Pharmaceutical Science, Pharmacy, Cancer Research, Biomaterials
8
Scopus Publications
235
Scholar Citations
6
Scholar h-index
3
Scholar i10-index
Scopus Publications
Therapeutic and Diagnostic Implications of Carbon Dot: An Advancement in the Avenue towards Cancer, Diabetes and Neurodegenerative Disorders Sreejan Manna, Sabyasachi Banerjee, Arnab De, Subhasis Banerjee, Stabak Das, Pallabita Rakshit, Ashok Kumar S K, Kalyan Kumar Sen, Sourav De Pharmaceutical Nanotechnology, 2026 Introduction: Carbon dots (CDs), by virtue of their electrical and optical properties, emit intense light and fluorescence. They have attributes like photostability, high quantum yield (QY), high emission, and scalability. In the recent past, theranostic-CDs have been widely used in sensing, imaging, and medication administration. Furthermore, CDs may provide significant promise to detect and ability to cross blood-brain barrier (BBB) along with a drug to treat numerous neurodegenerative disorders (ND), such as Parkinson's disease (PD), Alzheimer's disease (AD), and multiple sclerosis. Method: This review aims at exploring the immense utility of CDs in the arena of theranostics. The immense utility of CDs was investigated through a systematic exploration of previously published data in the relevant field. The application of CDs is well extended to treat life-threatening disorders, like diabetes and cancer. In order to keep harmful substances out of the brain, the blood- -brain barrier (BBB) forms a defensive barrier. Results: Water and gases being simple molecules can traverse the BBB without getting filtered out, but several large molecules suffer to reach the site of action owing to their poor solubility. CDs have recently been employed for delivering drugs to the brain and to assess the central nervous system. An in-depth study of relevant literature indicates that CDs are the next-generation carrier with an innate potential to subside the drawbacks of conventional nanoparticles. Conclusion: This review illustrates several biomedical applications of CDs, primarily focusing on neurological illnesses, diabetes, and cancers. It also confers the usefulness of CDs in diagnostic imaging.
Membrane Permeability and Drug Targeting Potential of Phospholipid-Based Nanocarriers in Lung Cancer Therapy Olivia Sen, Poulami Sarkar, Stabak Das, Nayan Kumar Giri, Sayantika Sarkar, Sougata Jana, Gouranga Nandi, Sreejan Manna Chemistryselect, 2024 Lung cancer has become the leading cause of cancer‐related deaths, surpassing all other forms of cancer. Among lung cancers, non‐small cell lung cancer (NSCLC) accounts for approximately 85% of cases. The use of tobacco, genetic traits, and radiation exposure are amongst the major reasons of lung cancer. The ongoing research in the medical field has considered the efficacy of nanocarriers in targeting various cancer cells. Among several biomaterials, lipid‐based nanocarriers have gained special attention due to their excellent compatibility, improved targeting efficacy, and encapsulation ability of diverse therapeutic agents. Phospholipids are naturally occurring amphiphilic moieties found in all living creatures. The presence of phospholipids in biomembrane aids the permeability of phospholipid‐based drug carrier. It can also facilitate targeting of therapeutic agents to cancer microenvironment without degrading the encapsulated drug. Phospholipids can be employed to develop conjugated nanocarriers and vesicular nanoformulation that can result in prolonged circulatory half‐life and controlled release of drugs. Phospholipids are also suitable biomaterials to attach a ligand for tissue‐specific targeting. Recent researches have reported effective targeting of chemotherapeutic agents, genes, and vaccines through phospholipid‐based nanocarriers to lung cancer cells. This review focuses on the rationality and applications of phospholipid‐based nanocarriers in lung cancer therapy.
Therapeutic Efficacy of Nanocarrier-Mediated Inhalable Gene Transfection for Lung Cancer Poulami Sarkar, Manami Sardar, Olivia Sen, Stabak Das, Sreejan Manna Chemistryselect, 2024 Lung cancer is now the leading cause of cancer‐related mortality, eclipsing all other cancer forms, and of all lung malignancies, non‐small cell lung cancer (NSCLC) makes up around 85%. Recently, the use of vectors in gene therapy besides chemotherapy to treat malignancies brought on by gene mutations has gained prominence. Therapeutic molecule inhalation is a direct approach to lung‐targeted medication delivery with low nonspecific toxicity and limited drug exposure. Treatment for lung cancer with chemotherapy and immunotherapy can be aided by inhalable nanomedicine through advanced mechanisms. Viral and nonviral vectors, such as lipid‐based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles, have all drawn a lot of interest for their ability to increase effects and decrease side effects. Nanocarriers have a significant impact on targeted gene delivery, bioavailability, stability, and residence in target areas. The inhaled pulmonary gene delivery approach, when combined with nanomedicine, will offer a noninvasive and successful way to treat lung cancer by taking use of the physiological properties of the lung. The authors have majorly used data from PubMed and Google Scholar to obtain the relevant information required for the article. In general, this review concentrates on the usage of various inhalable nanocarriers, which might serve as an inspiration for the creation and deployment of more potent genetic therapy for the treatment of lung cancer.
Current Status of Marine Animal Derived Polysaccharides in Sustainable Food Packaging Saurav Sarkar, Sreejan Manna, Stabak Das, Sourav De, Paramita Paul, Tarun Kumar Dua, Ranabir Sahu, Gouranga Nandi ACS Food Science and Technology, 2023 The dominant use of synthetic plastic derivatives is one of the major concerns across the world. The irrational use of plastic not only causes environmental pollution but also is reported to cause several health hazards. This has led researchers to develop biodegradable packaging materials derived from biomaterials. Polysaccharides are abundantly available biopolymers with excellent biodegradability. Marine animals are a vast source of obtained polysaccharides, including chitosan, hyaluronic acid, and chondroitin sulfate. The edible nature of the extracted marine-animal-derived polysaccharides makes it a useful alternative for synthetic derivatives in the food packaging industry. In addition, the antimicrobial and antioxidant behavior of marine-animal-derived polysaccharides has favored its emergence as a packaging material. The film forming, protective, and excellent barrier property has encouraged the scientists to investigate them as food packaging materials. The easy modifiability of these polysaccharides can improve the film forming ability. This Article focuses on the recent advancements in marine animal derived polysaccharides in sustainable food packaging applications.
Melatonin and its anti-glioma functions: A comprehensive review Sayantan Maitra, Debanjan Bhattacharya, Stabak Das, Subhrajit Bhattacharya Reviews in the Neurosciences, 2019 Melatonin (N-acetyl-5-methoxytryptamine) is a naturally synthesized hormone secreted from the pineal gland in a variety of animals and is primarily involved in the regulation of the circadian rhythm, which is the natural cycle controlling sleep in organisms. Melatonin acts on specific receptors and has an important role in overall energy metabolism. This review encompasses several aspects of melatonin activity, such as synthesis, source, structure, distribution, function, signaling and its role in normal physiology. The review highlights the cellular signaling and messenger systems involved in melatonin’s action on the body and their wider implications, the distribution and diverse action of different melatonin receptors in specific areas of the brain, and the pharmacological agonists and antagonists that have specific action on these melatonin receptors. This review also incorporates the antitumor effects of melatonin in considerable detail, emphasizing on melatonin’s role as an adjuvant therapeutic agent in glioma treatment. We conclude that the diminishing levels of melatonin have significant debilitating effects on normal physiology and can also be associated with malignant conditions such as glioma. Based on the review of the available evidence, our study provides a broad platform for a better understanding of the specific roles of melatonin and serves as a starting point for further investigation into the therapeutic effect of melatonin in glioma as an adjuvant therapeutic agent.
Therapeutic and diagnostic implications of carbon dot: an advancement in the avenue towards cancer, diabetes and neurodegenerative disorders S Manna, S Banerjee, A De, S Banerjee, S Das, P Rakshit, ... Pharmaceutical nanotechnology 14 (1), 94-121 , 2026 2026 Citations: 5
Bioactive‐Based Nanotherapeutics in Pain Management: A Revolutionary Approach S Giri, Z Irfan, SE Haque, SC Ganguly, S Das Bioactive‐Based Nanotherapeutics, 619-661 , 2025 2025
Exosomes and Their Therapeutic Potential in Cancer P Chakraborty, S Das, DD Chakraborty CRC Press , 2025 2025
Membrane permeability and drug targeting potential of phospholipid‐based nanocarriers in lung cancer therapy O Sen, P Sarkar, S Das, NK Giri, S Sarkar, S Jana, G Nandi, S Manna ChemistrySelect 9 (40), e202403174 , 2024 2024 Citations: 7
Therapeutic Efficacy of Nanocarrier‐Mediated Inhalable Gene Transfection for Lung Cancer P Sarkar, M Sardar, O Sen, S Das, S Manna ChemistrySelect 9 (37), e202402903 , 2024 2024 Citations: 3
Fabrication, evaluation, and enhanced penetration of vinyl and cellulose-engineered transdermal patch of nifedipine using essential oil as penetration enhancer S Das, S Das, S Bahadur, M Mukherjee, G Nandi, S Manna Journal of Biomaterials science, Polymer edition 35 (9), 1400-1420 , 2024 2024 Citations: 8
Advancements in nanoengineered paclitaxel formulations: A comprehensive review of blood-brain barrier infiltration strategies for glioblastoma therapy S Das, P Chakraborty, DD Chakraborty, LK Nath Biomedical Engineering Advances 7, 100122 , 2024 2024 Citations: 9
Current status of marine animal derived polysaccharides in sustainable food packaging S Sarkar, S Manna, S Das, S De, P Paul, TK Dua, R Sahu, G Nandi ACS Food Science & Technology 3 (11), 1877-1889 , 2023 2023 Citations: 23
A review on the therapeutic efficacy of Smart polymers in the pharmaceutical domain A Sen, S Das, S Das, S Ghosh, S Rai Int. J. Pharm. Res. Appl 7, 421-431 , 2022 2022 Citations: 3
Melatonin and its anti-glioma functions: a comprehensive review S Maitra, D Bhattacharya, S Das, S Bhattacharya Reviews in the neurosciences 30 (5), 527-541 , 2019 2019 Citations: 40
Role of Peptides, Biogenic Amines and Hypothalamic Drive in Dietary-Induced Obesity and Metabolic Syndrome S Maitra, S Das Global Perspectives on Childhood Obesity, 225-236 , 2019 2019 Citations: 2
Nutritional and therapeutic interventions for diabetes and metabolic syndrome D Bagchi, S Nair Academic Press , 2018 2018 Citations: 132
Diabetes, a potential threat to the development and progression of tumor cells in individuals S Maitra, S Das, P Banerjee Nutritional and Therapeutic Interventions for Diabetes and Metabolic … , 2018 2018 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
Nutritional and therapeutic interventions for diabetes and metabolic syndrome D Bagchi, S Nair Academic Press , 2018 2018 Citations: 132
Melatonin and its anti-glioma functions: a comprehensive review S Maitra, D Bhattacharya, S Das, S Bhattacharya Reviews in the neurosciences 30 (5), 527-541 , 2019 2019 Citations: 40
Current status of marine animal derived polysaccharides in sustainable food packaging S Sarkar, S Manna, S Das, S De, P Paul, TK Dua, R Sahu, G Nandi ACS Food Science & Technology 3 (11), 1877-1889 , 2023 2023 Citations: 23
Advancements in nanoengineered paclitaxel formulations: A comprehensive review of blood-brain barrier infiltration strategies for glioblastoma therapy S Das, P Chakraborty, DD Chakraborty, LK Nath Biomedical Engineering Advances 7, 100122 , 2024 2024 Citations: 9
Fabrication, evaluation, and enhanced penetration of vinyl and cellulose-engineered transdermal patch of nifedipine using essential oil as penetration enhancer S Das, S Das, S Bahadur, M Mukherjee, G Nandi, S Manna Journal of Biomaterials science, Polymer edition 35 (9), 1400-1420 , 2024 2024 Citations: 8
Membrane permeability and drug targeting potential of phospholipid‐based nanocarriers in lung cancer therapy O Sen, P Sarkar, S Das, NK Giri, S Sarkar, S Jana, G Nandi, S Manna ChemistrySelect 9 (40), e202403174 , 2024 2024 Citations: 7
Therapeutic and diagnostic implications of carbon dot: an advancement in the avenue towards cancer, diabetes and neurodegenerative disorders S Manna, S Banerjee, A De, S Banerjee, S Das, P Rakshit, ... Pharmaceutical nanotechnology 14 (1), 94-121 , 2026 2026 Citations: 5
Therapeutic Efficacy of Nanocarrier‐Mediated Inhalable Gene Transfection for Lung Cancer P Sarkar, M Sardar, O Sen, S Das, S Manna ChemistrySelect 9 (37), e202402903 , 2024 2024 Citations: 3
A review on the therapeutic efficacy of Smart polymers in the pharmaceutical domain A Sen, S Das, S Das, S Ghosh, S Rai Int. J. Pharm. Res. Appl 7, 421-431 , 2022 2022 Citations: 3
Diabetes, a potential threat to the development and progression of tumor cells in individuals S Maitra, S Das, P Banerjee Nutritional and Therapeutic Interventions for Diabetes and Metabolic … , 2018 2018 Citations: 3
Role of Peptides, Biogenic Amines and Hypothalamic Drive in Dietary-Induced Obesity and Metabolic Syndrome S Maitra, S Das Global Perspectives on Childhood Obesity, 225-236 , 2019 2019 Citations: 2
Bioactive‐Based Nanotherapeutics in Pain Management: A Revolutionary Approach S Giri, Z Irfan, SE Haque, SC Ganguly, S Das Bioactive‐Based Nanotherapeutics, 619-661 , 2025 2025
Exosomes and Their Therapeutic Potential in Cancer P Chakraborty, S Das, DD Chakraborty CRC Press , 2025 2025
