Haider Abdulhameed Rashid Alqaraghuli

@nahrainuniv.edu.iq

Department of Medicine/College of Medicine
Al-Nahrain University

Haider Abdulhameed Rashid Alqaraghuli


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https://researchid.co/dr.haider.abdulhameed

RESEARCH, TEACHING, or OTHER INTERESTS

Medicine, Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine, Education
6

Scopus Publications

37

Scholar Citations

4

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • EVALUATION OF SERUM INTERLEUKIN-17 AS DIAGNOSTIC MARKERS IN ASTHMA SEVERITY
    Mustafa Jawad Kadhim, Zinah Abd Ulelah Abd Ali, Haider Abdulhameed Alqaraghuli, Noor Mohammed Obaid
    Proceedings on Engineering Sciences, 2026
    Asthma continues to be a major health issue worldwide, with an increasing prevalence impacting over 300 million people and contributing significantly to morbidity and mortality.This study investigates the role of interleukin-17 in different asthma phenotypes, focusing on its potential as a biomarker for disease severity and control.The primary aim was to measure & compare the serum levels of IL-17 in asthmatic patients with healthy controls and to explore correlation of IL-17 levels with other inflammatory markers such as IgE, C-reactive protein (CRP), and eosinophil count.Additionally, the study sought to determine the relationship between IL-17 levels and asthma control status.The study encompassed 140 participants, divided equally between asthmatic cases and healthy controls, showing IL-17 levels were elevated in asthma patients though not reaching statistical significance.A clear association was observed between elevated IL-17 levels and other biomarkers with deteriorating control of asthma symptoms.While the direct correlation between serum IL-17 levels and asthma severity was not statistically significant, the study indicates the potential of IL-17 to be a contributing factor in severe asthma cases.Further studies are needed to confirm these findings and assess IL-17's utility in clinical practice for asthma diagnosis and treatment.
  • Alpha-1-Antitrypsin, Elastase Activity as Markers for Chronic Obstructive Pulmonary Disease Exacerbation
    Advancements in Life Sciences, 2025
  • Expert consensus on oral corticosteroids stewardship for the treatment of severe asthma in the Middle East and Africa
    Mona Al-Ahmad, Ashraf Al Zaabi, Ashraf Madkour, Haider Abdulhameed Alqaraghuli, Hajar Al Hayaan, Hassan Mobayed, Majdy Idrees, Nasser Al busaidi, Salah Zeineldine
    Respiratory Medicine, 2024
    In the Middle East and Africa (MEA) region, overuse of oral corticosteroids (OCS) for asthma management, both as burst and maintenance therapy, poses a significant challenge. Gaps in knowledge regarding the need to taper OCS in patients with severe asthma and the use of OCS in comorbid conditions have been noted. OCS stewardship can help attain optimal and effective OCS tapering along with reducing OCS overuse and over-reliance. In this paper, we discuss current practices regarding the use of OCS in asthma, globally and in the MEA region. Expert recommendations for achieving OCS stewardship in the MEA region have also been presented. Regional experts recommend increasing awareness among patients about the consequences of OCS overuse, engaging community pharmacists, and educating primary healthcare professionals about the benefits of prompt appropriate referral. Innovative local referral tools like ReferID can be utilized to refer patients with asthma to specialist care. The experts also endorse a multidisciplinary team approach and accelerating access to newer medicines like biologics to implement OCS stewardship and optimize asthma care in the MEA region.
  • The association of FKBP5 polymorphism with asthma susceptibility in asthmatic patients
    Sura F. Alsaffar, Haider A. Rasheed, Jabbar H. Yenzeel, Haider F. Ghazi
    Journal of Basic and Clinical Physiology and Pharmacology, 2021
    Objectives Inhaled corticosteroids are the most effective controllers of asthma, although asthmatics vary in their response. FKBP51 is a major component of the glucocorticoid receptor which regulates its responses to corticosteroids. Therefore, the present study aims to identify the role of FKBP5 gene polymorphism in asthma susceptibility and corticosteroid resistance. Methods DNA was extracted from the blood of 68 asthmatic and 40 control subjects. FKBP5 gene fragments were amplified by PCR and sequenced by the Sanger method. The sequencing results were aligned by mapping on the reference sequences of National center of Biotechnology Information (NCBI) and single nucleotide polymorphisms (SNPs) which were checked. Finally, the genotype, allele frequency and odds ratio (OR) were calculated. Results The FKBP5 fragment sequencing revealed the presence of rs1360780 and one novel SNP found in 17 samples taken from asthmatic patients as compared to db SNP data in the NCBI database. The FKBP5 variant (rs1360780) indicated that the allele frequency of risk allele T was 41.18% in patients and 20% in control group members p<0.001 and OR=2.8 when compared to a wild C allele frequency of 58.82% in patients and 64% in the control group members. The novel SNP FKBP5 was compared to the SNP database in the NCBI database in which wild T allele was substituted with G. The novel SNP was submitted to the ClinVar Submission Portal at NCBI with accession number: rs1581842283 and confirmed an asthma susceptibility risk factor with allele G frequency of 11.76% in asthmatics and 2.5% in the control group members (OR=5.2, p<0.05), as compared to a wild T allele frequency of 88.24% in asthmatics and 97.5% in the control group members. Conclusions The risk allele T of rs1360780 and the novel SNP rs1581842283 risk allele G predict asthma susceptibility but show no association with corticosteroid resistant.
  • Awareness for need of regular eye exams and retinal involvement in diabetes patients
    Archivos Venezolanos De Farmacologia Y Terapeutica, 2021
  • Vitamin D and its association with the severity and/or the control of asthma among adult Iraqi asthmatics
    Medico Legal Update, 2020

RECENT SCHOLAR PUBLICATIONS

  • Alpha-1-Antitrypsin, Elastase Activity as Markers for Chronic Obstructive Pulmonary Disease Exacerbation
    DAA Mezaal, RJM Al-Timimi, HA Alqaraghuli
    Advancements in Life Sciences 12 (3), 605-609 , 2025
    2025
  • Expert consensus on oral corticosteroids stewardship for the treatment of severe asthma in the Middle East and Africa
    M Al-Ahmad, A Al Zaabi, A Madkour, HA Alqaraghuli, H Al Hayaan, ...
    Respiratory Medicine 228, 107674 , 2024
    2024
    Citations: 9
  • Estimation of Serum Amyloid A, CRP, Homocysteine, and Neutrophils to Lymphocyte Ratio as an Inflammatory biomarker and their correlation with Cardiovascular risk in a sample of …
    HY Ali, MA Al-bayati, HA Alqaraghuli
    2021
    Citations: 2
  • Bacteriological Profile and Antibiogram of Bacteria in Sputum Culture of Iraqi Patients: A retrospective study
    HN Dawood, LA Zwain, HA Alqaraghuli
    Ibn AL-Haitham Journal For Pure and Applied Sciences 34 (3), 1-9 , 2021
    2021
    Citations: 5
  • The association of FKBP5 polymorphism with asthma susceptibility in asthmatic patients
    SF Alsaffar, HA Alqaraghuli, JH Yenzeel, HF Ghazi
    Journal of Basic and Clinical Physiology and Pharmacology 32 (4), 479-484 , 2021
    2021
    Citations: 11
  • Correlation of Lactate Dehydrogenase (LDH) activity, D-Dimer and Severity in a sample of COVID-19 patients in Iraq”
    RJ Al-Timimi, HA Alqaraghuli
    DOI: 10.51201/JUSST/21/07306 , 2021
    2021
  • The role of IL-13 Polymorphisms in Asthma
    AA Farhan, HA Alqaraghuli, AA Abbas
    Annals of Tropical Medicine and Public Health 24 (2) , 2021
    2021
  • Awareness for need of regular eye exams and retinal involvement in diabetes patients
    AAA Mohamad, HA Alqaraghuli, HA Mahdi
    Archivos Venezolanos de Farmacologia y Terapeutica 40 (2), 192–196 , 2021
    2021
    Citations: 2
  • Effect of favipiravir and standard COVID-19 therapy on amino transferase in a sample of Iraqi COVID-19 patients.
    AA Mikhwir, RJM Al-Timimi, HA Alqaraghuli
    2021
  • Risk Factors for Stroke Associated Pneumonia
    SH Abd Alit, HA Alqaraghul, HA Al-Hamadani
    Annals of Tropical Medicine and Public Health 23 (24) , 2020
    2020
    Citations: 1
  • Distinguishing Exudative from Transudative Effusion by Using Pleural Fluid Cholesterol and Bilirubin in Comparative Study to Light’s Criteria
    HJ Ismail, HA Alqaraghuli, HM Hashim
    https://ijop.net/index.php/mlu/article/view/1972 20 (4), 1088 , 2020
    2020
    Citations: 1
  • Association between Diabetic Retinopathy and (Albumin/Creatinine) Ratio in Diabetic Patients.
    AAA Mohamad, H Rashid, HA Mahdi
    Indian Journal of Public Health Research & Development 11 (2) , 2020
    2020
    Citations: 2
  • Vitamin D and its association with the severity and/or the control of asthma among adult Iraqi asthmatics
    HA Alqaraghuli, HM Hashim
    Medico Legal Update 20 (1), 655-60 , 2020
    2020
    Citations: 4

MOST CITED SCHOLAR PUBLICATIONS

  • The association of FKBP5 polymorphism with asthma susceptibility in asthmatic patients
    SF Alsaffar, HA Alqaraghuli, JH Yenzeel, HF Ghazi
    Journal of Basic and Clinical Physiology and Pharmacology 32 (4), 479-484 , 2021
    2021
    Citations: 11
  • Expert consensus on oral corticosteroids stewardship for the treatment of severe asthma in the Middle East and Africa
    M Al-Ahmad, A Al Zaabi, A Madkour, HA Alqaraghuli, H Al Hayaan, ...
    Respiratory Medicine 228, 107674 , 2024
    2024
    Citations: 9
  • Bacteriological Profile and Antibiogram of Bacteria in Sputum Culture of Iraqi Patients: A retrospective study
    HN Dawood, LA Zwain, HA Alqaraghuli
    Ibn AL-Haitham Journal For Pure and Applied Sciences 34 (3), 1-9 , 2021
    2021
    Citations: 5
  • Vitamin D and its association with the severity and/or the control of asthma among adult Iraqi asthmatics
    HA Alqaraghuli, HM Hashim
    Medico Legal Update 20 (1), 655-60 , 2020
    2020
    Citations: 4
  • Estimation of Serum Amyloid A, CRP, Homocysteine, and Neutrophils to Lymphocyte Ratio as an Inflammatory biomarker and their correlation with Cardiovascular risk in a sample of …
    HY Ali, MA Al-bayati, HA Alqaraghuli
    2021
    Citations: 2
  • Awareness for need of regular eye exams and retinal involvement in diabetes patients
    AAA Mohamad, HA Alqaraghuli, HA Mahdi
    Archivos Venezolanos de Farmacologia y Terapeutica 40 (2), 192–196 , 2021
    2021
    Citations: 2
  • Association between Diabetic Retinopathy and (Albumin/Creatinine) Ratio in Diabetic Patients.
    AAA Mohamad, H Rashid, HA Mahdi
    Indian Journal of Public Health Research & Development 11 (2) , 2020
    2020
    Citations: 2
  • Risk Factors for Stroke Associated Pneumonia
    SH Abd Alit, HA Alqaraghul, HA Al-Hamadani
    Annals of Tropical Medicine and Public Health 23 (24) , 2020
    2020
    Citations: 1
  • Distinguishing Exudative from Transudative Effusion by Using Pleural Fluid Cholesterol and Bilirubin in Comparative Study to Light’s Criteria
    HJ Ismail, HA Alqaraghuli, HM Hashim
    https://ijop.net/index.php/mlu/article/view/1972 20 (4), 1088 , 2020
    2020
    Citations: 1
  • Alpha-1-Antitrypsin, Elastase Activity as Markers for Chronic Obstructive Pulmonary Disease Exacerbation
    DAA Mezaal, RJM Al-Timimi, HA Alqaraghuli
    Advancements in Life Sciences 12 (3), 605-609 , 2025
    2025
  • Correlation of Lactate Dehydrogenase (LDH) activity, D-Dimer and Severity in a sample of COVID-19 patients in Iraq”
    RJ Al-Timimi, HA Alqaraghuli
    DOI: 10.51201/JUSST/21/07306 , 2021
    2021
  • The role of IL-13 Polymorphisms in Asthma
    AA Farhan, HA Alqaraghuli, AA Abbas
    Annals of Tropical Medicine and Public Health 24 (2) , 2021
    2021
  • Effect of favipiravir and standard COVID-19 therapy on amino transferase in a sample of Iraqi COVID-19 patients.
    AA Mikhwir, RJM Al-Timimi, HA Alqaraghuli
    2021