Public Health; Environmental Health; Social Communities; Virus and microbiological infection disease; Nurses jobs and actuaries; Problems of Health Popular Communities and Environmental involving Amazon region, Impetus social and Environmental
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Scopus Publications
Scopus Publications
WHOT, a Novel Tool to Assist Women Victims of Violence: A Case Study in the Brazilian Amazon Saulo William Da Silva Costa, Yomara Pinheiro Pires, Ailton Lopes De Sousa, Fernando Augusto Ribeiro Costa, Euzebio De Oliveira, et al. IEEE Access, 2021 Violence against women is a problem faced in several ways, in various societies; however, the introduction of computational tools is something still little explored in this confrontation. Thus, it is necessary to invest in researches that bring technological development closer to the prevention, discovery, and combat of this form of violence. This paper presents the Women’s Health Observer Tool (WHOT) that helps to build psychobehavioral profiles of women victims of violence, based on three features: i) recognition of facial expressions to infer emotions; ii) provision of digital questionnaires on intimate partner violence (IPV), adverse childhood experiences (ACE) and post-traumatic stress disorder (PTSD); and iii) generation of individual reports with cross-references of statistical analysis between the data obtained in each interview. To validate the tool, a case study was conducted with 50 women assisted in basic health units in a city of the Brazilian Amazon for prenatal care. The results are satisfactory for the use of the tool, which was able to infer emotions (joy, surprise, sadness, and anger), and the prevalence of sadness (25.24%) was verified among the interviewees. For ACE, the majority (21) of the women reported having suffered only physical abuse; as for IPV, the majority of the interviewees (27) reported no abuse; and 78% of the women (39) had no indicative signs of PTSD. The results further point out that there is 3.94 more chance that the group of women who reported any abuse, either in childhood or adulthood, compared to the reference group, would develop PTSD.
IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters Euzébio de Oliveira, Raimunda do Socorro Silva Azevedo, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Milene Silveira Ferreira, et al. Scientific Reports, 2019 In the present study, patients with acute OROV fever were classified as early seroconverters (IgM/IgG positive at baseline) or late seroconverters (IgM/IgG negative at baseline) and the timeline kinetics of the production of chemokines and cytokines were assessed at 1–3, 4–7, 8–10 and ≥11 days after patients have reported the first symptoms. Regardless immunoglobulin profile, all OROV fever patients presented higher levels of CXCL8, and IFN-α and lower levels of TNF and IL-10 at baseline as compared to healthy donors (HD). Lower levels of CCL2, CXCL10, and IFN-γ and higher levels of CCL2, CXCL10, IL-6, and IL-17A were detected in early and late seroconverters, respectively, as compared to HD. While early seroconverters presented the increasing levels of CCL2 along the timeline, late seroconverters displayed decreasing levels of CCL2, CXCL10, and IL-6 following days of disease onset. Noteworthy was that IFN-α was revealed as universal biomarker of human OROV fever, while CXCL8 & IL-5 and CXCL10 & IL-17 were consistently observed in early and late seroconverters, respectively. Thus, our results suggest that the production of IFN-α, CXCL10, and IL-17 precede the seroconversion bringing novel insights on the immunological events triggered by the OROV disease.
Is TGF-β important for the evolution of subcutaneuos chronic mycoses? Juarez Antonio Simões Quaresma, Euzébio de Oliveira, Arival Cardoso de Brito Medical Hypotheses, 2008 Summary Jorge Lobo's and chromoblastomycosis are chronic deep mycosis that clinically manifests as keloid and verrucous polymorphic lesions of solid consistency and variable size that contain small scales and crusts. Few studies are available in the literature characterizing the in situ cellular and humoral immune response, especially the involvement of cytokines which immunosuppressive and fibrogenic effects as the TGF-β. The hypothesis of the present paper is explaining the possible mechanism of this cytokine in cutaneous lesions pathology in chromoblastomycosis and lacaziosis (Jorge Lobo's disease). The results of this investigation are a new hypothesis for ethiopatogenesis of these diseases: TGF-β is a double effect that follows fibrosis and immunosuppression in local skin.
