Daria

@sechenov.ru

Department of Faculty Therapy No. 2, I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Daria


            Download Compact PDF  
https://researchid.co/dashaakv

RESEARCH, TEACHING, or OTHER INTERESTS

Cardiology and Cardiovascular Medicine
2

Scopus Publications

Scopus Publications

  • Ectopic adipose tissue: association of obesity phenotypes with integral metabolic indices of obesity
    V. I. Podzolkov, A. E. Bragina, Yu. N. Rodionova, K. K. Osadchiy, M. K. Vasilchenko, Zh. M. Sizova, E. V. Mospanova, N. S. Litvinenko, I. D. Muradova, D. V. Akvitskaya
    Rational Pharmacotherapy in Cardiology, 2024
    Aim. To study the relationship and predictive value of integral metabolic indices of obesity in the identification of ectopic obesity.Material and methods. The study included 326 patients (146 men and 180 women, mean age 61±9 years). Anthropometric data, degree of obesity, body mass index (BMI), waist circumference (WC), sagittal abdominal diameter (SAD), body obesity index (BAI), visceral obesity index (VAI), lipid accumulation index (LAP), triglycerides-glucose index (TyG) was assessed. Perivascular adipose tissue (PVAT) volume, pericardial adipose tissue (PAT) volume and thickness of perirenal fat tissue (PRF) were assessed with CT.Results. Patients were divided into groups: with isolated ectopic obesity (iEO) (n=17); with isolated abdominal obesity (iAO) (n=74); with EO variants: pericardial (PCO) (n=31), perivascular (PVO) (n=22) or perirenal (PRO) (n=33) with AO; with mixed ectopic obesity and AO (mEO+AO) (n=117), and patients without obesity (n=32). Significantly higher BMI, WC, SAD, and BAI indices were found in individuals with PCO+AO, PRO+AO and mEO+AO. The highest values of LAP were found in groups: PCO+AO, PVO+AO, PRO+AO. There was a correlation between ectopic fat depots and WC (r=0,62 for PAT, r=0,55 for PVAT and r=0,39 for PRF, p=0,01) and SAD (0,429, 0,329 and 0,435, respectively, p=0,01). Correlation was established between PAT, PRF and LAP (0,425 and 0,319, respectively, p=0,01). The highest AUC values>0,8 had models of WC and SAD in identification of PCO (0,801 and 0,801, respectively) and PRO (0,826 and 0,826, respectively). For PCO, the cut-off point of WC was 100,5 cm (specificity 72,9%, sensitivity 70,2%, p=0,000), SAD — 25 cm (specificity 73%, sensitivity 70,2%, p=0,000). For PRO, the cut-off of WC was 101 cm (specificity 71,4%, sensitivity 72,7%, p=0,000), SAD — 25 cm (specificity 71,4%, sensitivity 72,7%, p=0,000).Conclusion. Еctopic fat depots are related to the risk of metabolic disorders. Potential informative value of simple and accessible integral metabolic indices was established. WC>100,5 cm, SAD>25 cm may indicate to the presence of PCO; WC>101 cm, SAD>25 cm — to the presence of PRO.
  • Effective therapy of hypertension from the standpoint of patient-centered medicine
    V. I. Podzolkov, M. V. Vetluzhskaya, A. E. Bragina, A. A. Abramova, I. Zh. Loriya, I. D. Medvedev, D. V. Akvitskaya
    Cardiovascular Therapy and Prevention Russian Federation, 2023
    The article presents current data on the choice of antihypertensives from the standpoint of patient-centered medicine. The advantages of combined initial therapy includes high medical adherence, achievement of target blood pressure, and organ protection. Data on the effectiveness of a fixed-dose combination of an angiotensin-converting enzyme inhibitor and a thiazide-like diuretic, in particular, the most commonly used angiotensin-converting enzyme inhibitor lisinopril and long-acting indapamide, are presented. This combination is not only highly effective, but also metabolically neutral, which allows it to be used in patients with obesity, diabetes, and liver diseases. Data are presented on the new favorable effects of lisinopril and indapamide, in particular, on the effect of indapamide on the intestinal microbiota. The potential advantages of this combination as an initial therapy for hypertension in Russian patients are described.