Documenting ethnoveterinary practices of Tiruvannamalai district in Tamil Nadu, India V Porchezhiyan, J Ganesh, PS Subha, P Pandikumar, S Ignacimuthu Ethnobotany Research and Applications, 2025 Background: Ethnoveterinary practices are prevalent in India; yet this knowledge is poorly documented. This study documents the ethnoveterinary practices in Tiruvannamalai district in Tamil Nadu, India. Methods: Using successive free listing method, 23 healers were identified and the ethnoveterinary formulations used by them were recorded. The data were analyzed using Informant Consensus Factor (Fic) and Index of Agreement Remedies (IAR). Results: A total of 120 formulations was documented for treating about 50 veterinary health conditions. Alimentary tract ailments showed high consensus followed by dermatological ailments and poisonous bites. Musculo-skeletal ailments, genito-urinary ailments, sensory organ ailments and ectoparasitic infections showed average consensus. Considerable overlap was observed between human and veterinary applications; common medicinal plants like Curcuma longa, Piper nigrum, Allium sativum, Piper betle and Azadirachta indica were regularly cited. Conclusion: This preliminary study highlights the significance of validating traditional knowledge of veterinary practices in Tamil Nadu. Key words: Animal health; Botanicals; Siddha; Traditional Indian Medicine
Synthesis, characterization, in silico and in vitro evaluations of symmetrical 1,3-Diketones V. Porchezhiyan, D. Kalaivani, J. Shobana, S.E. Noorjahan Asian Journal of Chemistry, 2020 1,3-Dicarbonyl compounds have gained significant importance since they are abundantly available in the natural products and possess myriad biological activities. The new symmetrical 1,3-diketones bearing L-proline, 2-methyl-5-iodobenzoic acid, piperidine-3-carboxylic acid and naphthalene-1-acetic acid moieties were synthesized by coupling reaction of appropriate ketone with N-acyl triazole in the presence of MgBr2·Et2O and DIPEA. The chemical structure of the compounds were confirmed from the spectral data such as 1H, 13C NMR, FT-IR and HRMS. Molecular docking studies were carried out for all the compounds with tumor associated protein tyrosine kinase-6 (PTK6) and inflammatory protein cyclooxygenase-2 (COX2). The in vitro evaluation was carried out using breast cancer cell lines (MTT assay) and HRBC stabilization assays. During in silico studies, the ki values obtained against PTK6 and COX2 for (5a-d) compounds were in the range (-7.5 to -10.6) and (-7.6 to -9.8) kcal/mol, respectively. The compound 5d was selected for MTT assay, since it exhibited the highest binding affinity (-10.6 kcal/mol) against PTK6 and gave IC50 - 2.4 μg/mL against breast cancer cell lines. The HRBC stabilization of all the compounds (5a-5d) were in the range (59.28-93.4) %, with highest stabilization value by 5d, which also displayed higher binding affinity with -7.6 kcal/mol towards COX2. Thus, the synthesized symmetrical 1,3-diketones with suitable functionality can be both anticancer and anti-inflammatory agents.
Studies on composite PVA-Ca-NH4CF3SO3-Al2O3 polymer electrolyte for electrochemical devices S. Gurulakshmi, S. Madeswaran, S. Karthikeyan, V. Porchezhiyan Asian Journal of Chemistry, 2019 In the present study, polymer electrolyte with poly(vinyl alcohol) (PVA) blended with cellulose acetate (CA) was chosen to prepare composite electrolyte using ammonium triflate salt and nano sized alumina (Al2O3- < 50 nm) by the solution casting method. The as prepared samples were characterized by X-ray diffraction, FT-IR, differential scanning calorimetry and AC impedance spectra. The loss tangent and dielectric studies were carried out for all the prepared samples using AC impedance analysis. Activation energy with regression values and relaxation time were calculated and found to be low for the highest conducting membranes. The presence of 0.1 mol content of nano alumina has enhanced the ionic conductivity significantly to the value of 2.012 × 10-3 S/cm from that of the filler-free electrolyte (2.93 × 10-4 S/cm). Ionic transference number was calculated by electrostatic polarization method and it was found to be 0.9684, which shows the conducting species were ions. A proton battery fabricated using the configuration Zn+ZnSO4. H2O || PVA-CA-0.5 mol NH4CF3SO3-0.1 mol Al2O3 || PbO2 + V2O5 produced a steady state open circuit voltage of 1.39 V, which proves the prepared composite electrolyte is suitable solid electrolyte for electrochemical devices.
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