PhD in Pharmacy. Pyatigorsk state Pharmaceutical Academy, Pyatigorsk. Awarded in 2011
RESEARCH, TEACHING, or OTHER INTERESTS
Food Science, Agricultural and Biological Sciences, Pharmaceutical Science, Plant Science
22
Scopus Publications
411
Scholar Citations
12
Scholar h-index
13
Scholar i10-index
Scopus Publications
Phenolic Profiles and Antitumor Activity against Colorectal Cancer Cells of Seeds from Selected Ribes Taxa Svetlana Lyashenko, Rosalía López-Ruiz, Ana Minerva García-Cervantes, Ignacio Rodríguez-García, Svetlana Yunusova, José Luis Guil-Guerrero Applied Sciences Switzerland, 2024 Seeds from several Ribes taxa were surveyed for phenolic compounds and in vitro antiproliferative activity against HT-29 colorectal cancer cells. Total phenolic compounds were analyzed through the Folin–Ciocalteu procedure, while LC coupled to a single mass spectrometer (MS) Orbitrap using an electrospray interface (ESI) was performed to determine the phenolic profiles. Antitumor effects were established using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Total phenolics ranged from 11.4 in R. alpinum to 94.8 mg of caffeic acid equivalents (CAE)/g in R. nigrum ‘Koksa’. Concerning phenolic compounds, four were hydroxylated benzoic acids, four cinnamic acid derivatives, eight flavonoids, and nine flavonoid glycosides. The growth inhibition against HT-29 cancer cells was exercised much better by R. nigrum ‘Koksa’ and Ribes ‘Erkeeni’ (GI50 37 and 42 µg/mL). All Ribes extracts, except for R. nigrum ‘Hara katarlik’, showed higher activity than R. rubrum (GI50 at 72 h: 99 µg/mL). Interestingly, the extract from Ribes ‘Erkeeni’, which exhibited high bioactivity, contains all detected phenolic compounds, unlike R. nigrum ‘Koksa’, which lacks only populnin. Therefore, the high bioactivity found for such extracts could be due to a synergy of all detected compounds. This work constitutes a comprehensive action for expanding knowledge on the phenolic profiles and antitumor activity of GLA-rich Ribes seeds.
Screening of Lesser-Known Salted–Dried Fish Species for Fatty Acids, Tocols, and Squalene Svetlana Lyashenko, Tarik Chileh-Chelh, Miguel Ángel Rincón-Cervera, Svetlana P. Lyashenko, Zalina Ishenko, Oleg Denisenko, Valentina Karpenko, Irene Torres-García, José Luis Guil-Guerrero Foods, 2023 The fillets and roes of 29 species of dry-salted fishes consumed in Eurasian countries were analyzed for fatty acids (FAs), tocols, and squalene, looking for derived health benefits. FAs were analyzed by GC-FID, and tocols and squalene were analyzed by HPLC-DAD. With some exceptions, docosahexaenoic (DHA, 22:6n-3), eicosapentaenoic (EPA, 20:5n-3), and arachidonic (ARA, 20:4n-6) acids were the prominent polyunsaturated fatty acids (PUFAs). The fillets of Scardinius erythrophthalmus reached the highest amounts of total FAs, ARA, and DHA (23.1, 1.82, and 2.49 mg/100 g). The fillets of Seriola quinqueradiata showed the highest percentages of DHA (34.4% of total FAs). Nutritional quality indices for fish lipids were favorable in all samples, especially the n-6/n-3 PUFA ratio, which was below 1 in most cases. α-Tocopherol was found in all fillets and roes, especially in Cyprinidae and Pleuronectidae species, and the highest value was found in the roes of Abramis brama (5.43 mg/100 g). Most samples contained tocotrienols at trace levels. The fillets of Clupeonella cultriventris contained the highest amounts of squalene (1.83 mg/100 g). Overall, dry-salted fish stand out due to their high concentrations of ARA, EPA, and DHA, as well as for α-tocopherol concentrations in roes.
Arecaceae Seeds Constitute a Healthy Source of Fatty Acids and Phenolic Compounds Miguel Ángel Rincón-Cervera, Abdallah Lahlou, Tarik Chileh-Chelh, Svetlana Lyashenko, Rosalía López-Ruiz, José Luis Guil-Guerrero Plants, 2023 Seeds of most Arecaceae species are an underutilized raw material that can constitute a source of nutritionally relevant compounds. In this work, seeds of 24 Arecaceae taxa were analyzed for fatty acids (FAs) by GC-FID, for phenolics by HPLC-DAD and LC-MS, and for their antitumor activity against the HT-29 colorectal cancer cell line by the MTT assay. Lauric, oleic, and linoleic acids were the prominent FAs. Cocoseae species contained total FAs at 28.0–68.3 g/100 g seeds, and in other species total FAs were from 1.2 (Livistona saribus) to 9.9 g/100 g (Washingtonia robusta). Sabal domingensis, Chamaerops humilis, and Phoenix dactylifera var. Medjool had unsaturated/saturated FA ratios of 1.65, 1.33–1.78, and 1.31, respectively, and contained 7.4, 5.5–6.3, and 6.4 g FAs/100 g seeds, respectively. Thus, they could be used as raw materials for healthy oilseed production. Phenolics ranged between 39 (Livistona fulva) and 246 mg/100 g (Sabal palmetto), and of these, caffeic acid, catechin, dactylifric acid, and rutin had the highest values. (-)-Epicatechin was identified in most seed extracts by LC-MS. Hydroalcoholic extracts from five species showed a dose-dependent inhibitory effect on HT-20 cells growth at 72 h (GI50 at 1533–1968 µg/mL). Overall, Arecaceae seeds could be considered as a cheap source of health-promoting compounds.
Seed Lipids of Onosma Species from Various Climate Zones S. G. Yunusova, S. S. Lyashenko, N. I. Fedorov, M. S. Yunusov, J. L. Guil-Guerrero, O. N. Denisenko, L. M. Abramova, Zh. N. Shishlova Chemistry of Natural Compounds, 2023
Borage oil: Tocopherols, sterols and squalene in farmed and endemic-wild Borago species Dmitri Fabrikov, José Luis Guil-Guerrero, María José González-Fernández, Ignacio Rodríguez-García, Francisco Gómez-Mercado, Miguel Urrestarazu, María Teresa Lao, Miguel Ángel Rincón-Cervera, Juan E. Álvaro, Svetlana Lyashenko Journal of Food Composition and Analysis, 2019
СОВРЕМЕННЫЕ АСПЕКТЫ ПРОИЗВОДСТВА И ПЕРЕРАБОТКИ СЕЛЬСКОХОЗЯЙСТВЕННОЙ ПРОДУКЦИИ ЕВ ЖБАНОВА, ВВ АБЫЗОВ Москва 2, 332-340 , 2026 2026
СОВРЕМЕННЫЕ АСПЕКТЫ ПРОИЗВОДСТВА И ПЕРЕРАБОТКИ СЕЛЬСКОХОЗЯЙСТВЕННОЙ ПРОДУКЦИИ КЭ ГАБРИН, СС КУНЕВ Москва 2, 204-215 , 2026 2026
Antioxidant and Antitumor Activity Against Colorectal Cancer Cells of Lycium chinense Mill. Cultivated in Ukraine S Lyashenko, N Boiko, V Soloshenko, JL Guil-Guerrero Proceedings 119 (1), 8 , 2025 2025
Antioxidant and antitumor activity of Lycium chinense Linn. cultivated in Ukraine against colorectal cancer cells S Lyashenko, N Boiko, V Soloshenko, JL Guil-Guerrero MDPI , 2025 2025
Phenolic Profiles and Antitumor Activity against Colorectal Cancer Cells of Seeds from Selected Ribes Taxa S Lyashenko, R López-Ruiz, AM García-Cervantes, I Rodríguez-García, ... Applied Sciences 14 (6), 2428 , 2024 2024 Citations: 6
Screening of lesser-known salted–dried fish species for fatty acids, tocols, and squalene S Lyashenko, T Chileh-Chelh, MÁ Rincón-Cervera, SP Lyashenko, ... Foods 12 (5), 1083 , 2023 2023 Citations: 5
Screening of lesser known dry-salted fish species for fatty acids, tocopherols, and squalene S Lyashenko, T Chileh, MÁ Rincón Cervera, Z Ishenko, O Denisenko, ... MDPI , 2023 2023
Fatty acid profiling in the genus Pinus in relation to its chemotaxonomy and nutritional or pharmaceutical properties A Lahlou, S Lyashenko, T Chileh-Chelh, EH Belarbi, I Torres-García, ... Phytochemistry 206, 113517 , 2023 2023 Citations: 13
Arecaceae seeds constitute a healthy source of fatty acids and phenolic compounds MÁ Rincón-Cervera, A Lahlou, T Chileh-Chelh, S Lyashenko, ... Plants 12 (2), 226 , 2023 2023 Citations: 15
Seed Lipids of Onosma Species from Various Climate Zones SG Yunusova, SS Lyashenko, NI Fedorov, MS Yunusov, JL Guil-Guerrero, ... Chemistry of Natural Compounds 59 (1), 15-20 , 2023 2023 Citations: 4
Arecaceae fruits: Fatty acids, phenolic compounds and in vitro antitumor activity A Lahlou, T Chileh-Chelh, S Lyashenko, MÁ Rincón-Cervera, ... Food Bioscience 50, 102181 , 2022 2022 Citations: 17
Neutral Lipids of Common Borage ( Borago officinalis L.) Seeds: Stability to Oxidation During Long-Term Storage LR Yakupova, SG Yunusova, SS Lyashenko, RL Safiullin, MS Yunusov Pharmaceutical Chemistry Journal 56 (4), 475-479 , 2022 2022 Citations: 2
Buglossoides spp. seeds, a land source of health-promoting n-3 PUFA and phenolic compounds TC Chelh, S Lyashenko, A Lahlou, EH Belarbi, MA Rincon-Cervera, ... Food Research International 157, 111421 , 2022 2022 Citations: 12
Устойчивость к окислению при длительном хранении нейтральных липидов семян бурачника (Borago officinalis L.) ЛР Якупова, СГ Юнусова, СС Ляшенко, РЛ Сафиуллин, МС Юнусов Химико-фармацевтический журнал 56 (4), 13-17 , 2022 2022
Gamma-linolenic Acid from Fifty-seven Ribes Species and Cultivars E Golovenko, S Lyashenko, S Akimova, L Mitina, E Mulenkova, ... Plant Foods for Human Nutrition 76 (3), 385-393 , 2021 2021 Citations: 12
Phenolic composition and in vitro antiproliferative activity of Borago spp. seed extracts on HT-29 cancer cells S Lyashenko, D Fabrikov, MJ González-Fernández, F Gómez-Mercado, ... Food Bioscience 42, 101043 , 2021 2021 Citations: 19
Mertensia (Boraginaceae) seeds are new sources of γ-linolenic acid and minor functional compounds S Lyashenko, MJ González-Fernández, S Borisova, EH Belarbi, ... Food chemistry 350, 128635 , 2021 2021 Citations: 17
LED enhances plant performance and both carotenoids and nitrates profiles in lettuce F Ferron-Carrillo, JL Guil-Guerrero, MJ Gonzalez-Fernandez, ... Plant Foods for Human Nutrition 76 (2), 210-218 , 2021 2021 Citations: 44
Lipid Fractions, Fatty Acid Profiles, and Bioactive Compounds of Lithospermum officinale L. Seeds S Lyashenko, S Yunusova, R López‐Ruiz, E Vasfilova, O Kiseleva, ... Journal of the American Oil Chemists' Society 98 (4), 425-437 , 2021 2021 Citations: 6
РАСТИТЕЛЬНЫЕ ИСТОЧНИКИ БИОЛОГИЧЕСКИ АКТИВНЫХ ω-6, ω-3 ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ НА ТЕРРИТОРИИ РФ СГ Юнусова, СС Ляшенко, МС Юнусов, ОН Денисенко 2021
MOST CITED SCHOLAR PUBLICATIONS
LED enhances plant performance and both carotenoids and nitrates profiles in lettuce F Ferron-Carrillo, JL Guil-Guerrero, MJ Gonzalez-Fernandez, ... Plant Foods for Human Nutrition 76 (2), 210-218 , 2021 2021 Citations: 44
Highly concentrated very long-chain PUFA obtainment by Urea complexation methodology MJ González-Fernández, D Fabrikov, S Lyashenko, F Ferrón-Carrillo, ... Environmental Technology & Innovation 18, 100736 , 2020 2020 Citations: 36
Ribes taxa: A promising source of γ-linolenic acid-rich functional oils S Lyashenko, MJ González-Fernández, F Gomez-Mercado, S Yunusova, ... Food chemistry 301, 125309 , 2019 2019 Citations: 36
Borage oil: Tocopherols, sterols and squalene in farmed and endemic-wild Borago species D Fabrikov, JL Guil-Guerrero, MJ González-Fernández, ... Journal of Food Composition and Analysis 83, 103299 , 2019 2019 Citations: 35
Phenolic composition and in vitro antiproliferative activity of Borago spp. seed extracts on HT-29 cancer cells S Lyashenko, D Fabrikov, MJ González-Fernández, F Gómez-Mercado, ... Food Bioscience 42, 101043 , 2021 2021 Citations: 19
Arecaceae fruits: Fatty acids, phenolic compounds and in vitro antitumor activity A Lahlou, T Chileh-Chelh, S Lyashenko, MÁ Rincón-Cervera, ... Food Bioscience 50, 102181 , 2022 2022 Citations: 17
Mertensia (Boraginaceae) seeds are new sources of γ-linolenic acid and minor functional compounds S Lyashenko, MJ González-Fernández, S Borisova, EH Belarbi, ... Food chemistry 350, 128635 , 2021 2021 Citations: 17
Arecaceae seeds constitute a healthy source of fatty acids and phenolic compounds MÁ Rincón-Cervera, A Lahlou, T Chileh-Chelh, S Lyashenko, ... Plants 12 (2), 226 , 2023 2023 Citations: 15
Lipids and Lipophilic Constituents of Comfrey ( Symphytum Officinale L.) Seeds SG Yunusova, SS Lyashenko, NI Fedorov, MS Yunusov, ON Denisenko Pharmaceutical Chemistry Journal 50 (11), 728-731 , 2017 2017 Citations: 14
Fatty acid profiling in the genus Pinus in relation to its chemotaxonomy and nutritional or pharmaceutical properties A Lahlou, S Lyashenko, T Chileh-Chelh, EH Belarbi, I Torres-García, ... Phytochemistry 206, 113517 , 2023 2023 Citations: 13
Buglossoides spp. seeds, a land source of health-promoting n-3 PUFA and phenolic compounds TC Chelh, S Lyashenko, A Lahlou, EH Belarbi, MA Rincon-Cervera, ... Food Research International 157, 111421 , 2022 2022 Citations: 12
Gamma-linolenic Acid from Fifty-seven Ribes Species and Cultivars E Golovenko, S Lyashenko, S Akimova, L Mitina, E Mulenkova, ... Plant Foods for Human Nutrition 76 (3), 385-393 , 2021 2021 Citations: 12
Hermetia illucens Larvae as a Living Bioreactor for Simultaneous Food by‐Products Recycling and Useful Oil Production JL Guil‐Guerrero, MJ Sánchez‐Muros, D Fabrikov, B Rodríguez‐Lozano, ... Journal of the American Oil Chemists' Society 97 (7), 717-727 , 2020 2020 Citations: 11
Изучение анатомических признаков травы дерезы обыкновенной (Lycium barbarum L.) МА Секинаева, ФК Серебряная, ОН Денисенко, СС Ляшенко Успехи современного естествознания, 231-235 , 2015 2015 Citations: 9
γ‐Linolenic and Stearidonic Acids from Boraginaceae of Diverse Mediterranean Origin JL Guil‐Guerrero, MJ González‐Fernández, S Lyashenko, D Fabrikov, ... Chemistry & Biodiversity 17 (12), e2000627 , 2020 2020 Citations: 8
Липиды семян Borago officinalis L.(сем. Boraginaceae) СС Ляшенко, СГ Юнусова, МС Юнусов, ЕГ Галкин, ОН Денисенко Башкирский химический журнал 17 (4), 24-28 , 2010 2010 Citations: 8
Фенольные соединения и антиоксидантная активность плодов дерезы обыкновенной и дерезы русской МА Секинаева, СС Ляшенко, ФИ Исламова, АМ Алиев, ЛВ Челова, ... Медико-фармацевтический журнал «Пульс» 20 (3), 107-111 , 2018 2018 Citations: 7
Phenolic Profiles and Antitumor Activity against Colorectal Cancer Cells of Seeds from Selected Ribes Taxa S Lyashenko, R López-Ruiz, AM García-Cervantes, I Rodríguez-García, ... Applied Sciences 14 (6), 2428 , 2024 2024 Citations: 6
Lipid Fractions, Fatty Acid Profiles, and Bioactive Compounds of Lithospermum officinale L. Seeds S Lyashenko, S Yunusova, R López‐Ruiz, E Vasfilova, O Kiseleva, ... Journal of the American Oil Chemists' Society 98 (4), 425-437 , 2021 2021 Citations: 6
Аминокислотный состав плодов дерезы обыкновенной и дерезы русской МА Секинаева, СС Ляшенко, ОН Денисенко, ЮО Денисенко Медико-фармацевтический журнал «Пульс» 19 (9), 197-199 , 2017 2017 Citations: 6
