Dr Chetana Prabhu Hadimani

@jnmc.edu

Professor, Department of Biochemistry
KLE Academy of Education and research, Jawaharlal Nehru Medical college, Belagavi, Karmnataka, India

Dr Chetana Prabhu Hadimani


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https://researchid.co/vidwaanchetana

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry (medical), Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, Emergency Medicine
2

Scopus Publications

Scopus Publications

  • Osteoporosis in Indian Males: Lumbar Spine DEXA Findings Among the Clinically Referred Cases
    C P Hadimani, D S S K Raju, VEMAIAH ADIMULAM, Venkatanarayana Narapogu, Mahesh Vemavarapu, et al.
    Clinica Terapeutica, 2026
    Background: Osteoporosis in men is under-recognized despite substantial fracture-related morbidity. Indian evidence on biochemical correlates of male bone mineral density (BMD) is limited. Objectives: To estimate the burden of osteopenia/osteoporosis in adult males undergoing lumbar spine DEXA and to examine associations of serum 25-hydroxyvitamin D (25(OH)D) and total serum calcium with lumbar spine BMD. Methods: A retrospective study was conducted at a tertiary hospital. From 426 de-identified DEXA records, 94 eligible males (≥20 years) with L1-L4 DEXA plus contemporaneous serum 25(OH)D and calcium (≤2 weeks) were included after excluding systemic disorders and therapies affecting bone metabolism. BMD categories followed the WHO T-score criteria. Analyses used chi-square, Pearson correlation, and multiple linear regression (SPSS v20.0; p<0.05). Results: Mean lumbar spine BMD was 0.96±0.21 g/cm²; mean 25(OH)D 18.32±13.62 ng/mL; mean calcium 8.70±2.18 mg/dL. Overall, 36.17% had osteopenia and 35.11% osteoporosis. Vitamin D deficiency (≤20 ng/mL) occurred in 67.02%, and hypocalcemia (<8.6 mg/dL) in 60.63%. BMD correlated positively with 25(OH)D (r=0.5910; p=0.0001) and calcium (r=0.6366; p=0.0001). In regression, both 25(OH)D (β=0.0091; p=0.0001) and calcium (β=0.0041; p=0.0001) independently associated BMD. Conclusion: In clinically referred men, low lumbar spine BMD was frequent and closely linked to vitamin D and calcium status. Findings support combined DEXA and biochemical assessment for male osteoporosis risk stratification, with caution against generalising referral-based prevalence.
  • "Evaluating Asymmetric Dimethylarginine (ADMA) as a Biomarker for Preeclampsia: A Meta-Analysis"
    Abhishek Bansal, Chetana. P. Hadimani, Sadanand B Patil, Nik Ahmad Zuki Bin Nik Lah
    Journal of Neonatal Surgery, 2025
    Background: Preeclampsia (PE) is a serious pregnancy-related disorder characterized by hypertension, endothelial dysfunction, and multi-organ involvement. Despite advances in understanding its pathophysiology, early diagnosis and reliable biomarkers remain critical challenges. Asymmetric dimethylarginine (ADMA) is a natural inhibitor of nitric oxide synthase (NOS) that has been implicated in endothelial dysfunction, a key feature of PE. This study aims to evaluate the potential of ADMA as an early biomarker for the detection and assessment of preeclampsia.Methods: This systematic review and meta-analysis included 16 observational studies examining the association between serum ADMA levels and preeclampsia. Data from 767 women with PE and 896 healthy controls were analyzed to determine the mean difference in ADMA levels between the two groups. The analysis followed PRISMA guidelines, and heterogeneity was assessed using the I² statistic.Results: The pooled analysis revealed that serum ADMA levels were significantly higher in women with preeclampsia compared to healthy pregnant controls (mean difference = 0.38 µmol/L, 95% CI: 0.11–0.65 µmol/L, p = 0.01). Significant heterogeneity (I² = 99.9%) was observed across studies. Funnel plots indicated no significant publication bias.Conclusion: Elevated ADMA levels are associated with preeclampsia and may serve as a promising biomarker for early detection and disease severity evaluation. Despite significant heterogeneity across studies, the findings suggest ADMA's potential role in the pathophysiology of PE, particularly in endothelial dysfunction. Further prospective studies and standardization of measurement techniques are required to confirm ADMA’s clinical utility in preeclampsia diagnosis and management.