Alexandre Havt

@ufc.br

School of Medicine/ Department of Physiology and Pharmacology
Federal University of Ceara

2010 – Present Researcher at National Institute of Biomedicine of the Brazilian Semi-Arid Area
2010 – Present Researcher at Clinical Research Unit, UFC-CE.
2009 – Present Associate Professor of PhD and Master Program in Pharmacology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
2008 – Present Associate Professor of Medical Biochemistry at Federal University of Ceará, Fortaleza, CE, Brazil.
2008 – 2008 NIH-Fogarty Scholar.
2006 – 2008 Visitor Professor at the Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
2005 – 2006 Postdoctoral Fellow, Transcriptome of Venomous Animals, Department of Biochemistry, Federal University of Ceará, Fortaleza, CE, Brazil.
2003 – 2005 Postdoctoral Fellow, Molecular Biology of Cancer, Tulane University, New Orleans, LA, USA.
1999 – 2003 PhD Degree Program in Pharmacology Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil

EDUCATION

Veterinary School at State University of Ceará, Fortaleza, CE, Brazil from 1900 - 1995
Master in Pharmacology aty Federal University of Ceará, Fortaleza, CE, Brazil from 1996 to 1999
Doctorate in Pharmacology at Federal University of Ceará, Fortaleza, CE, Brazil from 1999 to 2003
Postdoctoral in Molecular Biology of Cancer at University of Tulane, New Orleans, LA - USA from 2003 to 2005
Postdoctoral in Transcriptrome of Venomous Animals at Federal University of Ceará, Fortaleza, CE, Brazil from 2005 to 2006
Postdoctoral in GWAS data analysis at University of Virginia from 2014 to 2015

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Genetics and Molecular Biology, Microbiology, Infectious Diseases, Pharmacology, Toxicology and Pharmaceutics
138

Scopus Publications

6911

Scholar Citations

41

Scholar h-index

98

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Preventive Effects of trans ‐4‐Methoxy‐β‐nitrostyrene on Monocrotaline‐Induced Pulmonary Arterial Hypertension in Rats
    MJ Rodrigues‐Silva, RJB de Siqueira, K Gonzaga‐Costa, YAS Guevara, ...
    Fundamental & Clinical Pharmacology 40 (3), e70078 , 2026
    2026
  • Post-COVID-19 Dyspepsia Is Not Due to Impairment of Duodenal Barrier Function
    LGM Saraiva, SM Paula, DSLL Feitosa, MKA de Sousa, IC Borges, ...
    Digestive Diseases 44 (2), 137-146 , 2026
    2026
  • The Protease Inhibitor Darunavir Prevents Esophagitis and Impairments in Esophageal Barrier Function in a Mouse Model of GERD
    TMAL Sales, AML Daniel, LMG da Silva, ÁX Franco, HB Costa Filho, ...
    American Journal of Physiology-Gastrointestinal and Liver Physiology , 2026
    2026
  • Integrated Resistome and Quantitative Proteomics Reveal Coordinated Resistance Architecture in MDR and XDR Gram-Negative ICU Pathogens
    AA Lima, D Silva, NE Sherman, L Nogueira, MA Clementino, A Havt, ...
    bioRxiv, 2026.04. 15.718841 , 2026
    2026
  • Research Article Insights of β-Lactams Resistance in Klebsiella pneumoniae Clinical Isolates: A Focus on Molecular Identification of Drug Resistance
    LFB Nogueira, MS Maia, MAF Clementino, IFN Lima, JLN Rodrigues, ...
    2026
  • Insights of β ‐Lactams Resistance in Klebsiella pneumoniae Clinical Isolates: A Focus on Molecular Identification of Drug Resistance
    LFB Nogueira, MS Maia, MAF Clementino, IFN Lima, JLN Rodrigues, ...
    International Journal of Microbiology 2026 (1), 2707907 , 2026
    2026
  • Impairment of Esophageal Barrier Integrity: New Insights into Esophageal Symptoms in Post-COVID-19
    DSLL Feitosa, LGM Saraiva, MKA de Sousa, LMG da Silva, IC Borges, ...
    Digestive Diseases and Sciences 70 (8), 2674-2683 , 2025
    2025
    Citations: 2
  • Comparison of the nephroprotective effect of [6]-gingerol and the [6]-gingerol-β-cyclodextrin complex against cisplatin-induced AKI
    D de Oliveira Silva, MA Lima, TM de Freitas, FCS Ferreira, AKL de Freitas, ...
    Naunyn-Schmiedeberg's Archives of Pharmacology 398 (8), 10557-10568 , 2025
    2025
  • Impact of Asymptomatic Enteroaggregative Escherichia coli Infection and Co-Pathogen Burden on Intestinal Barrier Function, Linear Growth, and Cognitive …
    AAM Lima, VLSC Urtiga, SA Ribeiro, JQS Filho, BLL Maciel, AES Alves, ...
    medRxiv, 2025.07. 04.25330823 , 2025
    2025
  • Epidemiology of Shigella species and serotypes in children: a retrospective substudy of the MAL-ED observational birth cohort study
    ETR McQuade, J Liu, M Mahfuz, A Havt, T Varghese, J Shrestha, F Kabir, ...
    The Lancet Microbe 6 (6) , 2025
    2025
    Citations: 14
  • Su1287: TOFACITINIB PRESERVES INTESTINAL BARRIER INTEGRITY THROUGH THE REDUCTION OF CLAUDIN-2 AND CLAUDIN-15 IN EXPERIMENTAL COLITIS.
    HB Costa Filho, GA Araújo, TM Sales, SM Paula, MA d Clementino, ...
    Gastroenterology 169 (1), S-731 , 2025
    2025
  • 1153: DARUNAVIR-INDUCED PEPSIN INHIBITION IN A GERD MODEL: HIF-2α DRIVEN INFLAMMATION REDUCTION AND TIGHT JUNCTION PROTEINS ENHANCING MUCOSAL INTEGRITY.
    TM Sales, LMG Silva, ÁX Franco, AM Daniel, HB Costa Filho, ...
    Gastroenterology 169 (1), S-285 , 2025
    2025
  • Restoration of colonic barrier function by tofacitinib in experimental colitis: anti-inflammatory effects and decreased expression of claudins-2 and claudin-15
    HB da Costa Filho, GAC Araújo, TMAL Sales, SM Paula, ...
    Intestinal Research 23 (4), 502-511 , 2025
    2025
    Citations: 3
  • Quantifying lactulose and mannitol using LC-MS/MS in a clinical study of children with environmental enteric disease
    L Magalhães, FAP Rodrigues, JQ Filho, R Gondim, SA Ribeiro, TBM Rôla, ...
    Brazilian Journal of Medical and Biological Research 58, e14156 , 2025
    2025
    Citations: 4
  • Time-Course physiopathology of Porthidium lansbergii lansbergii Envenomation in Swiss Webster Mice: Insights into Systemic Manifestations
    L Montealegre-Sánchez, MA Lima, A Montoya-Gómez, ...
    Science Progress 108 (1), 00368504241304205 , 2025
    2025
    Citations: 1
  • A polyphenol-rich açaí seed extract protects against 5-fluorouracil-induced intestinal mucositis in mice through the TLR-4/MyD88/PI3K/mTOR/NF-κBp65 signaling pathway
    CE da Silva Monteiro, B de Cerqueira Fiorio, FGO Silva, MFF de Souza, ...
    Nutrition Research 125, 1-15 , 2024
    2024
    Citations: 13
  • Role of β-lactamases and efflux pumps in multidrug resistance in Pseudomonas aeruginosa isolated from patients in the Intensive Care Unit in the northeast of Brazil
    M Maia, LFB Nogueira, MA Clementino, IF Lima, JK Sousa, DV Costa, ...
    2024
  • Contribution of Beta-Lactamases and Efflux Pumps to Multidrug Resistance in Pseudomonas aeruginosa Isolates from ICU Patients in Northeast Brazil
    MS Maia, LFB Nogueira, MAF Clementino, JQS Filho, IFN Lima, JK Sousa, ...
    medRxiv, 2024.04. 23.24306233 , 2024
    2024
    Citations: 2
  • Induced acute hyperglycemia modifies the barrier function of the intestinal epithelium by tissue inflammation and tight junction disruption resulting in hydroelectrolytic …
    F Siqueira, FAP Rodrigues, SA Ribeiro, HN Veras, FCS Ferreira, ...
    Brazilian Journal of Medical and Biological Research 57, e13309 , 2024
    2024
    Citations: 7
  • A new murine undernutrition model based on complementary feeding of undernourished children causes damage to the morphofunctional intestinal epithelium barrier
    SA Ribeiro, ELR Braga, ML Queiroga, MA Clementino, XMQC Fonseca, ...
    The Journal of Nutrition 154 (4), 1232-1251 , 2024
    2024
    Citations: 8

MOST CITED SCHOLAR PUBLICATIONS

  • Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED). Lancet Glob Health. 2015; 3 (9): e564–75
    JA Platts-Mills, S Babji, L Bodhidatta, J Gratz, R Haque, A Havt, ...
    S2214-109X (15), 00151-5 , 0
    Citations: 1045
  • Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis …
    JA Platts-Mills, J Liu, ET Rogawski, F Kabir, P Lertsethtakarn, M Siguas, ...
    The Lancet Global Health 6 (12), e1309-e1318 , 2018
    2018.0
    Citations: 436
  • Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal …
    ET Rogawski, J Liu, JA Platts-Mills, F Kabir, P Lertsethtakarn, M Siguas, ...
    The Lancet Global Health 6 (12), e1319-e1328 , 2018
    2018.0
    Citations: 413
  • Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study
    MN Kosek, T Ahmed, Z Bhutta, L Caulfield, R Guerrant, E Houpt, G Kang, ...
    EBioMedicine 18, 109-117 , 2017
    2017.0
    Citations: 283
  • Biomarkers of environmental enteropathy, inflammation, stunting, and impaired growth in children in northeast Brazil
    RL Guerrant, AM Leite, R Pinkerton, PHQS Medeiros, PA Cavalcante, ...
    PloS one 11 (9), e0158772 , 2016
    2016.0
    Citations: 253
  • Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study
    C Amour, J Gratz, E Mduma, E Svensen, ET Rogawski, M McGrath, ...
    Clinical infectious diseases 63 (9), 1171-1179 , 2016
    2016.0
    Citations: 218
  • Determinants and Impact of Giardia Infection in the First 2 Years of Life in the MAL-ED Birth Cohort
    ET Rogawski, LA Bartelt, JA Platts-Mills, JC Seidman, A Samie, A Havt, ...
    Journal of the Pediatric Infectious Diseases Society 6 (2), 153-160 , 2017
    2017.0
    Citations: 214
  • Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition
    MD DeBoer, RJ Scharf, AM Leite, A Férrer, A Havt, R Pinkerton, AA Lima, ...
    Nutrition 33, 248-253 , 2017
    2017.0
    Citations: 211
  • The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues
    A Havt, AV Schally, G Halmos, JL Varga, GL Toller, JE Horvath, ...
    Proceedings of the National Academy of Sciences of the United States of … , 2005
    2005.0
    Citations: 155
  • Early childhood cognitive development is affected by interactions among illness, diet, enteropathogens and the home environment: findings from the MAL-ED birth cohort study
    AM Acosta, RR De Burga, CB Chavez, JT Flores, MP Olotegui, SR Pinedo, ...
    BMJ Global Health 3 (4) , 2018
    2018.0
    Citations: 126
  • Microbiologic methods utilized in the MAL-ED cohort study
    E Houpt, J Gratz, M Kosek, AKM Zaidi, S Qureshi, G Kang, S Babji, ...
    Clinical Infectious Diseases 59 (suppl_4), S225-S232 , 2014
    2014.0
    Citations: 115
  • Norovirus infection and acquired immunity in 8 countries: results from the MAL-ED study
    S Rouhani, P Peñataro Yori, M Paredes Olortegui, M Siguas Salas, ...
    Clinical Infectious Diseases 62 (10), 1210-1217 , 2016
    2016.0
    Citations: 114
  • Prevalence of enteroaggregative Escherichia coli and its virulence-related genes in a case–control study among children from north-eastern Brazil
    IFN Lima, N Boisen, JQ Silva, A Havt, EB de Carvalho, AM Soares, ...
    Journal of medical microbiology 62 (5), 683-693 , 2013
    2013.0
    Citations: 112
  • Gingerol fraction from Zingiber officinale protects against gentamicin-induced nephrotoxicity
    FAP Rodrigues, MMG Prata, ICM Oliveira, NTQ Alves, REM Freitas, ...
    Antimicrobial agents and chemotherapy 58 (4), 1872-1878 , 2014
    2014.0
    Citations: 106
  • Epidemiology of enteroaggregative Escherichia coli infections and associated outcomes in the MAL-ED birth cohort
    ET Rogawski, RL Guerrant, A Havt, IFN Lima, PHQS Medeiros, ...
    PLoS neglected tropical diseases 11 (7), e0005798 , 2017
    2017.0
    Citations: 103
  • Epidemiology and risk factors for cryptosporidiosis in children from 8 low-income sites: results from the MAL-ED study
    PS Korpe, C Valencia, R Haque, M Mahfuz, M McGrath, E Houpt, M Kosek, ...
    Clinical Infectious Diseases 67 (11), 1660-1669 , 2018
    2018.0
    Citations: 99
  • Transcriptome analysis in venom gland of the predatory giant ant Dinoponera quadriceps: Insights into the polypeptide toxin arsenal of hymenopterans
    AFC Torres, C Huang, CM Chong, SW Leung, ÁRB Prieto-da-Silva, ...
    PLoS One 9 (1), e87556 , 2014
    2014.0
    Citations: 82
  • Update on molecular epidemiology of Shigella infection
    IFN Lima, A Havt, AAM Lima
    Current opinion in gastroenterology 31 (1), 30-37 , 2015
    2015.0
    Citations: 75
  • Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom
    PSF Barbosa, AMC Martins, A Havt, DO Toyama, J Evangelista, ...
    Toxicon 46 (4), 376-386 , 2005
    2005.0
    Citations: 75
  • Urinary N -methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children
    J Mayneris-Perxachs, AAM Lima, RL Guerrant, ÁM Leite, AF Moura, ...
    Scientific reports 6 (1), 19780 , 2016
    2016.0
    Citations: 73