Ghamyes, Randa R.

@mtu.edu.iq

Lecturer Dr. at Department of Criminal and Forensic Techniques, Medical Technical Institute-Mansour, Middle Technical University,
Middle Technical University

Ghamyes, Randa R.


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https://researchid.co/randa_rasool

RESEARCH, TEACHING, or OTHER INTERESTS

Biotechnology, Molecular Biology, Molecular Medicine, Genetics
4

Scopus Publications

Scopus Publications

  • Low GOPC mRNA expression is a novel candidate associated with increased risk of acute myeloid leukemia
    Taisir A. Kadhim, Randa R. Ghamyes, Dhay A. Azeez, Mustafa A. Bashi, Ali A. Alsodani, Mohammed K. Al-Qayyim, Noor T. Kadhim, Rawan A. Nijeeb, Dhuha F.N. Bani-Wais, Ali H. Ad'hiah
    Human Gene, 2026
    Acute myeloid leukemia (AML) is a genetically heterogeneous malignant hematopoietic disorder, and research continues to update its genetic drivers. Golgi-associated PDZ and coiled-coil motif-containing (GOPC) is a signaling protein implicated in regulating cellular trafficking of transmembrane proteins. Recent research has shown that the gene encoding GOPC exhibits dysregulated expression in colorectal cancer. In AML, the significance of GOPC expression in disease risk and pathogenesis has not been explored. Therefore, a case-control study was conducted to evaluate GOPC mRNA expression in a cohort of 100 AML patients and 100 controls. GOPC expression was quantified using a reverse transcription-quantitative PCR-based fold change method (2 –ΔCt ). Statistical data management included receiver-operating characteristic (ROC) curve analysis, disease-risk assessment, and assessment of correlation with AML characteristics. Results revealed that GOPC expression levels (median [interquartile range: 25–75 %]) were significantly decreased in patients compared to controls (0.04 [0.02–0.14] vs. 0.73 [0.18–1.16]; probability <0.001). ROC curve analysis demonstrated the reliability of GOPC expression in distinguishing between AML patients and controls (area under the curve = 0.91; probability <0.001). Disease-risk assessment indicated that low GOPC expression was linked to a 16.15-fold increased risk of AML. GOPC expression was not affected by clinical and genetic characteristics of AML or chemotherapy and was not correlated with diagnostic laboratory criteria . In conclusion, GOPC mRNA expression was down-regulated in AML and was not affected by the patient's clinical, genetic, or laboratory characteristics. Low GOPC expression may be considered a potential risk factor for AML. • GOPC mRNA expression was markedly down-regulated in AML patients. • GOPC mRNA expression is a reliable prognostic marker for AML. • Low GOPC mRNA expression is associated with an increased risk of AML.
  • Pathological significance of sex hormones (testosterone and estrogen) associated with pro-inflammatory cytokines (IL-12, IL-17A, and IL-23) in patients with psoriasis and psoriatic arthritis
    Randa R. Ghamyes, AbdulKareem A. Alkazaz
    Revista Colombiana De Reumatologia, 2025
  • The Impact of COVID-19 Infection on Prognostic Effect of Liver Laboratory Markers and Disease Outcome
    Randa R. Ghamyes, Hayjaa M. Alhamadani, Mohammed I. Rasool
    Asian Journal of Water Environment and Pollution, 2022
    Severe acute respiratory syndrome-related coronavirus 2 (SARS- CoV-2) is a viral pathogen that causes coronavirus disease 2019 (COVID-19). Angiotensin-converting enzyme 2 (ACE2), as a receptor, is crucial for SARS-CoV-2 to get access into the host cells. According to reports, ACE2 is expressed in the liver, placenta, heart, lungs and kidneys. This study sought to gain unique insights into the features of liver indicators in individuals suffering from COVID-19 disease in order to enhance their therapeutic care. The study groups included 50 people diagnosed with COVID-19 infection in the patient’s group and 25 healthy people without any systemic diseases in the control group. Human serum samples were used to measure liver function enzymes, CRP, D dimer, and ferritin all samples by using automated quantitative tests. The results revealed a statically significant difference between AST, ALP, TSB, and study groups, where it is found that the mean levels of AST (88.04±33.00) and ALP (99.61±41.93) were high in patients than in controls, while the mean levels of TSB were low in patients (0.51±0.21) than the controls. A significant difference was also obtained for each ferritin, CRP, and D dimer between the study groups, where it found the mean concentrations of D dimer, ferritin and CRP, i.e., 1208.09±667.32, 60.53±23.91 and 204.52±90.62, respectively, were high in the patient’s group than in controls.
  • Single nucleotide polymorphism of follicle stimulating hormone receptor gene in iraqi infertile men
    Indian Journal of Forensic Medicine and Toxicology, 2020