Saket Singh Chandel

@cvru.ac.in

Professor, Department of Pharmaceutical Sciences
Dr. C.V. Raman University, Kota, Bilaspur, Chhattisgarh, India

Saket Singh Chandel


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https://researchid.co/singhpharma

EDUCATION

Ph.D in Pharmacy, M.Pharm in Pharmacology

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics, General Pharmacology, Toxicology and Pharmaceutics, Drug Discovery
14

Scopus Publications

337

Scholar Citations

8

Scholar h-index

8

Scholar i10-index

Scopus Publications

  • A Novel Perspective in Drug Design and Drug Discovery (4D) With Computer-Aided Drug Design (CADD): A Review
    Sharad R Manapure, Shruti Kolte, Vipinchandra B Pande, Saket Singh Chandel, Pranjali Khanke, Kanchan Kohale
    International Journal of Drug Delivery Technology, 2026
    Nowadays there are so many types of diseases that are causing to human and animal health. This disease or disorder makes human health very severe, lethal, and life-threatening to survive. Several troubling diseases make the body's condition abnormal or cause a disturbance in the function and structure of the body or organ systems. It states that the person is ill or sick which is characterized by the manifestation or symptoms which may be seen internally or externally. To overcome these manifestations there are some specific substances or molecules are used. These substances are called drugs and can cure various diseases or disorders. A drug compound may be natural or synthetic obtained from a plant, animal sources, or any chemical compound which can treat and prevent diseases. There are some modern methods to produce a drug. To discover a new drug is called a drug discovery which saves time and trial discovery takes a lot of time for selecting, researching, optimization, of a drug. These drugs are beneficial and lifesavers. Several days or years pass or are required to discover a new molecule or to design a single molecule. Drug discovery is the research of new compounds and new moiety. Drug design is a very convenient and time-saving method for drug discovery. Drug design is a type of invention and it is a computational method and it is an important part of drug discovery. There are two techniques of drug design ligand-based and receptor-based drug design. Computer-aided drug design is a computational method in which there is a prediction of the structure and molecules by a mathematical equation. In LBDD QSAR & Pharmacophore model is there and in RBDD Molecular Docking & De Novo Design is present. In QSAR there are of the efficacy of a biologically active compound. It is a mathematical relationship that identifies and quantifies the molecule. These methods can be applied and then virtual screening. Then the identification of the molecule binds to the binding site or receptor and gives its action.
  • A Novel Perspective on Pharmaceutical Research: Mucoadhesive Patches
    Sharad R Manapure, Vipinchandra B Pande, Pranjali Khanke, T. Venkatachalam, Saket Singh Chandel
    International Journal of Drug Delivery Technology, 2025
    Mucosal drug delivery explores the significance of mucoadhesive drug delivery systems in enhancing drug bioavailability and sustained release. It delves into the mechanisms of muco-adhesion, highlighting the role of various polymers. The review also discusses challenges and recent advancements in formulating effective mucoadhesive drug delivery systems, offering insights into their potential applications for targeted and localized drug delivery. It examines the diverse range of polymers employed in mucoadhesive formulations, such as chitosan, alginate, and Carbopol, discussing their specific characteristics and advantages. This addresses the influence of physiological factors, such as pH and mucus composition, on the performance of mucoadhesive systems. Furthermore, light on recent advancements in the field, including the integration of nanotechnology and innovative polymer blends to optimize mucoadhesive properties. It emphasizes the potential of mucoadhesive drug delivery systems in achieving site-specific targeting, minimizing side effects, and improving patient compliance. In addition, the abstract highlights challenges associated with mucoadhesive formulations, including variability in mucosal surfaces and potential toxicity concerns, while proposing strategies to address these issues. A mucosal patch is a drug delivery system designed to adhere to mucosal surfaces, such as those found in the oral cavity, nasal passages, or vaginal area. These patches are formulated with mucoadhesive materials that enable them to stick to the mucosal membrane, allowing for controlled drug release directly at the site of application. The mucosal patch offers advantages like enhanced bioavailability, rapid onset of action, and reduced systemic side effects. These patches can be designed for various therapeutic purposes, including local treatment of mucosal infections, hormone delivery, or management of conditions affecting specific mucosal tissues. In addition to mucoadhesive polymers, mucosal patches may incorporate drug-loaded nanoparticles or microparticles for sustained release.
  • Herbal Medicine Formulation, Standardization, and Commercialization Challenges and Sustainable Strategies for Improvement
    Neelima Yadav, Saket Singh Chandel, T. Venkatachalam, Syeda Nishat Fathima
    Reference Series in Phytochemistry, 2024
  • Proximate Analysis of Herbal Drugs: Methods, Relevance, and Quality Control Aspects
    Milan Hait, Nand Kumar Kashyap, Saket Singh Chandel, M. M. Vaishnav
    Reference Series in Phytochemistry, 2024
  • Hepatotoxicity
    Plant Derived Hepatoprotective Drugs, 2023
  • Comparative Analysis in Hepatoprotective Activity of Crude Extracts of important Medicinal Plants
    Jitendra Patel, G. Shiva Kumar, Khemkaran Ahirwar, Mukesh K. Gupta, Sandeep K. Singh, Saket S. Chandel, Vijay K. Patel
    Research Journal of Pharmacy and Technology, 2023
    According to the World Health Organization, chronic liver diseases account for approximately 46% of all diseases and 59% of all deaths worldwide. It is critical to look for hepatoprotective crucial findings because they are important for human health. The aim of this study was to compare the hepatoprotective activity of six medicinal plants based on biochemical reduction on the animal study. The increased levels of ALT, AST, ALP, total bilirubin, direct bilirubin, and cholesterol in the blood have been marked to the damaged structural virtue of the liver. When the plant extract was given to rats after they were administered a hepatotoxicant and the level of marker enzymes was discovered to be lower than normal, it meant that the particular dose of the plant extract was considerably supporting the hepatoprotective action. The comparative study of hepatoprotective efficacy of six medicinal plants was determined by a biostatistical analysis of data received from an animal investigation. The Terminalia coriacea and Artocarpus hirsutus at 250 and 500mg/kg respectively revealed that the *P<0.05; **P< 0.01; ***P<0.001; when compared to the CCl4 group. The Cucumis melo revealed P<0.05 and P<0.01 as compared with the liver-damaged control to the drug-treated animal at doses of 100, 250, and 500mg/kg. Buchanania lanzan revealed significant at P<0.05*, 0.01** and 0.001*** at 100 mg/kg, 200mg/kg and 400 mg/kg for aqueous and alcoholic extract both. The Diospyros melanoxylon (Roxb) and Solanum americanum Mill at doses 100, 200, and 400 mg/kg and 200, 400, and 600 mg/kg respectively. The T. coriacea and A. hirsutus revealed a 5%, 1%, and less than 1% chance of false-positive, which is statistically significant at all levels.
  • Proximate Analysis of Herbal Drugs: Methods, Relevance, and Quality Control Aspects
    Milan Hait, Nand Kumar Kashyap, Saket Singh Chandel, M. M. Vaishnav
    Reference Series in Phytochemistry, 2023
  • Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats
    Pande V. Bhaskarrao, Chandel S. Singh, Soni . Vishal
    International Journal of Drug Delivery Technology, 2022
    Worldwide demand for new anti-diabetic drugs from plant sources has increased as diabetes mellitus has become a global epidemic. In the era of herbal medicines, polyherbal formulations offer higher therapeutic efficacy than single plants due to synergistic effects. Therefore, the objective was to develop a novel anti-diabetic polyherbal formulation containing mixtures of three plants: Azadirachta indica leaves, Tinospora cordifolia stem and Ocimum sanctum leaves extracts. The eight different plant formulations (F1 to F8) were formulated while F1 to F3 contained a single plant extract. Hyperglycemia was developed in rodents by ingestion of streptozotocin. The experimental animals’ serum sugar level, body weight and lipid profile were determined. In the diabetic rats treated orally with F1 to F8, the blood glucose level decreased significantly compared to the diabetic control group. Similar effects were also observed in the diabetic rats treated with glibenclamide. In addition, F1 to F8 controlled lipid level, namely total cholesterol (CHL), triglycerides (TGL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in rodents. The findings suggested that F7 showed higher anti-diabetic and antihyperlipidemic efficiency when equated to the other formulations. It was also found that the formulations (F1 to F3) containing a single plant extract exhibited lower therapeutic efficacy than the polyherbal formulations (F4 to F8). The results suggest that the higher therapeutic efficacy of the polyherbal formulation is due to the synergistic effect of the different phytoconstituents in the plant mixtures.
  • COVID-19: Sign, Symptoms and Transmission
    Herbal Immunity Boosters Against Covid 19, 2022
  • Plants used for the treatment of icterus (jaundice) in Central India: A review
    Vandana Janghel, Pushpendra Patel, Saket Singh Chandel
    Annals of Hepatology, 2019
    Jaundice is one of the most common medical condition affecting infants, children, and adults. Jaundice is not a disease but it is a visible sign and symptom of liver disease which occurs when there is an increase in the amount of bilirubin circulating in the blood due to the abnormal metabolism and excretion in the urine. Medicinal plants are being used long ago by our ancestors for the treatment of jaundice. At the present era, consumption of these herbal medicines is increasing at a high speed, due to its less or no side effect and cost-effectiveness as compared to synthetic medicines. This review describes approximately 55 medicinal plants which are used by rural and tribal people of different area of Chhattisgarh for curing jaundice. The data was collected from different kinds of literature survey from the year 1993 to 2018. This review has been conferred in a systematic way which includes plant's vernacular name, botanical name along with its family, part used and ethnomedicinal uses in a tabulated form and also the description of scientific evidence behind the folklore uses of some medicinal plants along with their mechanism of action which have been reported in different kinds of literature. The current study may be useful for the development of new medicines for the treatment of jaundice.
  • Preliminary phytochemical and physicochemical investigation of Woodfordia fruticosa (Linn) Kurz root
    Dr. Saket Singh Chandel
    International Journal of Green Pharmacy, 2018
  • Pharmacological models to appraisement of antianxiety activity in experimental animals
    International Journal of Green Pharmacy, 2018
  • Modulatory effect of dietary inclusion of Aegle marmelos fruits against cisplatin - Induced hepatotoxicity in wistar rats
    Saket S. Chandel, Mrunal Shirsat, Ram K. Sahu, Siva S. Nayak
    Annals of Hepatology, 2018
  • Protective effect of dietary inclusion of Aegle marmelos fruit on gentamicininduced hepatotoxicity in rats
    International Journal of Green Pharmacy, 2017

RECENT SCHOLAR PUBLICATIONS

  • Plant-Based Therapeutics for Ocular Diseases: From Ethnopharmacology to Nanomedicine
    RM Sharad, BP Vipinchandra, SA Pravin, Y Neelima, SC Saket
    International Journal of Drug Delivery Technology 16 (3), 735-746 , 2026
    2026
  • A Novel Perspective In Drug Design And Drug Discovery (4d) With Computer-Aided Drug Design (Cadd): A Review
    RM Sharad, K Shruti, BP Vipinchandra, SC Saket, K Pranjali, K Kanchan
    International Journal of Drug Delivery Technology 16 (2), 133-145 , 2026
    2026
  • A Novel Perspective on Pharmaceutical Research: Mucoadhesive Patches
    SR Manapure, VB Pande, P Khanke, T Venkatachalam, SS Chandel
    International Journal of Drug Delivery Technology 15 (4), 1776-1782 , 2025
    2025
  • Evaluation of Formulated Luliconazole Lipid Nano Particle Gel Targeting Topical Fungal Infections
    K Singh, M Rai, SS Chandel, N Yadav, A Vaishnaw
    Research Journal of Pharmaceutical Dosage Forms and Technology 17 (4), 239-246 , 2025
    2025
  • Red Grape Seed Extract for memory enhancement in Alzheimer’s Disease in rats with reference to the Glutamate metabolism
    P Kumar, SS Chandel, N Yadav, A Vaishnaw, M Rai
    Research Journal of Pharmacology and Pharmacodynamics 17 (4), 243-251 , 2025
    2025
  • Evaluation of oxidative protection of Mimosa pudica L. against Ethanol induced gastric inflammation in Rat models
    Omprakash, N Yadav, SS Chandel, A Vaishnaw, M Rai
    Research Journal of Pharmacology and Pharmacodynamics 17 (4), 252-256 , 2025
    2025
  • Evaluation of oxidative protection of Mimosa pudica L. against Ethanol induced gastric inflammation in Rat models
    Omprakash, N Yadav, SS Chandel, A Vaishnaw, M Rai
    Research Journal of Pharmacology and Pharmacodynamics 17 (4), 252-256 , 2025
    2025
  • Evaluating effectiveness of Nigella sativa L extract on Lipopolysaccharide-D-Galactosamine induced hepatic toxicity in rats
    RK Sahu, A Vaishnaw, SS Chandel, N Yadav, M Rai
    Research Journal of Pharmacology and Pharmacodynamics 17 (4), 263-268 , 2025
    2025
  • Phytochemical evaluation and Antimicrobial Study of Ethanolic Terminalia Chebula Extract
    JS Miri, SS Chandel, N Yadav, A Vaishnaw, M Rai
    Research Journal of Pharmacology and Pharmacodynamics 17 (4), 269-274 , 2025
    2025
  • Formulation and Assessment of Antidiabetic Polyherbal Preparations Containing Azadirachta indica, Tinospora cordifolia, and Ocimum sanctum in Streptozotocin-Nicotinamide …
    VB Pande, SR Manapure, SS Chandel, KB Bhelkar
    Asian Journal of Pharmaceutics 19 (4), 2309 , 2025
    2025
  • Bioactive Potential and Pharmacological Applications of Mushrooms: A Review
    N Yadav, SS Chandel
    Advances in Science and Agriculture: Addressing Global Challenges 2, 198-229 , 2025
    2025
  • TWO-STAGE MORRIS MAZE APPARATUS FOR SPATIAL MEMORY DETECTION
    DVB Pande, DSS Chandel, DA Bhattacharya
    IN Patent 456968-001 , 2025
    2025
  • A Text Book of Instrumental Methods of Analysis
    N Yadav, SS Chandel, VB Pande, SR Manapure, T Venkatachalam
    A&V Publications Raipur, Chhattisgarh 1, 194 , 2025
    2025
  • A Theory Book of Herbal Drug Technology
    N Yadav, SS Chandel, T Venkatachalam, R Devaliya, S Vaidya
    BP International 1, 1-137 , 2024
    2024
  • Device for Analysis of Multifactor Depression in Rodents
    DA Bhattacharya, DRK Sahu, PDSS Chandel, V Nautiyal
    IN Patent 395840-001 , 2024
    2024
  • Novel Pharmacotherapeutic Approaches for Management of Cystic Fibrosis
    SN Fathima, SS Chandel
    The Spectrum of Knowledge 1, 79-89 , 2024
    2024
  • Herbal Medicine Formulation, Standardization, and Commercialization Challenges and Sustainable Strategies for Improvement
    N Yadav, SS Chandel, T Venkatachalam, SN Fathima
    Herbal Medicine Phytochemistry 1, 1-27 , 2023
    2023
    Citations: 39
  • Proximate Analysis of Herbal Drugs: Methods, Relevance, and Quality Control Aspects
    H Milan, K Nand Kumar, C Saket Singh, V MM
    Herbal Medicine Phytochemistry, 1-30 , 2023
    2023
    Citations: 20
  • Pharmacognosy & Phytochemistry-I
    N Yadav, SS Chandel, R Devaliya
    Pharmacognosy and Phytochemistry–I, 1-112 , 2023
    2023
  • NOVEL THERAPEUTIC STRATEGIES FOR TREATMENT OF ALZHEIMER’S DISEASE
    SN Fathima, SS Chandel
    Advances in Science and Technology 4, 6-11 , 2023
    2023

MOST CITED SCHOLAR PUBLICATIONS

  • Plants used for the treatment of icterus (jaundice) in Central India: A review
    V Janghel, P Patel, SS Chandel
    Annals of hepatology 18 (5), 658-672 , 2019
    2019
    Citations: 81
  • A Detailed Review on Nociceptive Models for the Screening of Analgesic Activity in Experimental Animals
    SS Chandel, PK Patel, J Sahu
    International Journal of Neurologic Physical Therapy 2 (6), 44-50 , 2017
    2017
    Citations: 45
  • Herbal Medicine Formulation, Standardization, and Commercialization Challenges and Sustainable Strategies for Improvement
    N Yadav, SS Chandel, T Venkatachalam, SN Fathima
    Herbal Medicine Phytochemistry 1, 1-27 , 2023
    2023
    Citations: 39
  • Biocontrol of Anopheles gambiae larvae using fresh ripe and unripe fruit extracts of Capsicum frutescens var. baccatum
    SS Chandel, SC Izah
    International Journal of Green Pharmacy (IJGP) 13 (04), 1-5 , 2019
    2019
    Citations: 32
  • Potency of unripe and ripe express extracts of long pepper (Capsicum frutescens var. baccatum) against some common pathogens
    SC Izah, SS Chandel, NG Etim, JO Epidi, T Venkatachalam, R Devaliya
    Int J Pharm Phytopharmacol Res 9 (2), 56-70 , 2019
    2019
    Citations: 32
  • Proximate Analysis of Herbal Drugs: Methods, Relevance, and Quality Control Aspects
    H Milan, K Nand Kumar, C Saket Singh, V MM
    Herbal Medicine Phytochemistry, 1-30 , 2023
    2023
    Citations: 20
  • Madhuca indica (Mahua)-pharmaceutical, nutraceutical and economical importance for tribal people of Chhattisgarh state
    PK Patel, V Janghel, SS Chandel, J Sahu
    Int. J. Pharm. Phytopharm. Res 9 (3), 16-28 , 2019
    2019
    Citations: 19
  • Modulatory Effect of Dietary Inclusion of Aegle marmelos Fruits against Cisplatin-Induced Hepatotoxicity in Wistar Rats
    SS Chandel, RK Sahu, M Shirsat, SS Nayak
    Annals of Hepatology 17 (3), 482-489 , 2018
    2018
    Citations: 16
  • Synergistic and Safe Antidiabetic Effect of Polyherbal Formulation: Comprehensive Overview
    VB Pande, SS Chandel, V Soni
    International Journal of Lifescience and Pharma Research 11 (2), 51-57 , 2021
    2021
    Citations: 8
  • Coronavirus Disease 2019: The Emergence of Popular Unverified Myths and Realities to Its Spread.(2020)
    SC Izah, SS Chandel, AO Aigberua, T Venkatachalam, D Verma
    Int. J. Life Sci. Pharma Res 10 (5), P17-26 , 2020
    2020
    Citations: 8
  • Protective Effect of Dietary Inclusion of Aegle Marmelos Fruit on Gentamicin Induced Hepatotoxicity in Rats
    SS Chandel, RK Sahu
    International Journal of Green Pharmacy (IJGP) 11 (03), S597 - S603 , 2017
    2017
    Citations: 7
  • Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats
    PV Bhaskarrao, CS Singh, S Vishal
    International Journal of Drug Delivery Technology 12 (4), 1612-1617 , 2022
    2022
    Citations: 6
  • Comparative Analysis in Hepatoprotective Activity of Crude Extracts of important Medicinal Plants
    J Patel, GS Kumar, K Ahirwar, MK Gupta, SK Singh, SS Chandel, VK Patel
    Research Journal of Pharmacy and Technology 16 (2), 659-662 , 2022
    2022
    Citations: 6
  • Conventional extraction methods versus novel extraction methods of bioactive compounds from some medicinal plants
    N Yadav, P Patel, P Kashyap, R Tamboli, SS Chandel, SR Kirtane
    International Journal of Green Pharmacy 16 (3), 220-225 , 2022
    2022
    Citations: 4
  • Pharmacological models to appraisement of antianxiety activity in experimental animals
    SS Chandel
    International Journal of Green Pharmacy (IJGP) 12 (03) , 2018
    2018
    Citations: 4
  • Recent advances in curcumin: An integrative overview of its mode of action, pharmacological properties, and health benefits
    VKP Arvind Kumar, Saket Singh Chandel, Aayush Vaishnaw, Roshan Sonwani
    International Journal of Green Pharmacy 16 (3), 226-235 , 2022
    2022
    Citations: 3
  • Preliminary phytochemical and physicochemical investigation of Woodfordia fruticosa (linn) kurz root
    SS Chandel, V Janghel, T Venkatachalam, S Kumar, KBS Chouhan, ...
    International Journal of Green Pharmacy 12 (4), 840-846 , 2018
    2018
    Citations: 3
  • Effect of plant extracts against Fusarium wilt of carnation
    SS Chandel, M Kaur, M Tomar
    INDIAN PERFUMER 48 (2), 193-194 , 2004
    2004
    Citations: 2
  • Hepatotoxicity
    PDC Abu Md Ashif Ikbal, Parikshit Das, Saket Singh Chandel, Deepshikha Verma
    Plant-derived Hepatoprotective Drugs, 1-18 , 2023
    2023
    Citations: 1
  • Pharmacognostic Standardization of Azadirachta indica Leaves, Tinospora cordifolia Stem, and Ocimum sanctum Leaves
    VB Pande, SS Chandel, V Soni
    J Xian Univ. Archit. Technol 56, 0025-0422 , 2022
    2022
    Citations: 1