Raquel Tusi Tamiosso

@site.ufn.edu.br

Biomedicine Course | Postgraduate Program in Science and Mathematics Teaching
Universidade Franciscana

Raquel Tusi Tamiosso


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https://researchid.co/raqueltusi

RESEARCH, TEACHING, or OTHER INTERESTS

Education, Biochemistry, Genetics and Molecular Biology
8

Scopus Publications

Scopus Publications

  • Farnesol modulates seric and splenic purinergic signaling during disseminated sporotrichosis by Sporothrix brasiliensis: improvement of immune response
    Samanta Chagas Corrêa, Isabela Maraschin Vieira, Marcelo Leite da Veiga, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera
    Journal of Toxicology and Environmental Health Part A Current Issues, 2026
    Sporotrichosis is an implantation mycosis induced by exposure to thermodimorphic fungi of genus Sporothrix, which affects both humans and animals, resulting in severe inflammatory responses. Purinergic signaling has been implicated in pathogenesis of fungal infections, recognized as a critical system for modulating immune responses and triggering effector mechanisms during sporotrichosis. Natural products have emerged as promising modulators of immune responses, particularly through their influence on purinergic signaling. Among these, farnesol, a sesquiterpene alcohol, demonstrated anti-inflammatory effects during sporotrichosis. However, the pathways involved in farnesol anti-inflammatory effects during S. brasiliensis infection remain to be determined. The aim of this study was to determine whether farnesol exerts a protective effect against S. brasiliensis-induced inflammatory damage via modulation of purinergic enzymes and purinergic molecules. Serum and splenic E-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity for adenosine triphosphate (ATP) was stimulated in infected rats compared to uninfected rats, while E-adenosine deaminase (E-ADA) activity was reduced. Serum and splenic extracellular levels of ATP and adenosine were elevated in infected rats compared to uninfected, as well as serum levels of interleukin 2 (IL-2) and interleukin-6 (IL-6). Farnesol diminished S. brasiliensis-initiated rise in serum and splenic E-NTPDase and elevation in levels of IL-2 and IL-6. In addition, farnesol blocked fungal-mediated fall in serum and splenic E-ADA activities and decreased alterations on extracellular levels of ATP and adenosine. Farnesol exerted protective effects involved stimulation of purinergic signaling enzyme activities and consequently regulation of purine metabolism, associated with elevated cytokine levels, thereby ameliorating immune response during sporotrichosis.
  • Rutin prevents memory impairment by reducing brain oxidative stress and fungal burden in a rat model of cryptococcosis
    Camila Eduarda Justen, Alana Bianca de Moraes Chitolina, Isabela Andres Finamor, Maria Amália Pavanato, Marina Machado Maurente, Isabela Maraschin Vieira, Marcelo Leite da Veiga, Eduarda Saab, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera
    Journal of Toxicology and Environmental Health Part A Current Issues, 2026
    initiated memory loss via stimulation of the antioxidant defense system protecting the brain against free radical-mediated effects and lipid peroxidation, as well as exerting antifungal action. Thus, rutin may be considered as a potential source for cryptococcosis treatment.
  • Farnesol attenuates inflammation and protects the liver of rats experimentally infected with Sporothrix brasiliensis
    Helena Martins Ciliatto, Rúbia Schallenberger da Silva, Cinthia Melazzo de Andrade, Isabela Maraschin Vieira, Carlos Eurico Fernandes, Marcelo Leite da Veiga, Camila Eduarda Justen, Isabela Garcia, Samanta Chagas Corrêa, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera
    Journal of Toxicology and Environmental Health Part A Current Issues, 2026
    Sporotrichosis, a neglected tropical disease, is an emerging implantation mycosis considered a global public health concern attributed to thermodimorphic fungus of the genus Sporothrix. An important step in controlling sporotrichosis is the implementation of suitable treatments. However, resistance to first-line antifungal therapies represents a growing challenge for sporotrichosis management, reinforcing the need for alternative and effective treatments, such as farnesol. Farnesol is a sesquiterpene alcohol considered a potential compound due to its antifungal activity in vitro and anti-inflammatory and hepatoprotective effects noted in vivo. However, farnesol in-vivo antifungal activity against S. brasiliensis remains to be determined. The aim of this study was to determine whether farnesol exerts antifungal action in rats inoculated with S. brasiliensis, and whether this compound provides protection to hepatic. Farnesol (100 mg/kg daily for 21 days) did not significantly reduce hepatic and renal fungal burden compared to infected rats and those treated with corn oil. Farnesol treatment diminished elevation of total leukocytes, lymphocytes, and eosinophil counts compared to infected and corn oil-treated rats. In infected rats, farnesol reduced increase in activities of aspartate aminotransferase, alanine aminotransferase and levels of creatinine, and urea. Further, farnesol also restored hematological indices related to white blood parameters. Farnesol also improved biomarkers of hepatic and renal functions. Therapeutic use of farnesol may be considered an interesting approach to improve hematological and hepatic consequences during disseminated sporotrichosis.
  • Disseminated cryptococcosis impairs cerebral and pulmonary phosphotransfer network in rats experimentally infected with Cryptococcus neoformans var. grubii: the impact on energy metabolism
    Matheus Dellaméa Baldissera, Maria Fernanda Biscarra Bortolotto Paz, Laís Suarez da Silva de Oliveira, Marina Machado Maurente, Camila Eduarda Justen, Bernardo Andrade Constantino, Julia Salvagni Nicaretta, Isabela Maraschin Vieira, Jandora Lima Ortiz, Mariana Cancian, Marcelo Leite da Veiga, Raquel Tusi Tamiosso
    Comparative Clinical Pathology, 2025
  • Rutin mitigates hematological and hepatic damage in rats infected with Cryptococcus neoformans
    Mariana Tonelotto Lorenzoni, Helena Ritter Rebelato, Alice Rodrigues Mazaro, Rúbia Schallenberger da Silva, Cinthia Melazzo de Andrade, Teodoro Trevisan De Paula Martins, Isabela Maraschin Vieira, Maria Eduarda de Ávila Biscaglia Vieira, Marcelo Leite da Veiga, Carolina Rapachi Fortes, Aline Rossato, Larissa Da Silva Silveira, Liana Da Silva Fernandes, Michele Rorato Sagrillo, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera
    Comparative Clinical Pathology, 2025
  • Rutin inhibits inflammatory responses by modulating purinergic enzymes and purine metabolism in Cryptococcus neoformans var. grubii-infected rats
    Rita Laine Fernandes Colvero, Raquel Tusi Tamiosso, Maria Fernanda Biscarra Bortolotto Paz, Laís Suarez da Silva de Oliveira, Teodoro Trevisan De Paula Martins, Júlia Salvagni Nicaretta, Isabela Maraschin Vieira, Marcelo Leite da Veiga, Matheus Dellaméa Baldissera
    Microbial Pathogenesis, 2025
  • Educational Design Research: An Aligned Approach to Contemporary Educational Challenges
    Raquel Tusi Tamiosso, Susan McKenney, Aline Grohe Schirmer Pigatto
    Acta Scientiae, 2025
    Background: Historical evidences underscore the synergistic evolution of society and educational paradigms, highlighting their mutual influence and the transformative impact of novel scenarios on both domains. The interconnected evolution of societal dynamics and educational paradigms necessitates a departure from traditional linear pedagogical approaches to accommodate the continuous adaptation in teaching, learning, and research methodologies. Objective: In this sense, this paper focuses on identifying and discussing the synergies between Educational Design Research (EDR) and contemporary educational challenges. Methodological aspects: Through a theoretical essay on the historical aspects, uniqueness, and potential of EDR, this study illuminates how EDR contributes to the development of effective, innovative, and contextually relevant educational strategies, enriching the educational field, promoting better learning outcomes, and contributing to contemporary education. Results: EDR stands as a synchronous approach to modern educational challenges, integrating theory and practice to develop and refine innovative strategies that are responsive to the evolving landscape of learning, teaching, and technological advancements. Conclusions: EDR emerges as a potencial approach that bridges educational field with contemporary challenges, fostering innovative, contextually adaptive strategies to enhance teaching, learning, and research outcomes in an ever-evolving societal landscape.
  • Rutin attenuates oxidative damage-induced renal injury in rats experimentally infected with Cryptococcus neoformans by improving antioxidant capacity and reducing fungal burden
    Rafaela da Silva Rangel, Raquel Tusi Tamiosso, Rúbia Schallenberger da Silva, Laís Suarez da Silva de Oliveira, Maria Fernanda Biscarra Bortolotto Paz, Teodoro Trevisan De Paula Martins, Alice Mazaro, Alana Bianca de Moraes Chitolina, Marina Machado Maurente, Cinthia Melazzo de Andrade, Jandora Lima Ortiz, Isabela Maraschin Vieira, Marcelo Leite da Veiga, Matheus Dellaméa Baldissera
    Microbial Pathogenesis, 2025