PhD (Pharmaceutical Sciences), M. Pharm (Pharmaceutics)
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Pharmaceutical Science, Drug Discovery
1
Scopus Publications
641
Scholar Citations
8
Scholar h-index
8
Scholar i10-index
Scopus Publications
Design and Evaluate Polymeric Micelles Loaded with Paclitaxel, A Chemotherapy Drug, for Breast Cancer Treatment Diksha Joshi, Himani Hirvey, Divya Budarapu, Chaynika C. Dhar, Bhawana Kapoor, T. Maithili International Journal of Drug Delivery Technology, 2025 Breast cancer, particularly the aggressive triple-negative subtype (TNBC), remains a major therapeutic challenge due to a lack of targetable receptors and the severe limitations of conventional chemotherapy. Paclitaxel (PTX) is a cornerstone drug, but its clinical utility is hampered by poor aqueous solubility and severe side effects linked to its solubilizing vehicle, Cremophor® EL. This study aimed to develop a Cremophor-free, polymeric nanoparticle system to improve the delivery and therapeutic profile of PTX. Paclitaxel was encapsulated within poly (lactic-co-glycolic acid) (PLGA) nanoparticles using a double-emulsion solvent evaporation method, with polyvinyl alcohol (PVA) as a stabilizer. The optimized formulation (NP3) exhibited a high encapsulation efficiency (84.25%), a particle size of ~309 nm, a negative zeta potential, and a spherical morphology as confirmed by FESEM and TEM. FTIR and DSC studies confirmed the absence of chemical interactions and the crystalline state of the encapsulated drug. In vitro release studies demonstrated a sustained release profile over 30 days, fitting the Korsmeyer-Peppas model. Crucially, the NP3 formulation showed significantly enhanced cytotoxicity against HepG2 and Huh-7 liver cancer cell lines compared to free PTX and a commercial formulation, while blank nanoparticles were non-toxic. The results indicate that PLGA-based nanoparticulate delivery is a promising strategy to solubilize PTX without harmful excipients, provide controlled release, and enhance its anticancer efficacy, offering a potential improved therapeutic option for challenging cancers like TNBC.
RECENT SCHOLAR PUBLICATIONS
Development and Validation of a Novel HPLC Method for the Analysis of Andrographolide in Marketed Herbal Formulation VM Sidhant Naithani, Bhawana Kapoor, Surabhi Pokhriyal, Shagun Sharma ... Journal of Chemical Health Risks 15 (3), 1940-1944 , 2025 2025
Effect of Topical Creams for Treating Blood Cancer Nodes in DL with Nanotechnology DY Rao, DP Revathi, DS Narendhran, MB Kapoor, DA Vanitha, ... IN Patent App. 202231067168 A , 2022 2022
Development, characterization and in VIVO evaluation of diffusion controlled transdermal matrix patches of A model anti-Inflammatory drug B Kapoor, SP Bhatt, A Bilandi, S Sahiba, B Singh, P Kumar International Journal of Health Sciences 6 (S7), 2875-2890 , 2022 2022
PRETREATMENT OF ALBINO RATS WITH POLY HERBAL EXTRACT OF ANDROGRAPHIS PANICULATA, BOUGAINVILLEA SPECTABILIS AND CINNAMOMUM TAMALA FOR PROTECTION AGAINST STREPTOZOTOCIN INDUCED … SP Bhatt, K Bhawana, N Pooja, K Vishwadeepak, N Divya NeuroQuantology 20 (10), 4022 , 2022 2022
Evaluation of transdermal patches of lornoxicam B Kapoor, H Rangarh, S Sharma International journal of pharmaceutical sciences and research, 19 , 2020 2020
Prevalence of skin diseases in a dermatology outpatient department of a Tertiary Hospital B Kapoor, A Kapoor Journal of Advanced Medical and Dental Sciences Research 6 (7), 1-3 , 2018 2018
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY: AN EFFECTIVE TOOL FOR DRUG ESTIMATION B Kapoor, V Rai, S Sharma consultant 9, 0 , 2012 2012
Acute, Sub acute and Chronic Toxicity Studies: Rules and Methods D Gupta, B Kapoor, S Bhardwaj 2012
Solid dispersion: An evolutionary approach for solubility enhancement of poorly water soluble drugs KS Kapoor Bhawana, Kaur Ramandeep , Kaur Sukhdeep, Behl Himani International Journal of Recent Advances in Pharmaceutical Research 2 (2), 1-16 , 2012 2012 Citations: 73
Anti–bacterial evaluation of plant Nyctanthes arbor-tristis Linn S Sharma, B Kapoor, M Bhusal, K Sharma International Journal of Advances in Pharmaceutical Research 3 (7), 1004-1009 , 2012 2012 Citations: 5
Evolutionary approaches for drug and gene delivery by micro and nano magnetic carriers T Garg, A Bilandi, B Kapoor Indo-global Res J Pharm Sci 2 (1), 182-189 , 2012 2012 Citations: 5
Additives in topical dosage forms S Premjeet, B Ajay, K Sunil, K Bhawana, K Sahil, R Divashish, B Sudeep International Journal of Pharmaceutical, Chemical, and Biological Sciences 2 … , 2012 2012 Citations: 24
Stealth liposomes: a review. S Kataria, P Sandhu, A Bilandi, M Akanksha, B Kapoor International journal of research in ayurveda & pharmacy 2 (5) , 2011 2011 Citations: 124
Phytochemical screening and evaluation of anti-inflammatory activity of leaves extract of Holoptelea integrifolia roxb. S Sharma, V Rai, B Kapoor, BR Sarkar International Journal of Research in Pharmacy & Science 1 (1) , 2011 2011 Citations: 6
Autism spectrum disorders (ASD) M Akanksha, K Sahil, S Premjeet, K Bhawna International Journal of research in ayurveda & pharmacy 2 (5), 1541-1546 , 2011 2011 Citations: 20
Preliminary phytochemical screening and Evaluation of Antiinflammatory ac-tivity of Ethanolic extract of leaves of Indigofera tinctoria Linn BR Sarkar, VK Rai, B Kapoor, S Sharma, JP Mohanty, D Sarkar, ... Int. J. Res. Phytochem. Pharmacol 1 (2), 55-58 , 2011 2011 Citations: 5
Microsphere: A review S Kataria, A Middha, P Sandhu, A Bilandi, B Kapoor Int J Res Pharm Chem 1 (4), 1185-1198 , 2011 2011 Citations: 82
Review article on microsphere S Katarpia, A Middha, P Sandhu, B Ajay, K Bhawana Seth GL Bihani SD College of Technical Education, Institute of … , 2011 2011 Citations: 5
Review article: Microsphere K Sahil, M Akanksha, S Premjeet, A Bilandi, B Kapoor International Journal of Research In Pharmacy and Chemistry 1 (4), 1184-1198 , 2011 2011 Citations: 2
Current status and future directions of new drug delivery technologies T Garg, A Bilandi, B Kapoor, S Kumar, A Chanana International research journal of pharmacy 2, 61-68 , 2011 2011 Citations: 12
MOST CITED SCHOLAR PUBLICATIONS
Microsphere: A review K Sahil, M Akanksha, S Premjeet, A Bilandi, B Kapoor Int. J. Res. Pharm. Chem 1 (4), 1184-98 , 2011 2011.0 Citations: 222
Stealth liposomes: a review. S Kataria, P Sandhu, A Bilandi, M Akanksha, B Kapoor International journal of research in ayurveda & pharmacy 2 (5) , 2011 2011.0 Citations: 124
Microsphere: A review S Kataria, A Middha, P Sandhu, A Bilandi, B Kapoor Int J Res Pharm Chem 1 (4), 1185-1198 , 2011 2011.0 Citations: 82
Solid dispersion: An evolutionary approach for solubility enhancement of poorly water soluble drugs KS Kapoor Bhawana, Kaur Ramandeep , Kaur Sukhdeep, Behl Himani International Journal of Recent Advances in Pharmaceutical Research 2 (2), 1-16 , 2012 2012.0 Citations: 73
Organogels: advanced and novel drug delivery system T Garg, A Bilandi, B Kapoor, S Kumar, R Joshi Int Res J Pharm 2 (12), 15-21 , 2011 2011.0 Citations: 53
Additives in topical dosage forms S Premjeet, B Ajay, K Sunil, K Bhawana, K Sahil, R Divashish, B Sudeep International Journal of Pharmaceutical, Chemical, and Biological Sciences 2 … , 2012 2012.0 Citations: 24
Autism spectrum disorders (ASD) M Akanksha, K Sahil, S Premjeet, K Bhawna International Journal of research in ayurveda & pharmacy 2 (5), 1541-1546 , 2011 2011.0 Citations: 20
Current status and future directions of new drug delivery technologies T Garg, A Bilandi, B Kapoor, S Kumar, A Chanana International research journal of pharmacy 2, 61-68 , 2011 2011.0 Citations: 12
Phytochemical screening and evaluation of anti-inflammatory activity of leaves extract of Holoptelea integrifolia roxb. S Sharma, V Rai, B Kapoor, BR Sarkar International Journal of Research in Pharmacy & Science 1 (1) , 2011 2011.0 Citations: 6
Anti–bacterial evaluation of plant Nyctanthes arbor-tristis Linn S Sharma, B Kapoor, M Bhusal, K Sharma International Journal of Advances in Pharmaceutical Research 3 (7), 1004-1009 , 2012 2012.0 Citations: 5
Evolutionary approaches for drug and gene delivery by micro and nano magnetic carriers T Garg, A Bilandi, B Kapoor Indo-global Res J Pharm Sci 2 (1), 182-189 , 2012 2012.0 Citations: 5
Preliminary phytochemical screening and Evaluation of Antiinflammatory ac-tivity of Ethanolic extract of leaves of Indigofera tinctoria Linn BR Sarkar, VK Rai, B Kapoor, S Sharma, JP Mohanty, D Sarkar, ... Int. J. Res. Phytochem. Pharmacol 1 (2), 55-58 , 2011 2011.0 Citations: 5
Review article on microsphere S Katarpia, A Middha, P Sandhu, B Ajay, K Bhawana Seth GL Bihani SD College of Technical Education, Institute of … , 2011 2011.0 Citations: 5
Organogel: Advance and Novel drug delivery‖ International Research Journal of Pharmacy BA GargTarun, K Bhawana, K Sunil Nov-2011 pp, 3-4 , 0 Citations: 3
Review article: Microsphere K Sahil, M Akanksha, S Premjeet, A Bilandi, B Kapoor International Journal of Research In Pharmacy and Chemistry 1 (4), 1184-1198 , 2011 2011.0 Citations: 2
Development and Validation of a Novel HPLC Method for the Analysis of Andrographolide in Marketed Herbal Formulation VM Sidhant Naithani, Bhawana Kapoor, Surabhi Pokhriyal, Shagun Sharma ... Journal of Chemical Health Risks 15 (3), 1940-1944 , 2025 2025.0
Effect of Topical Creams for Treating Blood Cancer Nodes in DL with Nanotechnology DY Rao, DP Revathi, DS Narendhran, MB Kapoor, DA Vanitha, ... IN Patent App. 202231067168 A , 2022 2022.0
Development, characterization and in VIVO evaluation of diffusion controlled transdermal matrix patches of A model anti-Inflammatory drug B Kapoor, SP Bhatt, A Bilandi, S Sahiba, B Singh, P Kumar International Journal of Health Sciences 6 (S7), 2875-2890 , 2022 2022.0
PRETREATMENT OF ALBINO RATS WITH POLY HERBAL EXTRACT OF ANDROGRAPHIS PANICULATA, BOUGAINVILLEA SPECTABILIS AND CINNAMOMUM TAMALA FOR PROTECTION AGAINST STREPTOZOTOCIN INDUCED … SP Bhatt, K Bhawana, N Pooja, K Vishwadeepak, N Divya NeuroQuantology 20 (10), 4022 , 2022 2022.0
Evaluation of transdermal patches of lornoxicam B Kapoor, H Rangarh, S Sharma International journal of pharmaceutical sciences and research, 19 , 2020 2020.0
