Schiff bases-based metallo complexes and their crucial role in the realm of pharmacology. A review Raji Sankar, T.M. Sharmila Results in Chemistry, 2023 Three prominent health challenges affecting our society include cancer, diabetes, and antibiotic-resistant infections. Despite the availability of conventional drugs for these conditions, the pervasive problem of multidrug resistance significantly diminishes their effectiveness. Consequently, it is paramount to prioritize the development of novel drug compounds endowed with improved and desirable therapeutic properties. Utilizing metal-based drugs has proven to be an effective strategy in the realm of anticancer treatment and this approach holds significant promise for the enhanced treatment of multi-resistant infections and diabetes. Schiff bases, being bioactive organic compounds, have attracted considerable attention. Researchers have been actively exploring the potential therapeutic applications of metallo-based Schiff bases, including heterocyclic molecules and/or aromatic rings adorned with diverse functional groups across various illnesses. This review catalogs (2010 to 2023) the classification of metal-based Schiff base compounds that incorporate heterocyclic rings and/or aromatic rings with diverse functional groups, which possess antimicrobial, antidiabetic, and anticancer qualities. These insights can assist the medical chemist in identifying suitable drug candidates for developing innovative pharmaceuticals.
Determination of ammonia content in various drinking water sources in Malappuram District, Kerala and its removal by adsorption using agricultural waste materials J. Joseph, A.K. Sajeesh, K. Nagashri, E.H. Edinsha Gladis, T.M. Sharmila, C. Justin Dhanaraj Materials Today Proceedings, 2021 Sustainable measure to harmless drinking water attains a worldwide threat in the developing countries still consume water from untreated sources. Water sources were taken throughout the Malappuram Dist from open well, bore well, tube well, pond and river water samples. Nowadays, the chemical substance, ammonia is one of the important pollutants found in drinking water sources. The present study was also focused on the quantity of ammonia contamination in the various drinking water sources in Malappuram district, Kerala and also investigated the removal of ammonia from different samples through adsorption process with different charcoal materials. The experimental observations were indicated that the rate of ammonia adsorption on charcoal carbon increases with the increase of concentration in the solution. Among the studied charcoals, the rice husk charcoal imparted significant removal of ammonia as compared to others due to their surface chemical constituents (interacts with ammonia for effective removal).
