Avid academician,clinician and renal transplant nephrologist
EDUCATION
MD,DNB nephrology
RESEARCH, TEACHING, or OTHER INTERESTS
General Medicine, Nephrology, Multidisciplinary, Transplantation
54
Scopus Publications
42
Scholar Citations
3
Scholar h-index
Scopus Publications
Reappraisal of Goal-Directed Medical Therapy in Diabetic Kidney Disease: Beyond the Quadruple Therapy Paradigm Gerry George Mathew Giornale Italiano Di Nefrologia Organo Ufficiale Della Societa Italiana Di Nefrologia, 2026 Diabetic kidney disease (DKD) affects 40% of individuals with diabetes and is the leading cause of chronic kidney disease worldwide. While the KDIGO guidelines have established quadruple therapy comprising renin-angiotensin system inhibitors, SGLT2 inhibitors, GLP-1 receptor agonists, and mineralocorticoid receptor antagonists as the cornerstone of DKD management, substantial phenotypic and molecular heterogeneity among patients limits the efficacy of standardized protocols. Emerging evidence highlights distinct DKD subtypes defined by inflammatory, metabolic, fibrotic, and vascular pathobiological pathways, which may warrant tailored therapeutic strategies. Novel biomarkers, including tubular injury markers, inflammatory mediators, and genetic variants such as APOL1, offer opportunities for phenotype-driven treatment. Multi-omic integration, encompassing genomics, transcriptomics, proteomics, and metabolomics, combined with machine learning algorithms, enables the identification of treatment-responsive phenotypes and supports clinical decision-making. Emerging therapeutic targets, including complement system inhibitors, ketone metabolism modulators, and JAK-STAT pathway inhibitors, have further expanded the precision medicine landscape in DKD management. Implementation challenges include biomarker standardization, healthcare infrastructure requirements, cost-effectiveness, regulatory validation, and equitable access to diverse populations. Addressing these barriers through multidisciplinary collaboration, point-of-care diagnostics, and inclusive clinical trials is essential for personalized DKD management. Goal-directed personalized DKD management represents a transformative paradigm with the potential to optimize outcomes, minimize adverse effects, and reduce long-term healthcare costs.
Genotype-phenotype characteristics and disease progression of FAN1-related karyomegalic tubulointerstitial nephropathy Michelle Clince, Elhussein A.E. Elhassan, Kendrah O. Kidd, Emily Malamud, Susan M. McAnallen, Arbab Danial, Byung Ha Chung, Myungshin Kim, John A. Sayer, Intisar Al Alawi, Jelle Bernards, Mouna Jerbi, Rym Goucha, Lamia Ben Jemaa, Imen Rejeb, Chirag Patel, Andrew J. Mallett, C. John Sperati, Koen de Boeck, Maximilian Müller, Thomas Stehlé, Nisrine Bennani Guebessi, Thomas Robert, Bela Ivanyi, Ildiko Csaszar, Shirlee Shril, Sijie Zheng, Gerry George Mathew, Merve Guzel Dirim, Ahmet Burak Dirim, Laurent Mesnard, Lorraine Gueguen, Franz Schafer, Carsten Bergmann, Daniel P. Gale, Jan Halbritter, Kathleen J. Claes, Bertrand Knebelmann, Martina Živná, Stanislav Kmoch, Stanislas Faguer, Friedhelm Hildebrandt, Anthony J. Bleyer, Peter J. Conlon Kidney International, 2026 INTRODUCTION: Biallelic variants in Fanconi Anemia-associated Nuclease 1 (FAN1) cause karyomegalic tubulointerstitial nephropathy (KIN), a condition poorly characterized in terms of kidney survival, patient survival, and clinical characteristics. Therefore, we undertook a cross-sectional collaborative study to better characterize KIN-FAN1. METHODS: To gather data, we distributed a REDCap survey on clinical characteristics and genetic variants of KIN-FAN1 to colleagues and case report authors. RESULTS: Based on the survey, we identified 86 families affected (122 individuals) from 22 countries. There were 56 families (83 individuals) with a genetic diagnosis of KIN-FAN1, including 38 distinct FAN1 variants, and 30 families (39 individuals) with KIN with no predisposing risk factors and without molecular FAN1 testing. The median age at presentation was 38.5 years (interquartile range: 29-43), 62% male. Of the cohort, 46% had asymptomatic elevation of liver function tests, 39% had pulmonary complications, and 6% developed cancer. The median age of kidney failure was 45 years (95% confidence interval (CI): 38-56). Of the cohort, 27.1% died at a median age of 55 years (95% CI: 43-75). Pulmonary complications was/were the cause of death in 15.4% of patients on dialysis and 23.1% of kidney transplant recipients. Compared to other variants, patients with the p.W707X-FAN1 variant were at a significantly higher risk of pulmonary complications (adjusted odds ratio: 8.26 (95% CI: 1.7-40.1) and had a significantly shorter lifespan (hazard ratio: 3.24 (95% CI: 1.13-9.28). No genetic covariates were statistically associated with the progression to kidney failure. CONCLUSIONS: Patients with KIN-FAN1 develop kidney failure at a median age of 45 years. Survival is compromised with many dying of pulmonary disease.
Interpretation of glycaemic variability in type 2 diabetes mellitus patients on maintenance haemodialysis using continuous glucose monitoring Asokan Arunkumar, Varadharajan Jayaprakash, Rajendran Rajasekar, Rishabh Gupta, Mathew Gerry George Nefrologia, 2026 BACKGROUND: Diabetes mellitus is the leading cause of end-stage renal disease, accounting for approximately 40% of cases. Data on glycaemic metrics in diabetic population on maintenance haemodialysis is sparse. The role of continuous glucose monitoring in this population remains underexplored. METHODS: This prospective observational study aimed to comprehensively characterize glycaemic variability using continuous glucose monitoring in patients with type 2 diabetes mellitus undergoing maintenance haemodialysis. 25 patients aged between 18 and 70 years with more than 3 months of dialysis vintage were included in the study. After collecting socio-demographic and clinical data, an ambulatory glucose profile sensor was applied to the patient's upper limb before starting their scheduled dialysis session. Sensors measured the interstitial fluid glucose every 15min, and a total of 96 readings were taken per day, continuously for 14 days (336h). RESULTS: For statistical analysis, the study population was broadly divided into 2 major groups, one which required insulin for their glycaemic management and the other requiring an oral hypoglycaemic agent, linagliptin. Statistical analysis was performed using SPSS software version 26.0 (IBM Corp., Armonk, NY). In both the groups, glycaemic excursion was observed, with dialysis days having high mean glucose values than non-dialysis days, and the observation was more prominent in the insulin-treated group. The mean glucose levels were lower in the nocturnal period in both the groups. It was noticed that the overall glycaemic variability, glycaemic variability in both dialysis and non-dialysis days were lower in linagliptin-treated group. CONCLUSION: This study demonstrated significant differences in glycaemic variability based on antidiabetic treatment modality in haemodialysis population. Continuous glucose monitoring is an invaluable tool to study glycaemic metrics and guide therapy in haemodialysis population.
An observational study to assess the efficacy of ambulatory blood pressure monitoring in hypertension management among chronic kidney disease patients Rishabh Gupta, Varadharajan Jayaprakash, Arunkumar Asokan, Gerry George Mathew Revista Colombiana De Nefrologia, 2026 Introduction: Chronic kidney disease (CKD) poses a significant global health challenge and is often associated with hypertension (HTN) and cardiovascular diseases (CVD). Ambulatory blood pressure monitoring (ABPM) is a promising approach for precise blood pressure assessment, particularly in patients with chronic kidney disease. This study aimed to evaluate the efficacy of ABPM in managing blood pressure (BP) in patients with end-stage renal disease (ESRD) undergoing haemodialysis. Objective: This study aimed to compare the effectiveness of ambulatory blood pressure monitoring as an adjunct to routine blood pressure management in achieving optimal blood pressure control among patients on haemodialysis. The secondary objectives included a study of the variation in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) at baseline and at 3 months, along with variations of night-time and daytime blood pressure in haemodialysis patients. Materials and methods: A comparative prospective study was conducted, enrolling 62 patients with chronic kidney disease undergoing haemodialysis twice weekly. ABPM was added to the routine blood pressure monitoring in the experimental group, whereas only routine blood pressure monitoring was conducted in the control group. Demographic data, pre- and post-haemodialysis blood pressure, ABPM recordings, and laboratory parameters were collected. Data analysis included descriptive statistics, t-tests, and chi-square tests. Results: The mean ages of participants in the experimental and control groups were 52 ± 16.7 years and 47.9 ± 14.3 years, respectively. The study found that ABPM significantly improved blood pressure control compared with routine monitoring at the end of 3 months. Statistically significant differences were observed in mean systolic blood pressure (140 ± 12.7 vs. 151 ± 17.6, P=0.006), diastolic blood pressure (84 ± 6.2 vs. 89 ± 8.6, P=0.011) and mean arterial pressure (106 ± 7 vs. 110 ± 8.4, P=0.046) between the two groups. Conclusion: Our study emphasizes ABPM's vital role in improving blood pressure management in CKD patients on haemodialysis and also in identifying the nuances of blood pressure variation in this vulnerable population.
Ethical Aspects and Implications of Commercialization of Renal Transplantation: A Global Perspective Gerry George Mathew Indian Journal of Transplantation, 2026 End-stage renal disease affects approximately 4.9 million individuals globally, with kidney transplantation providing optimal treatment outcomes. However, organ scarcity has led to commercial transplantation practices that raise significant ethical concerns. A comprehensive literature review using PubMed, EMBASE, and Cochrane databases (2010–2024), focusing on clinical outcomes, ethical frameworks, and regulatory policies regarding commercial transplantation, was conducted. Commercial transplantation accounts for 5%–10% of kidney transplants performed annually worldwide. Clinical outcomes demonstrate consistently inferior results compared to altruistic transplant systems, with higher perioperative complications (40%–65% vs. 10%–15%), increased acute rejection rates (30%–50% vs. 10%–20%), and reduced 5-year graft survival (60%–75% vs. 85%–90%). Ethical concerns include exploitation of vulnerable population, commodification of human organs, and violation of fundamental bioethical principles. Commercial renal transplantation presents complex ethical challenges requiring a comprehensive policy that address underlying organ shortage while protecting the vulnerable population and maintaining the highest clinical standards.
Clinical implications of serum anti-PLA2R levels and glomerular PLA2R deposits in primary membranous nephropathy Giornale Italiano Di Nefrologia Organo Ufficiale Della Societa Italiana Di Nefrologia, 2024
Autosomal Dominant Calpainopathy in a Diabetic Patient Complicated by Functional Gitelman Syndrome VJ Kabilash Manivalli Peterpalaniswami , Krishnaswamy Madhavan , Gerry ... Case reports in medicine , 2026 2026
Cell based therapy in chronic kidney disease: emerging evidence for a fifth pillar in guideline directed medical therapy GG Mathew Clinical and experimental Nephrology , 2026 2026
Mitochondrial metabolism and dynamics in the development of diabetic kidney disease GG Mathew Kidney research and clinical practice , 2026 2026
Reappraisal of Goal-Directed Medical Therapy in Diabetic Kidney Disease: Beyond the Quadruple Therapy Paradigm GG Mathew Giornale Italiano Di Nefrologia , 2026 2026
An observational study to assess the efficacy of ambulatory blood pressure monitoring in hypertension management among chronic kidney disease patients R Gupta, V Jayaprakash, A Asokan, GG Mathew Revista Colombiana de Nefrología 13 (1) , 2026 2026
Fish Oil Supplementation and Cardiovascular Mortality in Chronic Kidney Disease: A Paradigm Shift from the PISCES Trial GG Mathew Turkish Journal of Nephrology , 2026 2026
Ethical Aspects and Implications of Commercialization of Renal Transplantation: A Global Perspective GG Mathew Indian Journal of Transplantation 20 (1) , 2026 2026
Cost-effective Approach for ABO-incompatible Renal Transplantation with High Titres GG Mathew Indian Journal of Transplantation 20 (1) , 2026 2026
Twice versus Thrice Weekly Haemodialysis in the Elderly: Are we ‘DLITE’d? GG Mathew Kidney international reports , 2026 2026
Genotype-phenotype characteristics and disease progression of FAN1-related karyomegalic tubulointerstitial nephropathy Kidney international , 2026 2026 Citations: 1
Role of Neutrophil Gelatinase–Associated Lipocalin in Early Acute Kidney Injury Detection and Hemodialysis Prediction V Maiti, J., Mathew, G. G., Ghosh, T., Viodhini, V. M., Suyampirakasam, I ... Turkish Journal of Nephrology , 2026 2026
Espironolactona na doença renal em estágio terminal: uma história de “desempenho abaixo do esperado” GG Mathew Brazilian Journal of Nephrology 48, e20250270 , 2026 2026
The utility of eGFR difference (eGFRCystatin C–eGFRCreatinine) in the diagnosis, prognosis, and management of chronic kidney disease: a comprehensive review GG Mathew Irish Journal of Medical Science (1971-), 1-10 , 2025 2025
Finrenone and sodium-glucose cotransporter 2 inhibitor polypill: how “CONFIDENT” are we? GG Mathew Korean Journal of Nephrology , 2025 2025
Unusual Cause of Headache in Lupus Nephritis GG Mathew, EG Chelvakumar, A Alwan International Journal of Rheumatic Diseases 28 (12), e70502 , 2025 2025
Interpretation of glycaemic variability in type 2 diabetes mellitus patients on maintenance haemodialysis using continuous glucose monitoring A Arunkumar, V Jayaprakash, R Rajasekar, R Gupta, MG George Nefrología, 501468 , 2025 2025
Spironolactone in end stage renal disease: A story of under’ACHIEVE’ment GG Mathew Brazilian Journal of Nephrology 48 (1), e20250270 , 2025 2025
Linagliptin-Induced Bullous Pemphigoid in Chronic Kidney Disease PCT Gerry George Mathew Turkish Journal of Nephrology , 2025 2025
Late‑onset Antibody‑mediated Rejection in a Failed Allograft Masquerading as Pyrexia with Hematuria ST Varadharajan Jayaprakash, Tanuj Moses Lamech, Gerry George Mathew* Indian Journal of Transplantation 9 (3) , 2025 2025
Role of hydroxychloroquine in primary glomerular disease - a systematic review and meta-analysis of the current evidence PMVJ Gerry George Mathew, Shanmugam Sundaramurthy BMC nephrology , 2025 2025 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Low-Dose Rituximab in the Treatment of Primary Membranous Nephropathy – A Systematic Review and Meta-Analysis VJ Gerry George Mathew, Shanmugam Sundaramurthy, Prakash Muthuperumal Giornale Italiano di nefrologia , 2024 2024 Citations: 9
Clinical implications of serum anti-PLA2R levels and glomerular PLA2R deposits in primary membranous nephropathy KC Gunda, GG Mathew, S Balasubramanian, KSS Kumar G Ital Nefrol 41 (2) , 2024 2024 Citations: 5
Kocuria rosea Sepsis in an Immunocompromised Patient: A Case Report JV Shanmuga Leela A , Jaya Lakshmi S S , Leela K V , Tanuj M. Lamech ... Cureus , 2024 2024 Citations: 3
The Effect of Dialysate Temperature on Dialysis Adequacy and Hemodynamic Stability: An Experimental Study with Crossover Design VJ Gerry George Mathew, Suganya Muthukarupiah, Muthamizh Muniappan, Judhajit ... Giornale Italiano di nefrologia , 2024 2024 Citations: 3
A Case Report and Literature Review of IgA Nephropathy Presenting as Nephrotic Syndrome in Polycythemia Vera KM R.Rajasekar,R.Nandakumar,Sourav.P.Singvi,Gerry George Mathew,V.Jayaprakash CEN Case Reports , 2024 2024 Citations: 3
The Educational Programs in Home Hemodialysis: Scoping Review F Cicala, F Fanari, M Petralito Giornale Italiano di Nefrologia 41 (5), 91-100 , 2024 2024 Citations: 2
Hashimoto’s thyroiditis masquerading as acute tubular injury and rhabdomyolysis GG Mathew, V Jayaprakash Brazilian Journal of Nephrology , 2024 2024 Citations: 2
Prevalence and Risk Factors of Heart Failure with Preserved Ejection Fraction in Middle-Aged Maintenance Haemodialysis Patients on a Twice-Weekly Schedule: Experience from a … VJ Gerry George Mathew, Narendhiran Pandurangan, Prakash Muthuperumal Giornale Italiano di Nefrologia 3 (41), 1-13 , 2024 2024 Citations: 2
Genotype-phenotype characteristics and disease progression of FAN1-related karyomegalic tubulointerstitial nephropathy Kidney international , 2026 2026 Citations: 1
Role of hydroxychloroquine in primary glomerular disease - a systematic review and meta-analysis of the current evidence PMVJ Gerry George Mathew, Shanmugam Sundaramurthy BMC nephrology , 2025 2025 Citations: 1
Molecular markers or clinical end points? What is the optimal monitoring tool for low-dose rituximab in membranous nephropathy in resource-limited settings? G mathew Journal of Nephrology , 2025 2025 Citations: 1
Spontaneous Colovaginal Fistula‐A Rare Chronic Complication in Lupus Nephritis I Rajakumar, J Nirmal, CD Anand, GG Mathew, V Jayaprakash International Journal of Rheumatic Diseases 28 (3), e70092 , 2025 2025 Citations: 1
Therapeutic efficacy of steroids in severe infection-related glomerulonephritis V Jayaprakash, D Jeyachandran, S Rathinam, S Sundararajan J Renal Inj Prev 14, e32213 , 2025 2025 Citations: 1
Stenotrophomonas maltophilia in Hemodialysis: An Opportunistic Pathogen or a Malevolent Foe TVJVLKVAAMGGV Jayaprakash Cureus , 2024 2024 Citations: 1
The Ineffectiveness of Osimertinib in Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Lung Adenocarcinoma With Bone Metastasis: A Case Report CH Livingston, B Harper, M George Cureus 16 (8) , 2024 2024 Citations: 1
An abysmal conundrum associated with a misplaced dialysis catheter GGMVJ Shruthi Muralidharan, Arunkumar Asokan, Nembian Raja Rajan Journal of Vascular Access , 2024 2024 Citations: 1
Correlation of Acoustic Radiation Force Impulse Imaging with Chronicity Markers in Native Renal Biopsy KSSK Gerry George Mathew, Krishna Chaitanya Gunda, K.C. Prakash, Sudhakar ... Giornale Italiano Di Nefrologia 4 (40) , 2023 2023 Citations: 1
Catheter related atrial thrombus caused by Abiotrophia defectiva: A case series and review of literature VR Gerry George Mathew , Kiran Kumar Kompella, Rajamahesh Jayabalan Journal of Vascular access , 2023 2023 Citations: 1
Lentiform fork sign in continuous ambulatory peritoneal dialysis S Muralidharan, GG Mathew, J Varadharajan, S Sailapathy, S Natarajan QJM: An International Journal of Medicine 116 (7), 586-587 , 2023 2023 Citations: 1
Case series of low dose rituximab for membranous nephropathy; a single centre experience SS Gerry George Mathew, Jayaprakash Varadharajan Journal of nephropathology 12 (DOI: 10.34172/jnp.2023.21440.) , 2023 2023 Citations: 1