Cardioprotective Effects of Gallic Acid on an Isoprenaline-Induced Myocardial Infarction Rat Model Abdelbaset Taher Abdelhalim, Sayed A.M. Mahmoud, Nuruddin Mohammed Nur, Mossad Abdelhak Shaban, Sherif Mansour, Suhaidah Ibrahim International Journal of Nutrition Pharmacology Neurological Diseases, 2021 The use of antioxidants to protect against a wide range of human disease, including ischemic heart disease, has moved to the forefront in cardiovascular research. Gallic acid has shown promising effects against oxidative stress-induced disease; however, its effect in ischemic heart disease has not been well-studied. We designed the current work to investigate the potential protective effect of gallic acid against isoprenaline (ISO)-induced myocardial infarction (MI). Rats were injected subcutaneously with ISO, 100 mg/kg for 2 days, to induce MI. Gallic acid treated rats received 15 mg/kg gallic acid orally for 10 days prior to ISO injection. The histopathological examination of the Hematoxylin and Eosin-stained heart sections from the ISO treated rats shows karyopyknosis, hypereosinophilia, loss of striation, infiltration of macrophage in the interstitium, and thrombosis of the blood vessels, all of which indicate the induction of MI. In addition, ISO treatment significantly increased the plasma level of malondialdehyde and troponin-I, as well as the activity of alanine aminotransferase, lactate dehydrogenase, and creatine kinase, compared to untreated controls. Pretreatment with gallic acid significantly attenuated the ISO-induced biochemical and histopathological changes, compared to untreated controls. Our results show that ISO induced oxidative stress-mediated MI, and that gallic acid protects the rat heart from MI, at least in part, through antioxidant mechanisms.
Cardioprotective effect of vitamin e against myocardial infarction induced by isoprenaline in albino rats Abdelbaset Taher Abdelhalim, Nuruddin Mohammed Nur, Sherif Mansour, Abdelnasser Ibrahim Asian Journal of Pharmaceutical and Clinical Research, 2018 Objective: Vitamin E is an antioxidant which can help in the prevention of cardiovascular disease. The objective of this study was to estimate the effects of Vitamin E on cardiac marker enzymes in isoprenaline (ISO)-induced myocardial infracted rats.Methods: Adult male albino rats were divided into three groups. The first group was the control negative group. The second group was the control positive group that was subcutaneously injected with ISO (100 mg/kg). The third group was pretreated with Vitamin E (100 mg/kg) once daily for 30 days, then subcutaneously injected with ISO at an interval of 24 h for 2 days. Aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), cardiac troponin-I (CTn-I), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and histopathological examinations were measured. Comparison between groups was achieved by one-way analysis of variance (ANOVA) test through SPSS software.Results: The levels of AST, ALT, LDH, creatine kinase (CK), and CTn-I significantly decreased in pretreated group with Vitamin E compared to its increasing in the control positive group. The level of GSH and SOD markedly increased in pretreated group with Vitamin E compared to its decreasing in the control positive group, while the level of MDA significantly decreased in pretreated group with Vitamin E compared to its increasing in the control positive group. ISO + Vitamin E rats group reflected a cardioprotective role of Vitamin E in myocardial infarcted rats.Conclusion: Pretreatment with Vitamin E can protect the myocardial membranes against ISO-induced oxidative stress in rats and can be used for routine clinical and epidemiological purposes.
Association of plasma C-Reactive Protein (CRP) and Coronary Heart Disease (CHD): A study in Bangladesh International Medical Journal, 2016
