Sayan Paul

@instem.res.in

Postdoctoral Researcher, Department of Biotechnology, Institute for Stem Cell Science and Regenerative Medicine
Institute for Stem Cell Science and Regenerative Medicine

Sayan Paul


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https://researchid.co/sayanpaul01

RESEARCH INTERESTS

Genomics, Genetics, Transcriptomics, Molecular Biology
36

Scopus Publications

690

Scholar Citations

15

Scholar h-index

24

Scholar i10-index

Scopus Publications

  • Examining sleep signals at the cradle of life: can phylogenomic analysis of the Last Universal Common Ancestor (LUCA) reveal the fundamental role of sleep?
    Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, David Warren Spence, Sayan Paul, Ganesh Pandian Namasivayam, Saravana Babu Chidambaram
    Molecular Genetics and Genomics, 2026
  • CX-5461 and doxorubicin activate a shared DNA damage-associated transcriptional response in human cardiomyocytes
    Sayan Paul, José A Gutiérrez, Alyssa R Bogar, E Renee Matthews, Michelle C Ward
    G3 Genes Genomes Genetics, 2026
    CX-5461 (CX) is under investigation for the treatment of late-stage cancers. While CX was first described as an RNA polymerase I inhibitor, it has recently been shown to primarily inhibit the beta isoform of topoisomerase II. This isoform is also inhibited by anthracycline drugs including doxorubicin (DOX) and mediates the toxic effects of these drugs on the heart. It is unclear whether CX will similarly cause cardiotoxicity. We therefore tested the effects of CX on iPSC-derived cardiomyocytes from 6 individuals. CX induces cell death in cardiomyocytes at micromolar concentrations. Transcriptome profiling following treatment over time reveals gene expression programs that correspond to the DNA damage response, which are pathways shared with DOX response genes. Micromolar CX concentrations affect heart-specific genes and 14 functionally validated genes in loci associated with DOX cardiotoxicity. Our data demonstrate the impact of CX on the transcriptome of cardiomyocytes, a potential off-target cell type of the drug.
  • Harnessing Simple Animal Models to Decode Sleep Mysteries
    Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, Saravana Babu Chidambaram
    Molecular Biotechnology, 2025
  • Role of stem cell-based therapy in neurodegenerative, ocular, and cardiovascular diseases
    Sayan Paul, Rajesh Srinivasan, Salma Mohammed, Anandhi Kannan, Vignesh Mariappan, et al.
    Handbook of Regenerative Medicine Stem Cell Based Approach, 2025
    Recent advancements in stem cell biology offer promise for treating patients suffering from previously untreatable diseases and disorders. Stem cell–based therapy is considered an essential aspect of regenerative medicine, with the primary objective of enhancing the body’s repair machinery by regulating and modulating the endogenous stem cell pool toward tissue regeneration and homeostasis. In past decades, stem cell therapies based on human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs) have emerged as promising therapeutic strategies in regenerative medicine. The hPSCs possess the unlimited capacity for self-renewing, and they can differentiate into various cell types, including the three embryonic germ layers. In contrast, the MSCs are multipotent progenitor cells with limited self-renewal capacity and can differentiate into the mesenchymal lineages. Apart from their multilineage differentiation potential, the MSCs migrate toward the injury site in response to environmental cues and facilitate tissue regeneration by releasing the paracrine factors with pleiotropic effects. Besides, MSCs interact with the host niche to inhibit the immune system and promote cell survival. Recently, literature has highlighted the therapeutic impact of MSCs in treating various pathologies, including cardiovascular, immune, neurodegenerative, kidney, and orthopedic diseases. The current chapter will provide a detailed narrative of the hPSCs and MSCs-based stem cell therapies, their clinical applications, associated challenges, and prospects in treating human neurodegenerative, ocular, and cardiovascular diseases.
  • Role of stem cells in diabetes, liver disease, and cancer treatment
    Rajamanikkam Kamaraj, Mohammad Javad Mehran, Harshita Tiwari, Monu Kumar Shukla, Mehmet Veysi Cetiz, et al.
    Handbook of Regenerative Medicine Stem Cell Based Approach, 2025
    Over the past century, humankind has made remarkable strides in knowledge and technology. One of the most exciting areas of advancement is in stem cell research, where we can create artificial intelligence that is difficult to distinguish from a live human being, launch rockets into space, use computers that can store terabytes of data and process billions of instructions per second, and create smartphones that can send and receive dozens of megabytes of data per second between far-flung locations on Earth. Despite these significant advancements, there are still many disorders that have no known treatments, and sometimes, we are even unable to determine the underlying cause of the illness. There are two alternative techniques for treating every given illness condition. For most patients, the most common accessible treatment choices are those that reduce or inhibit the state of illness. This kind of therapy is frequently administered as chemical or biological medications, either with or without surgery. The second treatment strategy aims to return the pathogenic environment to its initial or normal condition. This second, uncommon alternative is only appropriate for a few disorders for which medication is ineffective in healing the damage and cannot regenerate or restore the injured tissue’s or organ’s normal function. Organ transplantation and stem cell treatment are two significant ways regenerative medicine is used. Stem cell therapy, with its immunomodulatory activities, multilineage differentiation capabilities, and regeneration potential, represents a new and promising mode of treatment for diabetes, liver diseases, and cancer. In the context of diabetes, stem cells play a crucial role in regenerating functional insulin-producing cells; in liver disease, they aid in regenerating hepatocyte-like cells; and in cancer, they have the potential to target and destroy cancerous cells. Several types of stem cells, including induced pluripotent, embryonic, and adult stem cells, have been tested for their ability to regenerate these functional cells. In conclusion, the potential of stem cell therapy in treating terminal illnesses, including diabetes, liver disease, and different types of cancer treatments, is yet to be fully realized and holds the greatest hope for the future.
  • DNA-damage-associated protein co-expression network in cardiomyocytes informs on tolerance to genetic variation and disease
    Omar Darrel Johnson, Sayan Paul, José Angel Gutiérrez, William Kent Russell, Michelle Claire Ward
    Iscience, 2025
    Cardiovascular disease (CVD) is associated with genetic variants and environmental factors. A consequence of multiple risk factors is DNA damage. To examine how DNA damage influences the cardiomyocyte proteome and its relationship to CVD risk, we treated human induced pluripotent stem cell (iPSC)-derived cardiomyocytes with the DNA-damaging agent doxorubicin (DOX). A network constructed from 4,178 proteins reveals 12 co-expressed modules with 403 hub proteins. Five modules correlate with DOX and associate with RNA processing, chromatin regulation, and metabolism. DOX-correlated hub proteins are depleted for proteins that vary in expression across individuals due to genetic variation but are enriched for proteins encoded by loss-of-function intolerant genes. While not enriched for known CVD risk proteins, DOX-correlated hub proteins are enriched for the physical protein interactors of CVD risk proteins. These data demonstrate that protein connectivity in DNA-damage-associated modules influences the tolerance to genetic variation and supports the use of dynamic networks to explore complex traits.
  • Studying sleep orthologs in Epsilonproteobacteria through an evolutionary lens: investigating sleep mysteries through phylogenomics
    Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, David Warren Spence, Saravana Babu Chidambaram
    World Journal of Microbiology and Biotechnology, 2025
  • Applications of Gene Editing and Nanotechnology in Stem Cell-Based Therapies for Human Diseases
    Mansoor Bolideei, Rambod Barzigar, Razieh Bahrami Gahrouei, Elham Mohebbi, Khawaja Husnain Haider, Sayan Paul, Manash K. Paul, Mohammad Javad Mehran
    Stem Cell Reviews and Reports, 2025
  • Organoid: Biomedical application, biobanking, and pathways to translation
    Aprajita Sinha, Maheshree Maibam, Ronit Jain, Kalash Aggarwal, Asish Kumar Sahu, Pawan Gupta, Sayan Paul, Bharti Bisht, Manash K. Paul
    Heliyon, 2025
    Organoids are tiny stem cell-derived 3D in vitro cell culture systems mimicking the structural and functional aspects of the tissues in the human body and provide a means to study complex bio-physiological processes in normal and disease states (disease modeling) and also for therapeutic screening and clinical trials. Scientists have now developed protocols to maintain and use organoids from diverse human tissues, including the gut, liver, brain, and pancreas, and they have the potential to reduce or remove the dependency on animal models and have research utility and translational potential. One major advantage is that they can be generated from patients with specific genetic diseases, thereby providing options for exploring personalized medicine and rare diseases lacking robust animal models. Recent advances in multi-omics technologies, imaging technologies, biomaterial chemistry, bioengineering, microfluidics, and stem cell research have revolutionized organoid bioengineering, opening the opportunity for mass production, biobanking, and commercialization.
  • Cross-Kingdom Genomic Conservation of Putative Human Sleep-Related Genes: Phylogenomic Evidence From Chlamydomonas reinhardtii
    Seithikurippu R. Pandi‐Perumal, Konda Mani Saravanan, Sayan Paul, George C. Abraham, David Warren Spence, Saravana Babu Chidambaram
    Journal of Cellular Biochemistry, 2025
    Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life‐supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, sleep's evolution and adaptive significance continue to be debated. This study explores the evolutionary origins of sleep using Chlamydomonas reinhardtii as a model organism, identifying 112 putative sleep‐related genes across species and highlighting the evolutionary conservation of sleep‐regulatory pathways. Additionally, discovering uncharacterized proteins with high sequence similarity and significant e‐values suggests unexplored roles in sleep regulation, underscoring the potential of C. reinhardtii to reveal new insights into the molecular basis of sleep. This study provides a foundation for identifying previously unknown sleep‐associated proteins, particularly within single‐celled organisms, which may offer novel perspectives on the biological role of sleep. The study demonstrates that phylogenomic analysis of diverse model organisms can expand our understanding of the evolutionary trajectory of sleep and its fundamental function, paving the way for further research in sleep biology and its health implications. Overall, the fundamental functions of sleep observed in higher animal phyla originated from its primordial activities, demonstrating an evolutionary continuum wherein more specialized tasks were integrated with sleep's essential restorative properties.
  • Unraveling the Mysteries of Sleep: Exploring Phylogenomic Sleep Signals in the Recently Characterized Archaeal Phylum Lokiarchaeota near Loki’s Castle
    Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, David Warren Spence, Saravana Babu Chidambaram
    International Journal of Molecular Sciences, 2025
  • Clock-Sleep Communication
    Seithikurippu R. Pandi-Perumal, Sayan Paul, Konda Mani Saravanan, Ganesh Pandian Namasivayam, Saravana Babu Chidambaram
    Current Molecular Medicine, 2025
  • Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci
    E. Renee Matthews, Raodatullah O. Abodunrin, John D. Hurley, Sayan Paul, José A. Gutiérrez, Alyssa R. Bogar, Michelle C. Ward
    Plos Genetics, 2025
  • Expression of Helicobacter pylori CagA in Solanum melongena L-A Cost Effective Strategy for Vaccine Development
    Mohammad Javad Mehran, Rambod Barzigar, Basaralu Yadurappa Sathish Kumar, Nanjundappa Haraprasad, Bashasab Fakrudin, Sayan Paul, Sudhakar Malla, Mansoor Bolideei
    Indian Journal of Pharmaceutical Education and Research, 2025
  • Waking Up the Sleep Field: An Overview on the Implications of Genetics and Bioinformatics of Sleep
    Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, Ganesh Pandian Namasivayam, Saravana Babu Chidambaram
    Molecular Biotechnology, 2024
  • Application of single-cell sequencing on stem cell research
    Sayan Paul, Tungki Pratama Umar, Manash K. Paul, Harshita Tiwari, Monu Kumar Shukla, Lekha Kandasami, Ananya Joliholi, Drishanu Dey, Deokrishna Kumar Choudhary, Kavitha Govarthanan, Khawaja H. Haider
    Handbook of Stem Cell Applications, 2024
  • Effects of gut microbiome and obesity on the development, progression and prevention of cancer (Review)
    Ranjith Kumavath, Honey Pavithran, Sayan Paul, V. Anju, Siddhardha Busi, Madhu Dyavaiah
    International Journal of Oncology, 2024
  • Transcriptome analysis revealed the synergism of novel rhodethrin inhibition on biofilm architecture, antibiotic resistance and quorum sensing in Enterococcus faecalis
    Eswar Rao Tatta, Sayan Paul, Ranjith Kumavath
    Gene, 2023
  • Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis
    Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam, Deepak Kumar Kashyap, Dyuti Saha, Johan Ajnabi, Sayan Paul, Shashank Jayappa, Akhil S.H.P. Ananthan, Pankaj Kumar, Rania F. Zaarour, J. Haarshaadri, Gaurav Kansagara, Abrar Rizvi, Ravindra K. Zirmire, Krithika Badarinath, Sneha Uday Khedkar, Yogesh Chandra, Rekha Samuel, Renu George, Debashish Danda, Paul Mazhuvanchary Jacob, Rakesh Dey, Perundurai S. Dhandapany, You-Wen He, John Varga, Shyni Varghese, Colin Jamora
    Journal of Investigative Dermatology, 2023
  • Drug repurposing—an emerging strategy in cancer therapeutics
    Khadija Shahab Turabi, Ankita Deshmukh, Sayan Paul, Dayanand Swami, Shafina Siddiqui, Urwashi Kumar, Shreelekha Naikar, Shine Devarajan, Soumya Basu, Manash K. Paul, Jyotirmoi Aich
    Naunyn Schmiedeberg S Archives of Pharmacology, 2022
  • Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy
    Pratul Kumar Jain, Shashank Jayappa, Thiagarajan Sairam, Anupam Mittal, Sayan Paul, Vinay J Rao, Harshil Chittora, Deepak K Kashyap, Dasaradhi Palakodeti, Kumarasamy Thangaraj, Jayaprakash Shenthar, Rakesh Koranchery, Ranjith Rajendran, Haghighi Alireza, Kurukkanparampil Sreedharan Mohanan, Andiappan Rathinavel, Perundurai S Dhandapany
    Journal of Medical Genetics, 2022
  • Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae
    Sayan Paul, Subburathinam Balakrishnan, Arun Arumugaperumal, Saranya Lathakumari, Sandhya Soman Syamala, Vijithkumar Vijayan, Selvan Christyraj Jackson Durairaj, Vaithilingaraja Arumugaswami, Sudhakar Sivasubramaniam
    Functional and Integrative Genomics, 2022
  • Identification, tissue specific expression analysis and functional characterization of arrestin gene (ARRDC) in the earthworm Eudrilus eugeniae: a molecular hypothesis behind worm photoreception
    Sayan Paul, Sudalai Mani Dinesh Kumar, Sandhya Soman Syamala, Subburathinam Balakrishnan, Vijithkumar Vijayan, Vaithilingaraja Arumugaswami, Sivasubramaniam Sudhakar
    Molecular Biology Reports, 2022
  • Advances in targeting the WNT/β-catenin signaling pathway in cancer
    Avradip Chatterjee, Sayan Paul, Bharti Bisht, Shelley Bhattacharya, Sudhakar Sivasubramaniam, Manash K. Paul
    Drug Discovery Today, 2022
  • Phytoremediation for Co-contaminated Soils of Cadmium and Polychlorinated Biphenyls Using the Ornamental Plant Tagetes patula L.
    Xinyu Miao, Ramasamy Rajesh Kumar, Qiqi Shen, Zijiang Wang, Qingzi Zhao, Joginder Singh, Sayan Paul, Wei Wang, Xiaona Shang
    Bulletin of Environmental Contamination and Toxicology, 2022
  • Evaluation of icea1 gene expression of helicobacter pylori risk factor of gastric cancer in transgenic Brinjal
    Mohammad Javad Mehran, Basaralu Yadurappa Sathish Kumar, Nanjundappa Haraprasad, Rambod Barzigar, Bashasab Fakrudin, Sayan Paul
    Indian Journal of Pharmaceutical Education and Research, 2021
  • Emergence of cardiac glycosides as potential drugs: Current and future scope for cancer therapeutics
    Ranjith Kumavath, Sayan Paul, Honey Pavithran, Manash K. Paul, Preetam Ghosh, Debmalya Barh, Vasco Azevedo
    Biomolecules, 2021
  • The transcriptome of anterior regeneration in earthworm Eudrilus eugeniae
    Sayan Paul, Subburathinam Balakrishnan, Arun Arumugaperumal, Saranya Lathakumari, Sandhya Soman Syamala, Vaithilingaraja Arumugaswami, Sudhakar Sivasubramaniam
    Molecular Biology Reports, 2021
  • Finding of novel telomeric repeats and their distribution in the human genome
    Sathyalakshmi Alaguponniah, Deepa Velayudhan Krishna, Sayan Paul, Johnson Retnaraj Samuel Selvan Christyraj, Krishnan Nallaperumal, Sudhakar Sivasubramaniam
    Genomics, 2020
  • Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation
    Gustavo Garcia, Sayan Paul, Sara Beshara, V. Krishnan Ramanujan, Arunachalam Ramaiah, Karin Nielsen-Saines, Melody M.H. Li, Samuel W. French, Kouki Morizono, Ashok Kumar, Vaithilingaraja Arumugaswami
    American Journal of Pathology, 2020
  • The draft genome of a new Verminephrobacter eiseniae strain: A nephridial symbiont of earthworms
    Arun Arumugaperumal, Sayan Paul, Saranya Lathakumari, Ravindran Balasubramani, Sudhakar Sivasubramaniam
    Annals of Microbiology, 2020
  • Transcriptome sequencing, de novo assembly and annotation of the freeze tolerant earthworm, Dendrobaena octaedra
    Sayan Paul, Lars-Henrik Heckmann, Jesper G. Sørensen, Martin Holmstrup, Arun Arumugaperumal, Sudhakar Sivasubramaniam
    Gene Reports, 2018
  • Draft genome sequence of Escherichia coli phage CMSTMSU, isolated from shrimp farm effluent water
    Lelin Chinnadurai, Thirumalaikumar Eswaramoorthy, Abinaya Paramachandran, Sayan Paul, Rashmi Rathy, Arun Arumugaperumal, Sudhakar Sivasubramaniam, Citarasu Thavasimuthu
    Microbiology Resource Announcements, 2018
  • Data on genome annotation and analysis of earthworm Eisenia fetida
    Sayan Paul, Arun Arumugaperumal, Rashmi Rathy, Vasanthakumar Ponesakki, Palavesam Arunachalam, Sudhakar Sivasubramaniam
    Data in Brief, 2018
  • Data on genome sequencing, analysis and annotation of a pathogenic Bacillus cereus 062011msu
    Rashmi Rathy, Sayan Paul, Vasanthakumar Ponesakki, Paulkumar Kanniah, Suriya Prabha Muthu, Arun Arumugaperumal, Emmanuel Joshua Jebasingh Sathiya Balasingh Thangapandi, Subburathinam Balakrishnan, Rajendhran Jeyaprakash, Sudhakar Sivasubramaniam
    Data in Brief, 2018
  • Annotation of nerve cord transcriptome in earthworm Eisenia fetida
    Vasanthakumar Ponesakki, Sayan Paul, Dinesh Kumar Sudalai Mani, Veeraragavan Rajendiran, Paulkumar Kanniah, Sudhakar Sivasubramaniam
    Genomics Data, 2017

RECENT SCHOLAR PUBLICATIONS

  • Examining Sleep Signals at the Cradle of Life: Can phylogenomic analysis of the Last Universal Common Ancestor (LUCA) reveal the fundamental role of sleep?
    SR Pandi-Perumal, KM Saravanan, DW Spence, S Paul, ...
    Molecular Genetics and Genomics 301 (1), 17 , 2026
    2026
  • Conserved RNA–protein modules link early anthracycline responses to atrial fibrillation risk
    OD Johnson, ER Matthews, S Paul, JA Gutiérrez, WK Russell, MC Ward
    bioRxiv, 2026.02. 15.706019 , 2026
    2026
  • CX-5461 and Doxorubicin activate a shared DNA damage–associated transcriptional response in human cardiomyocytes
    S Paul, JA Gutiérrez, AR Bogar, ER Matthews, MC Ward
    G3: Genes, Genomes, Genetics , 2026
    2026
  • Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci
    ER Matthews, RO Abodunrin, JD Hurley, S Paul, JA Gutiérrez, AR Bogar, ...
    PLOS Genetics 21 (10), e1011900 , 2025
    2025
    Citations: 2
  • Abstract Thu100: CX-5461 induces a gene expression signature in cardiomyocytes that is shared with Doxorubicin, without the cardiotoxicity
    S Paul, J Gutierrez Jr, A Bogar, M Ward
    Circulation Research 137 (Suppl_1) , 2025
    2025
  • Topoisomerase II inhibitors CX-5461 and Doxorubicin differ in their cardiotoxicity profiles
    S Paul, JA Gutiérrez, AR Bogar, MC Ward
    bioRxiv, 2025.07. 20.665626 , 2025
    2025
    Citations: 1
  • Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases
    M Bolideei, R Barzigar, RB Gahrouei, E Mohebbi, KH Haider, S Paul, ...
    Stem Cell Reviews and Reports 21 (4), 905-934 , 2025
    2025
    Citations: 20
  • Studying sleep orthologs in Epsilonproteobacteria through an evolutionary lens: Investigating sleep mysteries through phylogenomics
    SR Pandi-Perumal, KM Saravanan, S Paul, DW Spence, ...
    World Journal of Microbiology and Biotechnology , 2025
    2025
    Citations: 3
  • DNA damage-associated protein co-expression network in cardiomyocytes informs on tolerance to genetic variation and disease
    OD Johnson, S Paul, JA Gutiérrez, WK Russell, MC Ward
    iScience 28 (5), 112474 , 2025
    2025
    Citations: 3
  • Cross-Kingdom Genomic Conservation of Putative Human Sleep-Related Genes: Phylogenomic Evidence From Chlamydomonas reinhardtii
    SR Pandi-Perumal, KM Saravanan, S Paul, GC Abraham, DW Spence, ...
    The Journal of Cellular Biochemistry 126, e70030 , 2025
    2025
    Citations: 1
  • Organoid: Biomedical application, biobanking, and pathways to translation
    A Sinha, M Maibam, R Jain, K Aggarwal, AK Sahu, P Gupta, S Paul, ...
    Heliyon 11 (10), e43028 , 2025
    2025
    Citations: 15
  • Role of Stem Cells in Diabetes, Liver Disease, and Cancer Treatment
    R Kamaraj, MJ Mehran, H Tiwari, MK Shukla, MV Cetiz, Z Basharat, ...
    Handbook of Regenerative Medicine, 404-420 , 2025
    2025
  • Role of Stem Cell-Based Therapy in Neurodegenerative, Ocular, and Cardiovascular Diseases
    S Paul, R Srinivasan, S Mohammed, A Kannan, V Mariappan, ÖÖ Özcan, ...
    Handbook of Regenerative Medicine, 149-166 , 2025
    2025
  • Expression of Helicobacter pylori CagA in Solanum melongena LA Cost Effective Strategy for Vaccine Development
    MJ Mehran, R Barzigar, BYS Kumar, N Haraprasad, B Fakrudin, S Paul, ...
    Indian Journal of Pharmaceutical Education and Research 59 (1), 196-209 , 2025
    2025
    Citations: 3
  • Unraveling the mysteries of sleep: exploring phylogenomic sleep signals in the recently characterized archaeal phylum lokiarchaeota near Loki’s castle
    SR Pandi-Perumal, KM Saravanan, S Paul, DW Spence, ...
    International journal of molecular sciences 26 (1), 60 , 2024
    2024
    Citations: 7
  • Clock-Sleep Communication
    SR Pandi-Perumal, S Paul, KM Saravanan, GP Namasivayam, ...
    Current Molecular Medicine 25 (4), 399 - 415 , 2024
    2024
    Citations: 10
  • Harnessing Simple Animal Models to Decode Sleep Mysteries
    SR Pandi-Perumal, KM Saravanan, S Paul, SB Chidambaram
    Molecular Biotechnology, 1-17 , 2024
    2024
    Citations: 8
  • Cross-Kingdom Genomic Conservation of Human Sleep-Related Gene Orthologs: Phylogenomic Evidence from Chlamydomonas reinhardtii
    SR Pandi-Perumal, KM Saravanan, S Paul, GC Abraham, DW Spence, ...
    BioRxiv, 2024.11. 02.621661 , 2024
    2024
    Citations: 1
  • Organoid: Biomedical Application, Biobanking, and Commercialization
    A Sinha, M Maibam, R Jain, K Aggarwal, AK Sahu, S Paul, B Bisht, ...
    Heliyon First look , 2024
    2024
  • Genomic analysis of Escherichia phage CMSTMSU isolated from shrimp farm effluent water
    C Lelin, E Thirumalaikumar, G Uma, RJ Anusha, P Sayan, S Sudhakar, ...
    Research Square , 2024
    2024

MOST CITED SCHOLAR PUBLICATIONS

  • Advances in targeting the WNT/β-catenin signaling pathway in cancer
    A Chatterjee, S Paul, B Bisht, S Bhattacharya, S Sivasubramaniam, ...
    Drug Discovery Today 27 (1), 82-101 , 2022
    2022
    Citations: 130
  • Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics
    R Kumavath, S Paul, H Pavithran, MK Paul, P Ghosh, D Barh, V Azevedo
    Biomolecules 11 (9), 1275 , 2021
    2021
    Citations: 74
  • Drug repurposing—an emerging strategy in cancer therapeutics
    KS Turabi, A Deshmukh, S Paul, D Swami, S Siddiqui, U Kumar, S Naikar, ...
    Naunyn-Schmiedeberg's Archives of Pharmacology 395 (10), 1139-1158 , 2022
    2022
    Citations: 56
  • Hippo signaling pathway has a critical role in Zika virus replication and in the pathogenesis of neuroinflammation
    G Garcia Jr, S Paul, S Beshara, VK Ramanujan, A Ramaiah, ...
    The American Journal of Pathology 190 (4), 844-861 , 2020
    2020
    Citations: 52
  • The transcriptome of anterior regeneration in earthworm Eudrilus eugeniae
    S Paul, S Balakrishnan, A Arumugaperumal, S Lathakumari, SS Syamala, ...
    Molecular biology reports 48 (1), 259-283 , 2021
    2021
    Citations: 27
  • Annotation of nerve cord transcriptome in earthworm Eisenia fetida
    V Ponesakki, S Paul, DKS Mani, V Rajendiran, P Kanniah, ...
    Genomics data 14, 91-105 , 2017
    2017
    Citations: 23
  • Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases
    M Bolideei, R Barzigar, RB Gahrouei, E Mohebbi, KH Haider, S Paul, ...
    Stem Cell Reviews and Reports 21 (4), 905-934 , 2025
    2025
    Citations: 20
  • Effects of gut microbiome and obesity on the development, progression and prevention of cancer
    R Kumavath, H Pavithran, S Paul, VT Anju, S Busi, M Dyavaiah
    International journal of oncology 64 (1), 4 , 2023
    2023
    Citations: 19
  • Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae
    S Paul, S Balakrishnan, A Arumugaperumal, S Lathakumari, ...
    Functional & Integrative Genomics 22, 1–32 , 2022
    2022
    Citations: 19
  • Waking up the sleep field: an overview on the implications of genetics and bioinformatics of sleep
    SR Pandi-Perumal, KM Saravanan, S Paul, GP Namasivayam, ...
    Molecular Biotechnology 66 (5), 919-931 , 2024
    2024
    Citations: 18
  • MINDIN (SPONDIN-2) IS ESSENTIAL FOR CUTANEOUS FIBROGENESIS IN A MOUSE MODEL OF SYSTEMIC SCLEROSIS
    I Rana, S Kataria, TL Tan, EY Hajam, DK Kashyap, D Saha, J Ajnabi, ...
    Journal of Investigative Dermatology 143 (5), 699-710 , 2022
    2022
    Citations: 18
  • Phytoremediation for Co-contaminated Soils of Cadmium and Polychlorinated Biphenyls Using the Ornamental Plant Tagetes patula L.
    X Miao, RR Kumar, Q Shen, Z Wang, Q Zhao, J Singh, S Paul, W Wang, ...
    Bulletin of environmental contamination and toxicology 108 (1), 129-135 , 2022
    2022
    Citations: 17
  • Identification, tissue specific expression analysis and functional characterization of arrestin gene (ARRDC) in the earthworm Eudrilus eugeniae: a molecular hypothesis behind …
    S Paul, DK Sudalai Mani, SS Sandhya, B Subburathinam, V Vijithkumar, ...
    Molecular Biology Reports, 1-12 , 2022
    2022
    Citations: 16
  • Organoid: Biomedical application, biobanking, and pathways to translation
    A Sinha, M Maibam, R Jain, K Aggarwal, AK Sahu, P Gupta, S Paul, ...
    Heliyon 11 (10), e43028 , 2025
    2025
    Citations: 15
  • Transcriptome analysis revealed the synergism of novel rhodethrin inhibition on biofilm architecture, antibiotic resistance and quorum sensing in Enterococcus faecalis
    ER Tatta, S Paul, R Kumavath
    Gene 871, 147436 , 2023
    2023
    Citations: 15
  • Impacts on dietary habits and health of Indian population during COVID-19 lockdown
    SP Ramasamy Rajesh Kumar, Saravanakumari Arumugham Dhanaraj, Rashmi Saini ...
    Public Health Review: International Journal of Public Health Research 7 (6 … , 2020
    2020
    Citations: 14
  • Transcriptome sequencing, de novo assembly and annotation of the freeze tolerant earthworm, Dendrobaena octaedra
    S Paul, LH Heckmann, JG Sørensen, M Holmstrup, A Arumugaperumal, ...
    Gene Reports 13, 180-191 , 2018
    2018
    Citations: 13
  • Data on genome annotation and analysis of earthworm Eisenia fetida
    S Paul, A Arumugaperumal, R Rathy, V Ponesakki, P Arunachalam, ...
    Data in brief 20, 525-534 , 2018
    2018
    Citations: 12
  • Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy
    PK Jain, S Jayappa, T Sairam, A Mittal, S Paul, VJ Rao, H Chittora, ...
    Journal of Medical Genetics, 1-9 , 2021
    2021
    Citations: 11
  • The draft genome of a new Verminephrobacter eiseniae strain: a nephridial symbiont of earthworms
    A Arumugaperumal, S Paul, S Lathakumari, R Balasubramani, ...
    Annals of microbiology 70 (1), 3 , 2020
    2020
    Citations: 11