Mohit Sharma

@sgtuniversity.ac.in

Professor, Department of Oral Pathology/mohit_fdsc@sgtuniversity.org
SGT Dental College Hospital & Research Institute, Gurgaon

Mohit Sharma


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https://researchid.co/prof.dr.mohitsharma
Dr. Mohit Sharma, Prof-Oral Pathol & Microbiol >15 yrs. > 52 publication high repute Journal ( [Google Scholar-948 Citation, 56 Articles, H-ind-16; Web of Science-465 Citation, 34 (Q1=16), H-Ind=12; Scopus 643 citations 37 (Q1=24,Q2=4 Q3=6, Q4=3),H index-14]. Co-investigator-couple of research grants. 6-Patents, Article in News: [pH Gradient Reversal: An Emerging Hallmark of Cancers. 1. , 2. , 3.. Reviewer:253 Peer Reviews (, Membership - IAOMP, ISDR & IDA. Editorial Board (8) Cancer Pain, Journal Current Problems in Cancer Case Reports, Molecular & Clinical Oncology, ABM-Heliyon, BMC Oral Health, Discover Applied Science, Scientific Reports, International Journal of Cell biology.

EDUCATION

BDS, MDS (Oral Pathology)

RESEARCH, TEACHING, or OTHER INTERESTS

Cancer Research, Cell Biology, Molecular Biology, Genetics

FUTURE PROJECTS

Bidirectional Realtionship between Oral Cancer and Pain

Title:/Research Question: Potential two-way associations b/w oral cancer and cancer pain mediators: An unobserved vicious cycle or Correlation between the tumorigenesis and oral cancer pain: A narrative review Aim: To prove a bidirectional association between cancer and the molecular pain mediators Objective: 1. To identify the molecular markers of pain in lieu of the above 2. To characterize the role of these markers in cancer pathogenesis 3. To Schematically illustrate this relationship


Applications Invited
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37

Scopus Publications

956

Scholar Citations

16

Scholar h-index

22

Scholar i10-index

Scopus Publications

  • Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis
    Smitha Sammith Shetty, Kanaka Sai Ram Padam, Mohit Sharma, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan
    Scientific Reports, 2025
    Oral submucous fibrosis (OSF) is a chronic, progressive, and fibrotic condition of the oral mucosa that carries an elevated risk of malignant transformation. We aimed to identify and validate novel genes associated with the regulation of epithelial-to-mesenchymal transition (EMT) in OSF. Genes regulating EMT were identified through differential gene expression analysis, using a LogFC threshold of -1 and + 1 and a padj value < 0.05, based on data from GEO datasets and the TCGA-HNSC datasets. The curated EMT genes were correlated with functional cancer states and subjected to clustering to identify candidate genes. Integration of bioinformatics and proteomics led to the discovery of the EMT genes MMP9, SPARC, and ITGA5 as novel candidates. Comprehensive pathway and immunohistochemical analyses confirmed their roles in regulating EMT in OSF, oral squamous cell carcinoma (OSCC), and OSF-associated squamous cell carcinoma (OSFSCC). The significant roles of MMP9, SPARC, and ITGA5 in fibrosis and malignancy suggest a novel mechanism in which fibrosis-associated type 2 EMT undergoes transition to type 3 EMT, driving OSF towards malignancy.
  • Salivary matrix metalloproteinases in periodontitis and cardiovascular disease: a systematic review
    Dax Abraham, Rajat Sharma, Alpa Gupta, Mohit Sharma, Sonal Soi
    Discover Applied Sciences, 2025
    This systematic review aimed to synthesize findings from existing studies to explore the role of matrix metalloproteinases (MMPs), particularly MMP-9 and MMP-8, in the pathophysiology of cardiovascular disease (CVD) and periodontitis. A comprehensive literature search was conducted across multiple electronic databases, including Medline, Scopus, Embase, Epistemonikos, and grey literature sources. Cross-sectional, cohort, and case-control studies that evaluated salivary MMP levels in patients with periodontitis and CVD were included. The Newcastle-Ottawa Scale was used to assess the quality and risk of bias of the included studies. Confounding factors were evaluated using a causal diagram and a confounder matrix. Eight studies with a total of 2,636 participants were included in the review. Elevated levels of salivary MMP-9 and MMP-8 were consistently observed in patients with both periodontitis and CVD, compared to healthy controls or patients with periodontitis alone. The imbalance between MMPs and their inhibitors, such as TIMP-1, was also evident in these patients, indicating dysregulated extracellular matrix remodeling. Salivary MMP levels were correlated with other inflammatory markers, including myeloperoxidase (MPO) and interleukin-1 beta (IL-1β), further supporting the interconnected nature of oral and systemic inflammation. This review highlights the potential of salivary MMPs, particularly MMP-9 and MMP-8, as biomarkers for the early diagnosis, risk stratification, and monitoring of the interrelated conditions of periodontitis and cardiovascular disease. Further, longitudinal studies are warranted to elucidate the causal relationships between these biomarkers and disease progression.
  • Systematic review and meta analysis of substance P in gingival crevicular fluid as a diagnostic biomarker for tooth pain
    Vishakha Kumar Mendiratta, Sonal Soi, Aakansha Puri, Mohit Sharma, Alpa Gupta, Raghu Radhakrishnan, Aakash Kumar
    Discover Applied Sciences, 2025
    Background The trigeminal sensory system releases numerous neuropeptides like neurokinin A (NKA), substance P (SP), and calcitonin gene-regulated protein (CGRP), which play crucial functions in orofacial pain. Pulpitis increases the production of these neuropeptides in pulp and peripheral body fluids like saliva and the GCF. Pain perception is the most investigated and well-researched role of SP. Moreover, SP was the first neuropeptide to be recognized in dental pulp. Methods Searches were performed in PubMed, Scopus, EBSCOhost, Epistemonikos, grey literature databases, and other available databases until July 2024. Three independent reviewers performed a grey literature search on Google to attain maximum coverage beyond peer review, and articles were resolved with agreement among the reviewers. The selection criteria were in vivo studies that evaluated SP levels in GCF at the site of tooth pain and a healthy tooth. Meta-analysis was performed using standardized mean differences by the method of Cohen using the random-effects inverse variance model with the DerSimonian-Laird estimator for tau². Results Six articles were included in the review according to the selection criteria. Five studies concluded that there is a significant elevation of levels of SP in GCF in a painful tooth when compared to a healthy tooth. These five studies were incorporated in the meta-analysis. However, one study concluded similar levels of SP in GCF in painful and healthy teeth. Conclusions The results indicate that SP concentrations in GCF could rise due to dental pain and inflammation. These findings must be interpreted conservatively since several possible confounding factors, such as differences in sampling methods, pain determination criteria, patient age, systemic health status, drug use, and periodontal status, could affect SP levels. Due to the paucity of studies and heterogeneity of methods, more high-quality research must be conducted to replicate these associations and define the clinical usefulness of SP as a pain biomarker for dentistry.
  • Interplay of epigenetics and epistasis drives oral submucous fibrosis
    Mohit Sharma, Smitha Sammith Shetty, Faisal Alhedyan, Raghu Radhakrishnan
    Discover Applied Sciences, 2025
    Persistent injury to oral mucosa due to habitual quid chewing, resulting in the upregulation of inflammatory cytokines and consequential myofibroblastic persistence, emphasizes the role of epigenetic aberration in the pathogenesis of oral submucous fibrosis (OSF). However, there is a dearth of research on the role epistasis plays in the pathophysiology of OSF. Among the important epistatic interactions in the pathophysiology of OSF are those between Phosphatase and Tensin Homologue (PTEN) and Insulin-Like Growth Factor 1, Transforming Growth Factor-β (TGF-β), Cyclooxygenases, and lipoxygenases (LOX). Additionally, PTEN and Nuclear Factor Kappa B (NF-κB) have an epistatic relationship that is particularly mediated by the p65 subunit of NF-κB. Given the importance of epigenetic modification in the pathogenesis of OSF, the potential use of DNA methyltransferase and Histone deacetylase inhibitors as a therapeutic option holds promise. Another in vivo epigenetic therapeutic option for treating OSF is using stimulatory microRNAs against antifibrotic genes and inhibitory microRNAs against profibrotic genes. This review aims to connect numerous epigenetic and epistatic components to the mechanism of OSF. A better understanding of the disease process may provide OSF management with newer therapeutic options. Graphical Abstract
  • Role of MMP inhibitors on levels of MMP‑2 and MMP‑9 in mammalian cell lines – A systematic review
    Palak Jain, Alpa Gupta, Mrinalini, Mohit Sharma
    Journal of Oral and Maxillofacial Pathology, 2025
    Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in extracellular matrix (ECM) degradation, contributing to various pathological conditions, including periapical lesions and periodontal diseases. This systematic review evaluates the inhibitory effects of different natural and synthetic MMP inhibitors on MMP-2 and MMP-9 activities in mammalian cells, which are critical enzymes implicated in ECM breakdown. A comprehensive literature search was performed across databases, including PubMed, Scopus, and Cochrane until June 2023, following PRISMA guidelines. The Office of Health Assessment and Translation (OHAT) risk of bias tool was used for quality assessment, revealing a low risk of bias across all studies. Our findings demonstrate that both natural and synthetic MMP inhibitors significantly reduce MMP-2 and MMP-9 activities in mammalian cells. These compounds offer potential therapeutic benefits in managing diseases characterized by excessive MMP activity, such as periapical lesions and periodontal disease. This review highlights the therapeutic potential of MMP inhibitors in dentistry, specifically focusing on the promising roles of natural and synthetic MMP inhibitors in protecting ECM integrity.
  • Myofibroblasts persist through immune privilege mechanisms to mediate oral submucous fibrosis: Uncovering the pathogenesis
    Mohit Sharma, Smitha Sammith Shetty, Sonal Soi, Raghu Radhakrishnan
    Journal of Oral Biology and Craniofacial Research, 2024
    Immune privilege is the ability to tolerate foreign antigens without eliciting an inflammatory immune response. Several mechanisms explain a structure's immune privilege status, which is regulated by innate and adaptive immune responses. The role of myofibroblasts in perpetuating fibrosis by acquiring an immune privileged phenotype against the backdrop of oral submucous fibrosis (OSF) is evolving. Myofibroblasts persist through the Fas/FasL autocrine pathway and induce apoptosis in epithelial cells, explaining the juxtaposition of apoptotic cells in areas of fibrosis. However, increased matrix stiffness, in addition to activating TGF-β, reduces Fas surface expression in myofibroblasts, increasing their resistance to apoptosis. The reciprocal amplification loop between the immune checkpoint proteins programmed death-ligand 1 (PD-L1) and TGF-β involves the YAP-TAZ and SMAD2,3 pathways and dramatically enhances profibrotic signalling. Increased matrix stiffness also enhances cMYC expression, which subsequently amplifies PD-L1 levels on myofibroblasts. The increase in PD-L1 on the myofibroblast microengineers the phenotype of CD4 + T cells homing to fibrotic areas by acting on the programmed cell death protein 1 (PD-1) receptor on the T-cell surface, converting these cells from antifibrotic cells to profibrotic cells that produce IL-17A and TGF-β. This manuscript provides mechanistic insight into how myofibroblasts avoid apoptosis in OSFs by evading the immune system. Targeting an immune-privileged phenotype in myofibroblasts with FAS-FASL pathway-dependent characteristics is an ideal strategy for reversing OSF.
  • Areca nut-induced oral fibrosis – Reassessing the biology of oral submucous fibrosis
    Mohit Sharma, Sachin C. Sarode, Gargi Sarode, Raghu Radhakrishnan
    Journal of Oral Biosciences, 2024
    BACKGROUND: Oral submucous fibrosis (OSF) is a pathological condition characterized by excessive tissue healing resulting from physical, chemical, or mechanical trauma. Notably, areca nut consumption significantly contributes to the development of oral fibrosis. The current definition of OSF, recognizing its potential for malignant transformation, necessitates a more comprehensive understanding of its pathophysiology and etiology. HIGHLIGHTS: Areca nut induces fibrotic pathways by upregulating inflammatory cytokines such as TGF-β and expressing additional cytokines. Moreover, it triggers the conversion of fibroblasts to myofibroblasts, characterized by α-SMA and γSMA expression, resulting in accelerated collagen production. Arecoline, a component of areca nut, has been shown to elevate levels of reactive oxygen species, upregulate the expression of various cytokines, and activate specific signaling pathways (MEK, COX2, PI3K), all contributing to fibrosis. Therefore, we propose redefining OSF as "Areca nut-induced oral fibrosis" (AIOF) to align with current epistemology, emphasizing its distinctive association with areca nut consumption. The refined definition enhances our ability to develop targeted interventions, thus contributing to more effective prevention and treatment strategies for oral submucous fibrosis worldwide. CONCLUSION: Arecoline plays a crucial role as a mediator in fibrosis development, contributing to extracellular matrix accumulation in OSF. The re-evaluation of OSF as AIOF offers a more accurate representation of the condition. This nuanced perspective is essential for distinguishing AIOF from other forms of oral fibrosis and advancing our understanding of the disease's pathophysiology.
  • To evaluate the role of mast cells on angiogenesis in various grades of oral squamous cell carcinoma: A histochemical study
    Yusra Khan, Shweta Rehani, Mohit Sharma
    Journal of Oral and Maxillofacial Pathology, 2024
    Background: Oral cancer is the sixth most common cancer, and 90% of them are oral squamous cell carcinomas (OSCC). As most OSCC are asymptomatic and are only detected at an advanced stage, the 5-year survival rate is only 50%. Thus, using novel prognosticators can minimise mortality and morbidity associated with OSCC. This study aims to evaluate the relationship between mast cells and angiogenesis in different grades of OSCC to analyse their role in its progression. Material and Methods: A total of 45 cases were included, comprising 10 well-differentiated SCCs (WDOSCC), 10 moderately differentiated SCCs (MDOSCC), and 10 poorly differentiated SCCs (PDOSCC). Additionally, five normal buccal mucosae (NBM) samples served as negative controls for OSCC. Five cases of neurofibroma and pyogenic granuloma were used as positive controls for mast cells and angiogenesis, respectively. Results: The mean MCD in WDOSCC, MDOSCC, and PDOSCC were 3.2620 ± 2.65177, 3.0310 ± 1.38276, and 4.1580 ± 2.49482, respectively. The MVD in WDOSCC, MDOSCC, and PDOSCC were 10.2850 ± 4.35032, 9.9240 ± 2.72533, and 7.1520 ± 2.26966, respectively. Discussion: MCD was the highest in PDOSCC, followed by WDOSCC and MDOSCC. These results indicate a redundant role of mast cells in OSCC, or they might jumpstart malignancy but are retarded with OSCC progression. The MVD decreased with higher grades, in contrast to the prevalent literature. The correlation analysis between MVD and MCD revealed no significant correlation between them. Conclusion: We found a non-significant role of mast cells in tumour biology and a decrease in vascularity with advancing grades. These results indicate a lower need for mast cell activation to augment vascularisation. A study with a larger sample size is needed to confirm our results.
  • The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis
    Smitha Sammith Shetty, Mohit Sharma, Kanaka Sai Ram Padam, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan
    Journal of Oral Biology and Craniofacial Research, 2024
    Background: Oral submucous fibrosis (OSF) is a persistent oral mucosal condition that carries an elevated risk of undergoing malignant transformation. Our objective was to elucidate the involvement of epithelial-to-mesenchymal transition (EMT) in OSF and its progression to malignancy by studying a panel of EMT markers, thereby understanding the molecular mechanisms. Methods: An immunohistochemical analysis was done to detect the presence of E-cadherin, N-cadherin, pan-cytokeratin (PanCK), vimentin, α-SMA (alpha-smooth muscle actin), and CD44 in a total of 100 tissue samples. These samples comprised 40 cases of OSF, 20 cases of oral squamous cell carcinoma associated with OSF (OSFSCC), and 40 cases of oral squamous cell carcinoma (OSCC). A whole transcriptomic analysis was performed on a group of seven matched samples encompassing NOM, OSF, OSFSCC, and OSCC. Results: We observed significantly decreased expression of E-cadherin and PanCK, while N-cadherin, vimentin, α-SMA, and CD44 showed significantly higher expression in OSFSCC and OSCC as compared to OSF, both at protein and RNA levels. CD44 expression was noticeably higher in OSFSCC (p < 0.001) than in OSCC. Conclusion: Downregulation of epithelial markers with concomitant upregulation of mesenchymal and stem cell markers suggests the potential role of EMT and stemness in accelerating the pathogenesis and malignant transformation of OSF. The high levels of CD44 expression seen in OSFSCC indicate a high propensity for aggressiveness and acquisition of stem-like characteristics by the cells undergoing EMT.
  • Role of osteopontin in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cell carcinoma
    Nasir A. Salati, Mohit Sharma, Nirmala N. Rao, Smitha S. Shetty, Raghu A. Radhakrishnan
    Journal of Oral and Maxillofacial Pathology, 2023
    Background: Inflammatory cells and cytokines in the chronically injured mucosa promote fibrosis in the oral submucous fibrosis (OSF) fibrotic milieu. Osteopontin (OPN) is a wound-healing mediator that upregulates the inflammatory response and is involved in the malignancy and fibrosis of multiple organ systems. Objectives: We investigated the expression of OPN in oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs) to determine its role in the malignant transformation and fibrosis of oral tissues. The expression of OPN in OPMDs and OSCCs was compared and correlated, and the role of OPN as a fibrotic mediator in OSF was explained. Study Design: A total of 30 cases of normal mucosa and OPMDs (mild dysplasia, severe dysplasia, OSF and OSCCs) were studied by purposive sampling. In these groups, OPN immunoreactivity was examined and correlated with clinical findings. Results: In mild dysplasia, OPN expression was restricted to the basal cell layer with moderate staining intensity. In severe dysplasia, it was extremely intense and extended throughout the epithelium. In the OSF, OPN expression was moderate in the perinuclear areas of the basal cell layer. The expression of OPN was very strong in OSCC. A flow diagram explaining the profibrotic role of OPN in OSF has been provided. Conclusion: A positive role of OPN in both pathogenesis and malignant transformation of OPMDs and OSCC has been demonstrated.
  • Comprehensive analysis of microRNAs and their target genes in oral submucous fibrosis
    Padacherri Vethil Jishnu, Sangeetha U. Shenoy, Mohit Sharma, Aditi Chopra, Raghu Radhakrishnan
    Oral Diseases, 2023
  • Should oral submucous fibrosis be restaged?
    Mohit Sharma, Raghu Radhakrishnan
    Oral Oncology Reports, 2023
  • Nicotine is an independent potential fibrogenic mediator in non-betel quid associated oral submucous fibrosis
    Mohit Sharma, Mandana Donoghue, Radhika Pathiyal, Raghu Radhakrishnan
    Medical Hypotheses, 2022
  • Targeting the immune-privileged myofibroblast in oral submucous fibrosis by CAR T-cell therapy
    Sachin C. Sarode, Nilesh Kumar Sharma, Gargi Sarode, Mohit Sharma, Raghu Radhakrishnan
    Medical Hypotheses, 2022
  • The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis
    Zoufang Huang, Mohit Sharma, Aparna Dave, Yuqi Yang, Zhe-Sheng Chen, R. Radhakrishnan
    Frontiers in Pharmacology, 2022
  • Novel Pathways and Mechanisms of Nicotine-Induced Oral Carcino-genesis
    Mohit Sharma, Smitha S. Shetty, Raghu A. Radhakrishnan
    Recent Patents on Anti Cancer Drug Discovery, 2022
  • Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation
    Mohit Sharma, Keith D. Hunter, Felipe Paiva Fonseca, Raghu Radhakrishnan
    Head and Neck, 2021
  • Genotoxicity in oral mucosal epithelial cells of petrol station attendants: A micronucleus study
    Shweta Rehani, Naresh Raj, Prabhakar Jerrgal, Mohit Sharma, KundenduArya Bishen, Ruchi Nagpal
    Journal of Cytology, 2021
  • Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis
    Mohit Sharma, Keith D. Hunter, Felipe Paiva Fonseca, Smitha Sammith Shetty, Raghu Radhakrishnan
    Archives of Oral Biology, 2021
  • Understanding the molecular mechanism associated with reversal of oral submucous fibrosis targeting hydroxylysine aldehyde-derived collagen cross-links
    Raghu Radhakrishnan, SmithaSammith Shetty, Mohit Sharma, ShamaPrasada Kabekkodu, NV Anil Kumar, Kapaettu Satyamoorthy
    Journal of Carcinogenesis, 2021
  • Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation
    Mohit Sharma, Felipe Paiva Fonseca, Keith D. Hunter, Raghu Radhakrishnan
    International Journal of Oral Science, 2020
  • Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma
    Smitha Sammith Shetty, Mohit Sharma, Felipe Paiva Fonseca, Pradyumna Jayaram, Ankit Singh Tanwar, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy, Raghu Radhakrishnan
    Japanese Dental Science Review, 2020
  • Porphyromonas gingivalis and adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms
    Aditi Chopra, Raghu Radhakrishnan, Mohit Sharma
    Critical Reviews in Microbiology, 2020
  • CD1A+ and CD207+ cells are reduced in oral submucous fibrosis and orasquamous cell carcinoma
    LC. Silva, FP. Fonseca, OP Almeida, BA. Mariz, MA. Lopes, R. Radhakrishnan, M. Sharma, LP. Kowalski, PA. Vargas
    Medicina Oral Patologia Oral Y Cirugia Bucal, 2020
  • Oral candidal carriage correlates with CD4+ cell count but not with HIV and highly active antiretroviral therapy status
    Parul Sah, Pratik Patel, Chetana Chandrashekar, Suganthi Martena, Mamatha Ballal, Manjayya Hegde, Vasudeva Guddattu, Craig Murdoch, Mohit Sharma, Raghu Radhakrishnan
    Journal of Investigative and Clinical Dentistry, 2019
  • A two-way relationship between the head and neck cancer and esophageal cancer
    Mohit Sharma, Raghu Radhakrishnan
    Oral Oncology, 2019
  • Revisiting and revising the definition of oral submucous fibrosis
    Mohit Sharma, Raghu Radhakrishnan
    Oral Oncology, 2019
  • Oral submucous fibrosis as an overhealing wound: Implications in malignant transformation
    Mohit Sharma, Smitha S. Shetty, Raghu Radhakrishnan
    Recent Patents on Anti Cancer Drug Discovery, 2018
  • Exploring the potential of laser capture microdissection technology in integrated oral biosciences
    A Thennavan, M Sharma, C Chandrashekar, K Hunter, R Radhakrishnan
    Oral Diseases, 2017
  • Micronucleus assay: An early diagnostic tool to assess genotoxic changes in patients with tobacco use, oral leukoplakia and oral submucous fibrosis
    Moulshree Kohli
    Journal of Clinical and Diagnostic Research, 2017
  • Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies
    Mohit Sharma, Raghu Radhakrishnan
    Journal of Oral Pathology and Medicine, 2017
  • CTGF is obligatory for TGF-β1 mediated fibrosis in OSMF
    Mohit Sharma, Raghu Radhakrishnan
    Oral Oncology, 2016
  • Unfavourable stoichiometry of PAI-1 and tPA foments OSMF
    Mohit Sharma, Raghu Radhakrishnan
    Oral Oncology, 2016
  • pH gradient reversal: An emerging hallmark of cancers
    Mohit Sharma, Madhusudan Astekar, Sonal Soi, Bhari Manjunatha, Devi Shetty, Raghu Radhakrishnan
    Recent Patents on Anti Cancer Drug Discovery, 2015
  • Viral carcinogenesis of oral region and recent trends in treatment
    Mohit Sharma, Madhusudan Astekar, Sonal Soi, Bhari Manjunatha, Devi Shetty
    Recent Patents on Biomarkers, 2015
  • Molecular changes in invasive front of oral cancer
    Raghu Radhakrishnan, Mohit Sharma, Parul Sah, SonalSoi Sharma
    Journal of Oral and Maxillofacial Pathology, 2013
  • Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis
    Mohit Sharma, Indira Bairy, Keerthilatha Pai, Kapaettu Satyamoorthy, Shailendra Prasad, Barry Berkovitz, Raghu Radhakrishnan
    Clinical Oral Investigations, 2011

RECENT SCHOLAR PUBLICATIONS

  • PORTABLE STERILIZATION DEVICE AND METHOD FOR STERILIZING ENDODONTIC FILES
    S Sonal, M Sharma, A Gupta, D Abraham, A Puri, SH Bukhari, ...
    IN Patent App. 202,611,009,804 , 2026
    2026
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    Scientific Reports , 2026
    2026
  • Radiation Related Caries in Oral Cancer: Molecular Pathogenesis, Cellular Mechanisms, and Contemporary Management Paradigms
    S Soi, M Sharma, S Sushant, M Mrinalini, SK Saini, A Dave, D Sharma
    Journal of Cancer Research and Therepeutics , 2026
    2026
  • Salivary matrix metalloproteinases in periodontitis and cardiovascular disease: a systematic review
    D Abraham, R Sharma, A Gupta, M Sharma, S Soi
    Discover Applied Sciences 7, 1265 , 2025
    2025
    Citations: 2
  • Anatomy of a research paper: A humanized approach
    BS Manjunatha, M Sharma
    Current Trends In Dentistry 2 (1), 62-63 , 2025
    2025
  • AUTOMATED EMERGENCY BATTERY JUMP STARTING SYSTEM FOR VEHICLES
    M Sharma, A Dave, P Saluja, N Tanwar, Y Singh, Rakshat, J Ruth
    IN Patent App. 202,511,096,155 , 2025
    2025
  • Interplay of epigenetics and epistasis drives oral submucous fibrosis
    M Sharma, SS Shetty, F Alhedyan, R Radhakrishnan
    Discover Applied Sciences 7, 878 , 2025
    2025
    Citations: 2
  • Systematic Review and Meta Analysis of Substance P in Gingival Crevicular Fluid as a Diagnostic Biomarker for Tooth Pain.
    VK Mendiratta, S Soi, A Puri, M Sharma, A Gupta, R Radhakrishnan, ...
    Discover Applied Sciences 7, 1191 , 2025
    2025
    Citations: 2
  • Role of MMP Inhibitors on Levels of MMP-2 and MMP-9 in mammalian cell lines – A Systematic Review
    P Jain, A Gupta, Mrinalini, M Sharma
    Journal of Oral and Maxillofacial Pathology 29 (1), 109‑16 , 2025
    2025
    Citations: 1
  • Novel Transcripts of EMT Driving the Malignant Transformation of Oral Submucous Fibrosis
    SS Shetty, KSR Padam, M Sharma, A Kudva, A Patel, R Radhakrishnan
    Scientific Reports 15, 3294 , 2025
    2025
    Citations: 11
  • PREANESTHETIC MUCOSAL CONDITIONING DEVICE (PMCD) AND METHOD
    S Soi, M Sharma, A Gupta, Wadhwa, D Abraham
    IN Patent App. 202411057917 A , 2024
    2024
  • Flexomagnetic file retrieval system for apical third
    TS Vakul, A Gupta, J Wadhwa, D Abraham, V Aggarwal, S Soi, P Batra, ...
    GB Patent 6,356,908 , 2024
    2024
  • Flexomagnetic file retrieval system for middle third
    TS Vakul, A Gupta, J Wadhwa, D Abraham, V Aggarwal, S Soi, P Batra, ...
    GB Patent 6,356,907 , 2024
    2024
  • Flexomagnetic file retrieval system for coronal third
    TS Vakul, A Gupta, J Wadhwa, D Abraham, V Aggarwal, S Soi, P Batra, ...
    GB Patent 6,356,906 , 2024
    2024
  • Cancer Insights: A Pathway and Network Analysis to Understand Oral Cancer
    SS Shetty, M Sharma, FP Fonseca, P Jayaram, AS Tanwar, ...
    Microbiome and Its Role in Shaping Planetary Health, 51 , 2024
    2024
  • Myofibroblast persists through immune privilege mechanisms to mediate oral submucous fibrosis: Uncovering the pathogenesis
    S Mohit, S Smitha Sammith, S Sonal, R Raghu
    J Oral Bio Craniofac Res 14 (6), 773-781 , 2024
    2024
    Citations: 7
  • To evaluate the role of mast cells on angiogenesis in various grades of oral squamous cell carcinoma: a histochemical study
    Y Khan, S Rehani, M Sharma
    Journal of Oral and Maxillofacial Pathology 28 (3), 403-408 , 2024
    2024
  • Areca Nut-induced Oral Fibrosis – Reassessing the Biology of Oral Submucous Fibrosis
    M Sharma, SC Sarode, G Sarode, R Radhakrishnan
    Jounal of Oral Biosciences 66, 320-328 , 2024
    2024
    Citations: 32
  • The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis
    SS Shetty, M Sharma, KSR Padam, A Kudva, P Patel, R Radhakrishnan
    Journal of Oral Biology and Craniofacial Research 14 (1), 63-71 , 2024
    2024
    Citations: 9
  • Comprehensive analysis of microRNAs and their target genes in oral submucous fibrosis
    PV Jishnu, US Shenoy, M Sharma, A Chopra, R Radhakrishnan
    Oral Diseases 29 (5), 1894-1904 , 2023
    2023
    Citations: 10

MOST CITED SCHOLAR PUBLICATIONS

  • Molecular changes in invasive front of oral cancer
    M Sharma, P Sah, SS Sharma, R Radhakrishnan
    Journal of oral and maxillofacial pathology 17 (2), 240 , 2013
    2013
    Citations: 105
  • Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis
    M Sharma, I Bairy, K Pai, K Satyamoorthy, S Prasad, B Berkovitz, ...
    Clinical oral investigations 15 (5), 705-714 , 2011
    2011
    Citations: 93
  • pH gradient reversal: an emerging hallmark of cancers
    M Sharma, M Astekar, S Soi, B S Manjunatha, D C Shetty, ...
    Recent patents on anti-cancer drug discovery 10 (3), 244-258 , 2015
    2015
    Citations: 90
  • Porphyromonas gingivalis and adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms
    A Chopra, R Radhakrishnan, M Sharma
    Critical reviews in microbiology 46 (2), 213-236 , 2020
    2020
    Citations: 84
  • Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation
    M Sharma, FP Fonseca, KD Hunter, R Radhakrishnan
    International journal of oral science 12 (1), 23 , 2020
    2020
    Citations: 59
  • Oral submucous fibrosis as an overhealing wound: implications in malignant transformation
    M Sharma, SS Shetty, R Radhakrishnan
    Recent patents on anti-cancer drug discovery 13 (3), 272-291 , 2018
    2018
    Citations: 57
  • Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma
    SS Shetty, M Sharma, FP Fonseca, P Jayaram, AS Tanwar, ...
    Japanese Dental Science Review 56 (1), 97-108 , 2020
    2020
    Citations: 55
  • Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies
    M Sharma, R Radhakrishnan
    Journal of Oral Pathology & Medicine 46 (6), 424-430 , 2017
    2017
    Citations: 49
  • CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma
    LC Da Silva, FP Fonseca, OP de Almeida, BAL de Almeida Mariz, ...
    Medicina oral, patologia oral y cirugia bucal 25 (1), e49–e55. , 2020
    2020
    Citations: 45
  • Understanding the molecular mechanism associated with reversal of oral submucous fibrosis targeting hydroxylysine aldehyde-derived collagen cross-links
    SS Shetty, M Sharma, SP Kabekkodu, NVA Kumar, K Satyamoorthy, ...
    Journal of Carcinogenesis 20 (1), 9 , 2021
    2021
    Citations: 41
  • Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation
    M Sharma, KD Hunter, FP Fonseca, R Radhakrishnan
    Head Neck 43 (10), 3153-3164 , 2021
    2021
    Citations: 34
  • Areca Nut-induced Oral Fibrosis – Reassessing the Biology of Oral Submucous Fibrosis
    M Sharma, SC Sarode, G Sarode, R Radhakrishnan
    Jounal of Oral Biosciences 66, 320-328 , 2024
    2024
    Citations: 32
  • Micronucleus assay: An early diagnostic tool to assess genotoxic changes in patients with tobacco use, oral leukoplakia and oral submucous fibrosis
    M Kohli, P Ahuja, M Mehendiratta, M Sharma, J Dutta
    Journal of clinical and diagnostic research: JCDR 11 (9), ZC28-ZC32 , 2017
    2017
    Citations: 19
  • Novel Pathways and Mechanisms of Nicotine-Induced Oral Carcinogenesis
    M Sharma, SS Shetty, R Radhakrishnan
    Recent Patents in Anticancer Drug Discov 17 (1), 66-79 , 2022
    2022
    Citations: 17
  • Genotoxicity in oral mucosal epithelial cells of petrol station attendants: A micronucleus study
    S Rehani, N Raj, P Jeergal, M Sharma, K Arya Bishen, R Nagpal
    Journal of Cytology 38 (4), 225-230 , 2021
    2021
    Citations: 17
  • CTGF is obligatory for TGF-β1 mediated fibrosis in OSMF
    M Sharma, R Radhakrishnan
    Oral oncology 56, e10-e11 , 2016
    2016
    Citations: 16
  • Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis
    M Sharma, KD Hunter, FP Fonseca, SS Shetty, R Radhakrishnan
    Archives of Oral Biology 128, 105164 , 2021
    2021
    Citations: 15
  • In Vitro Comparison of Apically Extruded Debris during Root Canal Preparation of Mandibular Premolars with Manual and Rotary Instruments
    S Soi, S Yadav, S Sharma, M Sharma
    Journal of Dental Research, Dental Clinics, Dental Prospects 9 (3), 131-137 , 2015
    2015
    Citations: 15
  • The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis
    Z Huang, M Sharma, A Dave, Y Yang, ZS Chen, R Radhakrishnan
    Frontiers in Pharmacology 13, 888280 , 2022
    2022
    Citations: 14
  • Oral candidal carriage correlates with CD4+ cell count but not with HIV and highly active antiretroviral therapy status
    P Sah, P Patel, C Chandrashekar, S Martena, M Ballal, M Hegde, ...
    Journal of investigative and clinical dentistry 10 (4), e12438 , 2019
    2019
    Citations: 13

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

1. Flexomagnetic file retrieval system for coronal third [Inventors -Toopalle Sai Vakul, Alpa Gupta, Jitesh Wadhwa, Dax Abraham, Vivek Aggarwal, Sonal Soi, Puneet Batra, Mohit Sharma, Date- 2024/5/15, UK Patent No 6356906]
2. Flexomagnetic file retrieval system for Middle third [Inventors -Toopalle Sai Vakul, Alpa Gupta, Jitesh Wadhwa, Dax Abraham, Vivek Aggarwal, Sonal Soi, Puneet Batra, Mohit Sharma, Date- 2024/5/15, UK Patent No 6356907]
3. Flexomagnetic file retrieval system for Middle third [Inventors -Toopalle Sai Vakul, Alpa Gupta, Jitesh Wadhwa, Dax Abraham, Vivek Aggarwal, Sonal Soi, Puneet Batra, Mohit Sharma, Date- 2024/5/15, UK Patent No 6356908]
4. PREANESTHETIC MUCOSAL CONDITIONING DEVICE (PMCD) [Name of App: MRIIRS, Inventors: 1. Dr Sonal Soi, Dr. Mohit Sharma, Dr Alpa Gupta, Dr Jitesh Wadhwa, Dr Dax Abraham, Date: 16/08/2024, Indian Patent]
5. AUTOMATED EMERGENCY BATTERY JUMP STARTING SYSTEM FOR VEHICLES [Name of Applicant: SGT University, Inventors: 1. Dr. Mohit Sharma 2. Dr. Aparna Dave 3. Dr. Pulin Saluja 4. Naresh Tanwar 5. Yash Singh 6. Rakshat 7. Juhi Ruth, Publication Date: 05/12/2025, India Patent, 202511096155]
6. PORTABLE STERILIZATION DEVICE AND METHOD FOR STERILIZING ENDODONTIC FILES [Name of Applicant: MRIIRS, Name of Inventors: 1. Dr Sonal Soi, 2. Dr. Mohit Sharma, 3. Dr Alpa Gupta, 4. Dr Dax Abraham, 5. Dr. Aakansha Puri, 6. Dr. Seema Hasna Bukhari, 7. Dr. Vishakha Kumar Mendiratta; Date: 13/03/2026, Indian Patent; App No 202611009804.