Uncovering the Emerging Prospects of Lipid-based Nanoparticulate Vehicles in Lung Cancer Management: A Recent Perspective Dhruv Sanjay Gupta, Divya Suares Pharmaceutical Nanotechnology, 2025 Lung cancer, a leading cause of cancer-related deaths globally, is gaining research interest more than ever before. Owing to the burden of pathogenesis on the quality of life of patients and subsequently the healthcare system, research efforts focus on its management and amelioration. In an effort to improve bioavailability, enhance stability, minimize adverse effects and reduce the incidence of resistance, nanotechnological platforms have been harnessed for drug delivery and improving treatment outcomes. Lipid nanoparticles, in particular, offer an interesting clinical opportunity with respect to the delivery of a variety of agents. These include synthetic chemotherapeutic agents, immunotherapeutic molecules, as well as phytoconstituents with promising anticancer benefits. In addition to this, these systems are being studied for their usage in conjunction with other treatment strategies. However, their applications remain limited owing to a number of challenges, chiefly clinical translation. There is a need to address the scalability of such technologies, in order to improve accessibility. The authors aim to offer a comprehensive understanding of the evolution of lipid nanoparticles and their application in lung cancer, the interplay of disease pathways and their mechanism of action and the potential for delivery of a variety of agents. Additionally, a discussion with respect to results from preclinical studies has also been provided. The authors have also provided a well-rounded insight into the limitations and future perspectives. While the possibilities are endless, there is a need to undertake focused research to expedite clinical translation and offer avenues for wider applications in disease management.
Exploration of the Growing Potentials of Nanosensor Usage: Future Perspectives and The Way Forward Dhruv Sanjay Gupta, Divya Suares, Nikhil Agarwal Nanosensors in Healthcare Design Applications and Regulatory Aspects, 2025 Over the last few decades, there has been an increased focus on nanotechnological interventions to improve processes spanning across various industries. One such application that has steadily gained interest is that of nanosensors. Nanosensors have gained popularity owing to their ease of usage, reproducibility and sensitivity. They find applications in a variety of industries, and serve as an integral tool for monitoring quality and ensuring compliance with regulatory standards. This ranges from evaluation of the bioburden and quantification of factors accelerating food spoilage, diagnosis and imaging in clinical settings as well as assessment of environmental factors to improve agricultural yield. This chapter offers a recent update on the applications of different types of nanosensors, an overview of their salient features that support their usage, and key parameters that must be taken into consideration to facilitate scaling-up and translation from laboratory-to-clinical settings, to enhance beneficial outcomes. Additionally, the authors address key challenges that impede nanosensor usage, such as environmental and physiological toxicity, lack of robust regulations and standardization, as well as the need to cultivate a thorough understanding of traditional processes and their limitations, before necessitating the focused application of nanosensors. Moving forward, there is a need to understand the potentials for harnessing artificial intelligence with respect to the designing and usage of nanosensors, and some important clinical applications, owing to a recent spike in the occurrence of viral infections. Such current developments in the domain and future perspectives have been briefly touched upon, to provide readers a holistic overview of the domain.
The Evolving Landscape of Magnetic Nanosensor Usage: Recent Developments and Promising Opportunities Galvina Pereira, Dhruv Sanjay Gupta, Divya Suares Nanosensors in Healthcare Design Applications and Regulatory Aspects, 2025 Magnetic nanosensors have emerged as powerful tools in the healthcare sector, showcasing significant advancements that hold great promise in diverse applications including diagnostics, therapeutics and theranostics. Magnetic nanosensors leverage the unique properties of nanomaterials to detect and respond to specific biomolecules with high sensitivity. Magnetic nanosensors enable the detection of biomarkers associated with various diseases, including cancer, cardiovascular disorders, and infectious diseases, at ultra-low concentrations. This facilitates early-stage disease diagnosis, allowing for prompt intervention and improved patient outcomes. The integration of magnetic nanosensors with advanced imaging modalities such as magnetic resonance imaging (MRI) has enhanced imaging resolution and provided clinicians with valuable insights into disease progression and treatment efficacy by enabling real-time monitoring of physiological processes at the molecular level. Furthermore, magnetic nanosensors play a pivotal role in targeted drug delivery systems. Their magnetic properties allow for precise navigation within the body under the influence of external magnetic fields. This targeted approach minimizes off-target effects, enhances drug efficacy, and reduces side-effects, thereby revolutionizing drug delivery strategies in the healthcare domain. In the realm of point-of-care diagnostics, the miniaturization of magnetic nanosensors has led to the development of portable and cost-effective devices, thus offering rapid and on-site detection of biomarkers, facilitating timely decision-making by healthcare professionals. In addition to their diagnostic applications, magnetic nanosensors have shown promise in therapeutic interventions. By incorporating magnetic nanoparticles into tissues and applying an external magnetic field, precise and controlled heating can be achieved. This localized hyperthermia is being explored for cancer treatment, demonstrating potential non-invasive and targeted therapeutic strategy. Nonetheless, widespread adoption of magnetic nanosensors also pose challenges such as biocompatibility, long-term safety, and scalability, which must be addressed to ensure the seamless translation of these technologies from the laboratory to clinical settings. As research in this field continues to progress, addressing the associated challenges will be crucial in unlocking the full potential of magnetic nanosensors for improving patient outcomes and advancing personalized medicine.
Preface Nanosensors in Healthcare Design Applications and Regulatory Aspects, 2025
Unveiling the Dynamic Realm of Ultrasound Nanosensors: Exploring its Advancements and Promising Prospects Atul Sherje, Dhruv Sanjay Gupta, Divya Suares, Prajakta Malli, Illham Dhala Nanosensors in Healthcare Design Applications and Regulatory Aspects, 2025 Recent research attempts have focused on the delicate interplay between complex physiological processes and the utilization of sensor-based technologies to aid detection, and subsequent therapy of several ailments. Amongst devices hinging on a variety of biophysical sensing principles, ultrasound nanosensors stand out owing to their ease of construction, versatility across a variety of pathological conditions, and overall cost-effectiveness. With applications ranging from site-specific, controlled delivery of agents for neoplasm management to benefits in early diagnosis through imaging, newer frontiers in this domain continue to emerge. These developments offer a ray of hope to clinicians and patients globally, chiefly for the management of metabolic disorders. Another noteworthy advancement has been the conjunction of conventional sensing principles with nanotechnological platforms, and this approach has been widely adopted to enhance drug delivery, improve precision, and minimize off-site effects. The authors of this chapter aim to offer an overview of ultrasound-mediated therapeutics and diagnostics, with a keen focus on the value-addition offered by combination with nanotechnological approaches. Stemming from this discussion is an overview of the evolution of materials used for the construction of such devices over time, key parameters influencing biomedical applications, as well as bench-to-bedside translation. Finally, a perspective has been offered on certain pitfalls and challenges that must be addressed, to widen the scope of benefits offered by such platforms in clinical settings. Certain trends expected to shape the nanosensors industry have also been touched upon by the authors, to provide a holistic viewpoint of the current scenario and prospective applications.
Development of Smart Hydrogel Using Polysaccharide-Based Graft Copolymer Graft Copolymers for Biomedical and Tissue Engineering Applications, 2025
The application of nanoparticles as advanced drug delivery systems in Attenuating COPD Victoria Jessamine, Samir Mehndiratta, Gabriele De Rubis, Keshav Raj Paudel, Saritha Shetty, Divya Suares, Dinesh Kumar Chellappan, Brian G. Oliver, Phillip M. Hansbro, Kamal Dua Heliyon, 2024 Chronic Obstructive Pulmonary Disease (COPD) is a dilapidating condition which is characterized by inflammation, an excess in free radical generation and airway obstruction. Currently, the drugs commercially available for the management of COPD pose several limitations such as systemic adverse effects, including bone density loss and an increased risk of developing pneumonia. Moreover, another limitation includes the need for regular and frequent dosing regimens; which can affect the adherence to the therapy. Furthermore, these current treatments provide symptomatic relief; however, they cannot stop the progression of COPD. Comparatively, nanoparticles (NPs) provide great therapeutic potential to treat COPD due to their high specificity, biocompatibility, and higher bioavailability. Furthermore, the NP-based drug delivery systems involve less frequent dosing requirements and in smaller doses which assist in minimizing side effects. In this review, the benefits and limitations of conventional therapies are explored, while providing an in-depth insight on advanced applications of NP-based systems in the treatment of COPD.
Preface Gabriele De Rubis, Ronan MacLoughlin, Hélder A. Santos, Saritha Shetty, Divya Suares, Kamal Dua Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders, 2024
Natural product-based compounds for chronic respiratory disorders Dheeraj Bisht, Deepak Chandra Joshi, Manoj Bisht, Nirmal Joshi, Shavkatzon Azizov, H. Lalhlenmawia, Deepak Kumar, Kamal Dua, Saritha Rakesh Shetty, Divya Suares Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders, 2024
Stability-indicating assay method for determination of rosuvastatin in nano-formulation and pharmaceutical dosage form by RP-HPLC International Journal of Pharmtech Research, 2016
Calotropis gigantea R. Br. (Asclepiadaceae): A review International Journal of Pharmaceutical Research, 2011
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Tumor microenvironment targeted nanotherapy C Fernandes, D Suares, MC Yergeri Frontiers in pharmacology 9, 1230 , 2018 2018 Citations: 188
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Preformulation in drug research and pharmaceutical product development PC Acharya, S Shetty, C Fernandes, D Suares, R Maheshwari, ... Dosage form design considerations, 1-55 , 2018 2018 Citations: 31
Comparison of nanoemulsion and aqueous micelle systems of paliperidone for intranasal delivery K Pidaparthi, D Suares AAPS PharmSciTech 18 (5), 1710-1719 , 2017 2017 Citations: 25
Calotropis gigantea R. Br.(Asclepiadaceae): a review H Joshi, MP Gururaja, D Suares Int J Pharm Res 3, 10-14 , 2011 2011 Citations: 22
Self micro-emulsifying drug delivery system (SMEDDS): A promising tool to improve bioavailability N Meghani, D Suares Journal of Pharmacy and Phytotherapeutics 2 (1), 17-21 , 2013 2013 Citations: 21
Dosage form design considerations PC Acharya, S Marwein, B Mishra, R Ghosh, A Vora, RK Tekade Dosage Form Design Considerations , 2018 2018 Citations: 17
Solubility and solubilization approaches in pharmaceutical product development PC Acharya, C Fernandes, D Suares, S Shetty, RK Tekade Dosage Form Design Considerations, 513-547 , 2018 2018 Citations: 16
Taste masked orodispersible formulation of fexofenadine hydrochloride using ion exchange resins D Suares, A Hiray Indian Journal of Pharmaceutical Sciences 77 (5), 550-555 , 2015 2015 Citations: 13
Hypoglycemic effect of Memecylon umbellatum root H Joshi, AB Joshi, H Sati, MP Gururaja, EVS Subrahmanyam, ... Pharmacognosy Magazine pp.1-4. 4 (15), 1-4 , 2008 2008 Citations: 11
Nanostructured polymer scaffolds for tissue engineering technology C Fernandes, D Suares, V Dhawan, P Prabhu Fundamentals of nanoparticles, 451-483 , 2018 2018 Citations: 9
Rheology and its implications on performance of liquid dosage forms PC Acharya, D Suares, S Shetty, C Fernandes, RK Tekade Dosage Form Design Considerations, 549-597 , 2018 2018 Citations: 8
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Lipid nanocarriers for intracellular delivery CB Fernandes, D Suares, V Dhawan Multifunctional Nanocarriers for Contemporary Healthcare Applications, 129-156 , 2018 2018 Citations: 5
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