Ts DR MOHAMAD HALIM BIN MOHAMAD SHARIFF

Scopus Publications

The Effect of Difference Training Intensity on Increased Adiponectin Levels in High-fructose-induced Mice (Mus musculus)
Dwi Indah Puspita, Purwo Sri Rejeki, Gadis Meinar Sari, Misbakhul Munir, Nabilah Izzatunnisa, et al.
Revista De Investigacion E Innovacion En Ciencias De La Salud, 2025
Introduction. The consumption of fructose in excessive quantities has been implicated in the onset of obesity and a spectrum of metabolic dysfunctions. Physical exercise is posited as a potent intervention to ameliorate obesity-induced metabolic anomalies, ostensibly through the elevation of adiponectin concentrations. However, the underlying molecular mechanisms of this effect remain inadequately understood. Objective. This study aims to demonstrate the impact of exercise intensity on increasing adiponectin levels in high-fructose-induced mice, highlighting the underlying molecular mechanisms. Methods. The experiment was carried out on 36 male mice (Mus musculus), aged ±8 weeks, with body weight ± 20 – 25 grams, in healthy condition and without defects. Mice were randomly divided into four groups. Control group without training (CN; n = 9); the low-intensity swimming training group with a 3% load of the mice's body weight (LI; n = 9); the moderate-intensity swimming training group with a 6% load of the mice's body weight (MI; n = 9); the heavy intensity swimming training group with a 9% load of the mice's body weight (HI; n = 9). The frequency of swimming training was carried out 3 times/week for 8 weeks, and the duration of swimming training was calculated as 80% of the maximum swimming time every session. All groups were orally (oral ad libitum) given 30% fructose solution for 8 weeks. Adiponectin levels were quantified via ELISA. Statistical interrogation employed one-way ANOVA and Tukey's HSD post hoc test, with a significance threshold set at 5%. Results. The results indicated a statistically significant divergence in adiponectin levels (p ≤ 0.001). Tukey's HSD post hoc test analysis revealed substantial disparities between CN and LI (p = 0.196), CN and MI (p = 0.0001), CN and HI (p = 0.001), LI and MI (p = 0.001), LI and HI (p = 0.001), and MI and HI (p = 0.001). Conclusion. This study found that moderate-intensity swimming training was more optimal in increasing adiponectin levels in fructose-induced mice compared to high-intensity, low-intensity, and control groups. Additionally, this research identified specific molecular pathways activated by moderate-intensity training, providing new insights for therapeutic interventions in tackling obesity-related metabolic dysfunctions.
Effects of Short-Term (20-Day) Alternate-Day Modified Fasting and Time-Restricted Feeding on Fasting Glucose and IGF-1 in Obese Young Women
Dian Aristia Rachmayanti, Purwo Sri Rejeki, Raden Argarini, Hermina Novida, Sri Soenarti, et al.
Diseases, 2025
Background: Obesity is a metabolic condition that may impair insulin sensitivity and disrupt glucose homeostasis. Since insulin and glucose affect insulin-like growth factor-1 (IGF-1), disruptions in this axis may elevate the risk of chronic diseases. Intermittent fasting (IF) modulates metabolic parameters, but the impacts on glucose regulation and IGF-1 remain underexplored. This study aimed to assess the short-term effects of two IF types, time-restricted feeding (TRF) and alternate-day modified fasting (ADMF), on fasting blood glucose (FBG) and IGF-1 in obese young women. Methods: A quasi-experimental pretest–posttest control group design was conducted over 20 days. The 31 subjects were allocated into ADMF (n = 10), TRF (n = 11), and Control (n = 10). After excluding dropouts and outliers, the final sample consisted of 22 subjects (ADMF = 7, TRF = 8, Control = 7). FBG and IGF-1 serum were measured pre- and post-intervention. Results: The FBG post-intervention significantly increased in TRF (p = 0.001) and ADMF (p = 0.036) groups, but not in Controls. Only the TRF group showed a significant reduction in IGF-1 levels (p < 0.001). Nevertheless, the ADMF group exhibited substantial decreases in body weight (p = 0.047) and visceral fat (p = 0.017). Conclusions: A 20-day IF in obese young women induced distinct metabolic effects: TRF lowered IGF-1, ADMF reduced adiposity, and both regimens increased FBG. These findings suggest that early changes in glucose regulation are highly dependent on the specific dietary regimen used. Specifically, TRF predominantly influences endocrine regulation (IGF-1 axis), while ADMF favours adiposity reduction. The concurrent rise in FBG may reflect a transient shift in glucose homeostasis during the early stages of fasting.
Ameliorative Effects of Olea europaea Oil on Morphine Withdrawal: Behavioural, Biochemical and Histological Evidence in Rats
Mohamad Halim Mohamad Shariff, Lavanya Bas Kara Rao, Purwo Sri Rejeki, Dwi Wahyu Indriati, Almanfaluthi Muhammad, et al.
Iium Medical Journal Malaysia, 2025
INTRODUCTION: Prolonged morphine use can trigger dependence and addiction leading to severe withdrawal symptoms upon cessation. Oxidative stress is a key factor in its pathogenesis. Olea europaea (olive) oil, rich in polyphenols and oleuropein, exhibits antioxidant, anti-inflammatory and neuroprotective properties. Thus, this study aimed to evaluate the effects of Olea europaea oil in alleviating morphine withdrawal symptoms in morphine-dependent rats. MATERIALS AND METHODS: A total of eighteen rats were randomly divided into three groups. The control group received normal saline, while the positive control group received intraperitoneal injections of morphine sulphate (2.5 mg/kg to 50 mg/kg) for seven days. The treatment group received the same morphine doses followed by oral administration of 250 mg/kg Olea Europaea oil for twenty-one days during morphine withdrawal period. Spontaneous morphine withdrawal behaviours of rats were observed. Subsequently the rats were sacrificed and the brain tissue was stained with H&E for histological markers. Blood serum and brain tissue were collected for Glutathione (GSH) level measurement using an ELISA kit. The findings were analysed using GraphPad Prism. RESULTS: The administration of Olea Europaea oil significantly reduced (p<0.05) spontaneous withdrawal symptoms. Findings show that Olea Europaea oil ameliorated histological brain signs of morphine toxicity and GSH levels in the brain tissue of the treated group were significantly higher (p<0.05) compared to the no treatment group. CONCLUSION: This study demonstrates that Olea Europaea oil supplementation significantly alleviates morphine withdrawal symptoms and restores antioxidant capacity likely due to its potent antioxidant and neuroprotective properties.
The Effects of Time-Restricted Eating and Alternate-Day Modified Fasting on Interferon-γ and Interleukin-10 Levels in Young Asian Women with Obesity: A Quasi-Experimental Study
Chy’as Diuranil Astrid Permataputri, Purwo Sri Rejeki, Raden Argarini, Shariff Halim, Sheeny Priska Purnomo, et al.
Immuno, 2025
Background/Objectives: Obesity induces chronic low-grade inflammation marked by elevated pro-inflammatory cytokines, such as interferon-gamma (IFN-γ), and reduced anti-inflammatory cytokines like interleukin-10 (IL-10), contributing to immune dysregulation. Intermittent fasting (IF) may restore immune balance through metabolic and circadian mechanisms. This study compared the effects of time-restricted eating (TRE) and alternate-day modified fasting (ADMF) on IFN-γ and IL-10 levels in young women with obesity. Methods: A 20-day quasi-experimental study with a pretest–posttest control group design included 23 non-diabetic women with obesity (aged 18–25 years; BMI ≥ 25 kg/m2 according to the Asia-Pacific classification), randomized into control (n = 8), TRE 18:6 (n = 8), and ADMF (n = 7) groups. IFN-γ and IL-10 serum levels were measured pre- and post-intervention using ELISA kits. Results: TRE significantly reduced IFN-γ levels (p = 0.025), while no significant change was observed in the ADMF or control groups. No significant changes were found in IL-10 levels. Conclusions: TRE effectively reduced pro-inflammatory IFN-γ levels without significantly altering anti-inflammatory IL-10 levels, suggesting an anti-inflammatory effect primarily mediated through suppression of IFN-γ rather than IL-10 upregulation. The absence of significant IL-10 changes may reflect complex immunoregulatory dynamics in obesity. ADMF showed no significant immunomodulatory impact. These findings support TRE as a promising non-pharmacologic strategy to attenuate inflammation and improve immune balance in young women with obesity.
The Pharmacological Potential of Marantodes pumilum: A Comprehensive Review of Its Medicinal Properties
Siti Hajar Adam, Nor Syaza Syahirah Amat Junaidi, Shariff Halim, Nurul Farisha Ramli, Mohd Helmy Mokhtar
International Journal of Molecular Sciences, 2025
Marantodes pumilum (MP) is one of the traditional plants to which various medicinal properties are attributed. Studies on the medicinal properties of MP and its characteristics are becoming more extensive and are attracting more and more attention. In this review, the findings on the pharmacological properties of MP have been summarised and analysed. The results show that in addition to its phytoestrogenic effects on the female reproductive system, MP also has bone-remodelling properties, anti-obesity, anti-cancer, anti-gout, antimicrobial, anti-inflammatory and wound-healing effects, as well as effects on the cardiovascular system. These findings show that MP has great potential for the prevention and complementary treatment of various diseases. However, further research is needed to explore its full clinical potential.
Regulation of Metabolic Aging Through Adenosine Mono Phosphate-Activated Protein Kinase and Mammalian Target of Rapamycin: A Comparative Study of Intermittent Fasting Variations in Obese Young Women
Sheeny Priska Purnomo, Purwo Sri Rejeki, Raden Argarini, Shariff Halim, Dian Aristia Rachmayanti, et al.
Nutrients, 2025
Background/Objectives: Obesity accelerates metabolic aging through oxidative stress, inflammation, and mitochondrial dysfunction. AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are nutrient-sensing pathways regulating metabolism. AMPK promotes energy metabolism and autophagy, while excessive mTOR activity contributes to aging. Intermittent fasting (IF), including time-restricted feeding (TRF)—limiting food intake to a 6 h window (18:6)—and alternate-day modified fasting (ADMF)—alternating 24 h fasting (≤25% daily caloric intake) with unrestricted feeding—may improve metabolic regulation. However, their effects on AMPK, mTOR, and metabolic age remain unclear. Methods: This quasi-experimental pre-test–post-test control group study compared the TRF and ADMF on metabolic age, AMPK, and mTOR in young obese women. Twenty-four participants (mean age: 21.29 ± 1.76 years; body fat: 36.92 ± 3.18%; BMI: 29.68 ± 3.70 kg/m2) were initially matched by BMI and assigned to Control, TRF, and ADMF groups. A total of 4 participants (1 Control, 3 ADMF) were excluded due to outlier values, yielding final group sizes: Control (n = 7), TRF (n = 8), and ADMF (n = 5). The intervention lasted 20 days. Results: A significant decrease in AMPK levels was observed in the ADMF group (p = 0.043), while changes in the TRF and Control groups were not significant. mTOR levels showed a decreasing trend but were not statistically significant. No significant changes were found in metabolic age. Conclusions: Twenty days of intermittent fasting intervention did not significantly affect AMPK, mTOR, or metabolic age in young obese women. TRF may more effectively enhance AMPK and reduce mTOR, while ADMF may better reduce metabolic age.
Herbal medicine and leptospirosis in Southeast Asia: a comprehensive bibliometric analysis (1973-2023)
Putri Ade Dian Shah, Widodo Stefani, Damayanti Irma Putri, Shariff Halim, Safithri Abidah, et al.
Bio Web of Conferences, 2025
This study provides a bibliometric analysis of research on herbal medicine and leptospirosis in Southeast Asia from 1973 to 2023. The investigation identified 3,043 documents through a systematic search in the Scopus database using keywords. One hundred forty-seven papers were published across 100 different sources, revealing an annual growth rate of 6.07%, indicating a growing interest in the intersection of herbal medicine and leptospirosis. The study shows significant collaboration, with 935 authors contributing to the body of research and an average of 7.55 co-authors per document. Notably, 40.14% of the publications involve international co-authorship, reflecting the global relevance and collaborative efforts in addressing leptospirosis through herbal remedies. Keyword analysis highlights “leptospirosis,” “leptospira,” and “DNA extraction” as central themes, demonstrating a focus on the genetic and diagnostic aspects of the disease alongside the exploration of plant-based treatments. The research also emphasizes the role of preclinical studies and the chemical analysis of herbal remedies for leptospirosis. The study identifies key contributors to the field, with prolific authors such as Chee HY, Sekawi Z, and Patarakul K leading the research efforts. Malaysia, Thailand, and Japan are highlighted as the most productive countries, significantly contributing to this domain’s research output and citation impact.
Herbal medicine and snakebite research in Southeast Asia: a bibliometric analysis (1974-2024)
Aflah Ilham Jaluludin, Widodo Stefani, Damayanti Irma Putri, Shariff Halim, Safithri Abidah, et al.
Bio Web of Conferences, 2025
This study presents a bibliometric analysis of research on herbal medicine and snakebite in Southeast Asia, focusing on publications from 1974 to 2023. The investigation involved 205 documents selected using specific keywords in the Scopus database. After applying inclusion criteria such as language and regional focus, the final selection yielded 202 documents across 145 sources. The analysis reveals an annual growth rate of 4.25%, indicating a steady increase in research interest over the past five decades. With contributions from 1,049 authors and an average of 6.08 coauthors per document, the field exhibits a high level of collaboration. Notably, nearly half of the publications (49.5%) involve international coauthorship, underscoring the global significance of the research in this domain. Keyword analysis identified “snakebite,” “venom,” and “medicinal plants” as central themes. The research also emphasizes preclinical studies, which are crucial for understanding the efficacy and safety of herbal remedies for snakebite treatment. The study further identifies key contributors to the field, with prolific authors such as Tan NH, Pithayanukul P, and Gopalakrishnakone P leading the scholarly discourse. Malaysia, Thailand, and Singapore are highlighted as the most productive countries, contributing significantly to the research output and citation impact.
A Mechanistic Review on Toxicity Effects of Methamphetamine
Fitri Fareez Ramli, Purwo Sri Rejeki, Nurul 'Izzah Ibrahim, Gulnar Abdullayeva, Shariff Halim
International Journal of Medical Sciences, 2025
The impact of aerobic exercise on enhancing SIRT1 and SIRT3 in the blood circulation among individuals with obesity
U. Al Qorni, N.R. Ardy, A. Nirwana, A.R. Sari, D. Damayanti, et al.
Comparative Exercise Physiology, 2025
Obesity is associated with a decrease in the levels of sirtuin 1 (SIRT1) and SIRT3 proteins. This reduction can impair the activity of SIRT1 and SIRT3, leading to diminished antioxidant defense, increased oxidative stress, disrupted fatty acid oxidation, and reduced energy expenditure. These changes can contribute to positive energy balance and long-term weight gain. This study aims to investigate the impact of moderate-intensity exercise on enhancing SIRT1 and SIRT3 levels in obese women. The method used in this research is a true-experimental design involving 20 obese women aged 20-30 years, divided into two experimental groups: the control group (CG, n = 10) and the exercise group (EXG, n = 10). The intervention consisted of 40 min of moderate-intensity exercise (60-70% HRmax), with a frequency of 5 times per week for 2 weeks. ELISA was utilised to measure SIRT1 and SIRT3 levels before and after exercise in all samples. The results showed that the average SIRT1 levels pre-exercise between CG and EXG were (1.08 ± 1.09 vs 0.89 ± 0.39 ng/ml, ), and post-exercise (1.01 ± 0.89 vs 2.32 ± 1.79 ng/ml, ) and has a large effect size with a Cohen’s d value of 0.927. SIRT3 levels pre-exercise between CG and EXG were (0.98 ± 0.77 vs 1.01 ± 0.84 ng/ml, ), and post-exercise (0.61 ± 0.21 vs 1.85 ± 1.45 ng/ml, ) and has a large effect size with a Cohen’s d value of 1.197. This study found an increase in SIRT1 and SIRT3 levels in the exercise group compared to the control group. Hence, incorporating moderate-intensity exercise can be recommended as a safe and cost-effective therapeutic strategy for managing obesity, offering a beneficial approach to improving metabolic health in obese individuals.
THE EFFECT OF NUTRITIONAL EDUCATION ON PARENTAL KNOWLEDGE OF BALANCED NUTRITION IN CHILDREN AT YAYASAN AN-NUSYUR AENG PANAS, SUMENEP MADURA
Sasha Anggita Ramadhan, Soraya Tri Widayani, Trias Mahmudiono, Amanda Fharadita Olivia Rakhmad, Ernadila Diasmarani Hargiyanto, et al.
Media Gizi Indonesia, 2024
Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females
Purwo Sri Rejeki, Adi Pranoto, Deandra Maharani Widiatmaja, Dita Mega Utami, Nabilah Izzatunnisa, et al.
Sports, 2024
Response of Pro-Inflammatory Cytokines After A Single Bout of Moderate-Intensity Endurance Exercise in Obese
Misbakhul Munir, Purwo Sri Rejeki, Adi Pranoto, Dewi Ratna Sari, Nabilah Izzatunnisa, et al.
Sport Mont, 2024
Protective Mechanism Pathway of Cinnamomum zeylanicum at High Dosage against Liver and Renal Damage in STZ-Induced Diabetic Rats
Maisarah Abdul Mutalib, Sakina Ruhi, Mohamad Halim Mohamad Shariff, Win Win May, Dhani Ramachandran
Iium Medical Journal Malaysia, 2024
Effects of moderate-intensity combination exercise on increase adiponectin levels, muscle mass, and decrease fat mass in obese women
Andre Andarianto, Purwo Sri Rejeki, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, et al.
Retos, 2024
High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity
Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, et al.
Journal of Basic and Clinical Physiology and Pharmacology, 2024
Aerobic Exercise Increases Release of Growth Hormone in the Blood Circulation in Obese Women
Adi Pranoto, Purwo Sri Rejeki, Muhammad Miftahussurur, Ghana Firsta Yosika, Mufarrihul Ihsan, et al.
Retos, 2024
The beneficial effects of six weeks of swimming exercise on growth hormone and cortisol levels in male mice (Mus musculus)
Hilda Noor Dharmasanti, Purwo Sri Rejeki, Sulistiawati Sulistiawati, Shariff Halim, Muhamad Fauzi Antoni, et al.
Retos, 2024
Moderate-Intensity exercise has most beneficial effect on inflammatory response in fructose-induced mice (Mus musculus)
Nabilah Izzatunnisa, Faiq Amirul Hakim, Wildan Maulana Ishom Putra, Purwo Sri Rejeki, Lilik Herawati, et al.
Retos, 2024
Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women
Afdhalia Rahma Sari, Rifat Danendra Risdayanto, Mohammad Haidar Pradipta, Uais Al Qorni, Purwo Sri Rejeki, et al.
Retos, 2024
The role of long-term combination training in reducing and maintaining of body fat in obese young adult women
Adi Pranoto, Roy Novri Ramadhan, Purwo Sri Rejeki, Muhammad Miftahussurur, Ghana Firsta Yosika, et al.
Retos, 2024
The Effect of Exercise Intensity on Anthropometric Parameters and Renal Damage in High Fructose-Induced Mice
Dewi Ratna Sari, Roy Novri Ramadhan, Dini Agustin, Misbakhul Munir, Nabilah Izzatunnisa, et al.
Retos, 2024
The Effect of Exercise Intensity on Pancreatic and Liver GLUT-2 Expression in High Fructose-Fed Mice
Tantia Dewi Harianto, Bagas Trio Pamungkas, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Joni Susanto, et al.
Retos, 2024
Unraveling Obesity: Transgenerational Inheritance, Treatment Side Effects, Flavonoids, Mechanisms, Microbiota, Redox Balance, and Bioavailability—A Narrative Review
Ruth Naomi, Soo Huat Teoh, Shariff Halim, Hashim Embong, Zubaidah Hasain, et al.
Antioxidants, 2023
Dietary Polyphenols as a Protection against Cognitive Decline: Evidence from Animal Experiments; Mechanisms and Limitations
Ruth Naomi, Muhammad Dain Yazid, Soo Huat Teoh, Santhra Segaran Balan, Halim Shariff, et al.
Antioxidants, 2023
The Positive Effect of Four-Week Combined Aerobic–Resistance Training on Body Composition and Adipokine Levels in Obese Females
Purwo Sri Rejeki, Adi Pranoto, Ilham Rahmanto, Nabilah Izzatunnisa, Ghana Firsta Yosika, et al.
Sports, 2023
The effect of 4 week-long swimming exercise intervention on increased serotonin levels in male mice (Mus musculus)
K.W. Wigati, M.P. Bintari, P.S. Rejeki, C.D.K. Wungu, A. Pranoto, et al.
Comparative Exercise Physiology, 2023
Knowledge, attitude, and practice of coral reef conservation among Terengganu community of Malaysia
Roy Rillera Marzo, Hana W. Jun Chen, Haryati Anuar, Mohamad Khairuddin Abdul Wahab, Mohamad Hairul Nizam Arifin, et al.
Frontiers in Environmental Science, 2023
Renal protective effect of Trigonella foenum-graecum seed extract on morphine withdrawal in rats
Sutha Sharminni A/P Krishnan, Ashok Kumar Jeppu, Shariff Halim, Thur Sina Alkesah, Kavitha Ashok Kumar, et al.
Biomedicine India, 2022
Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women
Purwo Sri Rejeki, Pradika Gita Baskara, Lilik Herawati, Adi Pranoto, Hayuris Kinandita Setiawan, et al.
Journal of Basic and Clinical Physiology and Pharmacology, 2022
Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study
Ruth Naomi, Muhammad Dain Yazid, Hasnah Bahari, Yong Yoke Keong, Retnagowri Rajandram, et al.
International Journal of Molecular Sciences, 2022
The Potential Role of Neuroprotective Effects of Kratom (Mitragyna Speciosa) on Brain Aging
Journal of Cellular and Molecular Anesthesia, 2021
Red Palm Oil Prevents Cognitive Impairment in a Rat Model of D-Galactose-Induced Aging
Journal of Cellular and Molecular Anesthesia, 2021
Potential neuroprotective effect of apis dorsata honey against morphine tolerance: An in vivo study
Journal of Cellular and Molecular Anesthesia, 2021
Elucidating the effects of olea europaea in eliminating neurotoxicity in methamphetamine (METH) induced rat
Shariff Halim, Nurin Q Roslan, Nor Amira Jasmi, Deborah Anna Van Oosterhout
International Journal of Medical Toxicology and Legal Medicine, 2021
Novel potential centella asiatica extract in ameliorating neurotoxicity induced oxidative stress in chronic morphine dependant rat model
Shariff Halim, Nor Amira Jasmi, P.M Ridzuan, Deborah Anna, Sarah Abdullah, et al.
International Journal of Medical Toxicology and Legal Medicine, 2020
Antioxidant activitiesof barringtonia racemosaleaf extract against acute morphine dependence rat model
Shariff Halim, Thur Sina, P.M Ridzuan, Deborah Anna, Sarah Abdullah, et al.
International Journal of Medical Toxicology and Legal Medicine, 2020
A review: Update on vertical transmission of HIV
Shariff Halim, Hamid Huda, Mohamed Luqman, Chee Weng Yan, Sabri Fatin
International Journal of Medical Toxicology and Legal Medicine, 2020
A review on opioid dependence, mechanism and treatments used: Option of treatments: Modern versus alternative medicine
Nor Zidah Ahmad, Khairi Che Mat, Nasir Mohamad, Rohayah Binti Husain, Nor Hidayah Abu Bakar, et al.
Bangladesh Journal of Medical Science, 2019
Potential pharmacotherapy of olea europaea (Olive) fruit oil against methamphetamine-induced neurotoxicity
Journal of Cellular and Molecular Anesthesia, 2019
In-vitro study: Camp overshoot caused by chronic morphine alleviated by the synergistic combination of zamzam water and methadone in human primary glioblastoma cell line (U-87 MG)
Iium Medical Journal Malaysia, 2019
Musa accuminata ETHONOLIC EXTRACT in ALLEVIATING MORPHINE INDUCED DEPENDENCE in RATS
Malaysian Journal of Biochemistry and Molecular Biology, 2019
The efficacy of piper aduncum extract as natural larvicides against aedes aegypti larvae
P.M. Ridzuan, H.Y. Alaina, A.R. Atika, C.M. Nazira, A. Afrina, et al.
International Journal of Medical Toxicology and Legal Medicine, 2019
Potential therapeutic effects of olea europaea (Olive) fruit oil as neuroprotective agent against neurotoxicity induced opioid
Journal of Cellular and Molecular Anesthesia, 2018
Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats
Siti Norhajah Hashim, Nasir Mohamad, Zulkifli Mustapha, Nor Hidayah Abu Bakar, Rohayah Husain, et al.
Bangladesh Journal of Medical Science, 2018
Effects of Zamzam water alone or in combination with methadone on attenuation of spontaneous withdrawal symptoms in morphine-dependent rats: A behavioural study
Shariff Halim, Nasir Mohamad, Mohd Ekhwan Toriman, Nor Hidayah Abu Bakar, Liyana Hazwani Mohd Adnan, et al.
Advanced Science Letters, 2017
Role of Zamzam water as a vital mineral supplement in the treatment of opioid dependence and tolerance: a review
Shariff Halim, Nasir Mohamad, Mohd EKhwan Toriman, Nor Hidayah Abu Bakar, Siti Norhajah Hashim, et al.
Research Journal of Pharmacy and Technology, 2016
Role of oxidative stress in opiate withdrawal and dependence: Exploring the potential use of honey
Nor Bakar, Siti Hashim, Nasir Mohamad, Rohayah Husain, Liyana Adnan, et al.
Journal of Applied Pharmaceutical Science, 2015
Analgesic effect of honey bioactive compounds and its role in reducing morphine tolerance
Nur Zakaria, Nor Ahmad, Siti Hashim, Liyana Adnan, Mohamad Shariff, et al.
Journal of Applied Pharmaceutical Science, 2015

Ts DR MOHAMAD HALIM BIN MOHAMAD SHARIFF

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