2018 Citations: 5
Antimitotic activity from soft coral genus Sinularia extracts WA Tanod, RE Mangindaan, M Kapojos OmniAkuatika 11 (2), 41-49 , 2015 2015 Citations: 5
Screening of Indonesian edible plants for bioactive constituents and a new protein tyrosine phosphatase 1B inhibitory acylbenzene derivative from leaves of Indonesian Syzygium … MM Kapojos, DB Abdjul, H Yamazaki, A Yagi, R Uchida Chemical and Pharmaceutical Bulletin 68 (9), 903-906 , 2020 2020 Citations: 4
PTP1B Inhibitors from Indonesian plants and its structure-activity relationship: A Review MM Kapojos, M Walean, DB Abdjul Tropical Journal of Natural Product Research 8 (3), 6480-6486 , 2024 2024 Citations: 2
Tropical Journal of Natural Product Research BI Amro, MNA Hajleh, F Afifi 2021 Citations: 1
MINI REVIEW: SENYAWA ANTIMIKOBAKTERI YANG DIISOLASI DARI SPONS SULAWESI UTARA DAN OKINAWA DB Abdjul, MM Kapojos Prosiding Seminar Nasional Pakar, 1.14. 1-1.14. 6 , 2019 2019 Citations: 1
