Sandeep Kumar Dixit

@sscollegespn.ac.in

Assistant Professor
Swami Shukdevanand College Shahjahanpur

Sandeep Kumar Dixit


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https://researchid.co/sdixit_123

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Organic Chemistry, Inorganic Chemistry, General Chemistry
8

Scopus Publications

475

Scholar Citations

7

Scholar h-index

6

Scholar i10-index

Scopus Publications

  • Fluorescent probe 7-(prop-2-yn-1-yloxy)-2H-chromen-2-one: Experimental and DFT based approach to photophysical properties
    Neesha Yadav, Shailja Singh, Shrawan Kumar Mangawa, Sandeep K. Dixit, Ujval Gupta, Yugal Khajuria, Satish Kumar Awasthi
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2015
  • In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; Their antiplasmodial action in rodent malaria model
    Drishti Agarwal, Manish Sharma, Sandeep K Dixit, Roshan K Dutta, Ashok K Singh, Rinkoo D Gupta, Satish K Awasthi
    Malaria Journal, 2015
    BACKGROUND: Emergence of drug-resistant parasite strains has surfaced as a major obstacle in attempts to ameliorate malaria. Current treatment regimen of malaria relies on the concept of artemisinin-based combination therapy (ACT). METHODS: Fluoroquinolone analogues, compounds 10, 12 and 18 were investigated for their anti-malarial interaction in combination with artemisinin in vitro, against Plasmodium falciparum 3D7 strain, employing fixed-ratio combination isobologram method. In addition, the efficacy of these compounds was evaluated intraperitoneally in BALB/c mice infected with chloroquine-resistant Plasmodium berghei ANKA strain in the Peters' four-day suppressive test. RESULTS: Promising results were obtained in the form of synergistic or additive interactions. Compounds 10 and 12 were found to have highly synergistic interactions with artemisinin. Antiplasmodial effect was further verified by the convincing ED50 values of these compounds, which ranged between 2.31 and 3.09 (mg/kg BW). CONCLUSIONS: In vivo studies substantiated the potential of the fluoroquinolone derivatives to be developed as synergistic partners for anti-malarial drug combinations.
  • Characterization & evaluation of antibacterial, Antifungal activity of environment friendly capparis decidua microemulsion
    International Journal of Pharmacy and Pharmaceutical Sciences, 2015
  • An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim]HSO4 Dedicated to my mentor Professor (Mrs.) Krishna Misra on her 76th birthday
    Satyanand Kumar, Sandeep Kumar Dixit, Satish Kumar Awasthi
    Tetrahedron Letters, 2014
  • Synthesis and antibacterial activity of novel fluoroquinolone analogs
    Sandeep Kumar Dixit, Neesha Yadav, Satyanand Kumar, Liam Good, Satish K. Awasthi
    Medicinal Chemistry Research, 2014
  • Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro
    Neesha Yadav, Sandeep K. Dixit, Amit Bhattacharya, Lokesh C. Mishra, Manish Sharma, Satish K. Awasthi, Virendra K. Bhasin
    Chemical Biology and Drug Design, 2012
    Twenty‐seven novel chalcone derivatives were synthesized using Claisen‐Schmidt condensation and their antimalarial activity against asexual blood stages of Plasmodium falciparum was determined. Antiplasmodial IC50 (half‐maximal inhibitory concentration) activity of a compound against malaria parasites in vitro provides a good first screen for identifying the antimalarial potential of the compound. The most active compound was 1‐(4‐benzimidazol‐1‐yl‐phenyl)‐3‐(2, 4‐dimethoxy‐phenyl)‐propen‐1‐one with IC50 of 1.1 μg/mL, while that of the natural phytochemical, licochalcone A is 1.43 μg/mL. The presence of methoxy groups at position 2 and 4 in chalcone derivatives appeared to be favorable for antimalarial activity as compared to other methoxy‐substituted chalcones. Furthermore, 3, 4, 5‐trimethoxy groups on chalcone derivative probably cause steric hindrance in binding to the active site of cysteine protease enzyme, explaining the relative lower inhibitory activity.
  • Synthesis and in vitro antiplasmodial activities of fluoroquinolone analogs
    Sandeep K. Dixit, Nidhi Mishra, Manish Sharma, Shailja Singh, Alka Agarwal, Satish K. Awasthi, V.K. Bhasin
    European Journal of Medicinal Chemistry, 2012
  • Short report: antifilarial activity of 1,3-diarylpropen-1-one: effect on glutathione-s-transferase, a phase ii detoxification enzyme
    Satish K. Awasthi, Nidhi Mishra, Sandeep Kumar Dixit, Alka Singh, Marshleen Yadav, Sudhanshu S. Yadav, Sushma Rathaur
    American Journal of Tropical Medicine and Hygiene, 2009
    Chalcone derivatives were evaluated for their antifilarial activity on Setaria cervi using glutathione-S-transferase (GST) as a drug target. The compounds 1-(4-benzotriazol-1-yl-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (5), and 3-(4-methoxyphenyl)-1-(4-pyrrolidin-1-yl-phenyl) prop-2-en-1-one (7) showed a significant suppression (P < 0.01) in GST activity of adult female parasite extract at 3 μM concentration in vitro. However, GST activity was detected along with depletion in GSH level. Except Compounds 1 and 2, all exhibited a significant effect on the motility and viability of adult parasites. Compounds 3-(4-chlorophenyl)-1-(4-piperidin-1-yl-phenyl)prop-2-en-1-one (3), 1-(4-benzotriazol-1-yl-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (5), and 3-(4-methoxyphenyl)-1-(4-pyrrolidin-1-yl-phenyl) prop-2-en-1-one (7) exhibited major irreversible effects on viability and resulted in parasite death and also inhibited the GST activity by 84–100% in vitro. We report for the first time the antifilarial activity of chalcones on GST of adult parasites. This study also strengthens our previous findings where GST is reported as a potential drug target for antifilarials.

RECENT SCHOLAR PUBLICATIONS

  • COUNTERING TUMOR CELLS USING SILVER NANOPARTICLES: A REVIEW
    AKSSK Dixit
    International journal of scientific research 12 (3), 35-36 , 2023
    2023.0
  • Fluorescent probe 7-(prop-2-yn-1-yloxy)-2H-chromen-2-one: Experimental and DFT based approach to photophysical properties
    N Yadav, S Singh, SK Mangawa, SK Dixit, U Gupta, Y Khajuria, ...
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 148, 311-317 , 2015
    2015.0
    Citations: 9
  • In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum ; their antiplasmodial action in rodent …
    D Agarwal, M Sharma, SK Dixit, RK Dutta, AK Singh, RD Gupta, ...
    Malaria Journal 14 (1), 48 , 2015
    2015.0
    Citations: 32
  • Green synthesis of silver nano particles by using Capparis decidua extract and its antibacterial studies
    K Punita, SK Dixit, S Dixit, R Prajapati, SK Raza, T LK
    African Journal of Science and Research 4 (6), 13-15 , 2015
    2015.0
    Citations: 2
  • Synthesis and antibacterial activity of novel fluoroquinolone analogs
    SK Dixit, N Yadav, S Kumar, L Good, SK Awasthi
    Medicinal Chemistry Research 23 (12), 5237-5249 , 2014
    2014.0
    Citations: 12
  • An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim] HSO4
    S Kumar, SK Dixit, SK Awasthi
    Tetrahedron Letters 55 (28), 3802-3804 , 2014
    2014.0
    Citations: 36
  • Euphorbia Tirucalli Traditional use: An overview
    SK Dixit, P Kumari, S Dixit, R Prajapati, SK Raza, LK Thakur
    Journal of Applicable Chemistry 3 (1), 228-236 , 2014
    2014.0
  • Characterization & evaluation of antibacterial, antifungal activity of environment friendly Capparis decidua microemulsion
    SK Dixit, P Kumari, R Prajapti, SK Raza, LK Thakur
    International Journal of Pharmacy and Pharmaceutical Sciences 17 (1), 255-7 , 2014
    2014.0
    Citations: 6
  • Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro
    N Yadav, SK Dixit, A Bhattacharya, LC Mishra, M Sharma, SK Awasthi, ...
    Chemical biology & drug design 80 (2), 340-347 , 2012
    2012.0
    Citations: 200
  • Synthesis and in vitro antiplasmodial activities of fluoroquinolone analogs
    SK Dixit, N Mishra, M Sharma, S Singh, A Agarwal, SK Awasthi, ...
    European journal of medicinal chemistry 51, 52-59 , 2012
    2012.0
    Citations: 71
  • Antifilarial activity of 1, 3-diarylpropen-1-one: effect on glutathione-S-transferase, a phase II detoxification enzyme
    SK Awasthi, N Mishra, SK Dixit, A Singh, M Yadav, SS Yadav, S Rathaur
    The American journal of tropical medicine and hygiene 80 (5), 764-768 , 2009
    2009.0
    Citations: 107
  • INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES
    S Dixit, SK Dixit, R Prajapti, SK Raza, LK Thakur
  • Prohibition of toxic chemicals for sustainable environment
    B Pani, SK Dixit, J Singh

MOST CITED SCHOLAR PUBLICATIONS

  • Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro
    N Yadav, SK Dixit, A Bhattacharya, LC Mishra, M Sharma, SK Awasthi, ...
    Chemical biology & drug design 80 (2), 340-347 , 2012
    2012.0
    Citations: 200
  • Antifilarial activity of 1, 3-diarylpropen-1-one: effect on glutathione-S-transferase, a phase II detoxification enzyme
    SK Awasthi, N Mishra, SK Dixit, A Singh, M Yadav, SS Yadav, S Rathaur
    The American journal of tropical medicine and hygiene 80 (5), 764-768 , 2009
    2009.0
    Citations: 107
  • Synthesis and in vitro antiplasmodial activities of fluoroquinolone analogs
    SK Dixit, N Mishra, M Sharma, S Singh, A Agarwal, SK Awasthi, ...
    European journal of medicinal chemistry 51, 52-59 , 2012
    2012.0
    Citations: 71
  • An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim] HSO4
    S Kumar, SK Dixit, SK Awasthi
    Tetrahedron Letters 55 (28), 3802-3804 , 2014
    2014.0
    Citations: 36
  • In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum ; their antiplasmodial action in rodent …
    D Agarwal, M Sharma, SK Dixit, RK Dutta, AK Singh, RD Gupta, ...
    Malaria Journal 14 (1), 48 , 2015
    2015.0
    Citations: 32
  • Synthesis and antibacterial activity of novel fluoroquinolone analogs
    SK Dixit, N Yadav, S Kumar, L Good, SK Awasthi
    Medicinal Chemistry Research 23 (12), 5237-5249 , 2014
    2014.0
    Citations: 12
  • Fluorescent probe 7-(prop-2-yn-1-yloxy)-2H-chromen-2-one: Experimental and DFT based approach to photophysical properties
    N Yadav, S Singh, SK Mangawa, SK Dixit, U Gupta, Y Khajuria, ...
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 148, 311-317 , 2015
    2015.0
    Citations: 9
  • Characterization & evaluation of antibacterial, antifungal activity of environment friendly Capparis decidua microemulsion
    SK Dixit, P Kumari, R Prajapti, SK Raza, LK Thakur
    International Journal of Pharmacy and Pharmaceutical Sciences 17 (1), 255-7 , 2014
    2014.0
    Citations: 6
  • Green synthesis of silver nano particles by using Capparis decidua extract and its antibacterial studies
    K Punita, SK Dixit, S Dixit, R Prajapati, SK Raza, T LK
    African Journal of Science and Research 4 (6), 13-15 , 2015
    2015.0
    Citations: 2
  • COUNTERING TUMOR CELLS USING SILVER NANOPARTICLES: A REVIEW
    AKSSK Dixit
    International journal of scientific research 12 (3), 35-36 , 2023
    2023.0
  • Euphorbia Tirucalli Traditional use: An overview
    SK Dixit, P Kumari, S Dixit, R Prajapati, SK Raza, LK Thakur
    Journal of Applicable Chemistry 3 (1), 228-236 , 2014
    2014.0
  • INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES
    S Dixit, SK Dixit, R Prajapti, SK Raza, LK Thakur
  • Prohibition of toxic chemicals for sustainable environment
    B Pani, SK Dixit, J Singh