Dr. Sanvidhan G Suke

@pcenagpur.edu.in

Professor (Asst), Biotechnology
Priyadarshini College of Engineering, Nagpur

Dr. Sanvidhan G Suke


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https://researchid.co/sanvidhan
Dr. Sanvidhan G Suke has more than 22 years of experience in research and teaching. He is working as faculty of Biotechnology at Priyadarshini College of Engineering, Nagpur. He did M.Pharm. from RTM Nagpur University, Nagpur; also post graduate M.Tech. in Biotechnology from Jadavpur University, Kolkata. He obtained his Ph.D. in year 2009 from University of Delhi. He has received different fellowships, awards and grants from government and various national/international scientific bodies; for pre-doctoral work from CSIR, ICMR and post-doctoral work from DST (Govt. of India). He is the member of different national and international scientific societies. He guided number of graduate, post graduate students and Ph.D. scholar for their research activities and published number of papers in high impact journals, conference proceedings and book chapters. He also associated as Adjunct faculty with DMIHER (Deemed to be University) Wardha and guiding Ph.D. students. He chaired scientific session

EDUCATION

Ph.D. : Biochemistry, University of Delhi, Delhi, India
M.Tech. : Biotechnology, Jadavpur University, Kolkata, India
M.Pharm. : Pharmacology, RTM Nagpur University, Nagpur India
B.Pharm. : Pharmaceutical Science, Nagpur University, Nagpur, India

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Pharmacology, Toxicology and Pharmaceutics, Health Professions, Environmental Science
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Scopus Publications

Scopus Publications

  • Leveraging Artificial Intelligence for the Detection, Monitoring, and Forecasting of Plant Diseases
    Prasad V. Sherekar, Divyesha A. Pathak, Sanvidhan G. Suke
    Cutting Edge Agri Technologies for Next Generation Farming, 2026
    Plant diseases significantly impact agricultural yield, food security, and economic stability. Traditional disease detection methods are slow, laborious, and prone to errors, demanding automated solutions. The introduction of Artificial Intelligence (AI), particularly deep learning (DL) and machine learning (ML) over the last decade, has transformed identification, tracking, and forecasting of plant diseases. AI models, such as convolutional neural networks (CNNs) and transfer learning techniques, improve classification accuracy while addressing challenges like data insufficiency, environmental variability, and overfitting. Hyperspectral imaging and image processing enhance disease recognition, allowing early interventions. This chapter explores AI-driven approaches for detecting major plant diseases along with key AI applications, including mobile-based disease classification, IoT-integrated precision agriculture, and real-time disease forecasting. Additionally, the detailed information about evaluation metrics, including accuracy, precision, recall, and F1 score, that determine model reliability has been discussed. The information about available open-source plant disease detection datasets has been tabulated in the chapter. Moreover, the methods and results of the studies that developed successful AI models for various plant disease detection have been outlined. In conclusion, AI-driven plant disease detection offers promising benefits for sustainable farming, helping mitigate yield losses and strengthen global food security.
  • Preparation and performance of waterborne intumescent coatings with mechanical, thermal properties and optimization of flame retardant paints
    Gajanan Lakhawat, Sanvidhan Suke, Arti Fulkar, Ganesh Satpute, Vijay Pawade, et al.
    Indian Journal of Chemical Technology, 2026
    Many industries typically like chemical industry, petrochemical and oil refineries etc. are prone to fire. In such a case intumescent (IMT) paint will provide extra protection to substrate wherever it is applied. The aim of present work was to optimize the fire protection performance and thermal properties of water-based IMT fire protective coatings on steel structures through the use of flame-retardant paints. The IMT coating paint was prepared using water-based styrene acrylic emulsion (SAE), flame-retardant additives (Ammonium phosphate, Pentaerithritol, Melamine and Dicyanadamide and flame-retardant fillers (TiO2 and CaCO3). All these ingredients are mixed using mortal pestle. The coating paints with and without fire retardant have been characterized by studying chemical properties by using FTIR, mechanical properties (Flexibility test, Impact resistance test and Pull off test) and thermal properties (Bunsen burner test, furnace test, and Thermogravimetric analysis test). The results demonstrated that mild steel specimens coated with IMT paint exhibited effective fire protection performance; excellent adhesion strength, improved uniform char layer formation, and enhanced thermal stability.It revealed that fire retardant coating had better or same properties than without fire retardant coating. Hence, formulated IMT coating paint proved effective in protecting steel structures against fire.
  • Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes
    Prasad Sherekar, Sanvidhan G. Suke, Archana Dhok, Srikant Malegaonkar, Shrikrishna A. Dhale
    Toxicology Reports, 2025
    Silicosis is an occupational fibrotic lung disease caused by exposure to respirable crystalline silica dust particles produced during industrial activities. Other crystalline silica-induced pulmonary disorders include a predisposition to mycobacterial infections , obstructive airway diseases , idiopathic pulmonary fibrosis , and lung cancer. This review paper discusses the burden of silicosis and associated co-morbidities in developed as well as developing countries globally using the published data of various government agencies, related organizations, and epidemiological findings. Moreover, it sheds light on diverse mechanisms of silicosis, outlining molecular events and peculiar alterations in lung parenchyma leading to this occupational lung disease . Evaluation of pathophysiological mechanisms could aid in the identification of novel target molecules and treatments; to date, there is no curative treatment for silicosis. In recent periods, a lot of attention has been focused on the development and fabrication of suitable nanocarriers for improved and sustained drug delivery in the pulmonary system. Nanoparticle-based therapeutic modality has been evaluated in in-vitro and ex-vivo silicosis models for prolongation of drug activity and improved therapeutic outcomes. The preclinical findings open the doors to clinical trials for operational and regenerative nanoformulations, which eventually create a positive change in medical practice. The following review summarizes various therapeutic approaches available and in the pipe line for silicosis and also stresses the preventive practices for effectively combating this occupational hazard.
  • Effects of Dust Particles on Provoking the Risk of Lung Cancer
    Prasad Sherekar, Sanvidhan G. Suke, Pooja Patel, Basu Dev Banerjee
    Environmental Toxicants and Lifestyle Diseases, 2025
  • In vitro toxicity assessment of bioavailable iron in coal varieties of Central India
    Ruchika Kishor Jain, Anshumali, Prasad Sherekar, Amit Nayak, Shraddha Jaiswal, Komal Pimpalghare, Rajani Tumane, Aruna Jawade, Shubhangi Kailas Pingle, Sanvidhan G. Suke, Rajpal Singh Kashyap, Bibhuti Bhusan Mandal
    Plos One, 2024
    Introduction Information on bioavailable Iron (BAI) content in respirable coal dust (RCD) is crucial to address occupational health and safety, especially in preventing coal workers’ pneumoconiosis (CWP). Materials and methods In the present study, we determined BAI concentrations in seventy-seven coal samples collected from ten coal mining regions of Central India. The cytotoxic potential of BAI-RCD was established invitro by using alveolar epithelial (A549) and macrophage (U937) cell lines. The oxidative/antioxidant status, inflammations, and genotoxicity attributed to BAI-RCD exposure were evaluated and correlated with CWP pathophysiology. Results The mean BAI concentrations in the coal samples (n = 77) range from (275 to 9065 mg kg-1) and showed wide variability. Both cell lines were exposed to low (275 mg kg-1), moderate (4650 mg kg-1), and high (9065 mg kg-1) BAI-RCD samples showed significant (p < 0.001) cytotoxicity in a dose-dependent manner (low < moderate < high) compared to the control. After BAI-RCD treatment, both cell lines showed a decrease in antioxidant stress measures (SOD, CAT, and GSH) and a significant (p < 0.001) increase in oxidative stress parameters (NADPH, MPO, LPO, and PC). Furthermore, these cell line models demonstrated a statistically significant (p < 0.001) dose-dependent increase in cytokines (TGF-β1, IL-1β, TNF-α, MCP-1, and IL-6 cytokines) and oxidative DNA damage marker (8-OH-dG). Conclusion Results indicated that the central India coals (even at low BAI content) may be accountable for inflammatory responses and cytotoxicity. Hence, BAI can be important characteristic to establish safety standards for coal dust exposure before active mining.
  • Nano-enabled delivery of diosgenin and emodin ameliorates respirable silica dust-induced pulmonary fibrosis silicosis in rats
    Prasad Sherekar, Sanvidhan G. Suke, Archana Dhok, Raunak Harode, Shubhada Mangrulkar, Shubhangi Pingle
    Ecotoxicology and Environmental Safety, 2024
    Oxidative stress and inflammation play a fundamental role in the beginning and advancement of silicosis. Hence, questing active phytocompounds (APCs) with anti-oxidative and anti-inflammatory properties such as diosgenin (DG) and emodin (ED) can be a therapeutic intervention targeting silica-induced pulmonary inflammation and fibrosis. Hydrophobicity and low bioavailability are the barriers that restrict the therapeutic efficacy of DG and ED against pulmonary defects. Encapsulating these APCs in polymeric nanoparticles can overcome this limitation. The present study has thus explored the anti-inflammatory and anti-fibrotic effects of polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) individually loaded with DG (DGn) or ED (EDn) and in combine DG+ED [(DG+ED)n] in respirable silica dust (RSD)-induced pulmonary fibrosis silicosis rat model. Our study found that individual and combined NPs revealed physiochemical characteristics appropriate for IV administration with sustained-drug release purposes. Physiological evaluations of RSD-induced silicosis rats suggested that no treatment could improve the body weight. Still, they reduced the lung coefficient by maintaining lung moisture. Only (DG+ED)n significantly cleared free lung silica. All interventions were found to attribute the increased per cent cell viability in BALF, reduce cytotoxicity via minimizing LDH levels, and balance the oxidant-antioxidant status in silicotic rats. The expression of inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1, and TGF-β1) were efficiently down-regulated with NPs interventions compared to pure (DG+ED) treatment. All drug treatments significantly declined, the 8-HdG and HYP productions indicate that RSD-induced oxidative DNA damage and collagen deposition were successfully repaired. Moreover, histopathological investigations proposed that individual or combined drugs NPs interventions could decrease the fibrosis and alveolitis grades in RSD-induced silicosis rats. However, (DG+ED)n intervention significantly inhibited pulmonary fibrosis and alveolitis compared to pure (DG+ED) treatment. In conclusion, the RSD can induce oxidative stress and inflammation in rats, producing reactive oxygen species (ROS)-mediated cytotoxicity to pulmonary cells and leading to silicosis development. The IV administration of combined NP suppressed lung inflammation and collagen formation by maintaining oxidant-antioxidant status and effectively interrupting the fibrosis-silicosis progression. These results may be attributed to the improved bioavailability of DG and ED through their combined nano-encapsulation-mediated targeted drug delivery.
  • Nanoformulation, Characterization, and In Vivo Pharmacokinetic Studies of Diosgenin- and Emodin-Loaded Polymeric Nanoparticles
    Prasad Sherekar, Sanvidhan G. Suke, Ragini Dani, Shubhada Mangrulkar, Archana Dhok
    Bionanoscience, 2024
  • Ambazari lake water treatment using hybrid membrane bioreactor and nanofiltration system
    Kiran D. Bhuyar, Sanvidhan G. Suke, Vilas S. Sapkal, Rajendra S. Sapkal
    Journal of Applied Research in Water and Wastewater, 2022
    Advanced water treatment methods are needed for good quality of lake water. In this study, the hybrid membrane bioreactor (MBR) and nanofiltration (NF) system was investigated to treat Ambazari lake water. The performance of the hybrid system was checked as removal efficiency of chemical oxygen demand (COD), total dissolved solids (TDS), biochemical oxygen demand (BOD), and permeate flow rate (PFR). All parameters in the hybrid MBR-NF system were operated batch-wise for 5 h. The COD and BOD removal efficiencies were observed to be 95.67 % and 94.64 %, respectively. TDS removal efficiency was obtained to be 92.33%. The highest TSS removal efficiency was reported to be 36.0 % for airflow rates of 1.0 L/min. The pH variation at different airflow rates was found to be significantly low. Hence, from above information, we conclude that this hybrid system treated Ambazari lake water successfully. The treated water had high quality as good as potable water.
  • Role of Pyrite in Aggravating Coal Worker’s Pneumoconiosis
    Prasad Sherekar, Ruchika Jain, Shubhangi Pingle, Sanvidhan Suke
    Springer Geology, 2022
  • Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos-induced hepatic oxidative damage and immunotoxicity in Wistar rats
    Sanvidhan G Suke, Prasad Sherekar, Vivek Kahale, Shaktipal Patil, Dharmendra Mundhada, Vivek M Nanoti
    Journal of Biochemical and Molecular Toxicology, 2018
    The theme of the present work is to evaluate the protective effect of nanoencapsulated quercetin (NEQ) against chlorpyrifos (CPF)‐induced hepatic damage and immune alterations in animals. Nanoparticles (NP) drug encapsulation was prepared. Forty male Wistar rats were divided into eight groups. Two groups served as control and CPF (13.5 mg/kg) treatment for 28 days. Other three groups were free quercetin (QC), NP and NEQ treated with 3 mg/kg respectively for 15 days; whereas remaining three groups received treatment of CPF and QC, NP, NEQ, respectively, for 15 days. The results show that significantly altered oxidative stress in the liver tissue and liver enzyme parameters in blood and immune responses in CPF‐treated rats compared to controls. Administration of NEQ attenuated biochemical and immunological parameters. The liver histopathological analysis confirmed pathological improvement. Hence, use of NEQ appeared to be beneficial to a great extent in attenuating and restoring hepatic oxidative damage and immune alteration sustained by pesticide exposure.
  • Effect of lipase from different source on high fat content wastewater of dairy industry
    Indian Journal of Biotechnology, 2018
  • Roxithromycin potency quantification in pharmaceutical preparation by applying a validated bioassay method and comparison with HPLC analysis
    S.G. Suke, A.D. Chahande, R.H. Kasliwal, A.J. Asnani
    Annales Pharmaceutiques Francaises, 2015
  • Treatment of milk wastewater using up-flow anaerobic packed bed reactor
    Kiran D. Bhuyar, Sanvidhan G. Suke, S. D. Dawande
    Polish Journal of Chemical Technology, 2015
  • Anti-arthritic and anti-inflammatory activity of combined pioglitazone and prednisolone on adjuvant-induced arthritis
    Sanvidhan G. Suke, Harsh Negi, P.K. Mediratta, B.D. Banerjee, K.K. Sharma
    European Journal of Pharmacology, 2013
  • Effect of phosphamidon on cognition and oxidative stress and its modulation by ascorbic acid and 4′-chlorodiazepam in rats
    Sanvidhan G. Suke, Anand Shukla, Dharmendra Mundhada, B.D. Banerjee, Pramod K. Mediratta
    Pharmacology Biochemistry and Behavior, 2013
  • Effect of piracetam and vitamin E on phosphamidon-induced impairment of memory and oxidative stress in rats
    Prabhat Kosta, Ashish K. Mehta, Amit K. Sharma, Naresh Khanna, Pramod K. Mediratta, Dharmendra R. Mundhada, Sanvidhan Suke
    Drug and Chemical Toxicology, 2013
  • Organochlorine pesticide residue levels and oxidative stress in preterm delivery cases
    Rahul Pathak, Sanvidhan G Suke, Tanzeel Ahmed, Rafat S Ahmed, AK Tripathi, Kiran Guleria, CS Sharma, SD Makhijani, BD Banerjee
    Human and Experimental Toxicology, 2010
  • Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: Attenuation by Withania somnifera
    Indian Journal of Biochemistry and Biophysics, 2010
  • Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: Ameliorating effect of N-acetylcysteine and curcumin
    Tanzeel Ahmed, Ashok K. Tripathi, Sanvidhan G. Suke, Vivek Kumar, Rafat S. Ahmed, Shukla Das, Basu Dev Banerjee
    Toxicology in Vitro, 2009
  • Protective effects of different antioxidants against endosulfan-induced oxidative stress and immunotoxicity in albino rats
    Indian Journal of Experimental Biology, 2009
  • Endosulfan-induced apoptosis and glutathione depletion in human peripheral blood mononuclear cells: Attenuation by N-acetylcysteine
    Tanzeel Ahmed, Ashok K. Tripathi, Rafat S. Ahmed, Shukla Das, Sanvidhan G. Suke, Rahul Pathak, Ayanabha Chakraboti, Basu Dev Banerjee
    Journal of Biochemical and Molecular Toxicology, 2008
  • Melatonin treatment prevents modulation of cell-mediated immune response induced by propoxur in rats
    Indian Journal of Biochemistry and Biophysics, 2008
  • Endosulfan and other organochlorine pesticide residues in maternal and cord blood in North Indian population
    Rahul Pathak, Sanvidhan G. Suke, Rafat S. Ahmed, A. K. Tripathi, Kiran Guleria, C. S. Sharma, S. D. Makhijani, Meenu Mishra, B. D. Banerjee
    Bulletin of Environmental Contamination and Toxicology, 2008
  • Protective effects of dietary ginger (Zingiber officinales Rose.) on lindane-induced oxidative stress in rats
    Rafat S. Ahmed, Sanvidhan G. Suke, Vandana Seth, Ayanabha Chakraborti, Ashok K. Tripathi, Basu D. Banerjee
    Phytotherapy Research, 2008
  • Xenobiotic-induced immune alterations: Implications in health and disease
    Indian Journal of Biochemistry and Biophysics, 2008
  • Attenuation of phosphamidon-induced oxidative stress and immune dysfunction in rats treated with N-acetylcysteine
    S.G. Suke, R.S. Ahmed, R. Pathak, A.K. Tripathi, B.D. Banerjee
    Brazilian Journal of Medical and Biological Research, 2008
  • Xenobiotic-induced immune alterations: Implications in health and disease
    Indian Journal of Geo Marine Sciences, 2008
  • Alteration of superoxide- and nitric oxidemediated antimicrobial function of macrophages by in vivo cocaine exposure
    Asok K. Tripathi, Niraj Rathi, Sanvidhan G. Suke, Basu D. Banerjee, Rafat S. Ahmed, Prabha Mahajan, Swapan K. Bhattacharya
    Canadian Journal of Physiology and Pharmacology, 2008
  • Comparative effect of topical application of lindane and permethrin on oxidative stress parameters in adult scabies patients
    Seema Oberoi, Rafat S. Ahmed, Sanvidhan G. Suke, Sambit Nath Bhattacharya, Ayanabha Chakraborti, Basu Dev Banerjee
    Clinical Biochemistry, 2007
  • Impact of oral vitamin E supplementation on oxidative stress & lipid peroxidation in patients with polymorphous light eruption
    Indian Journal of Medical Research, 2006
  • Immunotoxicity of phosphamidon following subchronic exposure in albino rats
    Indian Journal of Experimental Biology, 2006
  • Protective effect of melatonin against propoxur-induced oxidative stress and suppression of humoral immune response in rats
    Indian Journal of Experimental Biology, 2006
  • Lindane-induced immunological alterations in human poisoning cases
    Vandana Seth, Rafat S. Ahmad, Sanvidhan G. Suke, Sayed T. Pasha, Abhijit Bhattacharya, Basu D. Banerjee
    Clinical Biochemistry, 2005

Publications

LIST OF RESEARCH PUBLICATIONS OF DR. S. G. SUKE

[A] In Peer Reviewed Indexed Journals (Citation:>1051; h-Index:18 till March 2026,Total IF:>77)

1. GP Lakhawat, Sanvidhan G Suke, AB Fulkar, GD Satpute, VB Pawade, JB Modak, WAS Deshmukhe, Kiran Bhuyar. Preparation and performance of waterborne intumescent coatings with mechanical, thermal properties and optimization of flame retardant paints. Indian Journal of Chemical Technology 2025; 33(1): 20-28 IF:1.0 (Q4) (CSIR-NIScPR) ISSN: 0971-457X (Scopus)
2. Prasad Sherekar, Sanvidhan G Suke, Archana Dhok, Srikant Malegaonkarc, Shrikrishna A Dhale. Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes. Toxicology Report 2025; 14: 101941 (Q2) (Elsevier) ISSN: 2214-7500 (Scopus)
3. RK Jain, Anshumali, P Sherekar, A Nayak, S Jaiswal, K Pimpalghare, R Tumane, A Jawade, SK Pingle, Sanvidhan G. Suke, RS Kashyap, BB Manda. In Vitro Toxicity Assessment of Bioavailable Iron in Coal Varieties of Central India. PLoS ONE 2024; 19(9): e0309237. IF:2.9 (Q1) ISSN:1932-6203 (Scopus)
4. Prasad Sherekar, Sanvidhan G Suke, Archana Dhok, Raunak Harode, Shubhada Mangrulkar, Shubhangi Pingle. Nano-enabled delivery of diosgenin and emodin ameliorates respirable silica dust-induced pulmonary fibrosis silicosis in rats. Ecotoxicology and Environm

GRANT DETAILS

Principal investigator/Project Guide of Funded Research Project
• Completed collaborative project “Possible implications of Bioavailable iron in Coal mine dust on Coal workers’ Lung disease”. CMPDI, Ministry of Coal (Govt. of India), (Rs. 96.54 Lakhs). 2016-2018. (Reference no. EE48/2016)
• Completed as Project Guide SRF Project “To study the effects of nanoencapsulated herbal compound on silica-induced lung fibrosis in rats” ICMR, Ministry of Health (Govt. of India), (Rs. 16.46 Lakhs). 2021-2024 (Reference No. 3/1/2(4)/COPD/2020-NCD-II).

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Intellectual Property Rights (IPR)
• Copyright: “Drug Info Apps” Registration no. L-67535/2017 (Indian IPR)
• Patent: “Process of synthesizing Silver nanoparticles from Geodorum laxiflorum Griff Extract” Application no. 202421073422 (Indian IPR) Patent No. 574166
• Design Patent: “Experimental rats head exposure inhalation box” Application no. 442455-001 (Indian IPR)