Organic Chemistry, Organic Chemistry, General Chemistry
7
Scopus Publications
Scopus Publications
An antibacterial agent based on diamine conjugated thenil Schiff Base: synthesis, crystal structure, and activity studies Nidhi, Siddharam, Devendra Pratap Rao, Amit Kumar Gautam, Ashish Verma, Yashveer Gautam, Sanjay Singh, Chandra Prakash Singh, Alok Kumar Srivastava, Shiv Govind Prasad Discover Applied Sciences, 2025 A unique asymmetric Schiff base compound originated from thenil underwent synthesis and characterization via analytical and spectroscopic methods. The compound was obtained through thenil (Di-2-thienylethanedione) and 1, 2-diaminotoluene reaction using standard synthetic procedures in various solvents. The compound displayed an asymmetric structure and was devoid of all symmetry elements. Antibacterial activity of the synthesized compounds was performed by it’s biological efficacy against S. aureus and S. typhi in-vitro agar-well diffusion testing as compared to doxycycline. The prepared compound exhibited potential as a superior antimicrobial drug candidate, although further scrutiny and evaluation as opposed to other trademark compounds remains a necessary step to evaluate the real potential of the molecule as a potential therapeutics against a variety of infectious diseases.
Flacourtia jangomas (Lour.) raeus. (Paniala): An important nutraceutical tree of the tropics Deepanjali Sinha, Alok K. Srivastava, Shakti K. Prabhuji, Govind P. Rao, Gaurav K. Srivastava Medicinal Plants, 2019 Flacourtia jangomas (Lour.) Raeus, belonging to family Flacourtiaceae, is a medium-sized tree of very important nutraceutical value of eastern Uttar Pradesh. The ripe fruits contain high fibre content together with quality protein and low fat along with high vitamins and minerals. The plant contains limnoids like limolin and jangomolide. The karyomorphology, micropropagation and organogenesis of the plant has been described. The antibacterial, antioxidant, anti-diabetic and anti-tumour potentials of this plant has been explored and discussed in the review.
Synthesis of chalcones and nucleosides incorporating [1, 3, 4]oxadiazolenone core and evaluation of their antifungal and antibacterial activities Alok K. Srivastava, Lokesh K. Pandey Current Bioactive Compounds, 2019 Background: [1, 3, 4]oxadiazolenone core containing chalcones and nucleosides were synthesized by Claisen-Schmidt condensation of a variety of benzaldehyde derivatives, obtained from oxidation of substituted 5-(3/6 substituted-4-Methylphenyl)-1, 3, 4-oxadiazole-2(3H)-one and various substituted acetophenone. The resultant chalcones were coupled with penta-O-acetylglucopyranose followed by deacetylation to get [1, 3, 4] oxadiazolenone core containing chalcones and nucleosides. Various analytical techniques viz IR, NMR, LC-MS and elemental analysis were used to confirm the structure of the synthesised compounds.The compounds were targeted against Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and Aspergillus flavus, Aspergillus niger and Fusarium oxysporum for antifungal activity. Methods: A mixture of Acid hydrazides (3.0 mmol) and N, Nʹ- carbonyl diimidazole (3.3 mmol) in 15 mL of dioxane was refluxed to afford substituted [1, 3, 4]-oxadiazole-2(3H)-one. The resulted [1, 3, 4]- oxadiazole-2(3H)-one (1.42 mmol) was oxidized with Chromyl chloride (1.5 mL) in 20 mL of carbon tetra chloride and condensed with acetophenones (1.42 mmol) to get chalcones 4. The equimolar ratio of obtained chalcones 4 and β -D-1,2,3,4,6- penta-O-acetylglucopyranose in presence of iodine was refluxed to get nucleosides 5. The [1, 3, 4] oxadiazolenone core containing chalcones 4 and nucleosides 5 were tested to determined minimum inhibitory concentration (MIC) value with the experimental procedure of Benson using disc-diffusion method. All compounds were tested at concentration of 5 mg/mL, 2.5 mg/mL, 1.25 mg/mL, 0.62 mg/mL, 0.31 mg/mL and 0.15 mg/mL for antifungal activity against three strains of pathogenic fungi Aspergillus flavus (A. flavus), Aspergillus niger (A. niger) and Fusarium oxysporum (F. oxysporum) and for antibacterial activity against Gram-negative bacterium: Escherichia coli (E. coli), and two Gram-positive bacteria: Staphylococcus aureus (S. aureus) and Bacillus subtilis(B. subtilis). Result: The chalcones 4 and nucleosides 5 were screened for antibacterial activity against E. coli, S. aureus and B. subtilis whereas antifungal activity against A. flavus, A. niger and F. oxysporum. Compounds 4a-t showed good antibacterial activity whereas compounds 5a-t containing glucose moiety showed better activity against fungi. The glucose moiety of compounds 5 helps to enter into the cell wall of fungi and control the cell growth. Conclusion: Chalcones 4 and nucleosides 5 incorporating [1, 3, 4] oxadiazolenone core were synthesized and characterized by various spectral techniques and elemental analysis. These compounds were evaluated for their antifungal activity against three fungi; viz. A. flavus, A. niger and F. oxysporum. In addition to this, synthesized compounds were evaluated for their antibacterial activity against gram negative bacteria E. Coli and gram positive bacteria S. aureus, B. subtilis. Compounds 4a-t showed good antibacterial activity whereas 5a-t showed better activity against fungi.
Antioxidant potential of the ripe fruits of Flacourtia jungomas (Lour.) Raeus. Deepanjali Sinha, Alok K. Srivastava, Shakti K. Prabhuji, Gaurav K. Srivastava Medicinal Plants, 2018 The antioxidant potential of the ripe fruits of Flacourtia jungomas (Lour.) Raeus. was investigated. The free radical scavenging activity of the ethanol-aqueous extract was assayed using DPPH method, reducing power activity using ferricyanide method and total antioxidant activity using phospho-molybdenum method. Results indicated that the free radical scavenging activity ranged from 45.2 to 98.6; reducing power from 11.8 to 78.5 and total antioxidant activity from 0.048 to 0.187; and these results were concentration dependent. Comparison with earlier observation indicated that the ripe fruits of Flacourtia jungomas have better antioxidant potential than the unripe fruits.
Synthesis and fungicidal activity of some 8-aryl-3-(β-D-glucopyranosyl)-4-oxo-4H,5H-1,2,4-triazolo-[4,3-b]-1,4,2,6-dithiadiazine-1,1-dioxides Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2015
Synthesis and fungicidal activity of some 3-(5-aryl-1,3,4-thiadiazol-2-yl)- 1-(β-D-glucopyranosyl)-5-alkyl-2-thio-4-imidazolidinones Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2007
Synthesis and fungicidal activity of some 6-aryl-2-(-β-D- glucopyranosyl)-3-oxo-2,3-dihydro-1,3,4-oxadiazolo [3,2-b]-1,2,4,6-thiatriazine- 1,1-dioxides Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2005
