PhD- IIT Indore
MSc- Jiwaji University Gwalior
BSc- Lucknow University
RESEARCH INTERESTS
Organic synthesis & catalysis
33
Scopus Publications
Scopus Publications
Synthetic Routes of Biologically Active Indole Derivatives with Antibacterial and Antifungal Properties Shivangi Sharma, Shivendra Singh Letters in Organic Chemistry, 2026 Natural alkaloids have long been recognized for their potent biological activities, particularly their antimicrobial properties. This review comprehensively explores the antibacterial and antifungal potential of alkaloid-based compounds, with a special emphasis on indole-derived frameworks. It discusses the natural antibacterial mechanisms of alkaloids and delves into the synthetic strategies employed to develop indole-based antibacterial agents. The structure-activity relationships (SAR) governing these activities are critically examined to understand the key molecular features influencing their efficacy. In the context of antifungal activity, this review highlights both natural and synthetic developments, including synthetic methodologies and SAR insights that guide the design of effective antifungal agents. Special attention is given to recent advances in synthetic chemistry that address current limitations, such as metal-catalyzed reactions, cross-coupling strategies, multi-component reactions, and organocatalysis, which offer promising routes for the development of novel antimicrobial agents. Finally, the review outlines the existing challenges and proposes future directions for biological evaluation, emphasizing the need for deeper mechanistic studies to better understand the action of both antibacterial and antifungal agents. By integrating synthetic innovation with biological insight, this review aims to guide future research toward the development of more effective and targeted antimicrobial therapies.
4-Amino-3-hydrazino-5-mercapto-1,2,4,-triazole (PURPALD) in organic chemicals analysis: Distinguishing aldehydes and ketones Journal of Integrated Science and Technology, 2024
Coumarins and their derivatives as anti-inflammatory agents Shivangi Sharma, Raman Singh, Kuldeep Singh, Shivendra Singh Heterocyclic Anti Inflammatory Agents A Guide for Medicinal Chemists, 2024 Coumarins are a diverse class of phytochemicals found in many human diets and have been shown to have various pharmacological actions. The chapter discusses the role of coumarins in disease prevention and treatment and their classification based on structure. It also highlights that the various schemes of coumarin possess antiinflammatory properties, making them a promising scaffold for the synthesis of a new class of anti-inflammatory drugs. Overall, this chapter provides valuable information on the potential use of coumarins as anti-inflammatory agents and their synthetic aspects. This book chapter focuses on the development of various possible potential anti-inflammatory molecules having a coumarin core.
Thiazole and thiazolidinone derivatives as antiinflammatory agents Raman Singh, Shivangi Sharma, Shivendra Singh, Kuldeep Singh Heterocyclic Anti Inflammatory Agents A Guide for Medicinal Chemists, 2024 The significant potential of thiazole and thiazolidinone derivatives as antiinflammatory drugs can be observed in their ability to inhibit a variety of inflammatory mediators. These derivatives also inhibit factors that catalyze the synthesis of inflammatory mediators. The anti-inflammatory effects of the derivatives of thiazole and thiazolidinone demonstrated this potential. In addition, they have antioxidant properties that help to reduce oxidative stress and inflammation that the body experiences. These derivatives represent promising molecules for the development of new medications in the near future because they successfully reduce inflammation in various preclinical and clinical studies. The potential of thiazole derivatives as COX inhibitors and anti-inflammatory drugs has also been investigated, with promising results. Further research is needed to explore their mechanisms of action, optimize their therapeutic potential, and evaluate their safety and efficacy in clinical settings.
ß-Carbolines as Antibacterial Agents: Synthesis and Biological Study Shivendra Singh, Shivangi Sharma Carbolines A Privileged Scaffold for Modern Drug Discovery, 2024 Among the many nitrogen-containing heterocycles found in nature, the β-carboline stand out as an exceptional group with wide-ranging therapeutic applications. In this chapter we provide a high-level overview of the structure and antibacterial properties of β-carboline skeletons and discuss the wide range of bioactivities possessed by these compounds. With appropriate examples, we discuss in detail the nature and existence of β-carboline frameworks. In addition, we elucidate the evolutionary history, chemical make-up, and potential biological functions of a number of other useful natural products with a beta-carboline skeleton. As an added bonus, this chapter also delves into the synthetic side of things, as well as a number of extremely important uses for compounds with a β-carboline core.
Biochar, Clay, Zeolites, and Microorganism-based Methods for Remediation of Heavy Metals Yukti Monga, Shivangi Sharma, Shivendra Singh, Ashu Gupta Current Green Chemistry, 2024 The modern world of chemistry needs to find a sustainable solution for the remediation of heavy metals. The method of solving heavy metal problems using abundant and easily available ways is an integral part of green chemistry. This approach stimulates innovation among scientists. These procedures increase performance and decrease the consumption of non-renewable resources, minimizing negative impacts on the environment and less use of harmful chemicals. In this review, we have included some natural ways for the remediation of heavy metals such as Biochar, Clay, Zeolites, and Microorganismbased methods. We have also incorporated the mechanism of action of each of these procedures for the betterment of the reader.
Heterocyclic-Based Analogues against Sarcine-Ricin Loop RNA from Escherichia coli: In Silico Molecular Docking Study and Machine Learning Classifiers Shivangi Sharma, Rahul Choubey, Manish Gupta, Shivendra Singh Medicinal Chemistry, 2024 Background: Heterocyclic-based drugs have strong bioactivities, are active pharmacophores, and are used to design several antibacterial drugs. Due to the diverse biodynamic properties of well-known heterocyclic cores, such as quinoline, indole, and its derivatives, they have a special place in the chemistry of nitrogen-containing heterocyclic molecules. Objective: The objective of this study is to analyze the interaction of several heterocyclic molecules using molecular docking and machine learning approaches to find out the possible antibacterial drugs. Methods: The molecular docking analysis of heterocyclic-based analogues against the sarcin-Ricin Loop RNA from E. coli with a C2667-2'-OCF3 modification (PDB ID: 6ZYB) is discussed. Results: Many heterocyclic-based derivatives show several residual interaction, affinity, and hydrogen bonding with sarcin-Ricin Loop RNA from E. coli with a C2667-2'-OCF3 alteration which are identified by the investigation of in silico molecular docking analysis of such heterocyclic derivatives. Conclusion: The dataset from the molecular docking study was used for additional optimum analysis, and the molecular descriptors were classified using a variety of machine learning classifiers, including the GB Classifier, CB Classifier, RF Classifier, SV Classifier, KNN Classifier, and Voting Classifier. The research presented here showed that heterocyclic derivatives may operate as potent antibacterial agents when combined with other compounds to produce highly efficient antibacterial agents.
Spider Silk: Biosynthesis, Properties & Bioengineering Shivendra Singh, Shivangi Sharma, Snigdha Das, Amlan Kumar Das Current Nanomaterials, 2024 Due to the remarkable and unique qualities of spider silk, it has much applicability in the coming days. The complicated diversity and structure of spider silk ensure its use in both nature and industry. Based on the uniqueness and distinctive qualities associated with spider silks, advancements in cloning and expression of these silks are a growing area of research and industrial use. The environmentally triggered spider silk assembly and further disassembly, the creation of fibers, films, and novel chimeric composite materials from genetically modified spider silks are interesting areas of research in nanotechnology. In this context, we have discussed the creation of hybrids made of spider silk that combine with organic nanoparticles, both naturally occurring and bioengineered spider silk proteins. The diversity of spider silk, its composition and architecture, the distinctions between spider silk and silkworm silk, and the biosynthesis of natural silk are also discussed. This article describes the current issues and expected outcomes using biochemical data and processes.
Investigating Bacopa monnieri L. Therapeutic Potential for the Treatment of Neurological Diseases Pratima Srivastava, Dhananjay Yadav, Santosh Kumar Singh, Sung Hae Kim, Shivendra Singh, Shweta Katiyar, Minseok Song Current Pharmaceutical Design, 2024 The popular perennial creeping plant known as Bacopa monnieri(also known as Brahmi) is being utilized in the Indian Ayurvedic medicine practice. It has a variety of bioactive phytoconstituents that have been used therapeutically to treat a number of serious illnesses. Ancient Vedic scholars used this herb because of its pharmacological effects, particularly as a nerve booster and nootropic supporter. However, it is vital to comprehend the active phytochemical components of Bacopa monnieri extract (BME) and their molecular mechanisms in order to better grasp the effect of BME on neurological illnesses and diseases. Understanding its active phytochemical constituents and their molecular processes is essential. Numerous clinical investigations indicated that BME may have neuroprotective benefits, so it is worthwhile to re-evaluate this well known plant. Here, we focused on neurological problems as we examined the pharmacological and phytochemical characteristics of BME. For their effective usage in neuroprotection and cognition, many clinical concerns and the synergistic potential of Bacopa extract have been investigated. Alzheimer’s disease is a neurological condition caused by the production of reactive oxygen species, which also causes amyloid-beta (Aβ) and tau protein aggregation and increases neuro-inflammation and neurotoxicity. Our review offers a more indepth molecular understanding of the neuroprotective functions of BME, which can also be connected to its therapeutic management of neurological illnesses and cognitive-improving effects.
