Dedicated pharmaceutical professional currently serving as an Assistant Professor at the Faculty of Pharmacy, Vidya University, Meerut. Specialized in Computer-Aided Drug Design (CADD) and Pharmaceutical Chemistry, with strong expertise in drug discovery, molecular modeling, and computational research. Committed to academic excellence, innovative teaching, and interdisciplinary research for advancing healthcare solutions.
EDUCATION
M. Pharm (Pharmaceutical Chemistry)
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Drug Discovery, Oncology, Pharmacy
7
Scopus Publications
Scopus Publications
The Role of Rainfall in the Control of Norovirus Outbreaks Sandhya Chaudhary, Rahul Kumar, Kalpana Rahate, Shriyansh Srivastava, Sathvik Belagodu Sridhar Emerging Infectious Disease Unravelling Norovirus and Pandemic Dynamics, 2027 Noroviruses are non-enveloped, positive-sense, single-stranded RNA viruses classified within the Caliciviridae family of viruses. “Norwalk virus,” initially identified and dubbed, caused a gastroenteritis outbreak in 1968 in Norwalk, Ohio. Research has demonstrated that noroviruses, which are significant human infections, cause devastating gastroenteritis epidemic outbreaks in assisted living facilities, hospitals, and communities. The environment and food are two other potential pathways for the norovirus to spread, even though direct human-to- human spread is thought to be a main method of spread for most of the occurrences. These epidemics annually cause over 267,000,000 illnesses worldwide. Climate change influences the frequency of norovirus outbreaks, a fact well acknowledged but not fully understood. Despite the widespread acceptance of the virus’ seasonality and winter occurrence, the relationship between environmental factors and norovirus outbreaks remains unclear. Studies have demonstrated the crucial and intricate role of rainfall in determining the norovirus’ ability to spread. With a focus on how rainfall affects both direct and indirect transmission channels, this chapter examines the dynamic role that precipitation plays in controlling norovirus outbreaks. Rainfall drastically impacts virus flow and water quality, which contributes to norovirus spread. The findings of this book chapter improve our understanding of the relationship between environmental factors and norovirus outbreaks and provide guidance for future investigations into these outbursts. To fully comprehend the things of the other problems on the occurrence of norovirus, further study is necessary.
Prognostic and Therapeutic Relevance of PELP1 in Estrogen Receptor Positive Breast Cancer: A Systematic Review Rahul Kumar, Prem Shankar Mishra, S.K. Abdul Rahaman, Sakshi Patel Current Signal Transduction Therapy, 2026 Introduction: PELP1 is an oncogenic scaffold protein characterized by proline-, glutamic acid-, and leucine-rich domains, and serves as a crucial coregulator of the estrogenic receptor (ER). It facilitates tumour growth, metastasis, and a worse prognosis in ER+ breast cancer. This review examines PELP1 expression, prognostic relevance, and therapeutic potential, integrating prior studies to underscore its clinical importance. Methods: This systematic review includes publications from 2014–2024, retrieved via database searches using keywords like “PELP1,” “ER-positive breast cancer,” and “PELP1 expression” on PubMed, Google Scholar, and ScienceDirect. Articles were selected based on their relevance to PELP1 expression and its correlation with tumour behaviour and survival outcomes in ER+ breast cancer. Results: Six studies were identified that investigated the correlation between PELP1 levels and breast cancer outcomes. Findings suggest that elevated PELP1, particularly in the NH2 region, is associated with larger tumours, higher grade, and poorer prognosis. A statistical link was found between high PELP1 expression and elevated estrogen levels in ER+ tumours. However, small sample sizes and the absence of validation cohorts limit the conclusion. Discussion: Evidence suggests that PELP1 enhances ER signaling and may contribute to endocrine resistance. Its dual genomic and non-genomic roles underline its potential as a biomarker and therapeutic target. Conclusion: Although preliminary findings may indicate that PELP1 has the potential to be a clinically useful biomarker and therapeutic target for ER+ breast cancer, the current studies fail to sufficiently demonstrate that PELP1 is clinically beneficial. There is a need for more research with larger, more reliable group samples and more involved mechanistic studies.
Integrating small molecules into multimodal treatment strategies Sakshi Patel, Prem Shankar Mishra, S. K. Abdul Rahaman, Rahul Kumar, Mudassir Jan Makhdoomi, Abid Ali Sheikh Small Molecules in Neurodegeneration, 2025 This chapter discusses the rationale behind designing multiple ligands (DMLs) to develop disease-modifying treatment plans for Parkinson’s disease (PD) and Alzheimer’s disease (AD), the two most common NDDs. The alarming rise in both incidence and frequency of PD and AD, greatly affects quality and life expectancies, even with the global improvement in the health care. Despite these findings, there has been limited success in developing and commercialising innovative medicines to prevent or delay the onset of PD and AD. Since these diseases share a complex etiopathology, with the dysregulation of multiple processes and pathways. Hence, it is unlikely that a single medication operating on a specific pathway or target could improve the complex patho-etiological process that causes diseases or the advancement of various disorders. Numerous studies have demonstrated that redox dysregulation plays a crucial role in the development of these NDDs. Thus, reducing the free radicals is thought to be one of the potential novel treatment approaches for mitigating NDDs. Here, we focused our attention on the biological effectiveness of small molecules with respect to their therapeutic potential for the amelioration of NDDs.
Contemporary Developments in PROTACs for Cancer Management: An In-Depth Review Shaik Abdul Rahaman, Garla Venkateswarlu, Sakshi Patel, Prem Shankar Mishra, Rahul Kumar, Nayyar Parvez Current Topics in Medicinal Chemistry, 2025 Proteolysis-Targeting Chimeras (PROTACs) represent a novel and promising cancer treatment strategy considered a direct alternative to conventional small-molecule inhibitors. PROTACs selectively degrade disease-causing proteins (including previously 'undruggable' targets such as transcription factors and scaffolding proteins) by harnessing the cellular ubiquitin proteasome system. In this review, we look at the most recent developments in PROTAC technology and their oncology applications. Versatility, while maintaining substrate selectivity and degradation efficiency, has also been enhanced by the expanded range of E3 ligases used in PROTAC design. Improvements in the stability, bioavailability, and systemic delivery of PROTACs are being achieved through innovations in pharmacokinetics and cell permeability, enabling their clinical translations. Initial clinical trials have confirmed the potential of these agents in human patients, and early preclinical studies have shown them to be highly efficacious in models of solid tumors and hematologic malignancies. Despite these encouraging developments, crucial challenges remain, including reducing off-target effects, addressing resistance mechanisms, and clarifying the significance of PROTAC-mediated degradation pathways. Future efforts must focus on refining the selectivity and tunability of degrader compounds, enhancing treatment efficacy via combination therapies, and optimizing PROTAC design through computational and structural biology. As the field continues to evolve, PROTACs remain a highly promising strategy for addressing unmet clinical needs in oncology. In this review, recent advancements in PROTAC technology are discussed, along with its contribution to cancer therapy and ways to circumvent existing challenges to its full therapeutic potential.
Designing Aptamers for Cancer Diagnosis Therapy Rahul Kumar, Sakshi Patel, Shriyansh Srivastava, Shaik Abdul Rahaman, Deepika Sharma, Biplab Pal, Malakapogu Ravindra Babu Biosensors and Aptamers A New Era in Cancer Diagnosis and Treatment, 2025
RECENT SCHOLAR PUBLICATIONS
Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy AK Sah, S Patel, R Kumar, PS Mishra, R Mishra, AI Umarovich, ... Life 16 (6), 873 , 2026 2026.0
Current Challenges in Prostate Cancer Biosensing B Shukla, R Kumar, D Vasishtha, F Taghizadeh-Hesary Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
The Role of Biomarkers in Prostate Cancer Diagnosis R Kumar, V Bhagwani, R Sahu, A Kabi Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
Electrochemical Biosensor for Prostate Cancer R Kumar, AK Sirbaiya, S Srivastava, G Bhat Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
Multiplex Biosensing for Prostate Cancer M Ravindra Babu, A Tripathi, S Srivastava, R Kumar Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
Diagnostic and Therapeutic Approaches to Neurodegenerative Disorders: Biomarkers for Early Detection SKA Rahaman, S Patel, S Jain, PS Mishra, R Kumar, NR Kagithala, ... Metals and Neurological Disorders: Exploring Neurotoxicity Mechanisms and … , 2026 2026.0
Prognostic and Therapeutic Relevance of PELP1 in Estrogen Receptor Positive Breast Cancer: A Systematic Review R Kumar, PS Mishra, SKA Rahaman, S Patel Current Signal Transduction Therapy 21 (2), E15743624385247 , 2026 2026.0
AI-Enhanced Precision Detection and Diagnosis of Cancers AK Sah, R Kumar, S Patel, RK Choudhary, PS Mishra AI and Precision Medicine in Cancer Management, 56-73 , 2026 2026.0
Contemporary Developments in PROTACs for Cancer Management: An In-Depth Review SA Rahaman, G Venkateswarlu, S Patel, PS Mishra, R Kumar, N Parvez Current Topics in Medicinal Chemistry , 2026 2026.0
Ethical and Regulatory Considerations in AI-Driven Healthcare AK Sah, R Kumar, S Patel, PS Mishra, H Doshi, R Mishra Advancing Personalized Medicine With AI-Driven Microbiome and Nutrigenomics … , 2026 2026.0
Spatial Multi-Omics in Infectious Diseases AK Sah, S Mishra, R Kumar, PS Mishra, RK Choudhary, SKA Rahaman Spatially Resolved Single-Cell and Multiple Omics in Human Diseases, 177-216 , 2026 2026.0
Chemical Perspectives on Epigallocatechin-3-Gallate (EGCG): Mechanisms and Therapeutic Potential in Breast Cancer Treatment S Patel, SKA Rahaman, PS Mishra, R Kumar Reviews on recent clinical trials , 2025 2025.0
Designing Aptamers for Cancer Diagnosis Therapy R Kumar, S Patel, S Srivastava, SA Rahaman, D Sharma, B Pal, ... Biosensors and Aptamers: A New Era in Cancer Diagnosis and Treatment, 189-219 , 2025 2025.0
Integrating Small Molecules into Multimodal Treatment Strategies S Patel, PS Mishra, SKA Rahaman, R Kumar, MJ Makhdoomi, AA Sheikh Small Molecules in Neurodegeneration, 151-171 , 2025 2025.0
Recurrent pregnancy loss: Immunogenetic factors, clinical implications, diagnostic approaches, and future perspectives R Kumar, PS Mishra, S Patel, SKA Rahaman, R Mishra, AA Sheikh Reproductive Immunogenetics: A Molecular and Clinical Overview, Vol. 3, 165-200 , 2025 2025.0
Magnetic Biosensors: Innovations R Kumar, P Yadav, D Sharma Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 0
MOST CITED SCHOLAR PUBLICATIONS
Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy AK Sah, S Patel, R Kumar, PS Mishra, R Mishra, AI Umarovich, ... Life 16 (6), 873 , 2026 2026.0
Current Challenges in Prostate Cancer Biosensing B Shukla, R Kumar, D Vasishtha, F Taghizadeh-Hesary Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
The Role of Biomarkers in Prostate Cancer Diagnosis R Kumar, V Bhagwani, R Sahu, A Kabi Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
Electrochemical Biosensor for Prostate Cancer R Kumar, AK Sirbaiya, S Srivastava, G Bhat Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
Multiplex Biosensing for Prostate Cancer M Ravindra Babu, A Tripathi, S Srivastava, R Kumar Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 2026 2026.0
Diagnostic and Therapeutic Approaches to Neurodegenerative Disorders: Biomarkers for Early Detection SKA Rahaman, S Patel, S Jain, PS Mishra, R Kumar, NR Kagithala, ... Metals and Neurological Disorders: Exploring Neurotoxicity Mechanisms and … , 2026 2026.0
Prognostic and Therapeutic Relevance of PELP1 in Estrogen Receptor Positive Breast Cancer: A Systematic Review R Kumar, PS Mishra, SKA Rahaman, S Patel Current Signal Transduction Therapy 21 (2), E15743624385247 , 2026 2026.0
AI-Enhanced Precision Detection and Diagnosis of Cancers AK Sah, R Kumar, S Patel, RK Choudhary, PS Mishra AI and Precision Medicine in Cancer Management, 56-73 , 2026 2026.0
Contemporary Developments in PROTACs for Cancer Management: An In-Depth Review SA Rahaman, G Venkateswarlu, S Patel, PS Mishra, R Kumar, N Parvez Current Topics in Medicinal Chemistry , 2026 2026.0
Ethical and Regulatory Considerations in AI-Driven Healthcare AK Sah, R Kumar, S Patel, PS Mishra, H Doshi, R Mishra Advancing Personalized Medicine With AI-Driven Microbiome and Nutrigenomics … , 2026 2026.0
Spatial Multi-Omics in Infectious Diseases AK Sah, S Mishra, R Kumar, PS Mishra, RK Choudhary, SKA Rahaman Spatially Resolved Single-Cell and Multiple Omics in Human Diseases, 177-216 , 2026 2026.0
Chemical Perspectives on Epigallocatechin-3-Gallate (EGCG): Mechanisms and Therapeutic Potential in Breast Cancer Treatment S Patel, SKA Rahaman, PS Mishra, R Kumar Reviews on recent clinical trials , 2025 2025.0
Designing Aptamers for Cancer Diagnosis Therapy R Kumar, S Patel, S Srivastava, SA Rahaman, D Sharma, B Pal, ... Biosensors and Aptamers: A New Era in Cancer Diagnosis and Treatment, 189-219 , 2025 2025.0
Integrating Small Molecules into Multimodal Treatment Strategies S Patel, PS Mishra, SKA Rahaman, R Kumar, MJ Makhdoomi, AA Sheikh Small Molecules in Neurodegeneration, 151-171 , 2025 2025.0
Recurrent pregnancy loss: Immunogenetic factors, clinical implications, diagnostic approaches, and future perspectives R Kumar, PS Mishra, S Patel, SKA Rahaman, R Mishra, AA Sheikh Reproductive Immunogenetics: A Molecular and Clinical Overview, Vol. 3, 165-200 , 2025 2025.0
Magnetic Biosensors: Innovations R Kumar, P Yadav, D Sharma Biosensor Technologies for Prostate Cancer: Early Detection and Precision … , 0
