Solomiia Kadubets

EDUCATION

• Since September 2024 - PhD student of the Ophthalmology department FPGE in SNE «Danylo
Halytsky Lviv National Medical University»
• 2022-2024 - internship in Ophthalmology - Ophthalmology department FPGE in Danylo
Halytsky Lviv National Medical University, Ophthalmology department in Ternopil regional
clinical hospital )
• 2016-2022 - Master’s degree in Medicine – Danylo Halytsky Lviv National Medical
University

RESEARCH, TEACHING, or OTHER INTERESTS

Ophthalmology

Scopus Publications

Comparative analysis of etiological factors, and incidence of complications of bacterial keratitis in patients with and without type 2 diabetes mellitus under martial law in Ukraine
V.A. Serhiyenko, A.S. Hudz, S.V. Kadubets, L.L. Davtian, G.Ye. Zakharevych
Archive of Ukrainian Ophthalmology, 2025
Background. Bacterial keratitis (BK) remains one of the leading causes of infectious vision loss. Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of BK due to hyperglycemia, corneal neuropathy, and impaired local immunity. Under martial law in Ukraine, limited access to ophthalmological care aggravates the problem of timely treatment of such patients. The purpose was to perform a comparative analysis of etiological factors and complication rates of bacterial keratitis in patients with and without type 2 diabetes mellitus during the wartime in Ukraine. Materials and methods. A total of 110 patients (110 eyes) with BK were examined and divided into two groups: 57 individuals with T2DM (group 1) and 53 people without diabetes (group 2). All of them underwent standard ophthalmological and microbiological assessments. Statistical processing was performed using Microsoft Excel 2019 and IBM SPSS Statistics 26 programs with Pearson’s χ² test, Fisher’s exact test, and a significance level of p 0.05). The most common complication in non-diabetic patients was corneal opacity (37.74 %), while in T2DM patients, it occurred in 17.54 % (p 0.05). Conclusions. Patients with T2DM had a more severe clinical course of bacterial keratitis with a higher tendency toward complications, while non-diabetic individuals more often develop corneal opacity without deep stromal involvement. These findings emphasize the importance of early diagnosis and individualized management of BK in T2DM patients, particularly under wartime conditions.
Features of etiological factors, clinical course, and incidence of complications of bacterial keratitis in patients with type 2 diabetes mellitus under martial law in Ukraine
A.S. Hudz, S.V. Kadubets
Archive of Ukrainian Ophthalmology, 2025
Background. Bacterial keratitis (BK) is a common and serious infectious eye condition that poses a threat to visual function. Type 2 diabetes mellitus (T2DM) increases the risk of developing BK, as evidenced by a higher incidence of eye infections in patients with diabetes. Under the conditions of martial law in Ukraine, access to timely ophthalmological care is limited, which worsens the clinical course and complicates the treatment of BK in patients with T2DM. Modern methods, including optical coherence tomography (OCT), allow assessment of the morphofunctional state of the cornea and monitoring treatment dynamics. Objective: to investigate the features of etiological factors, clinical course, and the incidence of complications of bacterial keratitis in patients with type 2 diabetes mellitus under martial law in Ukraine. Materials and methods. Fifty-seven patients (57 eyes) with bacterial keratitis and T2DM were observed. Etiology, clinical features, visual acuity, and corneal OCT parameters were analyzed at baseline and during follow-up, within up to 3 months. Statistical analysis was performed using ANOVA, χ², and other tests with a significance level of p < 0.05. Results. The most frequent etiological factors were improper contact lens use (28.07 %), traumatic corneal injury by foreign bodies (22.81 %), dry eye syndrome (17.54 %), and chemical injuries (10.53 %). A gradual and significant improvement in visual acuity was noted: uncorrected visual acuity increased 5-fold, and best-corrected visual acuity increased 4-fold (p < 0.001). According to OCT data, there was a significant decrease in corneal thickness (by 22 %), stromal thickness (by 25 %), and thickness, width, and area of an infiltrate (by 86–91 %) over 3 months of treatment (p < 0.001). The most common complications were corneal opacities (17.54 %), vascularization (12.28 %), and anterior uveitis (8.77 %). Conclusions. In patients with type 2 diabetes mellitus, bacterial keratitis is most commonly associated with contact lens use and corneal trauma. Significant improvement in visual function and corneal morphological parameters was observed during treatment. These findings highlight the importance of timely diagnosis and adequate therapy of BK in patients with T2DM, especially under conditions of limited access to medical care.
Myo-inositol supplementation in women of reproductive age with subclinical hypothyroidism and obesity on the background of vitamin D deficiency
N.V. Pasyechko, V.M. Kulchinska, S.V. Kadubets
Miznarodnij Endokrinologicnij Zurnal, 2021
Background. In recent years, thyroid diseases occupy the top places in the structure of the endocrine pathology. There exists a tight functional relationship between the thyroid and reproductive systems, which leads to a high probability of the development of combined disorders in one of these links of homeostasis. The problem of reproductive health disorders is of particular concern around the world and is relevant to the study of the impact of thyroid diseases on both fertility and pregnancy, especially in conditions of comorbidity. The purpose of the study was to investigate the effect of myo-inositol on the reproductive function of women with subclinical hypothyroidism on the background of autoimmune thyroiditis and obesity. Materials and methods. The study included 98 patients aged 18–40 years with subclinical hypothyroidism, overweight, or obesity on the background of autoimmune thyroiditis. They were randomly subdivided into two groups. Patients of the first group (n = 49) before the basic treatment received myo-inositol at a dose of 2000 mg/day and cholecalciferol at a dose of 2000 IU/day. Patients of the second group (n = 49) before the basic treatment received only cholecalciferol at a dose of 2000 IU/day. Results. Vitamin D deficiency was observed in 90.81 % of women with subclinical hypothyroidism, and vitamin D insufficiency in 9.19 %. A negative correlation was found between the level of 25(OH)D and the level of TPO-Ab (r =–0.189; p < 0.05). There was a weak negative correlation between the level of 25(OH)D and the level of the HOMA-IR (r = –0.168; p < 0.05). The administration of myo-inositol together with vitamin D led to a significant increase in the content of 25(OH)D, as well as to a decrease in the titer of TPO-Ab. Conclusions. The positive effect of myo-inositol drugs together with vitamin D on the functional state of the thyroid gland, on the level of TPO-Ab and HOMA-IR in women of reproductive age with subclinical hypothyroidism and obesity has been established.
Primary hypothyroidism as a predictor of the hypogonadism development
N.V. Pasyechko, T.Y. Krytskyi, S.V. Kadubets, U.V. Naumova, L.V. Naumova
Miznarodnij Endokrinologicnij Zurnal, 2021
Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reproductive age with primary hypothyroidism. Materials and methods. Totally 60 males with primary hypothyroidism were included in the study. Acomparative analysis of hormonal, anthropometric, and metabolic parameters in 60 men with hypothyroidism (basic group) and 25 men without hypothyroidism and other chronic somatic diseases (control group) was performed. The mean age of the subjects was 42.4±2.7 years. Results. It has been established that hypothyroidism was accompanied by an increase in serum concentrations of cholesterol and low-density lipoprotein cholesterol in comparison with control group (25 men without hypothyroidism) indicating metabolic disturbance. The data shows the significant effect of hypothyroidism on testosterone and follicle-stimulating hormone (FSH) serum concentration but not on luteinizing hormone, estradiol levels. Patients with hypothyroidism had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in men with hypothyroidism can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido, and alteration in spermatogenesis. Conclusions. In men with hypothyroidism, changes in hormonal status have been found, which manifested in a decrease in testosterone and an increase in the blood level of follicle-stimulating hormone. The effect of hypothyroidism on the blood level of other hormones (luteinizing, estradiol, cortisol) has not been established. Hypothyroidism in men is accompanied by changes in lipid metabolism (increased levels of total cholesterol and low-density lipoprotein cholesterol).