Jan Malik

@cuni.cz

Third Department of Internal Medicine
General University Hospital in Prague and First Faculty of Medicine, Charles University

Jan Malik


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https://researchid.co/jan.malik

RESEARCH INTERESTS

cardionephrology; vascular access; heart failure
136

Scopus Publications

Scopus Publications

  • Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
    Marion Moseby-Knappe, Helena Levin, Susann Ullén, Henrik Zetterberg, Kaj Blennow, Alice Lagebrant, Josef Dankiewicz, Janus C Jakobsen, Gisela Lilja, Alistair D Nichol, Glenn Eastwood, Kate Ainscough, Matthew J C Thomas, Anders M Grejs, Thomas R Keeble, Christian Rylander, Joachim Düring, Matt P Wise, Jan Hovdenes, Christian Storm, Ola Borgquist, Alain Cariou, Nicolas Deye, Jean-Baptiste Lascarrou, Jonathan Bannard-Smith, Johan Undén, Philippe Vignon, Stéphane Legriel, Ondřej Šmíd, David Pogson, Jiri Karasek, Peter J McGuigan, Michael Joannidis, Hans Kirkegaard, Jeremy Bewley, Steffen Christensen, Maria Rita Maccaroni, Anna Valerianova, Andreas Lundin, Anna Lybeck, Christoph Leithner, Filip Varhaník, Katie Sweet, Andrew Walden, Hans Friberg, Tobias Cronberg, Niklas Nielsen, Jan Belohlávek, Ronny Beer, Frank Hartig, Raimund Helbok, Sebastian Klein, Andreas Peer, Michal Otáhal, Marek Flaksa, David Kemlink, Jan Malík, Jan Rulíšek, Michal Šíranec, Zdenek Stach, Petra Zavadilova, Anne Adolfsson, Anna Bjärnroos, Kajsa Jönsson, Susann Schrey, Erik Westhall, Frida Antonsson, Git Bergman, Jörgen Gamroth, Maria Meirik, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Lucy Howie, Zoe Garland, Rebekah Johnson, Chloe Searles, Agnieszka Skorko, Victoria Taylor, Deborah Peripoorani, Peter Juhl-Olsen, Ida Katrine Thomsen, Lisa Gregersen Østergaard, Julien Charpentier, Pierre Dupland, Arianne Gavaud, Pierre Jaubert, Mathieu Jozwiak, Nathalie Marin, Jean-Paul Mira, Frederic Pene, Guillaume Savary, Bruno Megarbane, Pierre Mora, Katarina Rudolfsson, Helena Sandberg, Martin Thorsson, Kristin Savolainen, Maria Hansbo, Malin Helliksson, Björne Nödtveidt, Johan Sanner, Victoria Sem, Gill Adams, Rajesh K Aggarwal, Jo-Anne Cartwright, Steven Church, Gerald J Clesham, Denise Webster, John R Davies, Kelly Farrell, Reto Gamma, Laetitia Sutterlin, Isabelle Malissin, Nicolas Peron, Karim Jaffal, Hélène Migueres, Aymen Mrad, Caroline Grant, Foued El Gharbi, Sebastian Voicu, Hugo Bellut, Guillaume Lacave, Marine Paul, Carole Ouisse, Thomas Daix, Camilla Sund Lindquist, Stefan Persson, Ida Berglund, Eric Bergström, Cathrine Törnqvist, Ingela Östman, Jade Cole, Helen Hill, Michelle Davies, Jane Harding, Rohan Jagathesan, Alamgir Kabir, Paul A Kelly, Lauren Kittridge, Arnaud Desachy, Marco Mion, Naveen Nain, Raghunath Nalgirkar, Bruno Evrard, Bruno Francois, Anne-Laure Fedou, Marine Goudelin, Jens Nee, Roman Desta Lindgren, Elisabeth Myhrman, Birgitta Ryding, Patrik Martner, Louise Martinell, Simon Schmidbauer, Tim Schröder, Åse Rasmussen, Andreas Espinoza, Kristin Wisløff-Aase, Simon Jakobsson, Sven Olav Løstegaard, Ingrid Eiving, Marita Ahlqvist, Rhys Davies, Jenny Brooks, Angharad Williams, Jacqueline Curtain, Emma Thomas, Stephen Fernandez, Matt Morgan, Oscar Lundberg, Mattias Bergström, Julie Highfield, Eve Cocks, Gyanesh Namjoshi, Stacey Pepper, Emily Redman, Nicholas M Robinson, Jeremy Sayer, Amanda Solesbury, Kare H Tang, Sali Urovi, Kunal Waghmare, Ingrid Didriksson, Patrik Johnsson, Marina Larsson, Stefan Hau-Olsson, Petrea Frid, Fredrik Buchwald, Lydia Pennant, Sofia Rose, Stephen Haffey, Aisling O'Neill, Kathryn Ward, Anna Chillingworth, Julie Cloake, Libby Cole, Hilary Galvin, Noel Watson, Teresa Webber, Parminder Bhuie, Nicola Jacques, Zoe Daly, Steve Rose, Rachael Quayle, Anila Sukumaran
    Lancet Respiratory Medicine, 2026
    BACKGROUND: Prognostication of recovery in patients who are unconscious following cardiac arrest can be guided by concentrations of brain injury biomarkers in the blood. The optimal biomarker and cutoff concentrations for the prediction of outcome remain unknown. In this study, we aimed to evaluate which biomarker of brain injury is most accurate for predicting functional outcome after cardiac arrest, and to evaluate cutoff levels for the prediction of good and poor outcome. METHODS: This study was a prospective, international, observational biomarker study within the international Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial including adults aged 18 years or older with a presumed cardiac cause or unknown cause of arrest. Patients were recruited from 24 European hospitals. Serum samples were collected at 0, 24, 48, and 72 h after admission to intensive care units. Concentrations of neuron-specific enolase, S100, neurofilament light, and glial fibrillary acidic protein were analysed with Elecsys electrochemiluminescence immunoassays. The primary outcome was 6-month good (modified Rankin Scale 0-3) or poor (modified Rankin Scale 4-6) functional outcome. Prognostic accuracy was evaluated by the area under the receiver operating characteristic curve (AUROC). The biomarker with the highest AUROC at each timepoint was compared with that of the second highest marker using DeLong's test. As pre-specified, to account for multiple comparisons using Bonferroni correction, a p value of less than 0·0125 was considered statistically significant. FINDINGS: Between April, 2018, and January, 2020, 113 (12%) of 932 eligible patients were excluded due to death, missed sampling, or missing outcome data. 661 (81%) of 819 included patients were male and 158 (19%) were female, the mean age was 64 years (SD 13), and 418 (51%) had a poor outcome. In patients who were unconscious, neurofilament light predicted functional outcome with AUROCs at 0, 24, 48, and 72 h of 0·77 (95% CI 0·73-0·80), 0·92 (0·90-0·94), 0·93 (0·91-0·95), and 0·93 (0·91-0·95), respectively. Glial fibrillary acidic protein achieved an AUROC of 0·74 (95% CI 0·70-0·77) at 0 h, 0·87 (0·84-0·90) at 24 h, 0·87 (0·84-0·90) at 48 h, and 0·87 (0·84-0·91) at 72 h. Neuron-specific enolase predicted functional outcome with an AUROC of 0·61 (95% CI 0·56-0·65) at 0 h, 0·78 (0·75-0·82) at 24 h, 0·85 (0·81-0·88) at 48 h, and 0·86 (0·82-0·89) at 72 h. S100 achieved an AUROC of 0·74 (95% CI 0·71-0·78) at 0 h, 0·84 (0·81-0·87) at 24 h, 0·79 (0·75-0·82) at 48 h, and 0·78 (0·74-0·82) at 72 h. Neurofilament light had a statistically significantly higher AUROC than the second highest marker, glial fibrillary acidic protein, at 24, 48, and 72 h (p<0·0001), but not at 0 h (p=0·27). INTERPRETATION: Neurofilament light is a highly accurate predictor of long-term outcome after cardiac arrest and superior to other relevant biomarkers evaluated in this study. FUNDING: The Swedish Research Council (Vetenskapsrådet), the Swedish Heart-Lung Foundation, the Stig and Ragna Gorthon Foundation, the Knutsson Foundation, the Laerdal Foundation, the Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research, the Bundy Academy at Lund University, Regional Research Support in Skåne, the Swedish Government, and Roche Diagnostics International.
  • How to Define High-Flow Arteriovenous Fistula? Comment on Kim et al. Hemodynamic Adaptation and Cardiac Effects of High-Flow Arteriovenous Access in Hemodialysis Patients: A Prospective Study. J. Clin. Med. 2025, 14, 4556
    Jan Malik, Anna Valerianova, Kristina Buryskova Salajova, Pavel Michalek
    Journal of Clinical Medicine, 2026
    We have read the manuscript by Yaeni Kim et al [...]
  • Classifications of haemodialysis vascular access-induced limb ischaemia
    Katerina Lawrie, Stephen O’Neill, Jan Malik, Peter Balaz, Michael Corr, Petr Waldauf
    Journal of Vascular Access, 2026
    Vascular access-induced limb ischaemia is a potentially severe complication. A classification system for clinical assessment and treatment would be a useful clinical tool for standardising management. There are several classifications described in the current literature using inconsistent terminology. The aim of this review is to identify all the reported classification systems of vascular access-induced limb ischaemia and to present a comprehensive summary. PubMed, Scopus, Web of Science, Google Scholar and the ClinicalTrials.gov registry were searched from inception to the 17th of October 2024. All articles containing newly proposed classifications regarding haemodialysis vascular access were eligible. There were no restrictions to the full text’s language or the type of study. The classifications were evaluated using a modified Buchbinder’s classification critical appraisal tool. From 4694 screened papers, 59 full-text papers were retrieved, and eight articles contained classifications based only on the severity of vascular access-induced limb ischaemia. According to the modified Buchbinder critical appraisal, the classifications identified were overall good quality. The systems are all based on clinical symptoms but use inconsistent terminology and do not consider various aetiologies. We present a summary and propose a unified classification based on the anatomical location of the pathology, which leads to high- or low-flow ischaemia, along with a suitable therapeutic approach for each type.
  • Improvement of the left atrial systolic function after a surgical reduction of the high flow arteriovenous fistula
    Vaclav Lejsek, Anna Valerianova, Kristyna Michalickova, Kristina Buryskova Salajova, Marcela Slavikova, Martin Rybar, Jan Malik
    Frontiers in Medicine, 2026
    Background High-output heart failure (HOHF) is a distinct cardiac complication in end-stage kidney disease (ESKD) patients with high-flow arteriovenous fistulae (AVFs). While AVF flow reduction improves hemodynamics and left atrial (LA) volume, its effect on LA systolic function remains unclear. Objective To evaluate changes in left atrial systolic function and left ventricular (LV) filling pressures following surgical AVF flow reduction in haemodialysis patients with high-flow fistulae. Methods In this prospective, single-centre interventional study, 28 ESKD patients (mean age 63 ± 15 years) with high-flow AVFs (&amp;gt;1,500 mL/min) and clinical heart failure (NYHA ≥ II) underwent surgical AVF flow reduction. Echocardiographic assessments were performed before and 6 weeks after intervention. LA ejection fraction (LAEF) and LV filling pressures (E/e′ ratio) were determined from digitally stored imaging data. Results Surgical intervention reduced AVF flow by approximately 50% [2,525 [1,388] to 1,250 [700] mL/min, p = 0.00006]. LA volume index decreased significantly (44.7 ± 17.3 to 38.5 ± 15.4 mL/m 2 , p = 0.01), accompanied by an improvement in LAEF (49.6 ± 14.9% to 53.2 ± 13.5%, p = 0.046). Dyspnoea improved or resolved in all patients. Baseline LAEF correlated negatively with age, LA volume index, and NYHA class, but no independent predictors of post-operative LAEF improvement were identified. Conclusions In patients with high-flow AVF–associated HOHF, surgical AVF flow reduction leads to a significant improvement in LA systolic function alongside decreased LA volume. These findings suggest partial reversibility of atrial remodeling induced by chronic hyperkinetic circulation and highlight the potential cardiovascular benefits of AVF flow optimization in selected dialysis patients.
  • Correction: Improvement of the left atrial systolic function after a surgical reduction of the high flow arteriovenous fistula (Frontiers in Medicine, (2026), 12, (1732862), 10.3389/fmed.2025.1732862)
    Vaclav Lejsek, Anna Valerianova, Kristyna Michalickova, Kristina Buryskova Salajova, Marcela Slavikova, Marian Rybar, Jan Malik
    Frontiers in Medicine, 2026
    Chronic kidney disease (CKD) is a condition associated with high morbidity and mortality, affecting an estimated 700 million individuals globally, and posing a substantial economic and healthcare burden: diabetes and hypertension account for the majority of cases [1] [2].Cardiovascular disease is the leading cause of death in the CKD population [3]. In patients with endstage kidney disease (ESKD) requiring maintenance dialysis, cardiovascular disease accounts for approximately 40% of all deaths. [3] This increased cardiovascular risk is partly due to traditional atherosclerotic risk factors common in the CKD population such as hypertension, diabetes, and smoking as well as CKD-specific mechanisms, including chronic inflammation, endothelial dysfunction, accumulation of uremic toxins, and disturbances in calcium-phosphate metabolism) [4].Chronic heart failure (CHF) is also highly prevalent in patients with CKD, affecting nearly 44% of individuals on dialysis in the United States [5]. The most common phenotype is heart failure with preserved ejection fraction (HFpEF), typically associated with diastolic dysfunction due to left ventricular hypertrophy and stiffening, leading to elevated filling pressures [6,7]. A distinct mechanism contributing to heart failure in dialysis patients is hyperkinetic circulation, which may result from fluid overload, anaemia, systemic inflammation, or the presence of a high-flow arteriovenous fistula (AVF) used for maintenance haemodialysis [8]. Hyperkinetic circulation is a key contributor to a specific heart failure phenotype known as high-output heart failure (HOHF). This phenotype is characterized by typical signs and symptoms of heart failure in the presence of an elevated cardiac index (>3.9 L/min/m²) and increased circulating biomarkers, particularly brain natriuretic peptide (BNP) [9]. HOHF is echocardiographically associated with a complex array of structural and functional cardiac alterations, including biventricular dilation, secondary atrioventricular valves regurgitation, left ventricular hypertrophy, increased left ventricular filling pressures, and impaired diastolic function [10,11]. Elevated left atrial (LA) pressure results in LA enlargement, and such pressure overload is a recognized risk factor for atrial fibrillation, which is also frequently encountered in the CKD population [12].Although often considered a passive chamber by non-cardiologists, the left atrium plays a crucial role in cardiac function. Its systolic (contractile) function contributes significantly to late diastolic filling of the left ventricle, and its reservoir function helps unloading the pulmonary venous pressure, thereby mitigating pulmonary congestion. However, in ESKD patients on long-term haemodialysis, both left atrial dilation and impaired contractile function have been consistently documented [13,14]. Previous studies have demonstrated that surgical reduction of AVF flow in patients with haemodialysis-associated HOHF leads to a decrease in left atrial volume and left ventricular filling pressures. However, it remains unclear whether these changes are accompanied by an improvement in left atrial systolic function. In other words: Does LV filling pressure improvement after AVF flow reduction accompany improvement in the left atrial systolic function?" Therefore, we analysed left atrial systolic function and left ventricular filling pressures in a cohort of patients undergoing surgical AVF flow reduction due to high-flow fistulae.This study represents a secondary analysis of previously published prospective investigations assessing the effects of arteriovenous fistula (AVF) flow reduction on cardiovascular parameterssee references [10,11] for details.This was a prospective, single-centre, interventional study approved by the local institutional ethics committee. The study was approved by the Ethical committee of the General University Hospital in Prague. All participants provided written informed consent, and the study adhered to the principles outlined in the Declaration of Helsinki.Patients aged ≥18 years with a high-flow AVF (defined as AVF flow > 1500 mL/min), documented heart failure symptoms (New York Heart Association [NYHA] class II or higher), and sinus rhythm were eligible for inclusion. Surgical AVF flow reduction was performed using one of the following techniques: banding (with or without patch) or revision using distal inflow (RUDI). Procedure selection was according to the vascular surgeon (MS) with the experience of >30years. For this secondary analysis, we included only patients with sinus rhythm and adequate echocardiographic video loops for adequate left atrial border detections.Patients underwent clinical and imaging evaluations before and six weeks after the surgical intervention. Haemodialysis settings were maintained unchanged throughout the study period. To minimize the influence of volume status, all imaging examinations were conducted at a standardized time interval after the most recent dialysis session.Echocardiographic and AVF ultrasonographic assessments were performed using a Vivid E9 system (GE Healthcare, USA), and all data were digitally stored for off-line analysis using EchoPAC software (GE Healthcare, USA).For this secondary analysis, left atrial ejection fraction (LAEF) was derived from the archived echocardiographic video loops. The left atrial largest (=diastolic, LADV) and smallest (=systolic, LASV) volumes were measured by the Simpson method from the apical 4 and 2 chambers views. The left atrial ejection fraction (LAEF) was calculated as follows: LAEF = (LADV-LASV)/LADV and expressed in percentages. Left ventricular filling pressures were estimated using standard Doppler parameters, specifically the E/e′ ratio, where E represents the transmitral early filling velocity and e′ the early diastolic mitral annular velocity. Left ventricular diastolic function was graded according to current echocardiographic guidelines.Dyspnoea was assessed via NYHA functional classification. Blood pressure was measured using an automated BP monitor (Omron, Japan). All parameters were obtained non-invasively. Statistical analyses were conducted using Statistica software (StatSoft, USA).Distribution of all used variables was calculated. Data distribution was assessed by the Shapiro-Wilk test and visual inspection of histograms. All but one variables had normal distribution. Therefore, data are presented as mean±SD and differences calculated using the paired t-test. Only Qa had a non-Gaussian distribution and is presented as median (quartile range) and differences calculated using the Wilcoxon matched pairs test. P-values below 0.05 were considered significant. Covariates of the left atrial ejection fraction were calculated by Pearson correlation analysis.Power analysis: High-flow AVF is a relatively rare disease. When we were considering to perform this study, we had experience with 3 patients, in whom LAEF increased. We performed a power analysis to estimate the sample size required in the intervention group to ensure high probability of detecting the expected effect. Based on these preliminary 3 pilot patients, we assumed a mean change from baseline LAEF 51% to 56%. Using a two-tailed alpha 0.05, statistical power of 0.80 and assumed between group correlation 0.8, the analysis indicated that a minimum of 25 patients would be required. Our relatively low sample size fulfilled these assumptions.We enrolled 28 Caucasian patients (mean age 63.3 ± 15.3 years) with high-flow arteriovenous fistulae (AVF), all undergoing maintenance haemodialysis.The aetiology of ESKD in the cohort was as follows: Hypertension (5 pts), Glomerulopathy (3 pts), IgA nephropathy (4 pts), Diabetes mellitus (5 pts), Polycystic kidney disease (3 pts), Tubulointerstitial nephritis (3 pts), Obstructive nephropathy (3pts) and Multiple myeloma (2 pts).Following surgery, AVF flow was significantly reduced by approximately 50% -from 2525 (1388) mL/min to 1250 (700) mL/min, p = 0.00006. Dyspnoea resolved completely in 20 patients (NYHA class II prior to surgery, NYHA I after the surgery) and improved in the remaining 8 patients (from NYHA class III to II). Further hemodynamic and echocardiographic outcomes are detailed in Table 1. Two different procedures of surgical flow reduction were used: banding and RUDI. The latter was used in patients with higher initial AVF flow and led to more pronounced flow decrease. However, there was no significant difference in the heart effects (see Table 2 for details).At baseline, left atrial ejection fraction (LAEF) showed the following significant correlations: Negative correlations with age (r = -0.43, p = 0.02), left atrial volume index (LAVi) (r = -0.64, p < 0.0001) and with NYHA functional class (r = -0.56, p = 0.02). LAEF was positively related to the diastolic blood pressure (r = 0.43, p = 0.026). No significant predictors of postoperative increase in LAEF were identified.The main finding of this study is that, in patients with high-output heart failure (HOHF) caused by high-flow arteriovenous fistulae (AVFs), surgical flow reduction leads not only to a decrease in left atrial volume, but also to a significant improvement in left atrial systolic function, as reflected by the increase in left atrial ejection fraction (LAEF). Before surgical intervention, LAEF was inversely correlated with left atrial volume, patient age, and NYHA functional class, suggesting that older patients and those with more advanced heart failure tend to have more impaired atrial function.The presence of ESKD treated by maintenance haemodialysis is associated with impaired left atrial systolic function [13][14][15] even among children, where it was related to fibroblast growth factor-23 levels [16]. Our findings therefore suggest a unique and potentially reversible mechanism of atrial dysfunction in the context of high AVF flow. Unlike volume reduction achieved through a single haemodialysis session, which typically does not improve LAEF [14,15], surgical AVF flow reduction appears to exert a more profound and sustained effect on left atrial function. This distinction highlights that the pathophysiological impact of chronic high-flow AVFs cannot be equated with transient fluid overload, and that chronic hyperdynamic circulation induces more complex structural and functional remodelling of the atrium. Apart from the conversion of atrial fibrillation to sinus rhythm [16], studies documented improved left atrial systolic function after physical training. In non-CKD heart failure patients, a supervised concurrent training improves the left atrial contractile function [17]. Speculatively, the hyperkinetic circulation due to a high-flow arteriovenous fistula could have some similar effects as physical training.Interestingly, the main covariates of the left atrial systolic function prior to flow reduction were age and left atrial volume also in these patients with HOHF. We observed the same associations in in ESKD patients on haemodialysis without HOHF [14]. Therefore, these effects seem to be strong and independent. Indeed, left atrial systolic function worsens with age also in the general population [18]. Decreased left atrial systolic function predicts development of atrial fibrillation in non-CKD heart failure patients [19].Importantly, left atrial dysfunction should not be viewed in isolation. It frequently coexists with left ventricular diastolic or systolic dysfunction. Indeed, several studies have demonstrated a strong association between impaired LA systolic function and elevated left ventricular filling pressures [20], reinforcing the concept that left atrial performance serves as an integrated marker of overall diastolic burden.Possible limitation of our study could be the use of the "classical" left atrial assessment by echocardiography. Nowadays, many authors prefer the left atrial strain. However, lower frame rate and other settings of the echocardiography device in this secondary analysis study prevented adequate use of the left atrial strain. Nevertheless, the left atrial systolic function assessment by strain is the least precise [21] and therefore, classical LAEF is considered as a more robust method. Other limitations include smaller sample size (caused by a relatively low occurrence of the high flow fistulas and similar to other studies [22][23][24]), single-centre design and especially short follow-up that precludes evaluation of flow reduction durability, long-term atrial remodelling, atrial fibrillation incidence, or clinical outcomes.Taken together, our findings support the hypothesis that reducing AVF flow in selected dialysis patients with HOHF may not only improve haemodynamics but may also reverse some aspects of atrial remodelling, potentially leading to better cardiovascular outcomes. These changes are similar to that after a physical training in heart failure patients. Further prospective studies with larger cohorts and longer follow-up are warranted to assess the clinical significance of these echocardiographic improvements, particularly with respect to atrial arrhythmias, exercise tolerance, and quality of life.
  • Corrigendum: Vascular Access Management After Kidney Transplantation Position Paper on Behalf of the Vascular Access Society and the European Kidney Transplant Association (Transplant International, (2025), 38, (14712), 10.3389/ti.2025.14712)
    Barış Akin, Tamara K. Jemcov, David Cucchiari, Jan Malik, Gavin J. Pettigrew, Ulrika Hahn Lundström, Gianluigi Zaza, Joris I. Rotmans
    Transplant International, 2026
    [This corrects the article DOI: 10.3389/ti.2025.14712.].
  • Negative impact of very mild volume overload on the heart function in patients on chronic hemodialysis
    Kristyna Michalickova, Jan Malik, Anna Valerianova, Zdenka Hruskova, Vladimira Bednarova, Frantisek Lopot, Kristina Buryskova Salajova, Zuzana Hladinova, Tereza Vychodilova, Satu Sinikka Pesickova, Katarina Rocinova, Monika Tothova, Barbora Szonowska, Marketa Kratochvilova, Lucie Kaiserova, Simona Janakova, Vladimir Tesar
    Renal Failure, 2026
    OBJECTIVES: Heart failure is associated with higher mortality of hemodialysis patients. Fluid overload is a major risk factor for cardiovascular disease in these patients, but it is frequently clinically silent. The optimal assessment of ideal dry weight is still searched for. We hypothesized that even very mild fluid overload would be associated with the left ventricular ejection fraction and on the size of heart chambers. METHODS: Inclusion visit data of a cohort observation study were analyzed: bioelectrical impedance, echocardiography with hemodynamic estimations and basic laboratory tests. Fluid overload was defined by using the fluid overload/extracellular water index (FO/ECW, relative hydration index) > median value. Moreover, analyses according to FO/ECW quartiles were performed. All these measurements were done within an hour and at least 24 h after the previous hemodialysis. RESULTS: = 0.0002), dilatation of all heart chambers, more pronounced hypertrophy of the left ventricle with higher NTproBNP, significantly lower serum albumin levels and lower body mass. The relationship between the relative hydration index and heart changes was gradual. Fluid overload, as defined by the mild criteria, was associated with a worse ejection fraction, but also with other functional and structural heart changes. CONCLUSIONS: Our study demonstrates that in patients on dialysis, even mild (often subclinical) fluid overload is associated with structural and functional heart changes. Early identification of fluid overload with improved methods of volume assessment is thus warranted and especially in lean patients.
  • Lower cholesterol level on admission predicts poor outcome after prolonged cardiac arrest
    Jan Malik, Anna Valerianova, Tomas Janota, Jana Smalcova, Nikol Kubinova, Dan Rob, Jan Pudil, Milan Dusik, Petra Kavalkova, Pavel Michalek, Michal Huptych, Jan Belohlavek
    Scientific Reports, 2025
    Higher cholesterol level is a risk factor of coronary artery disease, the major cause of sudden cardiac death (SCD). However, smaller studies observed worse outcomes in SCD patients having lower total and LDL-cholesterol levels. Therefore, the prognostic role of cholesterol itself in patients with SCD remains to be clarified. We aimed to assess the relationship of on-admission cholesterol level to the neurological outcome in a secondary analysis of the randomized Prague OHCA trial population (extracorporeal cardiopulmonary resuscitation (ECPR) vs. standard approach in refractory cardiac arrest). Of 256 included patients with refractory cardiac arrest, 123 were analyzed. The effects of total, HDL and non-HDL cholesterol levels drawn at admission on the best cerebral performance category (CPC) within 180 days were examined. Results are presented as median (interquartile range) and differences compared by the Wilcoxon test. Patients with CPC 1-2 had higher initial levels of total cholesterol [3.70 (3.23-4.27) mmol/L vs. 2.98 (2.35-4.02) mmol/L, p = 0.005], non-HDL cholesterol [2.68 (2.08-3.24) vs. 1.93 (1.62-2.97) mmol/L, p = 0.007 and HDL-cholesterol [0.93 (0.67-1.07) mmol/L vs. 0.74 (0.49-0.96) mmol/L, p = 0.014] compared to patients with CPC 3-5. Chronic use of statins did not influence the outcome. Only the low levels of total and non-HDL cholesterol remained consistent predictors of poor neurological outcomes in all patients and in both separate arms. Lower total and non-HDL cholesterol levels on admission are associated with worse neurological outcomes in patients with refractory cardiac arrest treated by both ECPR and standard approach.
  • Using ultrasound in preoperative mapping and surveillance of arteriovenous grafts for haemodialysis improves patency rates: Single-centre experience
    Julia Jarosciakova, Petr Utikal, Jan Malik, Jana Janeckova
    Journal of Vascular Access, 2025
    Background: This study aimed to evaluate patency outcomes of arteriovenous grafts (AVGs) before and after using Duplex doppler ultrasonography (DUS) in preoperative mapping and surveillance of AVG. Methods: In this single-centre, retrospective cohort study 212 patients receiving AVGs from January 2009 to December 2022 were included. In group 1, the creation of AVG as well as screening was based on physical examination alone. In contrast, DUS was used in the preoperative mapping and surveillance of AVG in group 2. The patients also received sulodexide as supplemental medication. Outcomes included primary and secondary patency. The Mann-Whitney U-test was used to compare the differences between groups in number of thrombectomies and preemptive percutaneous transluminal angioplasties (PTAs). Results: Group 1 included 90 AVGs. The mean follow-up time was 333 days (range: 1–1230 days, standard deviation: 318 days). The primary and secondary graft patency rates were 13.3%, 62.2% at 6 months; 2.2%, 52.1% at 12 months; 0%, 44.3% at 24 months and 0%, 44.3% at 36 months respectively. During the 7-year surveillance of AVG, significantly more thrombectomies were performed than preemptive PTA ( p &lt; 0.0001). Group 2 included 122 AVGs. The mean follow-up time was 584 days (range: 1–2040 days, standard deviation: 463 days). The primary and secondary graft patency rates were 54.9%, 95.9% at 6 months; 29.5%, 77.8% at 12 months; and 9.8%, 56.5% at 24 months; 2.5%, 47.1% at 36 months respectively. The primary and secondary graft patency was significantly longer ( p &lt; 0.0001, p = 0.002). During the 7-year surveillance of AVG there were significantly more preemptive PTAs performed ( p = 0.0004). Conclusions: The primary and secondary patency of AVG were significantly improved after using DUS in preoperative mapping and surveillance. DUS surveillance led to a decrease in AVG occlusion. A potential positive effect of sulodexide on patency rate of AVG needs more research.
  • The significance of possible non-occlusive mesenteric ischemia in relation to neurological outcomes in patients with refractory cardiac arrest – Secondary analysis of the Prague OHCA study
    Jana Smalcova, Jacky Suen, Michal Huptych, Ondrej Franek, Petra Kavalkova, Helena Lahoda Brodska, Martin Balik, Jan Malik, Jan Pudil, Ondrej Smid, Martin Fajkus, Molly-rose McInerney, Jan Belohlavek
    Resuscitation, 2025
  • Reasons for death in patients receiving ECPR for refractory out-of-hospital cardiac arrest
    Klaudia Farkasovska, Daniel Rob, Marie Dacev, Petra Kavalkova, Jaromir Macoun, Milan Dusík, Jan Pudil, Eliska Mockova, Eva Svobodová, Jan Malík, Anna Valerianova, Jan Belohlavek
    Resuscitation, 2025
  • Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study
    Jana Smalcova, Lahoda Helena Brodska, Jacky Suen, Zdislava Vanickova, Petra Kavalkova, Nicole White, Barbora Kolosova, Hideaki Nonaka, Jan Pudil, Eva Svobodova, Martin Balik, Jan Malik, Jan Belohlavek
    Resuscitation Plus, 2025
  • Management of vascular access inflow-outflow imbalance: A bimodal approach
    Gerald A Beathard, William C Jennings, Jan Malik, Haimanot Wasse, Bart L Dolmatch, John Ross, Surendra Shenoy, Roy-Chaudhury Pabir, Bharat Sachdeva, Dheeraj Rajan, Vandana Dua Niyyar, George M Nassar, Eric Peden, Timmy Lee, Gordon McLennan, Robert Shahverdyan
    Journal of Vascular Access, 2025
  • Nephrology Partnership for Advancing Technology in Healthcare (N-PATH) Erasmus+ project: The Renal Expert in Vascular Access (REVAC) module
    Carlo Lomonte, Jose Ibeas, Panagiotis Kitrou, Antonio Giusto, Marta Baratto, Valentina Bocchibianchi, Giuliano Brunori, Nicola Pirozzi, Rafael Ponikvar, Giacomo Forneris, Jan Malik, Konstantinos Katsanos, Maarten Snoeijs, Matteo Tozzi, Maurizio Gallieni, Loreto Gesualdo
    Journal of Vascular Access, 2025
  • Impact of routine extracorporeal cardiopulmonary resuscitation service on the availability of donor organs
    Jana Smalcova, Petra Krupickova, Eva Pokorna, Ondrej Franek, Michal Huptych, Petra Kavalkova, Martin Balik, Jan Malik, Ondrej Smid, Eva Svobodova, Roman Keleman, Jan Belohlavek
    Journal of Heart and Lung Transplantation, 2025
  • Classifications of haemodialysis vascular access stenosis: a scoping review
    Katerina Lawrie, Stephen O’Neill, Jan Malik, Libor Janousek, Michael Corr, Stepan Maly, Jaroslav Chlupac, Petr Waldauf
    BMJ Open, 2025
  • First Real-Time Imaging of Acute Effects of Arteriovenous Fistula on Regional Distribution of Pulmonary Perfusion in a Novel Porcine Model
    J Borges, A Valerianova, L Tejkl, J Malik, M Mlček, O Kittnar
    Physiological Research, 2025
  • Translumbar access to the inferior vena cava – rescue option for insertion of a central venous catheter
    P Michálek, T Brožek, J Kaván, L Forejtová, M Novák, J Malík
    Anesteziologie A Intenzivni Medicina, 2025
  • Vascular Access Management After Kidney Transplantation Position Paper on Behalf of the Vascular Access Society and the European Kidney Transplant Association
    Barış Akin, Tamara K. Jemcov, David Cucchiari, Jan Malik, Gavin J. Pettigrew, Ulrika Hahn Lundström, Gianluigi Zaza, Joris I. Rotmans
    Transplant International, 2025
  • Right ventricular-pulmonary arterial coupling and pulmonary hypertension in hemodialysis: insights into structural cardiac changes and clinical implications
    Kristina Buryskova Salajova, Jan Malik, Lucie Kaiserova, Zuzana Hladinova, Zdenka Hruskova, Simona Janakova, Vladimir Tesar, Satu Sinikka Pesickova, Kristyna Michalickova, Katarina Rocinova, Barbora Szonowska, Anna Valerianova
    Renal Failure, 2025
  • Vascular access ultrasonography: The risk of simplification
    Cora de Bont, Jan Malik
    Journal of Vascular Access, 2024
  • Non-invasively assessed haemodynamics in patients with high flow arteriovenous fistula and high output cardiac failure
    Kristína Burýšková Salajová, Jan Malík, Anna Valeriánová
    Esc Heart Failure, 2024
  • Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
    Vojtech Kratky, Anna Valerianova, Zdenka Hruskova, Vladimir Tesar, Jan Malik
    Current Atherosclerosis Reports, 2024
  • Cardiorenal Syndromes and Their Role in Water and Sodium Homeostasis
    K Buryskova Salajova, J Malik, A Valerianova
    Physiological Research, 2024
  • CZecking heart failure in patients with advanced chronic kidney disease (Czech HF-CKD): Study protocol
    Jan Malik, Anna Valerianova, Satu Sinikka Pesickova, Zdenka Hruskova, Vladimira Bednarova, Pavel Michalek, Vladimir Polakovic, Vladimir Tesar
    Journal of Vascular Access, 2024
  • The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations
    Sara Turella, Josef Dankiewicz, Hans Friberg, Janus Christian Jakobsen, Christoph Leithner, Helena Levin, Gisela Lilja, Marion Moseby-Knappe, Niklas Nielsen, Andrea O. Rossetti, Claudio Sandroni, Frédéric Zubler, Tobias Cronberg, Erik Westhall, , Jan Bělohlávek, Clifton Callaway, Alain Cariou, Tobias Cronberg, Glenn Eastwood, David Erlinge, Jan Hovdenes, Michael Joannidis, Hans Kirkegaard, Matt P. G Morgan, Alistair D Nichol, Per Nordberg, Mauro Oddo, Paolo Pelosi, Christian Rylander, Manoj Saxena, Christian Storm, Fabio S Taccone, Susann Ullén, Matt P Wise, Paul J Young, Kathy Rowan, Paul Mouncey, Manu Shankar-Hari, Duncan Young, Susann Ullén, Theis Lange, Karolina Palmér, Susann Ullén, Ulla-Britt Karlsson, Simon Heissler, Manoj Saxena, Frances Bass, Naomi Hammond, John Myburgh, Colman Taylor, Alain Cariou, Adele Bellino, Marwa Abel-all, Ben Finfer, Carolyn Koch, Yang Li, Anne O’Connor, Julia Pilowsky, Tina Schneider, Anna Tippett, Bridget Ady, Tessa Broadley, Amanda Brown, Liz Melgaard, Mimi Morgan, Vanessa Singh, Rebecca Symons, Kathrin Becker, Nathalie Van Sante, Vendula Saleova, Silvie Zerzanova, Samia Sefr-Kribel, Ute Lübeck, Martina Carrara, Kathryn Fernando, Diane Mackle, Leanlove Navarra, Judith Riley, Elin Westerheim, Marianne Flatebø, Ameldina Ceric, Zana Haxhija, Lovisa Terling, Lena Bossmar, Liz Jergle, Helén Holm Månsson, Samia Abed Maillard, Andreja Vujicic Zagar, Christina Jodlauk, Helen Hill, Jennifer Scrivens, Kate Ainscough, Ciara Fahey, Rinaldo Bellomo, Glenn Eastwood, Leah Peck, Helen Young, Winston Cheung, Rosalba Cross, Michael Hayes, Nitin Jain, Mark Kol, Asim Shah, Atul Wagh, Helen Wong, F. Eduardo Martinez, Gail Brinkerhof, Dustin Bush, Antony Stewart, Anders Aneman, Lien Lombardo, Peter McCanny, James Penketh, Ian Seppelt, Rebecca Gresham, Julie Lowrey, Kristy Masters, Christina Whitehead, James Walsham, Meg Harward, Josephine Mackay, Jason Meyer, Emma Saylor, Ellen Venz, Krista Wetzig, Wade Stedman, Angela Ashelford, Frances Bass, Naomi Hammond, Sharon Mar, Julia Pilowsky, Miyuki Tokumitsu, Elizabeth Yarad, Hergen Buscher, Claire Reynolds, Andrew Udy, Aidan Burrell, Jasmin Collins, Dashiell Gantner, Victoria Emma-Leah Martin, Phoebe Mccracken, Vinodh Nanjayya, Alistair Nichol, Alexander Sacha Richardson, Meredith Young, Angaj Ghosh, Simone Said, Michael Joannidis, Ronny Beer, Frank Hartig, Raimund Helbok, Sebastian Klein, Andreas Peer, Fabio S Taccone, Jacques Creteur, Dominique Durand, Matthias Dupont, Sigrid Christiaens, Carola Claes, Sebastiaan Deckx, Bert Ferdinande, Sanne Lenaerts, Wilifred Mullens, Sarah Stroobants, Evi Theunissen, David Verhaert, Ondřej Šmíd, Marek Flaksa, David Kemlink, Jan Malík, Michal Otáhal, Jan Rulíšek, Michal Šíranec, Zdeněk Stach, Anna Valeriánová, Petra Zavadilova, Miroslav Solař, Róber Bánszky, Jana Červená, Renata Černá Pařízková, Libor Šimůnek, Filip Varhaník, Jiří Karásek, Matěj Strýček, Anders Grejs, Stefen Christensen, Peter Juhl-Olsen, Ida Katrine Thomsen, Lisa Gregersen Østergaard, Alain Cariou, Albert Cao, Pierre Dupland, Ariane Gavaud, Paul Jaubert, Mathieu Jozwiak, Nathalie Marin, Guillaume Savary, Nicolas Deye, Bruno Megarbane, Pierre Mora, Laetitia Sutterlin, Stephane Legriel, Hugo Bellut, Alexis Ferre, Guillaume Lacave, Marine Paul, Jean-Baptiste Lascarrou, Emmanuel Canet, Charlotte Garret, Arnaud Felix Miaihle, Jean Reignier, Philippe Vignon, Thomas Daix, Arnaud Desachy, Bruno Evrard, Bruno Francois, Anne-Laure Fedou, Marine Goudelin, Christian Storm, Gabriele Kress, Jens Nee, Kaspar Josche Streitberger, Iole Brunetti, Lorenzo Ball, Denise Battaglini, Giulia Bonatti, Iacopo Firpo, Paolo Frisoni, Arianna Iachi, Simona Maiani, Maura Mandelli, Chiara Robba, Fabio Tarantino, Alberto Barbieri, Elisabetta Bertellini, Enrico Giuliani, Gabriele Melegari, Erik Roman-Pognuz, Giorgio Berlot, Umberto Lucangelo, Elisabetta Macchini, Jan Hovdenes, Vibeke Aune, Tomas Drægni, Simon Jacobsen, Søren Pieschke, Åse Rasmussen, Gro Ringstad Akselsen, Halvor Langeland, Daniel Bergum, Therese M. Erbe, Pål Klepstad, Helle M Næss, Roy Bjørkholt Olsen, Lena Eriksen Skjelnes, Marius Holen, Joakim Iver Post, Rune Fanebust, Linda Hårteig Sørensen, Ken Åge Kårstad, Carsten Fredrik Wickman, Paul Young, Colin Barnes, Ben Barry, Nina Beehre, Dick Dinsdale, Sam Edney, Anna Hunt, Harriet Judd, Charlotte Latimer-Bell, Cassie Lawrence, James Moore, Shaanti Olatunji, Alex Psirides, Chelsea Robinson, Kate Tietjens, Jason Wright, David Knight, Brandon Birker, David Bowie, Tara Burke, David Closey, Rosalind Crombie, Neil Davidson, Seton Henderson, Louise Hitchings, James McKay, Jan Mehrtens, Emmeline Minto, Stacey Morgan, Anna Morris, Jay Ritzemar-Carter, Jessica Roberts, Geofrey Shaw, Katherine Townend, Kymbalee Vander Heyden, Christian Rylander, Marita Ahlqvist, Roman Desta Lindgren, Ingrid Eiving, Andreas Lundin, Patrik Martner, Elisabeth Myhrman, Birgitta Ryding, Joachim Düring, Mattias Bergström, Mattias Bohm, Ingrid Didriksson, Petrea Frid, Katarina Heimburg, Marina Larsson, Oscar Lundberg, Stefan Olsson Hau, Simon Schmidbauer, Ola Borgquist, Anne Adolfsson, Anna Bjärnroos, Erik Blennow-Nordström, Irina Dragancea, Thomas Kander, Anna Lybeck, Gustav Mattiasson, Olof Persson, Malin Rundgren, Susann Schrey, Martin Annborn, Sara Andertun, Florian Ebner, Nerida Gustavsson, Lisa Hassel, Jesper Johnsson, Marie Nelderup, Heléne Petersson, Jörgen Petersson, Frideriki Staflidou, Johan Undén, Frida Antonsson, Git Bergman, Jörgen Gamroth, Maria Meirik, Katarina Rudolfsson, Helena Sandberg, Martin Thorsson, Kristin Savolainen, Maria Hansbo, Malin Helliksson, Björne Nödtveidt, Johan Sanner, Victoria Sem, Camilla Sund Lindquist, Per Nordberg, Akil Awad, Anna-Sofa Börjesson, Malin Hedberg, Mia Henning, Jacob Hollenberg, Per Petersen, Emelia Dahlberg, Johan Forshammar, Veronica Svensson, Michael Wanecek, Håkan Eskilsson, Daniel Rodriguez-Santos, Åsa Appelqvist, Henrietta Jidbratt, Elisabeth Johansson, Lars Kiszakiewicz, Åsa Nilsson, Sinnika Olsson, Anders Paulsson, Urszula Stempel, Andreas Thoren, Stefan Persson, Ida Berglund, Eric Bergström, Cathrine Törnqvist, Ingela Östman, Sten Rubertsson, Ing-Marie Larsson, Elin Söderman, Ewa Wallin, Joanna Wessbergh, Thomas Halliday, Filippa Engvall, Mauro Oddo, Nawfel Ben-Hamouda, Adriano Bernini, Pierre-Nicolas Carron, Philippe Eckert, Eva Favre, John-Paul Miroz, Paola Morelli, Olivier Muller, Jan Novi, Andrea Rosseti, Madeleine Schnorf, Matthias Haenggi, Anja Levis, Sandra Nansoz, Marianne Roth, Nicole Söll, Claudia Schrag, Mensur Alicajic, Philipp Baier, Joel Dütschler, Dominique Flügel, Edith Fässler, Ruth Gamio-Veis, Marc Güpfert, Yvonne Hilpertshauser, Stefan Hägele-Link, Gian-Reto Kleger, Peter Krähenmann, Maria Elisabeth Mair, Nadja Schai, Christoph Strohmaier, Peter Tangl, Dominik Zieglgänsberger, Marco Maggiorini, Gabriele Claus, Gabi Consani Vogel, Lukas Imbach, Samira Kaiser, Eva-Maria Kleinert, Pedro David Wendel Garcia, Tiziano Cassina, Pamela Agazzi, Bruno Capelli, Gabriele Casso, Martino Regazzi, Hervé Schlotterbeck, Gabriele Via, Michele Villa, Matt P Wise, Jenny Brooks, Eve Cocks, Jade Cole, Jacqueline Curtin, Michelle Davies, Rhys Davies, Stephen Fernandez, Julie Highfeld, Helen Hill, Matt P. G Morgan, Lydia Pennant, Sofa Rose, Emma Thomas, Angharad Williams, Peter McGuigan, Stephen Hafey, Aisling O’Neill, Kathryn Ward, Matthew Thomas, Jeremy Bewley, Anna Chillingworth, Julie Cloake, Libby Cole, Hilary Galvin, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Lucy Howie, Rebekah Johnson, Chloe Searles, Agnieszka Skorko, Katie Sweet, Victoria Taylor, Denise Webster, Thomas Keeble, Gill Adams, Rajesh K Aggarwal, Jo-Anne Cartwright, Steven Church, Gerald J Clesham, John R Davies, Kelly Farrell, Reto Gamma, Jane Harding, Rohan Jagathesan, Alamgir Kabir, Paul A Kelly, Lauren Kittridge, Maria Maccaroni, Gracie Maloney, Marco Mion, Naveen Nain, Raghunath Nalgirkar, Gyanesh Namjoshi, Stacey Pepper, Emily Redman, Nicholas M Robinson, Jeremy Sayer, Amanda Solesbury, Kare H Tang, Sali Urovi, Kunal Waghmare, Noel Watson, Teresa Webber, Peter Isherwood, Conor Bentley, Colin Bergin, Ronald Carrera, Amy Clark, Lauren Cooper, Liesl Despy, Natalie Dooley, Karen Ellis, Emma Fellows, Stephanie Goundry, Samantha Harkett, Christopher McGhee, Aoife Neal, Hazel Smith, Catherine Snelson, Elaine Spruce, Tony Whitehouse, Kamal Yakoub, Andrew Walden, Shauna Bartley, Parminder Bhuie, Matthew Frise, Nicola Jacques, Liza Keating, David Pogson, Zoe Daly, Steve Rose, Jonathan Bannard-Smith, Rachael Quayle, Nigel Chee, Nina Barratt, Katie Bowman, Debbie Branney, Elizabeth Howe, Maria Letts, Sally Pitts, Luke Vamplew, Clifton W Callaway, Sara Difore Sprouse, Ankur A Doshi, Jennifer Fugate, Amy M Headlee, Eelco F.M. Wijdicks
    Intensive Care Medicine, 2024
  • Significant differences between two commonly used bioimpedance methods in hemodialysis patients
    Ondrej Kade, Jan Malik, Kristyna Cmerdova, Martin Matoulek, Veronika Satrapova, Zuzana Hladinova, Anna Valerianova, Pavla Zurkova
    Clinical Nephrology, 2023
  • A large arteriovenous fistula steals a considerable part of systemic blood flow during veno-arterial extracorporeal circulation support in a porcine model
    A. Valerianova, M. Mlcek, O. Kittnar, T. Grus, L. Tejkl, V. Lejsek, J. Malik
    Frontiers in Physiology, 2023
  • Comparing the hemodynamic effect of a large arteriovenous fistula during high and low cardiac output states
    A. Valerianova, M. Mlcek, J. Malik, T. Grus, L. Tejkl, B. Kolosova, V. Lejsek, O. Kittnar
    Frontiers in Physiology, 2023
  • Heart failure with preserved ejection fraction is the most frequent but commonly overlooked phenotype in patients on chronic hemodialysis
    Jan Malik, Anna Valerianova, Satu Sinikka Pesickova, Kristyna Michalickova, Zuzana Hladinova, Zdenka Hruskova, Vladimira Bednarova, Katarina Rocinova, Monika Tothova, Marketa Kratochvilova, Lucie Kaiserova, Kristina Buryskova Salajova, Vaclav Lejsek, Martin Sevcik, Vladimir Tesar
    Frontiers in Cardiovascular Medicine, 2023
  • Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
    Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis, Alistair Nichol, Andreas Lundin, Jacob Hollenberg, Naomi Hammond, Manoj Saxena, Annborn Martin, Miroslav Solar, Fabio Silvio Taccone, Josef Dankiewicz, Niklas Nielsen, Anders Morten Grejs, Florian Ebner, Paolo Pelosi, Jan Bělohlávek, Clifton Callaway, Alain Cariou, Tobias Cronberg, David Erlinge, Jan Hovdenes, Hans Kirkegaard, Helena Levin, Matt P. G. Morgan, Per Nordberg, Mauro Oddo, Christian Rylander, Christian Storm, Susann Ullén, Matt P. Wise, Kathy Rowan, David Harrison, Paul Mouncey, Manu Shankar-Hari, Duncan Young, Theis Lange, Karolina Palmér, Ulla-Britt Karlsson, Simon Heissler, Frances Bass, John Myburgh, Colman Taylor, Adele Bellino, Marwa Abel-all, Ben Finfer, Carolyn Koch, Yang Li, Anne O’Connor, Julia Pilowsky, Tina Schneider, Anna Tippett, Bridget Ady, Tessa Broadley, Amanda Brown, Liz Melgaard, Mimi Morgan, Vanessa Singh, Rebecca Symons, Kathrin Becker, Nathalie Sante, Vendula Saleova, Silvie Zerzanova, Samia Sefir-Kribel, Ute Lübeck, Martina Carrara, Kathryn Fernando, Diane Mackle, Leanlove Navarra, Judith Riley, Elin Westerheim, Marianne Flatebø, Ameldina Ceric, Zana Haxhija, Lovisa Terling, Lena Bossmar, Liz Jergle, Helén Holm Månsson, Samia Abed Maillard, Andreja Vujicic Zagar, Christina Jodlauk, Jennifer Scrivens, Kate Ainscough, Ciara Fahey, Rinaldo Bellomo, Leah Peck, Helen Young, Winston Cheung, Rosalba Cross, Michael Hayes, Nitin Jain, Mark Kol, Asim Shah, Atul Wagh, Helen Wong, F. Eduardo Martinez, Gail Brinkerhoff, Dustin Bush, Antony Stewart, Anders Aneman, Lien Lombardo, Peter McCanny, James Penketh, Ian Seppelt, Rebecca Gresham, Julie Lowrey, Kristy Masters, Christina Whitehead, James Walsham, Meg Harward, Josephine Mackay, Jason Meyer, Emma Saylor, Ellen Venz, Krista Wetzig, Wade Stedman, Angela Ashelford, Sharon Mar, Miyuki Tokumitsu, Elizabeth Yarad, Hergen Buscher, Claire Reynolds, Andrew Udy, Aidan Burrell, Jasmin Collins, Dashiell Gantner, Victoria Emma-Leah Martin, Phoebe Mccracken, Vinodh Nanjayya, Alexander Sacha Richardson, Meredith Young, Angaj Ghosh, Simone Said, Ronny Beer, Frank Hartig, Raimund Helbok, Sebastian Klein, Andreas Peer, Jacques Creteur, Dominique Durand, Matthias Dupont, Sigrid Christiaens, Carola Claes, Sebastiaan Deckx, Bert Ferdinande, Sanne Lenaerts, Wilifred Mullens, Sarah Stroobants, Evi Theunissen, David Verhaert, Ondřej Šmíd, Marek Flaksa, David Kemlink, Jan Malík, Michal Otáhal, Jan Rulíšek, Michal Šíranec, Zdeněk Stach, Anna Valeriánová, Petra Zavadilova, Miroslav Solař, Róber Bánszky, Jana Červená, Renata Černá Pařízková, Libor Šimůnek, Filip Varhaník, Jiří Karásek, Matěj Strýček, Anders Grejs, Steffen Christensen, Peter Juhl-Olsen, Ida Katrine Thomsen, Lisa Gregersen Østergaard, Albert Cao, Pierre Dupland, Ariane Gavaud, Paul Jaubert, Mathieu Jozwiak, Nathalie Marin, Guillaume Savary, Nicolas Deye, Bruno Megarbane, Pierre Mora, Laetitia Sutterlin, Stephane Legriel, Hugo Bellut, Alexis Ferre, Guillaume Lacave, Marine Paul, Jean-Baptiste Lascarrou, Emmanuel Canet, Charlotte Garret, Arnaud Felix Miaihle, Jean Reignier, Philippe Vignon, Thomas Daix, Arnaud Desachy, Bruno Evrard, Bruno Francois, Anne-Laure Fedou, Marine Goudelin, Christoph Leithner, Jens Nee, Kaspar Josche Streitberger, Giulia Bonatti, Iacopo Firpo, Paolo Frisoni, Arianna Iachi, Simona Maiani, Maura Mandelli, Fabio Tarantino, Alberto Barbieri, Elisabetta Bertellini, Enrico Giuliani, Gabriele Melegari, Erik Roman-Pognuz, Giorgio Berlot, Umberto Lucangelo, Elisabetta Macchini, Vibeke Aune, Tomas Drægni, Simon Jacobsen, Søren Pieschke, Åse Rasmussen, Gro Ringstad Akselsen, Halvor Langeland, Daniel Bergum, Therese M Erbe, Pål Klepstad, Helle M Næss, Roy Bjørkholt Olsen, Lena Eriksen Skjelnes, Marius Holen, Joakim Iver Post, Rune Fanebust, Linda Hårteig Sørensen, Ken Åge Kårstad, CarstenFredrik Wickman, Colin Barnes, Ben Barry, Nina Beehre, Dick Dinsdale, Sam Edney, Anna Hunt, Harriet Judd, Charlotte Latimer-Bell, Cassie Lawrence, James Moore, Shaanti Olatunji, Alex Psirides, Chelsea Robinson, Kate Tietjens, Jason Wright, David Knight, Brandon Birker, David Bowie, Tara Burke, David Closey, Rosalind Crombie, Neil Davidson, Seton Henderson, Louise Hitchings, James McKay, Jan Mehrtens, Emmeline Minto, Stacey Morgan, Anna Morris, Jay Ritzemar-Carter, Jessica Roberts, Geoffrey Shaw, Katherine Townend, Kymbalee Vander Heyden, Marita Ahlqvist, Roman Desta Lindgren, Ingrid Eiving, Patrik Martner, Elisabeth Myhrman, Birgitta Ryding, Joachim Düring, Mattias Bergström, Mattias Bohm, Ingrid Didriksson, Petrea Frid, Katarina Heimburg, Marina Larsson, Oscar Lundberg, Stefan Olsson Hau, Simon Schmidbauer, Ola Borgquist, Anne Adolfsson, Anna Bjärnroos, Erik Blennow-Nordström, Irina Dragancea, Thomas Kander, Anna Lybeck, Gustav Mattiasson, Olof Persson, Malin Rundgren, Susann Schrey, Erik Westhall, Martin Annborn, Sara Andertun, Nerida Gustavsson, Lisa Hassel, Jesper Johnsson, Marie Nelderup, Heléne Petersson, Jörgen Petersson, Frideriki Stafilidou, Johan Undén, Frida Antonsson, Git Bergman, Jörgen Gamroth, Maria Meirik, Katarina Rudolfsson, Helena Sandberg, Martin Thorsson, Kristin Savolainen, Maria Hansbo, Malin Helliksson, Björne Nödtveidt, Johan Sanner, Victoria Sem, Camilla Sund Lindquist, Akil Awad, Anna-Sofia Börjesson, Malin Hedberg, Mia Henning, Per Petersen, Emelia Dahlberg, Johan Forshammar, Veronica Svensson, Michael Wanecek, Håkan Eskilsson, Daniel Rodriguez-Santos, Åsa Appelqvist, Henrietta Jidbratt, Elisabeth Johansson, Lars Kiszakiewicz, Åsa Nilsson, Sinnika Olsson, Anders Paulsson, Urszula Stempel, Andreas Thoren, Stefan Persson, Ida Berglund, Eric Bergström, Cathrine Törnqvist, Ingela Östman, Sten Rubertsson, Ing-Marie Larsson, Elin Söderman, Ewa Wallin, Joanna Wessbergh, Thomas Halliday, Filippa Engvall, Nawfel Ben-Hamouda, Adriano Bernini, Pierre-Nicolas Carron, Philippe Eckert, Eva Favre, John-Paul Miroz, Paola Morelli, Olivier Muller, Jan Novi, Andrea Rosseti, Madeleine Schnorf, Matthias Haenggi, Anja Levis, Sandra Nansoz, Marianne Roth & Team, Nicole Söll, Claudia Schrag, Mensur Alicajic, Philipp Baier, Joel Dütschler, Dominique Flügel, Edith Fässler, Ruth Gamio-Veis, Marc Güpfert, Yvonne Hilpertshauser, Stefan Hägele-Link, Gian-Reto Kleger, Peter Krähenmann, Maria Elisabeth Mair, Nadja Schai, Christoph Strohmaier, Peter Tangl, Dominik Zieglgänsberger, Marco Maggiorini, Gabriele Claus, Gabi Consani-Vogel, Lukas Imbach, Samira Kaiser, Eva-Maria Kleinert, Pedro David Wendel Garcia, Tiziano Cassina, Pamela Agazzi, Bruno Capelli, Gabriele Casso, Martino Regazzi, Hervé Schlotterbeck, Gabriele Via, Michele Villa, Jenny Brooks, Eve Cocks, Jade Cole, Jacqueline Curtin, Michelle Davies, Rhys Davies, Stephen Fernandez, Julie Highfield, Helen Hill, Lydia Pennant, Sofia Rose, Emma Thomas, Angharad Williams, Peter McGuigan, Stephen Haffey, Aisling O’Neill, Kathryn Ward, Jeremy Bewley, Anna Chillingworth, Julie Cloake, Libby Cole, Hilary Galvin, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Lucy Howie, Rebekah Johnson, Chloe Searles, Agnieszka Skorko, Katie Sweet, Victoria Taylor, Denise Webster, Thomas Keeble, Gill Adams, Rajesh K. Aggarwal, Jo-Anne Cartwright, Steven Church, Gerald J. Clesham, John R. Davies, Kelly Farrell, Reto Gamma, Jane Harding, Rohan Jagathesan, Alamgir Kabir, Paul A. Kelly, Lauren Kittridge, Maria Maccaroni, Gracie Maloney, Marco Mion, Naveen Nain, Raghunath Nalgirkar, Gyanesh Namjoshi, Stacey Pepper, Emily Redman, Jeremy Sayer, Amanda Solesbury, Kare H. Tang, Sali Urovi, Kunal Waghmare, Noel Watson, Teresa Webber, Peter Isherwood, Conor Bentley, Colin Bergin, Ronald Carrera, Amy Clark, Lauren Cooper, Liesl Despy, Natalie Dooley, Karen Ellis, Emma Fellows, Stephanie Goundry, Samantha Harkett, Christopher McGhee, Aoife Neal, Hazel Smith, Catherine Snelson, Elaine Spruce, Tony Whitehouse, Kamal Yakoub, Andrew Walden, Shauna Bartley, Parminder Bhuie, Matthew Frise, Nicola Jacques, Liza Keating, David Pogson, Zoe Daly, Steve Rose, Jonathan Bannard-Smith, Rachael Quayle, Nigel Chee, Nina Barratt, Katie Bowman, Debbie Branney, Elizabeth Howe, Maria Letts, Sally Pitts, Luke Vamplew, Clifton W. Callaway, Sara Difiore Sprouse, Ankur A. Doshi, Jennifer Fugate, Amy M. Headlee, Eelco F. M. Wijdicks, and
    Critical Care, 2022
  • Endovascular Arteriovenous Fistula Creation—Review of Current Experience
    Alexandros Mallios, Jan Malik, William C. Jennings
    Diagnostics, 2022
  • Arteriovenous Hemodialysis Access Stenosis Diagnosed by Duplex Doppler Ultrasonography: A Review
    Jan Malik, Cora de Bont, Anna Valerianova, Zdislava Krupickova, Ludmila Novakova
    Diagnostics, 2022
  • Skin autofluorescence corresponds to microvascular reactivity in diabetes mellitus
    Jan Škrha, Eva Horová, Jan Šoupal, Anna Valeriánová, Jan Malík, Martin Prázný, Tomáš Zima, Marta Kalousová, Jan Škrha
    Journal of Diabetes and Its Complications, 2022
  • New Porcine Model of Arteriovenous Fistula Documents Increased Coronary Blood Flow at the Cost of Brain Perfusion
    Anna Valerianova, Mikulas Mlcek, Tomas Grus, Jan Malik, Otomar Kittnar
    Frontiers in Physiology, 2022
  • When Is Arteriovenous Fistula Dangerous for Hemodialysis Patients?
    Jan Malík
    Kidney and Dialysis, 2022
  • Wall Shear Stress Alteration: a Local Risk Factor of Atherosclerosis
    Malik J., Novakova L., Valerianova A., Chytilova E., Lejsek V., Buryskova Salajova K., Lambert L., Grus T., Porizka M., Michalek P.
    Current Atherosclerosis Reports, 2022
  • Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest
    Jan Belohlavek, Jana Smalcova, Daniel Rob, Ondrej Franek, Ondrej Smid, Milana Pokorna, Jan Horák, Vratislav Mrazek, Tomas Kovarnik, David Zemanek, Ales Kral, Stepan Havranek, Petra Kavalkova, Lucie Kompelentova, Helena Tomková, Alan Mejstrik, Jaroslav Valasek, David Peran, Jaroslav Pekara, Jan Rulisek, Martin Balik, Michal Huptych, Jiri Jarkovsky, Jan Malik, Anna Valerianova, Frantisek Mlejnsky, Petr Kolouch, Petra Havrankova, Dan Romportl, Arnost Komarek, Ales Linhart, Michael Aschermann, Štěpán Jeřábek, Michal Paďour, Jan Šimek, Michal Otáhal, Marek Flaksa, Ilona Lálová, Markéta Hubatová, Michal Pořízka, Hana Skalická, and
    JAMA, 2022
  • Inside-out access to central vein – the first experience with The Surfacer® system
    Ceska Radiologie, 2022
  • Current role of ultrasound in hemodialysis access evaluation
    Meola Mario, Jose Ibeas, Jan Malik
    Journal of Vascular Access, 2021
  • Effect of roller pump pulse in the arterial needle area during hemodialysis
    Milos Kasparek, Ludmila Novakova, Jan Malik
    Diagnostics, 2021
  • Ultrasound evaluation of dialysis access-related distal ischaemia
    N Pirozzi, L De Alexandris, J Scrivano, L Fazzari, J Malik
    Journal of Vascular Access, 2021
  • Role of Doppler ultrasonography in the evaluation of hemodialysis arteriovenous access maturation and influencing factors
    Eva Chytilova, Tamara Jemcov, Jan Malik, Jernej Pajek, Branko Fila, Jan Kavan
    Journal of Vascular Access, 2021
  • Hemodialysis vascular access affects heart function and outcomes: Tips for choosing the right access for the individual patient
    Jan Malik, Carlo Lomonte, Joris Rotmans, Eva Chytilova, Ramon Roca-Tey, Mariusz Kusztal, Tomas Grus, Maurizio Gallieni
    Journal of Vascular Access, 2021
  • The role of Doppler ultrasonography in vascular access surveillance—controversies continue
    Jan Malik, Carlo Lomonte, Mario Meola, Cora de Bont, Robert Shahverdyan, Joris I Rotmans, Francois Saucy, Tamara Jemcov, Jose Ibeas
    Journal of Vascular Access, 2021
  • Changes in vascular access blood flow: Etiological factors and clinical implications
    František Lopot, Jan Malík, František Švára, Vladimír Polakovič
    Journal of Vascular Access, 2021
  • Reduction of arteriovenous access blood flow leads to biventricular unloading in haemodialysis patients
    Anna Valerianova, Jan Malik, Jana Janeckova, Lucie Kovarova, Vladimir Tuka, Pavel Trachta, Jana Lachmanova, Zuzana Hladinova, Zdenka Hruskova, Vladimir Tesar
    International Journal of Cardiology, 2021
  • The effect of high-flow arteriovenous fistulas on systemic haemodynamics and brain oxygenation
    Jan Malik, Anna Valerianova, Vladimir Tuka, Pavel Trachta, Vladimira Bednarova, Zdenka Hruskova, Marcela Slavikova, Mitchell H. Rosner, Vladimir Tesar
    Esc Heart Failure, 2021
  • Short-term manual compression of hemodialysis fistula leads to a rise in cerebral oxygenation
    Lucie Kovarova, Anna Valerianova, Martin Michna, Jan Malik
    Journal of Vascular Access, 2021
  • Expert consensus on the importance of iron deficiency and the possibility of its correction in patients with heart failure
    Vojtěch Melenovský, Miloš Táborský, Aleš Linhart, Jan Malík, Filip Málek, Radek Pudil, Jan Krejčí, Milan Šíranec
    Vnitrni Lekarstvi, 2021
  • Expert consensus statement on the significance of iron deficiency and the possibilities of its correction in patients with heart failure
    Vojtěch Melenovský, Miloš Táborský, Aleš Linhart, Jan Malík, Filip Málek, Radek Pudil, Jan Krejčí, Michal Širanec
    Cor Et Vasa, 2021
  • Decrease in hand and cerebral oxygenation after percutaneous transluminal angioplasty for arteriovenous fistula stenosis in a patient on chronic hemodialysis
    Mitsutoshi Shindo, Susumu Ookawara, Lucie Kovarova, Junki Morino, Saori Minato, Kiyonori Ito, Jan Malik, Yoshiyuki Morishita
    Radiology Case Reports, 2020
  • Quality assessment of vascular access procedures for hemodialysis: A position paper of the Vascular Access Society based on the analysis of existing guidelines
    Branko Fila, Ramon Roca-Tey, Jan Malik, Marko Malovrh, Nicola Pirozzi, Mariusz Kusztal, Maurizio Gallieni, Tamara Jemcov
    Journal of Vascular Access, 2020
  • Endorsement and evaluation of dialysis access guidelines from the standpoint of the Vascular Access Society
    Jose Ibeas, Jan Malik, Maurizio Gallieni
    Journal of Vascular Access, 2020
  • Review of the Structural and Functional Brain Changes Associated With Chronic Kidney Disease
    M Michna, L Kovarova, A Valerianova, H Malikova, J Weichet, J Malik
    Physiological Research, 2020
  • Diastolic dysfunction in asymptomatic hemodialysis patients in the light of the current echocardiographic guidelines
    Jan Malik, Jaroslav Kudlicka, Anna Valerianova, Lucie Kovarova, Tereza Kmentova, Jana Lachmanova
    International Journal of Cardiovascular Imaging, 2019
  • Intra- and interdialytic cerebral hypoxia: A culprit of cognitive decline going unpunished?
    Lucie Kovarova, Anna Valerianova, Jan Malik
    Nephrology, 2019
  • Factors responsible for cerebral hypoxia in hemodialysis population
    A. Valerianova, J. Lachmanova, L. Kovarova, T. Kmentova, M. Bartkova, J. Malik
    Physiological Research, 2019
  • Decrease of muscle strength in vascular access hand due to silent ischaemia
    Tereza Kmentova, Anna Valerianova, Lucie Kovarova, Jana Lachmanova, Zuzana Hladinova, Jan Malik
    Journal of Vascular Access, 2018
  • Diabetes, Cardiovascular Disorders and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Body Burden in Czech Patients 50 Years After the Intoxication
    Tomas Pelcl, Jan Skrha, Martin Prazny, Stepanka Vlckova, Zdenka Fenclova, Tomas Navratil, Jan Malik, Pavel Diblik, Vit Zikan, Daniela Pelclova
    Basic and Clinical Pharmacology and Toxicology, 2018
  • Echocardiography in patients with chronic kidney diseases
    Jan Malík, Vilém Danzig, Vladimíra Bednářová, Zdenka Hrušková
    Cor Et Vasa, 2018
  • Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients
    Lucie Kovarova, Anna Valerianova, Tereza Kmentova, Jana Lachmanova, Zuzana Hladinova, Jan Malik
    Nephron, 2018
  • Systemic consequences of dialysis vascular access
    Aktuality V Nefrologii, 2018
  • Heart disease in chronic kidney disease - Review of the mechanisms and the role of dialysis access
    Jan Malik
    Journal of Vascular Access, 2018
  • Antiinflammatory therapy with canakinumab for atherosclerotic disease
    Paul M Ridker, Brendan M. Everett, Tom Thuren, Jean G. MacFadyen, William H. Chang, Christie Ballantyne, Francisco Fonseca, Jose Nicolau, Wolfgang Koenig, Stefan D. Anker, John J.P. Kastelein, Jan H. Cornel, Prem Pais, Daniel Pella, Jacques Genest, Renata Cifkova, Alberto Lorenzatti, Tamas Forster, Zhanna Kobalava, Luminita Vida-Simiti, Marcus Flather, Hiroaki Shimokawa, Hisao Ogawa, Mikael Dellborg, Paulo R.F. Rossi, Roland P.T. Troquay, Peter Libby, Robert J. Glynn
    New England Journal of Medicine, 2017
  • Factors influencing dialysis arteriovenous graft survival
    Anna Valerianova, Jaroslav Kudlicka, Eva Chytilova, Barbora Grauova, Zdislava Krupickova, Jan Malik
    Journal of Vascular Access, 2017
  • Tissue ischemia worsens during hemodialysis in end-stage renal disease patients
    Jan Malik, Jaroslav Kudlicka, Jana Lachmanova, Anna Valerianova, Katarina Rocinova, Magdalena Bartkova, Vladimir Tesar
    Journal of Vascular Access, 2017
  • Lower Cerebral Oxygenation in Chronic Kidney Disease
    Jan Malik, Jaroslav Kudlicka, Jana Lachmanova
    Critical Care Medicine, 2016
  • Left Atrial Dysfunction in End-Stage Renal Disease Patients Treated by Hemodialysis
    Jan Malik, Jana Lachmanova, Jaroslav Kudlicka, Katarina Rocinova, Anna Valerianova, Magdalena Bartkova, Vladimir Tesar
    Nephron, 2016
  • Treatment of High Flow Arteriovenous Fistulas after Successful Renal Transplant Using a Simple Precision Banding Technique
    Georgios Gkotsis, William C. Jennings, Jan Malik, Alexandros Mallios, Kevin Taubman
    Annals of Vascular Surgery, 2016
  • Vascular stenosis asymmetry influences considerably pressure gradient and flow volume
    Physiological Research, 2016
  • Comparison of one-year patency rate and cost-effectiveness of stent graft vs. stent VS. PTA In dialysis av graft
    Ceska Radiologie, 2016
  • Arteriovenous Grafts: Early Ultrasonography Tells Their Fortune
    Jaroslav Kudlicka, Jan Malik, Vladimir Tuka, Eva Chytilova, Zdislava Krupickova, Barbora Grauova, Jaroslava Vorcakova, David Janak, Jan Kavan, Otomar Kittnar, Marcela Slavikova
    American Journal of Nephrology, 2015
  • Inducibility of ventricular fibrillation during mild therapeutic hypothermia: Electrophysiological study in a swine model
    Jaroslav Kudlicka, Mikulas Mlcek, Jan Belohlavek, Pavel Hala, Stanislav Lacko, David Janak, Stepan Havranek, Jan Malik, Tomas Janota, Petr Ostadal, Petr Neuzil, Otomar Kittnar
    Journal of Translational Medicine, 2015
  • Cardiac safety in vascular access surgery and maintenance
    Jan Malik, Jaroslav Kudlicka, Vladimir Tesar, Ales Linhart
    Contributions to Nephrology, 2015
  • Surveillance of arteriovenous accesses with the use of duplex Doppler ultrasonography
    Jan Malik, Jaroslav Kudlicka, Ludmila Novakova, Josef Adamec, Hana Malikova, Jan Kavan
    Journal of Vascular Access, 2014
  • Ultrasonography-guided PTA of haemodialysis fistula
    Ceska Radiologie, 2014
  • Pig model of pulmonary embolism: Where is the hemodynamic break point?
    Physiological Research, 2013
  • Report of the 8th international congress on vascular access, Prague, Czech Republic, April 25-27, 2013
    Jan Malik
    Blood Purification, 2013
  • Endotelial activation and flow-mediated vasodilation in young patients with breast cancer
    P. Tesarova, M. Kalousova, T. Zima, M. Suchanek, I. Malikova, J. Kvasnicka, D. Duskova, V. Tesar, J. Vachek, Z. Krupickova-Kasalova, J. Malik
    Neoplasma, 2013
  • Left ventricle remodeling in men with moderate to severe volume-dependent hypertension
    Tomáš Indra, Robert Holaj, Tomáš Zelinka, Ondřej Petrák, Branislav Štrauch, Ján Rosa, Zuzana Šomlóová, Jan Malík, Tomáš Janota, Jaromír Hradec, Jiří Widimský
    JRAAS Journal of the Renin Angiotensin Aldosterone System, 2012
  • Common carotid wall shear stress and carotid atherosclerosis in end-stage renal disease patients
    Physiological Research, 2012
  • More precise diagnosis of access stenosis: Ultrasonography versus angiography
    Jaroslav Kudlicka, Jan Kavan, Vladimir Tuka, Jan Malik
    Journal of Vascular Access, 2012
  • Arteriovenous fistula after femoral artery puncture leading to pulmonary edema: the role of ultrasonography.
    Jan Malík, R. Holaj, Z. Krupičková, T. Janota
    Prague Medical Report, 2012
  • Long-term arterial adaptation to high blood flow in the feeding artery of vascular access for hemodialysis
    Vladimir Tuka, Jan Malik, Eva Chytilova, Jaroslav Kudlicka, Marcela Slavikova, Edwin Wijnen, Jan HM Tordoir, Simon van Hooland
    Journal of Vascular Access, 2012
  • Vascular access for hemodialysis: From renal hypertension to hemodynamic
    Cor Et Vasa, 2011
  • Low-flow polytetrafluoroethylene accesses: Ultrasound surveillance and preemptive interventions ensure long-term patency
    Jan Malik, Vladimir Tuka, Eva Chytilova, Magdalena Mokrejsova, Martin Masek, Marcela Slavikova
    Kidney and Blood Pressure Research, 2010
  • Stent graft or balloon angioplasty alone for dialysis-access grafts
    Jan Malík, Vladimír Tuka
    New England Journal of Medicine, 2010
  • Hemodialysis vascular access ultrasonography: tips, tricks, pitfalls and a quiz.
    Simon van Hooland, Jan Malik
    Journal of Vascular Access, 2010
  • Mechanisms of chronic heart failure development in end-stage renal disease patients on chronic hemodialysis
    Physiological Research, 2009
  • Short-term outcomes of borderline stenoses in vascular accesses with PTFE grafts
    Vladimir Tuka, Marcela Slavikova, Zdislava Krupickova, Magdalena Mokrejsova, Eva Chytilova, Jan Malik
    Nephrology Dialysis Transplantation, 2009
  • Lower wall shear rate of the common carotid artery in treated type 2 diabetes mellitus with metabolic syndrome
    Physiological Research, 2009
  • Surprisingly delayed escalation of severe verapamil poisoning
    Vladimir Tuka, Bronislava Ricarova, Tomas Janota, Jan Malik, Eva Kotrlikova
    European Journal of Emergency Medicine, 2009
  • Local hemodynamics of the vascular access for hemodialysis
    J. Malik, V. Tuka, V. Tesař
    Kidney and Blood Pressure Research, 2009
  • Haemodialysis access via tissue-engineered vascular graft
    Jan Malik, Vladimir Tuka
    Lancet, 2009
  • Creation of dialysis vascular access with normal flow increases brain natriuretic peptide levels
    Jan Malík, Vladimir Tuka, Zdislava Krupickova, Eva Chytilova, Robert Holaj, Marcela Slavikova
    International Urology and Nephrology, 2009
  • Chronic health impairment due to 2,3,7,8-tetrachloro-dibenzo-p-dioxin exposure
    Neuroendocrinology Letters, 2009
  • Increased carotid intima-media thickness in patients with pheochromocytoma in comparison to essential hypertension
    R Holaj, T Zelinka, D Wichterle, O Petrák, B Štrauch, A Vránková, B Majtan, J Spáčil, J Malik, J Widimský
    Journal of Human Hypertension, 2009
  • Vascular Access Surveillance: No Benefit?
    Vladimir Tuka, Jan Malik
    American Journal of Kidney Diseases, 2008
  • Factors associated with impaired arterial adaptation to chronically high wall shear rate in the feeding artery of PTFE grafts
    Vladimir Tuka, Marcela Slavikova, Zdislava Kasalova, Jan Malik
    American Journal of Nephrology, 2008
  • Cardiovascular issues of dialysis patients referred for ultrasound examination of vascular access grafts
    Vladimír Tuka, Jan Malík, Vladimír Tesař
    Cor Et Vasa, 2008
  • Hyperlipidemia is associated with altered levels of insulin-like growth factor-I
    Physiological Research, 2008
  • Understanding the dialysis access steal syndrome. A review of the etiologies, diagnosis, prevention and treatment strategies
    J. Malik, V. Tuka, Z. Kasalova, E. Chytilova, M. Slavikova, P. Clagett, I. Davidson, B. Dolmatch, D. Nichols, M. Gallieni
    Journal of Vascular Access, 2008
  • Wall sheer stress in carotid artery and its role in the development of atherosclerosis
    Vnitrni Lekarstvi, 2007
  • Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients
    Michal Vrablik, Tomas Stulc, Zdislava Kasalova, Iuri Marinov, Jan Malik, Jan Simek, Helena Svobodova, Katerina Zidkova, Richard Ceska
    Nutrition Research, 2007
  • Dyslipidemia and anemia in chronically hemodialyzed patients.
    Prague Medical Report, 2007
  • Ultrasonography and graft patency [10]
    J. Malik
    Kidney International, 2006
  • Diabetes and distal access location are associated with higher wall shear rate in feeding artery of PTFE grafts
    Vladimir Tuka, Marcela Slavikova, Jaroslava Svobodova, Jan Malik
    Nephrology Dialysis Transplantation, 2006
  • Hemodynamics and autonomic control of heart rate turbulence
    DAN WICHTERLE, VOJTECH MELENOVSKY, JAN SIMEK, JAN MALIK, MAREK MALIK
    Journal of Cardiovascular Electrophysiology, 2006
  • Second derivative of the finger arterial pressure waveform: An insight into dynamics of the peripheral arterial pressure pulse
    Physiological Research, 2005
  • Matrix metalloproteinases in isolated hypercholesterolemia
    International Angiology, 2005
  • Pulse wave analysis during supine rest may identify subjects with recurrent vasovagal syncope
    Jan Simek, Dan Wichterle, Vojtech Melenovsky, Jan Malik, Jaroslava Svobodova, Stepan Svacina
    Clinical Science, 2005
  • Relation between actual heart rate and autonomic effects of beta blockade in healthy men
    Vojtech Melenovsky, Jan Simek, Michal Sperl, Jan Malik, Dan Wichterle
    American Journal of Cardiology, 2005
  • Reply from the authors [4]
    Jan Malik
    Kidney International, 2005
  • Regular ultrasonographic screening significantly prolongs patency of PTFE grafts
    Jan Malik, Marcela Slavikova, Jaroslava Svobodova, Vladimir Tuka
    Kidney International, 2005
  • Repeatability of noninvasive surrogates of endothelial function
    Jan Malik, Dan Wichterle, Tomas Haas, Vojtech Melenovsky, Jan Simek, Tomas Stulc
    American Journal of Cardiology, 2004
  • Wall shear stress and endothelium
    Casopis Lekaru Ceskych, 2004
  • Dialysis access-associated steal syndrome: The role of ultrasonography
    Journal of Nephrology, 2003
  • Total body composition of adult patients with growth hormone deficit before and after the hormone administration
    Vnitrni Lekarstvi, 2003
  • Effect of Atorvastatin and Fenofibrate on autonomic tone in subjects with combined hyperlipidemia
    Vojtech Melenovsky, Dan Wichterle, Jan Simek, Jan Malik, Tomas Haas, Richard Ceska, Marek Malik
    American Journal of Cardiology, 2003
  • Intima-media thickness of the common carotid artery is the significant predictor of angiographically proven coronary artery disease
    Canadian Journal of Cardiology, 2003
  • Ultrasonography of the vascular access complications - First experience
    Casopis Lekaru Ceskych, 2003
  • Would in-time screening ultrasonography diagnose clinically silent dialysis access stenosis?
    Casopis Lekaru Ceskych, 2003
  • Effect of folic acid on fenofibrate-induced elevation of homocysteine and cysteine.
    American Heart Journal, 2003
  • Heart Rate Turbulence - A new ECG risk predictor of sudden death
    Vnitrni Lekarstvi, 2002
  • Many clinically silent access stenoses can be identified by ultrasonography
    Journal of Nephrology, 2002
  • Lipid lowering and the assessment of endothelial function (multiple letters)
    K Lee
    Cardiovascular Research, 2002
  • Doppler ultrasonography of dialysis fistulas
    Ceska Radiologie, 2002
  • Possibilities of ultrasonographic examination of the carotid arteries
    Ceska Radiologie, 2002
  • Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action
    VOJTECH MELENOVSKY, DAN WICHTERLE, JAN MALIK, JAN SIMEK, JAROMIR HRADEC, RICHARD CESKA, MAREK MALIK
    PACE Pacing and Clinical Electrophysiology, 2002
  • Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia.
    American Heart Journal, 2002
  • Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial - FAT)
    J Malik
    Cardiovascular Research, 2001
  • Function and dysfunction of the endothelium
    Casopis Lekaru Ceskych, 2000
  • Relation of the thickness of the intima and media of the common carotid artery, atherosclerotic plaque in the carotids and manifestations of atherosclerosis in the vessels of the lower extremity in comparison to coronary atherosclerosis
    Casopis Lekaru Ceskych, 1998
  • Replacement treatment with growth hormone improves arterial intima thickness in hypopituitary adults
    Casopis Lekaru Ceskych, 1998
  • Initial experience of an endocrinologist with the treatment of hypophyseal adenomas with the Leksell gamma knife
    Casopis Lekaru Ceskych, 1995