Tushar Emran

Tushar Emran is a dedicated pharmaceutical professional and researcher with an M.Pharm in Pharmacology and Clinical Pharmacy from North South University. He is currently serving as a laboratory officer in the Department of Pharmaceutical Sciences at North South University, where he has gained extensive experience in animal studies, molecular biology techniques, biochemical analysis, and pharmaceutical laboratory instrumentation. He has contributed to several peer-reviewed international research publications focusing on oxidative stress, inflammation, hepatotoxicity, cardiovascular diseases, and natural product pharmacology. Tushar possesses strong analytical, communication, and teamwork skills, with a passion for academic research and pharmaceutical sciences.

EDUCATION

I have completed my Master of Pharmacy in Pharmacology and Clinical Pharmacy (M.Pharm) and Bachelor of Pharmacy (B.Pharm) from North South University, Dhaka 1212, Bangladesh. I did my Higher Secondary Certificate (HSC) from Narsingdi Model College and my Secondary School Certificate (SSC) from Mutiullah Bhuiya High School, Narsingdi 1600, Dhaka, Bangladesh.

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Biotechnology, Molecular Biology

Scopus Publications

Coenzyme Q10 alleviates oxidative stress, inflammation and fibrosis via activation of TGFβ1/TNF-α in FCA-Salt hypertensive rats
Nusrat Hossain, Sadia Shabnam, Tushar Emran, Zahidul Islam Zahid, Shaiful Alam, Asim Kumar Bepari, G.M. Sayedur Rahman, Hasan Mahmud Reza
Archives of Biochemistry and Biophysics, 2025
Hypertension is one of the most common factors contributing to cardiac remodeling that links to changes in both heart and kidney functions. Several studies have reported the beneficial effects of Coenzyme Q 10 (CoQ 10 ) in reducing oxidative stress due to its antioxidant properties. However, the cardioprotective and nephroprotective roles of CoQ 10 against the toxicity induced by fludrocortisone acetate (FCA) have yet to be investigated. Therefore, we evaluated the CoQ 10 effects on FCA-induced cardiotoxicity and nephrotoxicity in a rat model (FCA-Salt). We analyzed various oxidative stress parameters and antioxidant enzyme activities using biochemical assays. In addition, we examined inflammatory and fibrosis via histological staining of heart and kidney tissues. CoQ 10 significantly reduced lipid peroxidation product-malondialdehyde (MDA) while increased nitric oxide (NO) in the FCA-Salt rats. Antioxidant enzyme activities were also enhanced by CoQ 10 in these rats. Histopathological examination detected tissue damage and fibrosis in the FCA-Salt group, which was significantly reduced by CoQ 10 . Furthermore, enzyme-linked immunosorbent assay (ELISA) indicated the activation of Transforming growth factor-β1/Tumor necrosis factor-α (TGF-β1/TNF-α) by CoQ 10 . Consequently, our study suggests that CoQ 10 can effectively protect heart and kidney health against cardiotoxicity and nephrotoxicity in FCA-Salt hypertensive rats via TGF-β1/TNF-α pathway.
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats
Astrid Mukta Biswas, Tushar Emran, Sabrin Islam Khan, Sadia Shabnam, Preeti Jain, Asim Kumar Bepari, Manik Chandra Shill, Md Murad Hossain, Hasan Mahmud Reza
European Journal of Pharmacology, 2025
XAI-Enhanced Hybrid Models for Effective Chronic Kidney Disease Prediction
Pijush Kanti Roy Partho, Suchi Karmoker, Tushar Emran, Dipraj Sarker, Delowar Hossain, Eui-Nam Huh, Muhammad Aminur Rahaman, Tangina Sultana
Proceedings of 2025 International Conference on Sustainable Technology and Engineering I Coste 2025, 2025
Chronic Kidney Disease (CKD) is a major global health concern that requires early and accurate detection to prevent progression and improve patient outcomes. This study presents a predictive framework integrating traditional machine learning and deep learning with an ensemble approach for robust CKD diagnosis. To address data imbalancing, three resampling techniques, namely SMOTE, SMOTE-Tomek, and SMOTE-ENN, were proposed to balance the dataset. A single SHAP-based feature selection via XGBoost was applied to each resampled dataset, and the top features were aggregated across all three techniques. We also performed a comprehensive statistical analysis using SPSS software to identify the most important features. Nine machine learning classifiers and two ensemble strategies were trained and applied alongside several deep learning models, including Attention Autoencoder with XGBoost for latent features, TabNet, TabPFN, LightCNN, MLP, and Deep and Cross Network (DeepCrossNet). DeepCrossNet achieved the highest accuracy (97.38 %) among all deep learning models; meanwhile, the stacking ensembles model reached 97.50 %, and Random Forest led among traditional models with the accuracy of 97.71 %. Explainable AI, likely SHAP and LIME analysis, confirmed that the features GFR (glomerular filtration rate) and serum creatinine are the most influential predictors, supporting clinical interpretability. t-SNE and UMAP projections demonstrated clear class separation and highlighted ambiguous cases. These results demonstrate that combining aggregated, SHAP-selected features from resampled datasets with ensemble and deep learning methods yields accurate and interpretable CKD predictions.
Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway
Manoneeta Sarker, Nowreen Chowdhury, Anika Tabassum Bristy, Tushar Emran, Reatul Karim, Rezwana Ahmed, Md Mostaid Shaki, Shazid Md. Sharkar, G.M. Sayedur Rahman, Hasan Mahmud Reza
Biomedicine and Pharmacotherapy, 2024
Hypertensive rats serve as a good experimental model for studying the pathophysiology of cardiac hypertrophy and remodeling leading to heart failure. In this study, we aimed to analyze the effect of astaxanthin and possible mechanisms involved in alleviating oxidative stress, fibrosis and inflammation that triggers cardiac remodeling using male uninephrectomized Long Evans rats. Cardiac hypertrophy and hypertension were induced in rats termed as ‘FCA-Salt rats’ by an oral administration of fludrocortisone acetate (FCA) and 1 % NaCl in drinking water. Biochemical assays showed that FCA-Salt rats exhibited an upregulation of oxidative stress markers AOPP, MDA and downregulation of NO in heart and kidney, which was reversed by astaxanthin treatment. Astaxanthin further regularized the reduced activities of antioxidant enzymes GSH, SOD and CAT in these tissues. ELISA revealed that astaxanthin significantly reduced the inflammatory response by reducing the elevated levels of IL-1β, IL-17a, and TNF-α and pro-fibrotic marker TGF-β1 in plasma. Real-time qPCR depicted an upregulation of TNF-α, IL-1β, IL-6, IL-17A as well as signaling molecules TGF-β1, Smad2 and Smad3 in heart of FCA-Salt rats, which was reduced significantly by astaxanthin. Sirius red staining showed that the cardiac and renal fibrosis was significantly improved by astaxanthin treatment. Together, our results suggest that astaxanthin treatment is beneficial in protecting cardio-renal damage in hypertension through TGF-β/Smad signaling pathway, hence, this molecule may be considered for the maintenance of cardio-renal health. • Excessive ROS in cardiovascular diseases can cause cardiac damage. • Astaxanthin ameliorates oxidative stress and tissue fibrosis in the heart & kidney. • Here, astaxanthin shows alleviation of fibrosis in the heart & kidney in FCA-Salt rat. • Astaxanthin suppresses inflammatory gene expression via TGF-β/Smad pathway.
Anti-obesity effects and underlying molecular mechanisms of the ethanolic extract of figs from Ficus hispida using high fat-fed wister rats
Anika Tabassum Shama, Luluin Maknun Shova, Anika Tabassum Bristy, Tushar Emran, Sadia Shabnam, Manik Chandra Shill, Asim Kumar Bepari, Hasan Mahmud Reza
Heliyon, 2024
Obesity is a known risk factor for many chronic diseases and a substantial threat to public health. We investigated the effects of figs sourced from Ficus hispida on a high fat-fed experimental rat model. We found that a 500-mg dose of ethanolic extract of figs (EFH) reduced oxidative stress markers nitric oxide (NO), malondialdehyde (MDA), and advanced oxidation protein products (AOPP), which were increased in high fat-fed rats. Antioxidant enzymes superoxide dismutase (SOD), catalase, reduced glutathione (GSH), and myeloperoxidase (MPO), found elevated in high fat-fed rats, were also normalized to nearly regular levels by fig treatment. Administration of EFH further reduced fat deposition and expression of adipogenic genes leptin, fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPARγ), and sterol regulatory element-binding protein-1c (SERBP-1c). Our results suggest that figs have significant effects on reducing oxidative stress and mitigating obesity-associated liver and adipose tissue abnormalities via suppressing adipogenesis. Thus, we propose that F. hispida has potential benefits in reducing obesity.
Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats
Fatima Tuj Johra, Sukria Hossain, Preeti Jain, Anika Tabassum Bristy, Tushar Emran, Rezwana Ahmed, Shazid Md Sharker, Asim Kumar Bepari, Hasan Mahmud Reza
Scientific Reports, 2023
Liver disease is a serious health problem affecting people worldwide at an alarming rate. The present study aimed to investigate the protective effects ofGanoderma lucidumagainst CCl4-induced liver toxicity in rats. The experimental Long Evans rats were divided into five groups, of which four groups were treated with carbon tetrachloride (CCl4). Among the CCl4treated groups, one of the groups was treated with silymarin and two of them with ethanolic extract ofG. lucidumat 100 and 200 mg/Kg body weight. The oxidative stress parameters and endogenous antioxidant enzyme concentrations were assessed by biochemical tests. Liver enzymes ALT, AST, and ALP were determined spectrophotometrically. Histopathological examinations were carried out to assess hepatic tissue damage and fibrosis. Reverse transcription PCR (RT-PCR) was performed to determine the expression of IL-1β, IL-6, IL-10, TNF-α, and TGF-β genes. Gas Chromatography-Mass Spectroscopy (GC–MS) analysis revealed thatG. lucidumis rich in several phytochemicals including 6-Octadecanoic acid (55.81%), l-( +)-Ascorbic acid 2,6-dihexadecanoate (18.72%), Cis-11-Eicosenamide (5.76%), and Octadecanoic acid (5.26%). Treatment with theG. lucidumextract reduced the elevated ALT, AST, ALP levels, and cellular oxidative stress markers and increased the endogenous antioxidant levels. Histopathology observations revealed that the inflammation, infiltration of immune cells, and aberration of collagen fibers in the hepatocytes were altered by theG. lucidumtreatment. The increased expression of inflammatory cytokines TNF-α, TGF-β, IL-1 β, and IL-6 were markedly suppressed byG. lucidumextract treatment.G. lucidumalso prevented the suppression of protective IL-10 expression by CCl4. This study strongly suggests thatG. lucidumextract possesses significant hepatoprotective activity as evidenced by reduced oxidative stress and inflammation mediated by suppression in inflammatory cytokine expression and increased protective IL-10 cytokine expression.
QbD Approach towards Robust Design Space for Flutamide/PiperineSelf-Emulsifying Drug Delivery System with Reduced Liver Injury
Mithun Saha, Pallabi Sikder, Aditi Saha, Sharha Shah, Sharmin Sultana, Tushar Emran, Ananna Banik, Zahidul Islam, Muhammad Saiful Islam, Shazid Md. Sharker, Hasan Mahmud Reza
AAPS Pharmscitech, 2022
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction
Tushar Emran, Nowreen Islam Chowdhury, Manoneeta Sarker, Asim Kumar Bepari, Murad Hossain, G.M. Sayedur Rahman, Hasan Mahmud Reza
Biomedicine and Pharmacotherapy, 2021
BRIEF INTRODUCTION: Myocardial infarction (MI) is a common manifestation of certain cardiac diseases where oxidative stress and fibrosis aggravate the condition markedly. MAIN OBJECTIVE OF THE STUDY: Investigation of L-carnitine's cardioprotective roles and mechanism of action in a rat model of MI. METHODS: To develop a MI animal model, Isoproterenol (ISO) was administered in male Long Evans rats where animals were divided into five groups (six rats/group). The oxidative stress and antioxidant enzyme activities were determined by different biochemical tests. The real-time PCR was performed to determine the expression of TNF-α and Il-1β. Histopathological observations by hematoxylin-eosin and Masson trichrome were made to observe the tissue damage and fibrosis in heart and kidney. SIGNIFICANT FINDINGS FROM THE STUDY: The ISO-treated rats showed increased levels of troponin I and lipid peroxidation and lower antioxidant enzyme activity in heart and kidney tissues. The levels of TNF-α and IL-1β were also increased in ISO-rats. Co-administration of L-carnitine with ISO reversed all these parameters. The elevated levels of uric acid and creatinine kinase and ALP, AST and ALT activities in ISO-rats were also significantly reduced by L-carnitine administration. L-carnitine markedly decreased the infiltration of inflammatory cells and improved the tissue architecture in heart and kidney. Control animals did not show any appreciable response upon L-carnitine administration. RELEVANT CONTRIBUTION TO KNOWLEDGE: These results suggest that L-carnitine plays a defensive role against cardiac and renal damage in ISO-treated MI rat model via suppressing oxidative stress and increasing antioxidant enzyme functions through inhibition of TNF-α and IL-1β.
Coenzyme Q10 and silymarin reduce ccl4-induced oxidative stress and liver and kidney injury in ovariectomized rats-implications for protective therapy in chronic liver and kidney diseases
Samanta Sifat Lamia, Tushar Emran, Jubaida Khatun Rikta, Nowreen Islam Chowdhury, Manoneeta Sarker, Preeti Jain, Tabinda Islam, Zarin Tasnim Gias, Manik Chandra Shill, Hasan Mahmud Reza
Pathophysiology, 2021
Oxidative stress is one of the key factors in the pathophysiology of liver disease. The present study aimed to evaluate the potential impact of two antioxidants, namely coenzyme Q10 (CoQ10) and silymarin, on carbon tetrachloride (CCl4)-induced oxidative stress and hepatic damage in ovariectomized rats. Female Long Evans rats were divided into six groups (n = 6): control, CCl4, CCl4 + CoQ10 (200 mg/kg), CCl4 + silymarin (140 mg/kg), Control + CoQ10, and Control + silymarin. Plasma and tissues from liver and kidney were analyzed for oxidative stress parameters and antioxidant enzyme activities using biochemical assays. Infiltration of inflammatory cells and fibrosis were assessed by histological staining of tissue sections. Both CoQ10 and silymarin significantly lowered serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels that were detected to be higher in CCl4 rats compared to controls. Significant reduction in CCl4-induced elevated levels of oxidative stress markers malondialdehyde (MDA), nitric oxide (NO), and advanced protein oxidation product (APOP) was observed with both antioxidants. However, in control rats, CoQ10 and silymarin did not produce a significant effect. Histological analysis revealed that CCl4 markedly increased the level of inflammatory cells infiltration and fibrosis in liver and kidney tissues, but this was significantly reduced in CCl4 + CoQ10 and CCl4 + silymarin groups. Taken together, our results suggest that CoQ10 and silymarin can protect the liver against oxidative damage through improved antioxidant enzyme activities and reduced lipid peroxidation. Thus, supplementation of the aforementioned antioxidants may be useful as a therapeutic intervention to protect liver health in chronic liver diseases.

RECENT SCHOLAR PUBLICATIONS

Coenzyme Q10 alleviates oxidative stress, inflammation and fibrosis via activation of TGFβ1/TNF-α in FCA-Salt hypertensive rats
N Hossain, S Shabnam, T Emran, ZI Zahid, S Alam, AK Bepari, ...
Archives of Biochemistry and Biophysics 769, 110444 , 2025
2025
Citations: 1
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats
AM Biswas, T Emran, SI Khan, S Shabnam, P Jain, AK Bepari, MC Shill, ...
European Journal of Pharmacology 996, 177559 , 2025
2025
Citations: 2
Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway
M Sarker, N Chowdhury, AT Bristy, T Emran, R Karim, R Ahmed, ...
Biomedicine & Pharmacotherapy 181, 117703 , 2024
2024
Citations: 16
Anti-obesity effects and underlying molecular mechanisms of the ethanolic extract of figs from Ficus hispida using high fat-fed wister rats
AT Shama, LM Shova, AT Bristy, T Emran, S Shabnam, MC Shill, ...
Heliyon 10 (15) , 2024
2024
Citations: 8
Amelioration of CCl 4 -induced oxidative stress and hepatotoxicity by Ganoderma lucidum in Long Evans rats
FT Johra, S Hossain, P Jain, AT Bristy, T Emran, R Ahmed, SM Sharker, ...
Scientific Reports 13 (1), 9909 , 2023
2023
Citations: 55
QbD approach towards robust design space for flutamide/piperine self-emulsifying drug delivery system with reduced liver injury
M Saha, P Sikder, A Saha, S Shah, S Sultana, T Emran, A Banik, Z Islam, ...
AAPS PharmSciTech 23 (1), 62 , 2022
2022
Citations: 10
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against …
T Emran, NI Chowdhury, M Sarker, AK Bepari, M Hossain, GMS Rahman, ...
Biomedicine & Pharmacotherapy 143, 112139 , 2021
2021
Citations: 59
Coenzyme Q10 and Silymarin Reduce CCl 4 -Induced Oxidative Stress and Liver and Kidney Injury in Ovariectomized Rats—Implications for Protective Therapy in …
SS Lamia, T Emran, JK Rikta, NI Chowdhury, M Sarker, P Jain, T Islam, ...
Pathophysiology 28 (1), 50-63 , 2021
2021
Citations: 55

MOST CITED SCHOLAR PUBLICATIONS

L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against …
T Emran, NI Chowdhury, M Sarker, AK Bepari, M Hossain, GMS Rahman, ...
Biomedicine & Pharmacotherapy 143, 112139 , 2021
2021
Citations: 59
Amelioration of CCl 4 -induced oxidative stress and hepatotoxicity by Ganoderma lucidum in Long Evans rats
FT Johra, S Hossain, P Jain, AT Bristy, T Emran, R Ahmed, SM Sharker, ...
Scientific Reports 13 (1), 9909 , 2023
2023
Citations: 55
Coenzyme Q10 and Silymarin Reduce CCl 4 -Induced Oxidative Stress and Liver and Kidney Injury in Ovariectomized Rats—Implications for Protective Therapy in …
SS Lamia, T Emran, JK Rikta, NI Chowdhury, M Sarker, P Jain, T Islam, ...
Pathophysiology 28 (1), 50-63 , 2021
2021
Citations: 55
Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway
M Sarker, N Chowdhury, AT Bristy, T Emran, R Karim, R Ahmed, ...
Biomedicine & Pharmacotherapy 181, 117703 , 2024
2024
Citations: 16
QbD approach towards robust design space for flutamide/piperine self-emulsifying drug delivery system with reduced liver injury
M Saha, P Sikder, A Saha, S Shah, S Sultana, T Emran, A Banik, Z Islam, ...
AAPS PharmSciTech 23 (1), 62 , 2022
2022
Citations: 10
Anti-obesity effects and underlying molecular mechanisms of the ethanolic extract of figs from Ficus hispida using high fat-fed wister rats
AT Shama, LM Shova, AT Bristy, T Emran, S Shabnam, MC Shill, ...
Heliyon 10 (15) , 2024
2024
Citations: 8
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats
AM Biswas, T Emran, SI Khan, S Shabnam, P Jain, AK Bepari, MC Shill, ...
European Journal of Pharmacology 996, 177559 , 2025
2025
Citations: 2
Coenzyme Q10 alleviates oxidative stress, inflammation and fibrosis via activation of TGFβ1/TNF-α in FCA-Salt hypertensive rats
N Hossain, S Shabnam, T Emran, ZI Zahid, S Alam, AK Bepari, ...
Archives of Biochemistry and Biophysics 769, 110444 , 2025
2025
Citations: 1

Industry, Institute, or Organisation Collaboration

North South University, Dhaka 1212, Bangladesh

INDUSTRY EXPERIENCE

2 weeks of internship in Essential Drugs Company Limited, Tejgaon I/A, Dhaka 1208, Bangladesh